Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Platelet-derived growth factor receptor alpha

Gene

Pdgfra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca2+ and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.4 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Enzyme regulationi

Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by imatinib, nilotinib and sorafenib (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei627ATPPROSITE-ProRule annotation1
Active sitei818Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi599 – 607ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • adrenal gland development Source: MGI
  • anatomical structure morphogenesis Source: MGI
  • animal organ morphogenesis Source: MGI
  • cardiac myofibril assembly Source: UniProtKB
  • cell chemotaxis Source: UniProtKB
  • cell migration Source: UniProtKB
  • cellular response to amino acid stimulus Source: MGI
  • cellular response to reactive oxygen species Source: MGI
  • embryonic cranial skeleton morphogenesis Source: UniProtKB
  • embryonic digestive tract morphogenesis Source: UniProtKB
  • estrogen metabolic process Source: MGI
  • extracellular matrix organization Source: MGI
  • face morphogenesis Source: MGI
  • female gonad development Source: MGI
  • hematopoietic progenitor cell differentiation Source: MGI
  • in utero embryonic development Source: MGI
  • Leydig cell differentiation Source: MGI
  • lung development Source: MGI
  • luteinization Source: MGI
  • male genitalia development Source: MGI
  • metanephric glomerular capillary formation Source: UniProtKB
  • negative regulation of platelet activation Source: UniProtKB
  • odontogenesis of dentin-containing tooth Source: MGI
  • palate development Source: MGI
  • peptidyl-tyrosine phosphorylation Source: UniProtKB
  • phosphatidylinositol-mediated signaling Source: UniProtKB
  • platelet aggregation Source: UniProtKB
  • platelet-derived growth factor receptor-alpha signaling pathway Source: UniProtKB
  • platelet-derived growth factor receptor signaling pathway Source: MGI
  • positive regulation of cell migration Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway Source: BHF-UCL
  • positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  • positive regulation of DNA replication Source: UniProtKB
  • positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • positive regulation of fibroblast proliferation Source: UniProtKB
  • positive regulation of phosphatidylinositol 3-kinase activity Source: UniProtKB
  • positive regulation of phospholipase C activity Source: MGI
  • protein autophosphorylation Source: UniProtKB
  • regulation of chemotaxis Source: MGI
  • regulation of mesenchymal stem cell differentiation Source: UniProtKB
  • retina vasculature development in camera-type eye Source: UniProtKB
  • signal transduction involved in regulation of gene expression Source: MGI
  • skeletal system morphogenesis Source: MGI
  • wound healing Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Chemotaxis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-derived growth factor receptor alpha (EC:2.7.10.1)
Short name:
PDGF-R-alpha
Short name:
PDGFR-alpha
Alternative name(s):
Alpha platelet-derived growth factor receptor
Alpha-type platelet-derived growth factor receptor
CD140 antigen-like family member A
Platelet-derived growth factor alpha receptor
CD_antigen: CD140a
Gene namesi
Name:Pdgfra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:97530. Pdgfra.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 528ExtracellularSequence analysisAdd BLAST504
Transmembranei529 – 549HelicalSequence analysisAdd BLAST21
Topological domaini550 – 1089CytoplasmicSequence analysisAdd BLAST540

GO - Cellular componenti

  • cell surface Source: BHF-UCL
  • cytoplasm Source: UniProtKB
  • external side of plasma membrane Source: MGI
  • integral component of plasma membrane Source: UniProtKB
  • intrinsic component of plasma membrane Source: MGI
  • membrane Source: MGI
  • microvillus Source: MGI
  • nucleus Source: UniProtKB
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Embryonically lethal. Most embryos survive up to 13 dpc, but display important defects in skeleton development, including spina bifida, fusions of cervical vertebrae and ribs, and incomplete fusion of the skull parietal bone. Embryos display also abnormal mucosa lining the gastrointestinal tract, including fewer and misshapen villi and loss of pericryptal mesenchyme. At about 16 dpc, embryos display extensive hemorrhaging.3 Publications

Keywords - Diseasei

Proto-oncogene

Chemistry databases

ChEMBLiCHEMBL2096980.
GuidetoPHARMACOLOGYi1803.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001676125 – 1089Platelet-derived growth factor receptor alphaAdd BLAST1065

