P26524 (NU4LC_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NAD(P)H-quinone oxidoreductase subunit 4L
EC=1.6.5.-

Alternative name(s):
NAD(P)H dehydrogenase subunit 4L
NADH-plastoquinone oxidoreductase subunit 4L
NDH-1, subunit 4L
NDH-E

Gene names

Name:	ndhE
Ordered Locus Names:	sll0522

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	103 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration By similarity. HAMAP MF_01456
Catalytic activity	NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol. HAMAP MF_01456
Subunit structure	NDH-1 can be composed of about 15 different subunits; different subcomplexes with different compositions have been identified which probably have different functions By similarity.
Subcellular location	Cellular thylakoid membrane; Multi-pass membrane protein By similarity HAMAP MF_01456.
Sequence similarities	Belongs to the complex I subunit 4L family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane Thylakoid
Domain	Transmembrane Transmembrane helix
Ligand	NAD NADP Plastoquinone
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP synthesis coupled electron transport Inferred from electronic annotation. Source: InterPro transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW thylakoid membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	oxidoreductase activity, acting on NADH or NADPH Inferred from electronic annotation. Source: InterPro quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 103	103	NAD(P)H-quinone oxidoreductase subunit 4L HAMAP MF_01456		PRO_0000118521
Regions
	Transmembrane	5 – 25	21	Helical; Potential
	Transmembrane	32 – 52	21	Helical; Potential
	Transmembrane	66 – 86	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P26524 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: FD472DB5F7310315	FASTA	103	11,464
	10 20 30 40 50 60 MHLQLQYCLI LAAALFCIGI YGLITSRNAV RVLMSIELLL NAVNLNLMGF SNYLDPSNIR 70 80 90 100 GQVFAIFVIT IAAAEAAVGL AIVLAIYRNR ETTDMEQFNL LKW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and transcription analysis of the ndh(A-I-G-E) gene cluster and the ndhD gene of the cyanobacterium Synechocystis sp. PCC6803." Ellersiek U., Steinmueller K. Plant Mol. Biol. 20:1097-1110(1992) [PubMed: 1463844] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome." Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S. DNA Res. 2:153-166(1995) [PubMed: 8590279] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.
[3]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X62517 Genomic DNA. Translation: CAA44377.1. BA000022 Genomic DNA. Translation: BAA10882.1.
PIR	QXYB4L. S27975.
RefSeq	NP_442811.1. NC_000911.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P26524. 1 interaction.
STRING	P26524.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	952073.
GenomeReviews	Gene locus sll0522 in contig BA000022_GR.
KEGG	syn:sll0522.
NMPDR	fig|1148.1.peg.2912.
PATRIC	23843394. VBISynSp132158_3233.
Phylogenomic databases
eggNOG	COG0713.
HOGENOM	HBG673066.
OMA	AVNINLM.
PhylomeDB	P26524.
ProtClustDB	PRK05715.
Enzyme and pathway databases
BioCyc	SSP1148:SLL0522-MONOMER.
Family and domain databases
HAMAP	MF_01456. NDH1_NuoK. [Tree]
InterPro	IPR001133. NADH_UbQ_OxRdtase_chain4L/K. [Graphical view]
KO	K05576.
PANTHER	PTHR11434. Oxidored_4L. 1 hit.
Pfam	PF00420. Oxidored_q2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NU4LC_SYNY3

Accession

Primary (citable) accession number: P26524

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program