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Protein

High mobility group protein B2

Gene

HMGB2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner (By similarity). Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA (PubMed:14672558). Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi9 – 79HMG box 1PROSITE-ProRule annotationAdd BLAST71
DNA bindingi95 – 163HMG box 2PROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

  • DNA binding, bending Source: AgBase
  • drug binding Source: AgBase
  • four-way junction DNA binding Source: AgBase

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA recombination, Immunity, Inflammatory response, Innate immunity, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group protein B2
Alternative name(s):
High mobility group protein 2
Short name:
HMG-2
Gene namesi
Name:HMGB2
Synonyms:HMG2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000485382 – 207High mobility group protein B2Add BLAST206

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 45In disulfide HMGB2By similarity
Modified residuei23Cysteine sulfonic acid (-SO3H); alternateBy similarity1
Modified residuei45Cysteine sulfonic acid (-SO3H); alternateBy similarity1
Modified residuei106Cysteine sulfonic acid (-SO3H)By similarity1

Post-translational modificationi

Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB2 (HMGB2C23hC45hC106h), 2- disulfide HMGB2 (HMGB2C23-C45C106h) and 3- sulfonyl HMGB2 (HMGB2C23soC45soC106so).By similarity

Keywords - PTMi

Disulfide bond, Oxidation

Proteomic databases

PaxDbiP26584
PRIDEiP26584

Interactioni

Protein-protein interaction databases

BioGridi676729, 1 interactor
STRINGi9031.ENSGALP00000017462

Structurei

3D structure databases

ProteinModelPortaliP26584
SMRiP26584
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi186 – 207Asp/Glu-rich (acidic)Add BLAST22

Sequence similaritiesi

Belongs to the HMGB family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0381 Eukaryota
COG5648 LUCA
HOGENOMiHOG000197861
HOVERGENiHBG009000
InParanoidiP26584
KOiK11295
PhylomeDBiP26584

Family and domain databases

Gene3Di1.10.30.10, 2 hits
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR017967 HMG_boxA_CS
IPR031075 HMGB2
PANTHERiPTHR13711:SF181 PTHR13711:SF181, 1 hit
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF09011 HMG_box_2, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 2 hits
SUPFAMiSSF47095 SSF47095, 2 hits
PROSITEiView protein in PROSITE
PS00353 HMG_BOX_1, 1 hit
PS50118 HMG_BOX_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26584-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKGDPNKPR GKMSSYAYFV QTCREEHKKK HPDSSVNFAE FSRKCSERWK
60 70 80 90 100
TMSSKEKGKF EEMAKGDKAR YDREMKNYVP PKGEKKGKKK DPNAPKRPPS
110 120 130 140 150
AFFLFCSEHR PKIKNDHPGL SIGDTAKKLG EMWSEQLAKD KQPYEQKAAK
160 170 180 190 200
LKEKYEKDIA AYRAKSKSDA GKKGPGRPAG SKKKAEPEEE EEEEEDEEEE

EEEEDEE
Length:207
Mass (Da):23,828
Last modified:January 23, 2007 - v2
Checksum:i1099C6EF3CC0B7FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24 – 25RE → PR in AAA48819 (PubMed:1601311).Curated2
Sequence conflicti137L → S in AAA48819 (PubMed:1601311).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83235 mRNA Translation: AAA48818.1
M80574 mRNA Translation: AAA48819.1
PIRiJC1114
JC1129
RefSeqiNP_990817.1, NM_205486.1
UniGeneiGga.4061

Genome annotation databases

GeneIDi396482
KEGGigga:396482

Similar proteinsi

Entry informationi

Entry nameiHMGB2_CHICK
AccessioniPrimary (citable) accession number: P26584
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health