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P26477

- FLGM_SALTY

UniProt

P26477 - FLGM_SALTY

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Protein

Negative regulator of flagellin synthesis

Gene

flgM

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.

GO - Biological processi

  1. bacterial-type flagellum organization Source: UniProtKB-KW
  2. negative regulation of transcription, DNA-templated Source: InterPro
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Bacterial flagellum biogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1181-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Negative regulator of flagellin synthesis
Alternative name(s):
Anti-sigma-28 factor
Gene namesi
Name:flgM
Synonyms:flgR, mviS
Ordered Locus Names:STM1172
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

Subcellular locationi

Cytoplasm
Note: After completion of the hook-basal body structure, it is exported out of the cell through the completely assembled hook-basal body structures.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9797Negative regulator of flagellin synthesisPRO_0000087286Add
BLAST

Proteomic databases

PaxDbiP26477.
PRIDEiP26477.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM1172.

Structurei

3D structure databases

DisProtiDP00027.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain is essential for export and the C-terminal domain possess the FliA binding site.

Sequence similaritiesi

Belongs to the FlgM family.Curated

Phylogenomic databases

eggNOGiCOG2747.
HOGENOMiHOG000265658.
KOiK02398.
OMAiGTQDIDM.
OrthoDBiEOG68DD3J.

Family and domain databases

InterProiIPR007412. FlgM.
[Graphical view]
PfamiPF04316. FlgM. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03824. FlgM_jcvi. 1 hit.

Sequencei

Sequence statusi: Complete.

P26477-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIDRTSPLK PVSTVQTRET SDTPVQKTRQ EKTSAATSAS VTLSDAQAKL
60 70 80 90
MQPGVSDINM ERVEALKTAI RNGELKMDTG KIADSLIREA QSYLQSK
Length:97
Mass (Da):10,568
Last modified:August 1, 1992 - v1
Checksum:i78CC1779935E7E64
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74222 Genomic DNA. Translation: AAA27075.1.
U03631 Unassigned DNA. Translation: AAC38036.1.
D25292 Genomic DNA. Translation: BAA04978.1.
AE006468 Genomic DNA. Translation: AAL20102.1.
PIRiA41046.
RefSeqiNP_460143.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20102; AAL20102; STM1172.
GeneIDi1252690.
KEGGistm:STM1172.
PATRICi32380791. VBISalEnt20916_1240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74222 Genomic DNA. Translation: AAA27075.1 .
U03631 Unassigned DNA. Translation: AAC38036.1 .
D25292 Genomic DNA. Translation: BAA04978.1 .
AE006468 Genomic DNA. Translation: AAL20102.1 .
PIRi A41046.
RefSeqi NP_460143.1. NC_003197.1.

3D structure databases

DisProti DP00027.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM1172.

Proteomic databases

PaxDbi P26477.
PRIDEi P26477.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL20102 ; AAL20102 ; STM1172 .
GeneIDi 1252690.
KEGGi stm:STM1172.
PATRICi 32380791. VBISalEnt20916_1240.

Phylogenomic databases

eggNOGi COG2747.
HOGENOMi HOG000265658.
KOi K02398.
OMAi GTQDIDM.
OrthoDBi EOG68DD3J.

Enzyme and pathway databases

BioCyci SENT99287:GCTI-1181-MONOMER.

Family and domain databases

InterProi IPR007412. FlgM.
[Graphical view ]
Pfami PF04316. FlgM. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03824. FlgM_jcvi. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of flgM, a gene encoding a negative regulator of flagellin synthesis in Salmonella typhimurium."
    Gillen K.L., Hughes K.T.
    J. Bacteriol. 173:6453-6459(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LT2.
  2. "Mutation of flgM attenuates virulence of Salmonella typhimurium, and mutation of fliA represses the attenuated phenotype."
    Schmitt C.K., Darnell S.C., Tesh V.L., Stocker B.A.D., O'Brien A.D.
    J. Bacteriol. 176:368-377(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LT2.
  3. "Sequence analysis of the flgA gene and its adjacent region in Salmonella typhimurium, and identification of another flagellar gene, flgN."
    Kutsukake K., Okada T., Yokoseki T., Iino T.
    Gene 143:49-54(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LT2.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.
  5. "Molecular dissection of the flagellum-specific anti-sigma factor, FlgM, of Salmonella typhimurium."
    Iyoda S., Kutsukake K.
    Mol. Gen. Genet. 249:417-424(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiFLGM_SALTY
AccessioniPrimary (citable) accession number: P26477
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3