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P26619

- PGFRA_XENLA

UniProt

P26619 - PGFRA_XENLA

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Protein
Platelet-derived growth factor receptor alpha
Gene
pdgfra
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric pdgfa, homodimeric pdgfb, heterodimers formed by pdgfa and pdgfb or homodimeric pdgfc -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between pdgfra and pdgfrb. Phosphorylates pik3r1, plcg1, and ptpn11. Activation of plcg1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca2+ and the activation of protein kinase C. Phosphorylates pik3r1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the akt1 signaling pathway. Mediates activation of hras and of the MAP kinases mapk1/erk2 and/or mapk3/erk1. Promotes activation of stat family members stat1, stat3 and stat5a and/or stat5b. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor By similarity.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Enzyme regulationi

Present in an inactive conformation in the absence of bound ligand. Binding of pdgfa and/or pdgfb leads to dimerization and activation by autophosphorylation on tyrosine residues By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei629 – 6291ATP By similarity
Active sitei818 – 8181Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi601 – 6099ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. platelet-derived growth factor alpha-receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. chemotaxis Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Chemotaxis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 6726.

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-derived growth factor receptor alpha (EC:2.7.10.1)
Short name:
PDGF-R-alpha
Short name:
PDGFR-alpha
Alternative name(s):
Alpha platelet-derived growth factor receptor
Alpha-type platelet-derived growth factor receptor
Gene namesi
Name:pdgfra
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6072934. pdgfra.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein
Note: The activated receptor is rapidly internalized and degraded By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 530506Extracellular Reviewed prediction
Add
BLAST
Transmembranei531 – 55121Helical; Reviewed prediction
Add
BLAST
Topological domaini552 – 1087536Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 10871063Platelet-derived growth factor receptor alpha
PRO_0000016763Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 101 By similarity
Glycosylationi77 – 771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi104 – 1041N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi151 ↔ 192 By similarity
Glycosylationi216 – 2161N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi238 ↔ 293 By similarity
Glycosylationi282 – 2821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi309 – 3091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi356 – 3561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi362 – 3621N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi438 ↔ 503 By similarity
Glycosylationi461 – 4611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi471 – 4711N-linked (GlcNAc...) Reviewed prediction
Modified residuei574 – 5741Phosphotyrosine; by autocatalysis By similarity
Modified residuei576 – 5761Phosphotyrosine; by autocatalysis By similarity
Modified residuei722 – 7221Phosphotyrosine; by autocatalysis By similarity
Modified residuei733 – 7331Phosphotyrosine; by autocatalysis By similarity
Modified residuei744 – 7441Phosphotyrosine; by autocatalysis By similarity
Modified residuei756 – 7561Phosphotyrosine; by autocatalysis By similarity
Modified residuei764 – 7641Phosphotyrosine; by autocatalysis By similarity
Modified residuei849 – 8491Phosphotyrosine; by autocatalysis By similarity
Modified residuei988 – 9881Phosphotyrosine; by autocatalysis By similarity
Modified residuei1017 – 10171Phosphotyrosine; by autocatalysis By similarity

Post-translational modificationi

Ubiquitinated, leading to its degradation By similarity.
Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Interactioni

Subunit structurei

Interacts with homodimeric pdgfa, pdgfb and pdgfc, and with heterodimers formed by pdgfa and pdgfb. Monomer in the absence of bound ligand. Interaction with dimeric pdgfa, pdgfb and/or pdgfc leads to receptor dimerization, where both pdgfra homodimers and heterodimers with pdgfrb are observed By similarity.

Structurei

3D structure databases

ProteinModelPortaliP26619.
SMRiP26619. Positions 553-695, 785-951.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 11488Ig-like C2-type 1
Add
BLAST
Domaini118 – 21194Ig-like C2-type 2
Add
BLAST
Domaini217 – 30993Ig-like C2-type 3
Add
BLAST
Domaini315 – 40995Ig-like C2-type 4
Add
BLAST
Domaini417 – 519103Ig-like C2-type 5
Add
BLAST
Domaini595 – 970376Protein kinase
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004335.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR027290. PDGFRA.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016243. Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824. Tyr_kinase_rcpt_3_CS.
[Graphical view]
PANTHERiPTHR24416:SF52. PTHR24416:SF52. 1 hit.
PfamiPF07679. I-set. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF500950. Alpha-PDGF_receptor. 1 hit.
PIRSF000615. TyrPK_CSF1-R. 1 hit.
SMARTiSM00409. IG. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26619-1 [UniParc]FASTAAdd to Basket