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi49 ↔ 100PROSITE-ProRule annotation
Glycosylationi76N-linked (GlcNAc...)Sequence analysis1
Glycosylationi89N-linked (GlcNAc...)Sequence analysis1
Glycosylationi103N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi150 ↔ 189PROSITE-ProRule annotation
Glycosylationi179N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi235 ↔ 290PROSITE-ProRule annotation
Glycosylationi353N-linked (GlcNAc...)Sequence analysis1
Glycosylationi359N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi435 ↔ 501PROSITE-ProRule annotation
Glycosylationi458N-linked (GlcNAc...)Sequence analysis1
Glycosylationi468N-linked (GlcNAc...)Sequence analysis1
Glycosylationi506N-linked (GlcNAc...)Sequence analysis1
Modified residuei572Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei574Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei720Phosphotyrosine; by autocatalysisCurated1
Modified residuei731Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei742Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei754Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei762Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei768Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei849Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei988Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei1018Phosphotyrosine; by autocatalysisBy similarity1

Post-translational modificationi

Ubiquitinated, leading to its degradation.By similarity
Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-731 and Tyr-742 is important for interaction with PIK3R1. Phosphorylation at Tyr-720 and Tyr-754 is important for interaction with PTPN11. Phosphorylation at Tyr-762 is important for interaction with CRK. Phosphorylation at Tyr-572 and Tyr-574 is important for interaction with SRC and SRC family members. Phosphorylation at Tyr-988 and Tyr-1018 is important for interaction with PLCG1 (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP26618.
PaxDbiP26618.
PeptideAtlasiP26618.
PRIDEiP26618.

PTM databases

iPTMnetiP26618.
PhosphoSitePlusiP26618.
SwissPalmiP26618.

Expressioni

Tissue specificityi

Focally expressed in cortical interstitial cells and highly expressed in the interstitium of the papillary region. Also expressed by adventitial cells in arterial vessels. Up-regulated in areas of renal fibrosis. In mice with unilateral ureteral obstruction, expression in cortical interstitial cells becomes prominent at day 4 which increases progressively until day 14.1 Publication

Gene expression databases

BgeeiENSMUSG00000029231.
ExpressionAtlasiP26618. baseline and differential.
GenevisibleiP26618. MM.

Interactioni

Subunit structurei

Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand. Interaction with dimeric PDGFA, PDGFB and/or PDGFC leads to receptor dimerization, where both PDGFRA homodimers and heterodimers with PDGFRB are observed. Interacts (tyrosine phosphorylated) with SHB (via SH2 domain). Interacts (tyrosine phosphorylated) with SHF (via SH2 domain). Interacts (tyrosine phosphorylated) with SRC (via SH2 domain). Interacts (tyrosine phosphorylated) with PIK3R1. Interacts (tyrosine phosphorylated) with PLCG1 (via SH2 domain). Interacts (tyrosine phosphorylated) with CRK, GRB2 and GRB7 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202088. 1 interactor.
IntActiP26618. 3 interactors.
MINTiMINT-4107325.
STRINGi10090.ENSMUSP00000000476.

Chemistry databases

BindingDBiP26618.

Structurei

3D structure databases

ProteinModelPortaliP26618.
SMRiP26618.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 113Ig-like C2-type 1Add BLAST89
Domaini117 – 201Ig-like C2-type 2Add BLAST85
Domaini202 – 306Ig-like C2-type 3Add BLAST105
Domaini319 – 410Ig-like C2-type 4Add BLAST92
Domaini414 – 517Ig-like C2-type 5Add BLAST104
Domaini593 – 954Protein kinasePROSITE-ProRule annotationAdd BLAST362

