P26522 (NU1C_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NAD(P)H-quinone oxidoreductase subunit 1
EC=1.6.5.-

Alternative name(s):
NAD(P)H dehydrogenase I subunit 1
NDH-1 subunit 1
NDH-A

Gene names

Name:	ndhA
Ordered Locus Names:	sll0519

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	372 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. HAMAP MF_01350
Catalytic activity	NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol. HAMAP MF_01350
Subunit structure	NDH-1 is composed of at least 11 different subunits By similarity.
Subcellular location	Cellular thylakoid membrane; Multi-pass membrane protein By similarity HAMAP MF_01350.
Sequence similarities	Belongs to the complex I subunit 1 family.

Ontologies

Keywords
Cellular component	Membrane Thylakoid
Domain	Transmembrane Transmembrane helix
Ligand	NAD NADP Plastoquinone
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW thylakoid membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 372	372	NAD(P)H-quinone oxidoreductase subunit 1 HAMAP MF_01350		PRO_0000117520
Regions
	Transmembrane	29 – 51	23	Helical; Potential
	Transmembrane	98 – 120	23	Helical; Potential
	Transmembrane	130 – 152	23	Helical; Potential
	Transmembrane	165 – 187	23	Helical; Potential
	Transmembrane	202 – 224	23	Helical; Potential
	Transmembrane	254 – 276	23	Helical; Potential
	Transmembrane	305 – 327	23	Helical; Potential
	Transmembrane	340 – 362	23	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P26522 [UniParc]. Last modified October 1, 1993. Version 2. Checksum: 4D9E02576825E990	FASTA	372	40,548
	10 20 30 40 50 60 MTSGIDLQNS FLQSLQGFGL PPGLAKLFWI PLPSILMIIG ATVGVLVVVW LERKISAAAQ 70 80 90 100 110 120 QRIGPEYAGP LGVLQPVADG IKLVFKEDVV PAKADPWLFT LGPVLVVLPV FLSYLIVPFG 130 140 150 160 170 180 QNLVITDINV GIFLWIALSS IAPIGLLMSG YASNNKYSLL GGLRAAAQSI SYEIPLSLAV 190 200 210 220 230 240 LAIVMMSNSL STIDIVDQQS GYGILGWNIW RQPVGFLIFW IAALAECERL PFDLPEAEEE 250 260 270 280 290 300 LVAGYQTEYA GMKFALFYLG SYVNLVLSAL VFSVLYLGGW DFPIPLENVA NWLGVAPTTS 310 320 330 340 350 360 WLQVLMAALG ITMTVLKSYF LIFIAILLRW TVPRVRIDQL LNLGWKFLLP VALANLLITA 370 ALKLTFPMAF GG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and transcription analysis of the ndh(A-I-G-E) gene cluster and the ndhD gene of the cyanobacterium Synechocystis sp. PCC6803." Ellersiek U., Steinmueller K. Plant Mol. Biol. 20:1097-1110(1992) [PubMed: 1463844] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome." Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S. DNA Res. 2:153-166(1995) [PubMed: 8590279] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.
[3]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X62517 Genomic DNA. Translation: CAA44374.1. BA000022 Genomic DNA. Translation: BAA10885.1.
PIR	QXYB1. S27972.
RefSeq	NP_442814.1. NC_000911.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P26522. 8 interactions.
STRING	P26522.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	954915.
GenomeReviews	Gene locus sll0519 in contig BA000022_GR.
KEGG	syn:sll0519.
NMPDR	fig|1148.1.peg.2915.
PATRIC	23843400. VBISynSp132158_3236.
Phylogenomic databases
eggNOG	COG1005.
HOGENOM	HBG727670.
OMA	DRPAYDL.
PhylomeDB	P26522.
ProtClustDB	PRK06076.
Enzyme and pathway databases
BioCyc	SSP1148:SLL0519-MONOMER.
Family and domain databases
HAMAP	MF_01350. NDH1_NuoH. [Tree]
InterPro	IPR001694. NADH_UbQ_OxRdtase_su1/FPO. IPR018086. NADH_UbQ_OxRdtase_su1_CS. [Graphical view]
KO	K05572.
PANTHER	PTHR11432. Resp_NADH_DH_1. 1 hit.
Pfam	PF00146. NADHdh. 1 hit. [Graphical view]
PROSITE	PS00667. COMPLEX1_ND1_1. 1 hit. PS00668. COMPLEX1_ND1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NU1C_SYNY3

Accession

Primary (citable) accession number: P26522

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	October 1, 1993
Last modified:	January 25, 2012
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program