SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P26475

- ASRB_SALTY

UniProt

P26475 - ASRB_SALTY

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Anaerobic sulfite reductase subunit B

Gene
asrB, STM2549
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

This enzyme catalyzes the hydrogen sulfide production from sulfite. It is strictly anaerobic. It is regulated by electron acceptors rather than by cysteine.

Cofactori

Binds 1 2Fe-2S cluster per subunit By similarity.
Binds 1 FAD per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei166 – 1661NAD By similarity
Metal bindingi240 – 2401Iron-sulfur (2Fe-2S) Reviewed prediction
Metal bindingi245 – 2451Iron-sulfur (2Fe-2S) Reviewed prediction
Metal bindingi248 – 2481Iron-sulfur (2Fe-2S) Reviewed prediction
Metal bindingi256 – 2561Iron-sulfur (2Fe-2S) Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi113 – 12917FAD By similarityAdd
BLAST
Nucleotide bindingi168 – 21346NAD By similarityAdd
BLAST

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. flavin adenine dinucleotide binding Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
  4. oxidoreductase activity Source: InterPro

GO - Biological processi

  1. pyrimidine nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

2Fe-2S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, NAD

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-12545.
SENT99287:GCTI-2563-MONOMER.
UniPathwayiUPA00370.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic sulfite reductase subunit B
Gene namesi
Name:asrB
Ordered Locus Names:STM2549
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Anaerobic sulfite reductase subunit BPRO_0000148385Add
BLAST

Proteomic databases

PaxDbiP26475.
PRIDEiP26475.

Expressioni

Inductioni

By sulfite. Repressed by oxygen.

Interactioni

Subunit structurei

The anaerobic sulfite reductase seems to consist of three subunits.

Protein-protein interaction databases

STRINGi99287.STM2549.

Structurei

3D structure databases

ProteinModelPortaliP26475.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 10592FAD-binding FR-typeAdd
BLAST

Sequence similaritiesi

Belongs to the PyrK family.

Phylogenomic databases

eggNOGiCOG0543.
HOGENOMiHOG000225119.
KOiK16951.
OMAiMECGIGH.
OrthoDBiEOG6JX7JM.
PhylomeDBiP26475.

Family and domain databases

Gene3Di2.10.240.10. 1 hit.
InterProiIPR012165. Cyt_c3_hydrogenase_gsu.
IPR019480. Dihydroorotate_DH_Fe-S-bd.
IPR017927. Fd_Rdtase_FAD-bd.
IPR008333. OxRdtase_FAD-bd_dom.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
IPR014260. Sulphite_reductase_B.
[Graphical view]
PfamiPF10418. DHODB_Fe-S_bind. 1 hit.
PF00970. FAD_binding_6. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PIRSFiPIRSF006816. Cyc3_hyd_g. 1 hit.
SUPFAMiSSF63380. SSF63380. 1 hit.
TIGRFAMsiTIGR02911. sulfite_red_B. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26475-1 [UniParc]FASTAAdd to Basket

« Hide

MSHCSCHDKP QHSLLPAAYR ILSITRHTPL EWNFRVAVDF PAHWGQFVEV    50
SLPRVGEAPI SVSDYGDGWI DLLIRNVGKV TSALFTLKEG DNVWLRGCYG 100
NGYPVDTLRH KPLLVVAGGT GVAPVKGLMR YFVENPQEIG QLDMILGYKN 150
RDCVLYKEEM ATWRGKHNLV LTLDEGEADD RYQIGRVTDR LADMTLSDID 200
TMQAIVVGPP IMITFTVKML LQKGLKPEQI WVDYERRMAC SVGKCGHCRM 250
GEVYVCTDGP IFNYAVAQRF AD 272
Length:272
Mass (Da):30,609
Last modified:January 23, 2002 - v2
Checksum:i5C73ACCC200AE302
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161P → A in AAA99276. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57706 Genomic DNA. Translation: AAA99276.1.
AE006468 Genomic DNA. Translation: AAL21443.1.
PIRiB38453.
RefSeqiNP_461484.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL21443; AAL21443; STM2549.
GeneIDi1254071.
KEGGistm:STM2549.
PATRICi32383733. VBISalEnt20916_2689.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57706 Genomic DNA. Translation: AAA99276.1 .
AE006468 Genomic DNA. Translation: AAL21443.1 .
PIRi B38453.
RefSeqi NP_461484.1. NC_003197.1.

3D structure databases

ProteinModelPortali P26475.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM2549.

Proteomic databases

PaxDbi P26475.
PRIDEi P26475.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL21443 ; AAL21443 ; STM2549 .
GeneIDi 1254071.
KEGGi stm:STM2549.
PATRICi 32383733. VBISalEnt20916_2689.

Phylogenomic databases

eggNOGi COG0543.
HOGENOMi HOG000225119.
KOi K16951.
OMAi MECGIGH.
OrthoDBi EOG6JX7JM.
PhylomeDBi P26475.

Enzyme and pathway databases

UniPathwayi UPA00370 .
BioCyci MetaCyc:MONOMER-12545.
SENT99287:GCTI-2563-MONOMER.

Family and domain databases

Gene3Di 2.10.240.10. 1 hit.
InterProi IPR012165. Cyt_c3_hydrogenase_gsu.
IPR019480. Dihydroorotate_DH_Fe-S-bd.
IPR017927. Fd_Rdtase_FAD-bd.
IPR008333. OxRdtase_FAD-bd_dom.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
IPR014260. Sulphite_reductase_B.
[Graphical view ]
Pfami PF10418. DHODB_Fe-S_bind. 1 hit.
PF00970. FAD_binding_6. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF006816. Cyc3_hyd_g. 1 hit.
SUPFAMi SSF63380. SSF63380. 1 hit.
TIGRFAMsi TIGR02911. sulfite_red_B. 1 hit.
PROSITEi PS51384. FAD_FR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis and expression of the Salmonella typhimurium asr operon encoding production of hydrogen sulfide from sulfite."
    Huang C.J., Barrett E.L.
    J. Bacteriol. 173:1544-1553(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: EB303.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiASRB_SALTY
AccessioniPrimary (citable) accession number: P26475
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2002
Last modified: July 9, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi