P26523 (NU6C_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NAD(P)H-quinone oxidoreductase chain 6
EC=1.6.5.-

Alternative name(s):
NAD(P)H dehydrogenase I, chain 6
NDH-1, chain 6

Gene names

Name:	ndhG
Ordered Locus Names:	sll0521

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic activity	NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the complex I subunit 6 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	NAD NADP Plastoquinone
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	NAD(P)H-quinone oxidoreductase chain 6		PRO_0000118367
Regions
	Transmembrane	9 – 29	21	Helical; Potential
	Transmembrane	32 – 52	21	Helical; Potential
	Transmembrane	61 – 81	21	Helical; Potential
	Transmembrane	100 – 120	21	Helical; Potential
	Transmembrane	145 – 165	21	Helical; Potential
Experimental info
	Sequence conflict	168 – 198	31	RDLIP…TSASK → PGLNSRIVRGKQNRHGPDFA RASPGVNLRFQIDAA Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P26523 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: A92685FB148C5FEE	FASTA	198	21,523
	10 20 30 40 50 60 MNLAEGVQYI SFLILAFLVI GAALGVVLLS NIVYSAFLLG GVFLSISGIY ILLNADFVAA 70 80 90 100 110 120 AQVLVYVGAV SVLILFAIML VNKREDFSKI PGRWLRNVST ALVCTGIFAL LSTMVLITPW 130 140 150 160 170 180 QINETGPFVE NTLVTIGKHF FSDYLLPFEL ASVLLLMAMV GAIILARRDL IPELSEENKT 190 ATALTLPERP RELTSASK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and transcription analysis of the ndh(A-I-G-E) gene cluster and the ndhD gene of the cyanobacterium Synechocystis sp. PCC6803." Ellersiek U., Steinmueller K. Plant Mol. Biol. 20:1097-1110(1992) [PubMed: 1463844] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome." Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S. DNA Res. 2:153-166(1995) [PubMed: 8590279] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.
[3]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X62517 Genomic DNA. Translation: CAA44376.1. BA000022 Genomic DNA. Translation: BAA10883.1.
PIR	QXYB6. S76036.
RefSeq	NP_442812.1. NC_000911.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P26523. 7 interactions.
STRING	P26523.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	952070.
GenomeReviews	Gene locus sll0521 in contig BA000022_GR.
KEGG	syn:sll0521.
NMPDR	fig|1148.1.peg.2913.
PATRIC	23843396. VBISynSp132158_3234.
Phylogenomic databases
eggNOG	COG0839.
HOGENOM	HBG729722.
OMA	AQVLVYV.
PhylomeDB	P26523.
ProtClustDB	PRK06638.
Enzyme and pathway databases
BioCyc	SSP1148:SLL0521-MONOMER.
Family and domain databases
InterPro	IPR001457. NADH_UbQ/plastoQ_OxRdtase_su6. [Graphical view]
KO	K05578.
Pfam	PF00499. Oxidored_q3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NU6C_SYNY3

Accession

Primary (citable) accession number: P26523
Secondary accession number(s): Q55523

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	November 1, 1997
Last modified:	January 25, 2012
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program