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P26583

- HMGB2_HUMAN

UniProt

P26583 - HMGB2_HUMAN

Protein

High mobility group protein B2

Gene

HMGB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 150 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi9 – 7971HMG box 1PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi95 – 16369HMG box 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chemoattractant activity Source: UniProtKB
    2. damaged DNA binding Source: UniProtKB
    3. DNA binding Source: UniProtKB
    4. DNA binding, bending Source: UniProtKB
    5. double-stranded DNA binding Source: UniProtKB
    6. poly(A) RNA binding Source: UniProtKB
    7. protein binding Source: UniProtKB
    8. RAGE receptor binding Source: UniProtKB
    9. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    10. single-stranded DNA binding Source: UniProtKB
    11. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. apoptotic DNA fragmentation Source: Reactome
    2. apoptotic process Source: Reactome
    3. base-excision repair, DNA ligation Source: UniProtKB
    4. cell chemotaxis Source: UniProtKB
    5. cellular component disassembly involved in execution phase of apoptosis Source: Reactome
    6. cellular response to lipopolysaccharide Source: UniProtKB
    7. chromatin organization Source: UniProtKB
    8. DNA ligation involved in DNA repair Source: UniProtKB
    9. DNA topological change Source: UniProtKB
    10. male gonad development Source: Ensembl
    11. negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
    12. negative regulation of transcription, DNA-templated Source: BHF-UCL
    13. nucleosome assembly Source: UniProtKB
    14. phosphatidylinositol-mediated signaling Source: UniProtKB
    15. positive chemotaxis Source: GOC
    16. positive regulation of DNA binding Source: UniProtKB
    17. positive regulation of endothelial cell proliferation Source: UniProtKB
    18. positive regulation of erythrocyte differentiation Source: UniProtKB
    19. positive regulation of megakaryocyte differentiation Source: UniProtKB
    20. positive regulation of nuclease activity Source: UniProtKB
    21. positive regulation of transcription, DNA-templated Source: UniProtKB
    22. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    23. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    24. response to steroid hormone Source: Ensembl
    25. spermatid nucleus differentiation Source: Ensembl
    26. V(D)J recombination Source: UniProtKB

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_13462. Activation of DNA fragmentation factor.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    High mobility group protein B2
    Alternative name(s):
    High mobility group protein 2
    Short name:
    HMG-2
    Gene namesi
    Name:HMGB2
    Synonyms:HMG2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:5000. HMGB2.

    Subcellular locationi

    GO - Cellular componenti

    1. condensed chromosome Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. extracellular space Source: UniProtKB
    4. nucleoplasm Source: Reactome
    5. nucleus Source: UniProtKB
    6. perinuclear region of cytoplasm Source: UniProtKB
    7. protein complex Source: UniProtKB

    Keywords - Cellular componenti

    Chromosome, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35091.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 209208High mobility group protein B2PRO_0000048534Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei30 – 301N6-acetyllysine1 Publication
    Modified residuei114 – 1141N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP26583.
    PaxDbiP26583.
    PeptideAtlasiP26583.
    PRIDEiP26583.

    PTM databases

    PhosphoSiteiP26583.

    Miscellaneous databases

    PMAP-CutDBP26583.

    Expressioni

    Gene expression databases

    ArrayExpressiP26583.
    BgeeiP26583.
    CleanExiHS_HMGB2.
    GenevestigatoriP26583.

    Organism-specific databases

    HPAiHPA003506.

    Interactioni

    Subunit structurei

    Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. Directly interacts with SET.1 Publication

    Protein-protein interaction databases

    BioGridi109391. 28 interactions.
    IntActiP26583. 6 interactions.
    MINTiMINT-240190.
    STRINGi9606.ENSP00000296503.

    Structurei

    3D structure databases

    ProteinModelPortaliP26583.
    SMRiP26583. Positions 1-166.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi186 – 20924Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the HMGB family.Curated
    Contains 2 HMG box DNA-binding domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5648.
    HOGENOMiHOG000197861.
    HOVERGENiHBG009000.
    InParanoidiP26583.
    KOiK11295.
    OMAiFCAEHRP.
    OrthoDBiEOG7WHHBQ.
    PhylomeDBiP26583.
    TreeFamiTF105371.

    Family and domain databases

    Gene3Di1.10.30.10. 2 hits.
    InterProiIPR009071. HMG_box_dom.
    IPR017967. HMG_boxA_CS.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    PF09011. HMG_box_2. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 2 hits.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 2 hits.
    PROSITEiPS00353. HMG_BOX_1. 1 hit.
    PS50118. HMG_BOX_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P26583-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKGDPNKPR GKMSSYAFFV QTCREEHKKK HPDSSVNFAE FSKKCSERWK    50
    TMSAKEKSKF EDMAKSDKAR YDREMKNYVP PKGDKKGKKK DPNAPKRPPS 100
    AFFLFCSEHR PKIKSEHPGL SIGDTAKKLG EMWSEQSAKD KQPYEQKAAK 150
    LKEKYEKDIA AYRAKGKSEA GKKGPGRPTG SKKKNEPEDE EEEEEEEDED 200
    EEEEDEDEE 209
    Length:209
    Mass (Da):24,034
    Last modified:January 23, 2007 - v2
    Checksum:i5E65292BC4AD8373
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti163 – 1631R → G in CAA78938. (PubMed:1475204)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M83665 Genomic DNA. Translation: AAA58659.1.
    X62534 mRNA. Translation: CAA44395.1.
    BT019782 mRNA. Translation: AAV38585.1.
    AK311864 mRNA. Translation: BAG34805.1.
    CH471056 Genomic DNA. Translation: EAX04758.1.
    CH471056 Genomic DNA. Translation: EAX04759.1.
    BC001063 mRNA. Translation: AAH01063.1.
    BC100019 mRNA. Translation: AAI00020.1.
    Z17240 mRNA. Translation: CAA78938.1.
    CCDSiCCDS3816.1.
    PIRiA42425. NSHUH2.
    S30221.
    RefSeqiNP_001124160.1. NM_001130688.1.
    NP_001124161.1. NM_001130689.1.
    NP_002120.1. NM_002129.3.
    UniGeneiHs.434953.