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MMPAMRASLI LGCLLIIGPW AILAENPLPT IFPDKDELVQ ALHSSFTLKC     50
TGESEVSWQN PNSNPEKQNV VIRSEENNSG LFVSILEVSD ASAFDTGLYT 100
CYHNHTQTEE SEIEGTDIYI YVPDPNVPFA PPGLFDHIIV VEEDESALVP 150
CRTTDPSSEV TLKNIESSRT VFAFYDSKQG FAGNFPPGSY ICETTSNKMV 200
YQTEPYILQT WKATHNISVE MEAPKTMFRA GETIAIDCIV LDNEVVDLKW 250
TYPGKQRGVG IRNVEESKVP YQRLVYTLTL ANATTEDSGE YECAVIHATL 300
DNRVVKKTNI TVHEKGFIDL EPMFGSEEFA NLHEVKSFIV NLHAYPTPGL 350
FWLKDNRTLS ENLTEITTSI VTTKETRFQS KLKLIRAKEE DSGLYTLVAQ 400
NDRETKSYSF ILQIKVPALI LELVDKHHGA SGEQTVGCLA KGMPVPDVEW 450
LVCKDIKRCN NDTLWSILAT NGSEISMETH QDDEQIESQV TFKKIEETMA 500
IRCIAKNELG VVARELKLVA PTLRSELTVA AAVLVLLVIV IISLIVLVII 550
WKQKPRYEIR WRVIESISPD GHEYIYVDPM QLPYDSRWEF PRDGLVLGRI 600
LGSGAFGKVV EGAAYGLSRS QPVMKVAVKM LKPTARSSEK QALMSELKIM 650
THLGAHLNIV NLLGACTKSG PIYIITEYCF YGDLVNYLHK NRDNFQSRHP 700
EKPKKDLDIF GLNPADESTR SYVILSFENN GDYMDMKQAD TMQYVPMLEM 750
KEPSKYSDIQ RSLYDRPASY KKKPLSEVKN ILSDDGFEGL TVLDLLSFTY 800
QVARGMEFLA SKNCVHRDLA ARNVLLAHGK IVKICDFGLA RDIMHDSNYV 850
SKGSTFLPVK WMAPESIFDN LYTTLSDVWS FGILLWEIFS LGGTPYPGMI 900
VDSTFYNKIK SGYRMAKPDH ATHEVYDIMV KCWNSEPEKR PSFRHLSDIV 950
ESLLPMEYKR CYETVLHDFL KSDHPAVTRM RSDSDNSYIG VTYKNEHKMK 1000
DRESGFDEQR LSADSGYIIP LPDIDPVSED ESGKRNRHSS QTSEESAIET 1050
GSSSSTFIKR DDETIEDIDM MDDIGIDSSD LVEDSFL 1087
Length:1,087
Mass (Da):122,699
Last modified:August 1, 1992 - v1
Checksum:iA621E6B0A5BADCA6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M80798 mRNA. Translation: AAA49929.1.
PIRiI51552.
UniGeneiXl.20029.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M80798 mRNA. Translation: AAA49929.1 .
PIRi I51552.
UniGenei Xl.20029.

3D structure databases

ProteinModelPortali P26619.
SMRi P26619. Positions 553-695, 785-951.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Xenbasei XB-GENE-6072934. pdgfra.

Phylogenomic databases

HOVERGENi HBG004335.

Enzyme and pathway databases

BRENDAi 2.7.10.1. 6726.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR027290. PDGFRA.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016243. Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824. Tyr_kinase_rcpt_3_CS.
[Graphical view ]
PANTHERi PTHR24416:SF52. PTHR24416:SF52. 1 hit.
Pfami PF07679. I-set. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF500950. Alpha-PDGF_receptor. 1 hit.
PIRSF000615. TyrPK_CSF1-R. 1 hit.
SMARTi SM00409. IG. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The Xenopus platelet-derived growth factor alpha receptor: cDNA cloning and demonstration that mesoderm induction establishes the lineage-specific pattern of ligand and receptor gene expression."
    Jones S.D., Ho L., Smith J.C., Yordan C., Stiles C.D., Mercola M.
    Dev. Genet. 14:185-193(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPGFRA_XENLA
AccessioniPrimary (citable) accession number: P26619
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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