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P26563 (AATM_LUPAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aspartate aminotransferase P2, mitochondrial

EC=2.6.1.1
Alternative name(s):
Transaminase A
OrganismLupinus angustifolius (Narrow-leaved blue lupin)
Taxonomic identifier3871 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeGenisteaeLupinus

Protein attributes

Sequence length454 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Important for the metabolism of amino acids and Krebs-cycle related organic acids. In plants, it is involved in nitrogen metabolism and in aspects of carbon and energy metabolism.

Catalytic activity

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.

Cofactor

Pyridoxal phosphate.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion matrix.

Miscellaneous

In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

Sequence similarities

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide‹1 – 49›49Mitochondrion Potential
Chain50 – 454405Aspartate aminotransferase P2, mitochondrial
PRO_0000001212

Sites

Binding site861Aspartate; via amide nitrogen By similarity
Binding site1821Aspartate By similarity
Binding site2351Aspartate By similarity
Binding site4281Aspartate By similarity

Amino acid modifications

Modified residue2991N6-(pyridoxal phosphate)lysine By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P26563 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 744CC12F1D81E739

FASTA45449,916
        10         20         30         40         50         60 
SSLLSIPSLS LQYNDKLKVG GNSLRFSKEQ SNTFSNAKSS CRISMVAAVN VSRFEGIPMA 

        70         80         90        100        110        120 
PPDPILGVSE AFRADTSDAK LNLGVGAYRT EELQPYVLKV VNKAENLMLE RGQNKEYLAI 

       130        140        150        160        170        180 
EGLAAFNKAT AELLLGADNP AIKQQRVATV QGLSGTGSLR LGAALIERYF PGAKVLISAP 

       190        200        210        220        230        240 
TWGNHKNIFN DARVPWSEYR YYDPKTVGLD FEGMIEDIKA APEGTFVLLH GCAHNPTGID 

       250        260        270        280        290        300 
PTPEQWEKIA DVIQEKNHIP FFDVAYQGFA SGSLDEDAAS VRLFVARGLE VLVAQSYSKN 

       310        320        330        340        350        360 
LGLYAERIGA INVISSSPES AARVKSQLKR IARPMYSNPP VHGARIVADI VGNPALFDEW 

       370        380        390        400        410        420 
KVEMEMMAGR IKNVRQQLYD SISSKDKSGK DWSFILKQIG MFSYTGLNKN QSDNMTNKWH 

       430        440        450 
VYMTKDGRIS LAGLSLAKCE YLADAIIDSF HYVS 

« Hide

References

[1]"Molecular cloning of a cDNA encoding aspartate aminotransferase-P2 from lupin root nodules."
Reynolds P.H.S., Smith L.A., Jones W.T., Dickson J.M.J., Jones S.J., Rodber K., Liddane C.P.
Plant Mol. Biol. 19:465-472(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Uniharvest.
Tissue: Root nodule.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X59761 mRNA. Translation: CAA42430.1.
PIRXNYLB. S22465.

3D structure databases

ProteinModelPortalP26563.
SMRP26563. Positions 52-448.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP26563.
ProMEXP26563.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.640.10. 1 hit.
InterProIPR004839. Aminotransferase_I/II.
IPR000796. Asp_trans.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11879. PTHR11879. 1 hit.
PfamPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
PRINTSPR00799. TRANSAMINASE.
SUPFAMSSF53383. SSF53383. 1 hit.
PROSITEPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAATM_LUPAN
AccessionPrimary (citable) accession number: P26563
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: February 19, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families