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Protein

Citrate synthase

Gene

gltA

Organism
Mycobacterium smegmatis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Enzyme regulationi

Allosterically inhibited by NADH.

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Citrate synthase (citB), Citrate synthase (gltA), Citrate synthase (gltA2)
  2. no protein annotated in this organism
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei266PROSITE-ProRule annotation1
Active sitei317PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Transferase
Biological processTricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase (EC:2.3.3.16)
Gene namesi
Name:gltA
OrganismiMycobacterium smegmatis
Taxonomic identifieri1772 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001699511 – 375Citrate synthaseAdd BLAST375

Interactioni

Subunit structurei

Homohexamer.

Structurei

3D structure databases

ProteinModelPortaliP26491
SMRiP26491
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Phylogenomic databases

eggNOGiENOG4105BZN Bacteria
COG0372 LUCA

Family and domain databases

Gene3Di1.10.230.10, 1 hit
1.10.580.10, 2 hits
InterProiView protein in InterPro
IPR011278 2-MeCitrate/Citrate_synth_II
IPR016142 Citrate_synth-like_lrg_a-sub
IPR016143 Citrate_synth-like_sm_a-sub
IPR002020 Citrate_synthase
IPR019810 Citrate_synthase_AS
IPR024176 Citrate_synthase_bac-typ
IPR036969 Citrate_synthase_sf
PANTHERiPTHR11739 PTHR11739, 1 hit
PfamiView protein in Pfam
PF00285 Citrate_synt, 1 hit
PIRSFiPIRSF001369 Citrate_synth, 1 hit
PRINTSiPR00143 CITRTSNTHASE
SUPFAMiSSF48256 SSF48256, 1 hit
TIGRFAMsiTIGR01800 cit_synth_II, 1 hit
PROSITEiView protein in PROSITE
PS00480 CITRATE_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

P26491-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTATESEAP RIHKGLAGVV VDTTAISKVV PETNSLTYRG YPVQDLAAQC
60 70 80 90 100
SFEQVAYLLW HGELPTDQLA LFSQRERASR RIDRSMQALL AKLPDNCHPM
110 120 130 140 150
DVVRTAISYL GAEDLEEDVD TAEANYAKSL RMFAVLPTIV ATDIRRRQGL
160 170 180 190 200
TPIPPHSQLG YAQNFLNMCF GEVPEPVVVR AFEQSMVLYA EHSFNASTFA
210 220 230 240 250
ARVVTSTQSD IYSAVTAAIG ALKGSLHGGA NEAVMHDMLE IGSAEKAPEW
260 270 280 290 300
LHGKLSRKEK VMGFGHRVYK NGDSRVPTMK VALEQVAQVR DGQRWLDIYN
310 320 330 340 350
TLESAMFAAT RIKPNLDFPT GPAYYLMDFP IESFTPLFVM SRITGWTAHI
360 370
MEQAASNALI RPLSEYSGQP QRSLV
Length:375
Mass (Da):41,501
Last modified:August 1, 1992 - v1
Checksum:i95D6D4E0C954C994
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60513 Genomic DNA Translation: CAA43028.1
PIRiS17168 YKMY

Similar proteinsi

Entry informationi

Entry nameiCISY_MYCSM
AccessioniPrimary (citable) accession number: P26491
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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