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118923.
HOGENOMiHOG000112009.
HOVERGENiHBG004335.
InParanoidiP26618.
KOiK04363.
OMAiDSAIIPC.
OrthoDBiEOG091G01TL.
PhylomeDBiP26618.
TreeFamiTF325768.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR027290. PDGFRA.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016243. Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824. Tyr_kinase_rcpt_3_CS.
[Graphical view]
PANTHERiPTHR24416:SF52. PTHR24416:SF52. 3 hits.
PfamiPF07679. I-set. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF500950. Alpha-PDGF_receptor. 1 hit.
PIRSF000615. TyrPK_CSF1-R. 1 hit.
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P26618-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTSHQVFLV LSCLLTGPGL ISCQLLLPSI LPNENEKIVQ LNSSFSLRCV
60 70 80 90 100
GESEVSWQHP MSEEDDPNVE IRSEENNSGL FVTVLEVVNA SAAHTGWYTC
110 120 130 140 150
YYNHTQTDES EIEGRHIYIY VPDPDMAFVP LGMTDSLVIV EEDDSAIIPC
160 170 180 190 200
RTTDPETQVT LHNNGRLVPA SYDSRQGFNG TFSVGPYICE ATVKGRTFKT
210 220 230 240 250
SEFNVYALKA TSELNLEMDA RQTVYKAGET IVVTCAVFNN EVVDLQWTYP
260 270 280 290 300
GEVRNKGITM LEEIKLPSIK LVYTLTVPKA TVKDSGEYEC AARQATKEVK
310 320 330 340 350
EMKRVTISVH EKGFVEIEPT FGQLEAVNLH EVREFVVEVQ AYPTPRISWL
360 370 380 390 400
KDNLTLIENL TEITTDVQKS QETRYQSKLK LIRAKEEDSG HYTIIVQNED
410 420 430 440 450
DVKSYTFELS TLVPASILDL VDDHHGSGGG QTVRCTAEGT PLPEIDWMIC
460 470 480 490 500
KHIKKCNNDT SWTVLASNVS NIITELPRRG RSTVEGRVSF AKVEETIAVR
510 520 530 540 550
CLAKNNLSVV ARELKLVAPT LRSELTVAAA VLVLLVIVIV SLIVLVVIWK
560 570 580 590 600
QKPRYEIRWR VIESISPDGH EYIYVDPMQL PYDSRWEFPR DGLVLGRILG
610 620 630 640 650
SGAFGKVVEG TAYGLSRSQP VMKVAVKMLK PTARSSEKQA LMSELKIMTH
660 670 680 690 700
LGPHLNIVNL LGACTKSGPI YIITEYCFYG DLVNYLHKNR DSFMSQHPEK
710 720 730 740 750
PKKDLDIFGL NPADESTRSY VILSFENNGD YMDMKQADTT QYVPMLERKE
760 770 780 790 800
VSKYSDIQRS LYDRPASYKK KSMLDSEVKN LLSDDDSEGL TLLDLLSFTY
810 820 830 840 850
QVARGMEFLA SKNCVHRDLA ARNVLLAQGK IVKICDFGLA RDIMHDSNYV
860 870 880 890 900
SKGSTFLPVK WMAPESIFDN LYTTLSDVWS YGILLWEIFS LGGTPYPGMM
910 920 930 940 950
VDSTFYNKIK SGYRMAKPDH ATSEVYEIMV QCWNSEPEKR PSFYHLSEIV
960 970 980 990 1000
ENLLPGQYKK SYEKIHLDFL KSDHPAVARM RVDSDNAYIG VTYKNEEDKL
1010 1020 1030 1040 1050
KDWEGGLDEQ RLSADSGYII PLPDIDPVPE EEDLGKRNRH SSQTSEESAI
1060 1070 1080
ETGSSSSTFI KREDETIEDI DMMDDIGIDS SDLVEDSFL
Length:1,089
Mass (Da):122,683
Last modified:February 26, 2008 - v3
Checksum:i07AAFD2BAA12533A
GO
Isoform 2 (identifier: P26618-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     775-790: DSEVKNLLSDDDSEGL → GKSAHAHSGKYDLSVV
     791-1089: Missing.

Note: No experimental confirmation available.
Show »
Length:790
Mass (Da):88,629
Checksum:iFE13756876B68B95
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65D → E in AAA39733 (PubMed:2174116).Curated1
Sequence conflicti65D → E in AAA39904 (PubMed:1321404).Curated1
Sequence conflicti192T → A in AAA39733 (PubMed:2174116).Curated1
Sequence conflicti202E → A in AAA39733 (PubMed:2174116).Curated1
Sequence conflicti252E → G in AAA39733 (PubMed:2174116).Curated1
Sequence conflicti271L → V in AAA39733 (PubMed:2174116).Curated1
Sequence conflicti322G → S in AAA39733 (PubMed:2174116).Curated1
Sequence conflicti326A → P in AAA39733 (PubMed:2174116).Curated1
Sequence conflicti439 – 440GT → EG in AAA39733 (PubMed:2174116).Curated2
Sequence conflicti472I → V in BAE37548 (PubMed:16141072).Curated1
Sequence conflicti529A → E in AAA39733 (PubMed:2174116).Curated1
Sequence conflicti737A → D in AAA39733 (PubMed:2174116).Curated1
Sequence conflicti849Y → D in AAA39733 (PubMed:2174116).Curated1
Sequence conflicti936E → D in AAA39733 (PubMed:2174116).Curated1
Sequence conflicti950V → L in AAA39733 (PubMed:2174116).Curated1
Sequence conflicti1005G → S in AAA39904 (PubMed:1321404).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031877775 – 790DSEVK…DSEGL → GKSAHAHSGKYDLSVV in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_031878791 – 1089Missing in isoform 2. 1 PublicationAdd BLAST299

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57683 mRNA. Translation: AAA39733.1.
M84607 mRNA. Translation: AAA39904.1.
AK081664 mRNA. Translation: BAC38283.1.
AK136490 mRNA. Translation: BAE23004.1.
AK147267 mRNA. Translation: BAE27808.1.
AK163952 mRNA. Translation: BAE37548.1.
BC053036 mRNA. Translation: AAH53036.1.
CCDSiCCDS19351.1. [P26618-1]
PIRiI57511. S33727.
RefSeqiNP_001076785.1. NM_001083316.1. [P26618-1]
NP_035188.2. NM_011058.2. [P26618-1]
XP_006504324.1. XM_006504261.3. [P26618-1]
XP_006504325.1. XM_006504262.3. [P26618-1]
XP_006504326.1. XM_006504263.3. [P26618-1]
UniGeneiMm.221403.

