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P26477

- FLGM_SALTY

UniProt

P26477 - FLGM_SALTY

Protein

Negative regulator of flagellin synthesis

Gene

flgM

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.

    GO - Biological processi

    1. negative regulation of transcription, DNA-templated Source: InterPro
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Bacterial flagellum biogenesis, Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-1181-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Negative regulator of flagellin synthesis
    Alternative name(s):
    Anti-sigma-28 factor
    Gene namesi
    Name:flgM
    Synonyms:flgR, mviS
    Ordered Locus Names:STM1172
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    Subcellular locationi

    Cytoplasm
    Note: After completion of the hook-basal body structure, it is exported out of the cell through the completely assembled hook-basal body structures.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9797Negative regulator of flagellin synthesisPRO_0000087286Add
    BLAST

    Proteomic databases

    PaxDbiP26477.
    PRIDEiP26477.

    Interactioni

    Protein-protein interaction databases

    STRINGi99287.STM1172.

    Structurei

    3D structure databases

    DisProtiDP00027.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The N-terminal domain is essential for export and the C-terminal domain possess the FliA binding site.

    Sequence similaritiesi

    Belongs to the FlgM family.Curated

    Phylogenomic databases

    eggNOGiCOG2747.
    HOGENOMiHOG000265658.
    KOiK02398.
    OMAiGTQDIDM.
    OrthoDBiEOG68DD3J.

    Family and domain databases

    InterProiIPR007412. FlgM.
    [Graphical view]
    PfamiPF04316. FlgM. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03824. FlgM_jcvi. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P26477-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIDRTSPLK PVSTVQTRET SDTPVQKTRQ EKTSAATSAS VTLSDAQAKL   50
    MQPGVSDINM ERVEALKTAI RNGELKMDTG KIADSLIREA QSYLQSK 97
    Length:97
    Mass (Da):10,568
    Last modified:August 1, 1992 - v1
    Checksum:i78CC1779935E7E64
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M74222 Genomic DNA. Translation: AAA27075.1.
    U03631 Unassigned DNA. Translation: AAC38036.1.
    D25292 Genomic DNA. Translation: BAA04978.1.
    AE006468 Genomic DNA. Translation: AAL20102.1.
    PIRiA41046.
    RefSeqiNP_460143.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL20102; AAL20102; STM1172.
    GeneIDi1252690.
    KEGGistm:STM1172.
    PATRICi32380791. VBISalEnt20916_1240.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M74222 Genomic DNA. Translation: AAA27075.1 .
    U03631 Unassigned DNA. Translation: AAC38036.1 .
    D25292 Genomic DNA. Translation: BAA04978.1 .
    AE006468 Genomic DNA. Translation: AAL20102.1 .
    PIRi A41046.
    RefSeqi NP_460143.1. NC_003197.1.

    3D structure databases

    DisProti DP00027.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM1172.

    Proteomic databases

    PaxDbi P26477.
    PRIDEi P26477.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL20102 ; AAL20102 ; STM1172 .
    GeneIDi 1252690.
    KEGGi stm:STM1172.
    PATRICi 32380791. VBISalEnt20916_1240.

    Phylogenomic databases

    eggNOGi COG2747.
    HOGENOMi HOG000265658.
    KOi K02398.
    OMAi GTQDIDM.
    OrthoDBi EOG68DD3J.

    Enzyme and pathway databases

    BioCyci SENT99287:GCTI-1181-MONOMER.

    Family and domain databases

    InterProi IPR007412. FlgM.
    [Graphical view ]
    Pfami PF04316. FlgM. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03824. FlgM_jcvi. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of flgM, a gene encoding a negative regulator of flagellin synthesis in Salmonella typhimurium."
      Gillen K.L., Hughes K.T.
      J. Bacteriol. 173:6453-6459(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: LT2.
    2. "Mutation of flgM attenuates virulence of Salmonella typhimurium, and mutation of fliA represses the attenuated phenotype."
      Schmitt C.K., Darnell S.C., Tesh V.L., Stocker B.A.D., O'Brien A.D.
      J. Bacteriol. 176:368-377(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: LT2.
    3. "Sequence analysis of the flgA gene and its adjacent region in Salmonella typhimurium, and identification of another flagellar gene, flgN."
      Kutsukake K., Okada T., Yokoseki T., Iino T.
      Gene 143:49-54(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: LT2.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.
    5. "Molecular dissection of the flagellum-specific anti-sigma factor, FlgM, of Salmonella typhimurium."
      Iyoda S., Kutsukake K.
      Mol. Gen. Genet. 249:417-424(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.

    Entry informationi

    Entry nameiFLGM_SALTY
    AccessioniPrimary (citable) accession number: P26477
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3