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P26624 (GST28_SCHJA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase class-mu 28 kDa isozyme

Short name=GST 28
EC=2.5.1.18
Alternative name(s):
Sj28 antigen
Sj28GST
OrganismSchistosoma japonicum (Blood fluke)
Taxonomic identifier6182 [NCBI]
Taxonomic lineageEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

Protein attributes

Sequence length206 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer.

Miscellaneous

There are at least two isoenzymes of GST in S.japonicum.

Sequence similarities

Belongs to the GST superfamily. Mu family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Molecular functionTransferase
Gene Ontology (GO)
   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 206›206Glutathione S-transferase class-mu 28 kDa isozyme
PRO_0000185814

Regions

Domain‹1 – 81›81GST N-terminal
Domain83 – 206124GST C-terminal
Region36 – 405Glutathione binding By similarity
Region65 – 662Glutathione binding By similarity

Sites

Binding site51Glutathione By similarity
Binding site111Glutathione By similarity
Binding site481Glutathione; via amide nitrogen and carbonyl oxygen

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P26624 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: D1AD3707EDEABAA7

FASTA20623,393
        10         20         30         40         50         60 
VKLIYFNGRG RAEPIRMILV AAGVEFEDER IEFQDWPKIK PTIPGGRLPI VKITDKRGDV 

        70         80         90        100        110        120 
KTMSESLAIA RFIARKHNMM GDTDDEYYII EKMIGQVEDV ESEYHKTLIK PPEEKEKISK 

       130        140        150        160        170        180 
EILNGKVPIL LQAICETLKE STGNLTVGDK VTLADVVLIA SIDHITDLDK EFLTGKYPEI 

       190        200 
HKHRKHLLAT SPKLAKYLSE RHATAF 

« Hide

References

[1]"Comparison of the cloned genes of the 26- and 28-kilodalton glutathione S-transferases of Schistosoma japonicum and Schistosoma mansoni."
Henkle K.J., Davern K.M., Wright M.D., Ramos A.J., Mitchell G.F.
Mol. Biochem. Parasitol. 40:23-34(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sorsogon / Philippines.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M26914 mRNA. Translation: AAA29890.1.
PIRB44941.

3D structure databases

ProteinModelPortalP26624.
SMRP26624. Positions 1-206.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6182.P26624.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG122057.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGST28_SCHJA
AccessionPrimary (citable) accession number: P26624
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families