Genome annotation databases

EnsembliENSMUST00000000476; ENSMUSP00000000476; ENSMUSG00000029231. [P26618-1]
ENSMUST00000168162; ENSMUSP00000127173; ENSMUSG00000029231. [P26618-1]
ENSMUST00000201711; ENSMUSP00000143891; ENSMUSG00000029231. [P26618-2]
ENSMUST00000202681; ENSMUSP00000143906; ENSMUSG00000029231. [P26618-2]
GeneIDi18595.
KEGGimmu:18595.
UCSCiuc008xub.1. mouse. [P26618-2]
uc008xuc.1. mouse. [P26618-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57683 mRNA. Translation: AAA39733.1.
M84607 mRNA. Translation: AAA39904.1.
AK081664 mRNA. Translation: BAC38283.1.
AK136490 mRNA. Translation: BAE23004.1.
AK147267 mRNA. Translation: BAE27808.1.
AK163952 mRNA. Translation: BAE37548.1.
BC053036 mRNA. Translation: AAH53036.1.
CCDSiCCDS19351.1. [P26618-1]
PIRiI57511. S33727.
RefSeqiNP_001076785.1. NM_001083316.1. [P26618-1]
NP_035188.2. NM_011058.2. [P26618-1]
XP_006504324.1. XM_006504261.3. [P26618-1]
XP_006504325.1. XM_006504262.3. [P26618-1]
XP_006504326.1. XM_006504263.3. [P26618-1]
UniGeneiMm.221403.

3D structure databases

ProteinModelPortaliP26618.
SMRiP26618.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202088. 1 interactor.
IntActiP26618. 3 interactors.
MINTiMINT-4107325.
STRINGi10090.ENSMUSP00000000476.

Chemistry databases

BindingDBiP26618.
ChEMBLiCHEMBL2096980.
GuidetoPHARMACOLOGYi1803.

PTM databases

iPTMnetiP26618.
PhosphoSitePlusiP26618.
SwissPalmiP26618.

Proteomic databases

MaxQBiP26618.
PaxDbiP26618.
PeptideAtlasiP26618.
PRIDEiP26618.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000476; ENSMUSP00000000476; ENSMUSG00000029231. [P26618-1]
ENSMUST00000168162; ENSMUSP00000127173; ENSMUSG00000029231. [P26618-1]
ENSMUST00000201711; ENSMUSP00000143891; ENSMUSG00000029231. [P26618-2]
ENSMUST00000202681; ENSMUSP00000143906; ENSMUSG00000029231. [P26618-2]
GeneIDi18595.
KEGGimmu:18595.
UCSCiuc008xub.1. mouse. [P26618-2]
uc008xuc.1. mouse. [P26618-1]

Organism-specific databases

CTDi5156.
MGIiMGI:97530. Pdgfra.

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118923.
HOGENOMiHOG000112009.
HOVERGENiHBG004335.
InParanoidiP26618.
KOiK04363.
OMAiDSAIIPC.
OrthoDBiEOG091G01TL.
PhylomeDBiP26618.
TreeFamiTF325768.

Enzyme and pathway databases

BRENDAi2.7.10.1. 3474.

Miscellaneous databases

ChiTaRSiPdgfra. mouse.
PROiP26618.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029231.
ExpressionAtlasiP26618. baseline and differential.
GenevisibleiP26618. MM.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR027290. PDGFRA.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016243. Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824. Tyr_kinase_rcpt_3_CS.
[Graphical view]
PANTHERiPTHR24416:SF52. PTHR24416:SF52. 3 hits.
PfamiPF07679. I-set. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF500950. Alpha-PDGF_receptor. 1 hit.
PIRSF000615. TyrPK_CSF1-R. 1 hit.
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGFRA_MOUSE
AccessioniPrimary (citable) accession number: P26618
Secondary accession number(s): Q3TQ37
, Q62046, Q7TSJ3, Q8C4N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: February 26, 2008
Last modified: November 30, 2016
This is version 173 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.