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Protein

Aspartate aminotransferase P2, mitochondrial

Gene
N/A
Organism
Lupinus angustifolius (Narrow-leaved blue lupine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Important for the metabolism of amino acids and Krebs-cycle related organic acids. In plants, it is involved in nitrogen metabolism and in aspects of carbon and energy metabolism.

Miscellaneous

In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei86Aspartate; via amide nitrogenBy similarity1
Binding sitei182AspartateBy similarity1
Binding sitei235AspartateBy similarity1
Binding sitei428AspartateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate aminotransferase P2, mitochondrial (EC:2.6.1.1)
Alternative name(s):
Transaminase A
OrganismiLupinus angustifolius (Narrow-leaved blue lupine)
Taxonomic identifieri3871 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeGenisteaeLupinus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei‹1 – 49MitochondrionSequence analysisAdd BLAST›49
ChainiPRO_000000121250 – 454Aspartate aminotransferase P2, mitochondrialAdd BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei299N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PRIDEiP26563

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP26563
SMRiP26563
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR000796 Asp_trans
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11879 PTHR11879, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
PRINTSiPR00799 TRANSAMINASE
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26563-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SSLLSIPSLS LQYNDKLKVG GNSLRFSKEQ SNTFSNAKSS CRISMVAAVN
60 70 80 90 100
VSRFEGIPMA PPDPILGVSE AFRADTSDAK LNLGVGAYRT EELQPYVLKV
110 120 130 140 150
VNKAENLMLE RGQNKEYLAI EGLAAFNKAT AELLLGADNP AIKQQRVATV
160 170 180 190 200
QGLSGTGSLR LGAALIERYF PGAKVLISAP TWGNHKNIFN DARVPWSEYR
210 220 230 240 250
YYDPKTVGLD FEGMIEDIKA APEGTFVLLH GCAHNPTGID PTPEQWEKIA
260 270 280 290 300
DVIQEKNHIP FFDVAYQGFA SGSLDEDAAS VRLFVARGLE VLVAQSYSKN
310 320 330 340 350
LGLYAERIGA INVISSSPES AARVKSQLKR IARPMYSNPP VHGARIVADI
360 370 380 390 400
VGNPALFDEW KVEMEMMAGR IKNVRQQLYD SISSKDKSGK DWSFILKQIG
410 420 430 440 450
MFSYTGLNKN QSDNMTNKWH VYMTKDGRIS LAGLSLAKCE YLADAIIDSF

HYVS
Length:454
Mass (Da):49,916
Last modified:August 1, 1992 - v1
Checksum:i744CC12F1D81E739
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59761 mRNA Translation: CAA42430.1
PIRiS22465 XNYLB

Similar proteinsi

Entry informationi

Entry nameiAATM_LUPAN
AccessioniPrimary (citable) accession number: P26563
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 25, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health