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P26477 (FLGM_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Negative regulator of flagellin synthesis
Alternative name(s):
Anti-sigma-28 factor
Gene names
Name:flgM
Synonyms:flgR, mviS
Ordered Locus Names:STM1172
OrganismSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]
Taxonomic identifier99287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length97 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.

Subcellular location

Cytoplasm. Note: After completion of the hook-basal body structure, it is exported out of the cell through the completely assembled hook-basal body structures.

Domain

The N-terminal domain is essential for export and the C-terminal domain possess the FliA binding site.

Sequence similarities

Belongs to the FlgM family.

Ontologies

Keywords
   Biological processBacterial flagellum biogenesis
Transcription
Transcription regulation
   Cellular componentCytoplasm
   Molecular functionRepressor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: InterPro

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9797Negative regulator of flagellin synthesis
PRO_0000087286

Sequences

Sequence LengthMass (Da)Tools
P26477 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 78CC1779935E7E64

FASTA9710,568
        10         20         30         40         50         60 
MSIDRTSPLK PVSTVQTRET SDTPVQKTRQ EKTSAATSAS VTLSDAQAKL MQPGVSDINM 

        70         80         90 
ERVEALKTAI RNGELKMDTG KIADSLIREA QSYLQSK 

« Hide

References

« Hide 'large scale' references
[1]"Molecular characterization of flgM, a gene encoding a negative regulator of flagellin synthesis in Salmonella typhimurium."
Gillen K.L., Hughes K.T.
J. Bacteriol. 173:6453-6459(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: LT2.
[2]"Mutation of flgM attenuates virulence of Salmonella typhimurium, and mutation of fliA represses the attenuated phenotype."
Schmitt C.K., Darnell S.C., Tesh V.L., Stocker B.A.D., O'Brien A.D.
J. Bacteriol. 176:368-377(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: LT2.
[3]"Sequence analysis of the flgA gene and its adjacent region in Salmonella typhimurium, and identification of another flagellar gene, flgN."
Kutsukake K., Okada T., Yokoseki T., Iino T.
Gene 143:49-54(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: LT2.
[4]"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2."
McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. expand/collapse author list , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K.
Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LT2 / SGSC1412 / ATCC 700720.
[5]"Molecular dissection of the flagellum-specific anti-sigma factor, FlgM, of Salmonella typhimurium."
Iyoda S., Kutsukake K.
Mol. Gen. Genet. 249:417-424(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M74222 Genomic DNA. Translation: AAA27075.1.
U03631 Unassigned DNA. Translation: AAC38036.1.
D25292 Genomic DNA. Translation: BAA04978.1.
AE006468 Genomic DNA. Translation: AAL20102.1.
PIRA41046.
RefSeqNP_460143.1. NC_003197.1.

3D structure databases

DisProtDP00027.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING99287.STM1172.

Proteomic databases

PaxDbP26477.
PRIDEP26477.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL20102; AAL20102; STM1172.
GeneID1252690.
KEGGstm:STM1172.
PATRIC32380791. VBISalEnt20916_1240.

Phylogenomic databases

eggNOGCOG2747.
HOGENOMHOG000265658.
KOK02398.
OMAGTQDIDM.
OrthoDBEOG68DD3J.
ProtClustDBPRK10810.

Enzyme and pathway databases

BioCycSENT99287:GCTI-1181-MONOMER.

Family and domain databases

InterProIPR007412. FlgM.
[Graphical view]
PfamPF04316. FlgM. 1 hit.
[Graphical view]
TIGRFAMsTIGR03824. FlgM_jcvi. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFLGM_SALTY
AccessionPrimary (citable) accession number: P26477
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: February 19, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families