    Genome annotation databases

    EnsembliENST00000296503; ENSP00000296503; ENSG00000164104.
    ENST00000438704; ENSP00000404912; ENSG00000164104.
    ENST00000446922; ENSP00000393448; ENSG00000164104.
    GeneIDi3148.
    KEGGihsa:3148.
    UCSCiuc003ita.3. human.

    Polymorphism databases

    DMDMi123374.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M83665 Genomic DNA. Translation: AAA58659.1 .
    X62534 mRNA. Translation: CAA44395.1 .
    BT019782 mRNA. Translation: AAV38585.1 .
    AK311864 mRNA. Translation: BAG34805.1 .
    CH471056 Genomic DNA. Translation: EAX04758.1 .
    CH471056 Genomic DNA. Translation: EAX04759.1 .
    BC001063 mRNA. Translation: AAH01063.1 .
    BC100019 mRNA. Translation: AAI00020.1 .
    Z17240 mRNA. Translation: CAA78938.1 .
    CCDSi CCDS3816.1.
    PIRi A42425. NSHUH2.
    S30221.
    RefSeqi NP_001124160.1. NM_001130688.1.
    NP_001124161.1. NM_001130689.1.
    NP_002120.1. NM_002129.3.
    UniGenei Hs.434953.

    3D structure databases

    ProteinModelPortali P26583.
    SMRi P26583. Positions 1-166.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109391. 28 interactions.
    IntActi P26583. 6 interactions.
    MINTi MINT-240190.
    STRINGi 9606.ENSP00000296503.

    PTM databases

    PhosphoSitei P26583.

    Polymorphism databases

    DMDMi 123374.

    Proteomic databases

    MaxQBi P26583.
    PaxDbi P26583.
    PeptideAtlasi P26583.
    PRIDEi P26583.

    Protocols and materials databases

    DNASUi 3148.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296503 ; ENSP00000296503 ; ENSG00000164104 .
    ENST00000438704 ; ENSP00000404912 ; ENSG00000164104 .
    ENST00000446922 ; ENSP00000393448 ; ENSG00000164104 .
    GeneIDi 3148.
    KEGGi hsa:3148.
    UCSCi uc003ita.3. human.

    Organism-specific databases

    CTDi 3148.
    GeneCardsi GC04M174252.
    HGNCi HGNC:5000. HMGB2.
    HPAi HPA003506.
    MIMi 163906. gene.
    neXtProti NX_P26583.
    PharmGKBi PA35091.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5648.
    HOGENOMi HOG000197861.
    HOVERGENi HBG009000.
    InParanoidi P26583.
    KOi K11295.
    OMAi FCAEHRP.
    OrthoDBi EOG7WHHBQ.
    PhylomeDBi P26583.
    TreeFami TF105371.

    Enzyme and pathway databases

    Reactomei REACT_13462. Activation of DNA fragmentation factor.

    Miscellaneous databases

    ChiTaRSi HMGB2. human.
    GeneWikii HMGB2.
    GenomeRNAii 3148.
    NextBioi 12476.
    PMAP-CutDB P26583.
    PROi P26583.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P26583.
    Bgeei P26583.
    CleanExi HS_HMGB2.
    Genevestigatori P26583.

    Family and domain databases

    Gene3Di 1.10.30.10. 2 hits.
    InterProi IPR009071. HMG_box_dom.
    IPR017967. HMG_boxA_CS.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    PF09011. HMG_box_2. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 2 hits.
    PROSITEi PS00353. HMG_BOX_1. 1 hit.
    PS50118. HMG_BOX_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Structure of a gene coding for human HMG2 protein."
      Shirakawa H., Yoshida M.
      J. Biol. Chem. 267:6641-6645(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta and Skin.
    7. "A human HMG2 cDNA with a novel 3'-untranslated region."
      Alexandre S., Li W.W., Lee A.S.
      Nucleic Acids Res. 20:6413-6413(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-209.
    8. "HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A."
      Fan Z., Beresford P.J., Zhang D., Lieberman J.
      Mol. Cell. Biol. 22:2810-2820(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE SET COMPLEX, INTERACTION WITH SET.
    9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-30, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHMGB2_HUMAN
    AccessioniPrimary (citable) accession number: P26583
    Secondary accession number(s): B2R4K8, D3DP37, Q5U072
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 150 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3