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P26471 (RFAL_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
O-antigen ligase
Gene names
Name:rfaL
Synonyms:rfbT, waaL
Ordered Locus Names:STM3713
OrganismSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]
Taxonomic identifier99287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Adds the O-antigen on the glucose(II) group of LPS.

Pathway

Bacterial outer membrane biogenesis; LPS core biosynthesis.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the O-antigen polymerase family.

Ontologies

Keywords
   Biological processLipopolysaccharide biosynthesis
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processlipopolysaccharide core region biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionligase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 404404O-antigen ligase
PRO_0000208067

Regions

Transmembrane66 – 8419Helical; Potential
Transmembrane184 – 20320Helical; Potential
Transmembrane227 – 24418Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P26471 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 1B84F7B3C757D2AB

FASTA40446,034
        10         20         30         40         50         60 
MLTTSLTLNK EKWKPIWNKA LVFLFVATYF LDGITRYKHL IIILMVITAI YQVSRSPKSF 

        70         80         90        100        110        120 
PPLFKNSVFY SVAVLSLILV YSILISPDMK ESFKEFENTV LEGFLLYTLL IPVLLKDETK 

       130        140        150        160        170        180 
ETVAKIVLFS FLTSLGLRCL AESILYIEDY NKGIMPFISY AHRHMSDSMV FLFPALLNIW 

       190        200        210        220        230        240 
LFRKNAIKLV FLVLSAIYLF FILGTLSRGA WLAVLIVGVL WAILNRQWKL IGVGAILLAI 

       250        260        270        280        290        300 
IGALVITQHN NKPDPEHLLY KLQQTDSSYR YTNGTQGTAW ILIQENPIKG YGYGNDVYDG 

       310        320        330        340        350        360 
VYNKRVVDYP TWTFKESIGP HNTILYIWFS AGILGLASLV YLYGAIIRET ASSTLRKVEI 

       370        380        390        400 
SPYNAHLLLF LSFVGFYIVR GNFEQVDIAQ IGIITGFLLA LRNR 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, characterization, and DNA sequence of the rfaLK region for lipopolysaccharide synthesis in Salmonella typhimurium LT2."
Maclachlan P.R., Kadam S.K., Sanderson K.E.
J. Bacteriol. 173:7151-7163(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: LT2.
[2]"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2."
McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. expand/collapse author list , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K.
Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M73826 Genomic DNA. Translation: AAA27206.1.
AE006468 Genomic DNA. Translation: AAL22572.1.
PIRB41317.
RefSeqNP_462613.1. NC_003197.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING99287.STM3713.

Proteomic databases

PaxDbP26471.
PRIDEP26471.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL22572; AAL22572; STM3713.
GeneID1255237.
KEGGstm:STM3713.
PATRIC32386261. VBISalEnt20916_3927.

Phylogenomic databases

eggNOGCOG3307.
HOGENOMHOG000028346.
KOK02847.
OMANDVYDSV.
OrthoDBEOG6G4VRD.

Enzyme and pathway databases

BioCycSENT99287:GCTI-3738-MONOMER.
UniPathwayUPA00958.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameRFAL_SALTY
AccessionPrimary (citable) accession number: P26471
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways