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P26471

- RFAL_SALTY

UniProt

P26471 - RFAL_SALTY

Protein

O-antigen ligase

Gene

rfaL

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    Adds the O-antigen on the glucose(II) group of LPS.

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW

    GO - Biological processi

    1. lipopolysaccharide core region biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Lipopolysaccharide biosynthesis

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-3738-MONOMER.
    UniPathwayiUPA00958.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    O-antigen ligase
    Gene namesi
    Name:rfaL
    Synonyms:rfbT, waaL
    Ordered Locus Names:STM3713
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 404404O-antigen ligasePRO_0000208067Add
    BLAST

    Proteomic databases

    PaxDbiP26471.
    PRIDEiP26471.

    Interactioni

    Protein-protein interaction databases

    STRINGi99287.STM3713.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei66 – 8419HelicalSequence AnalysisAdd
    BLAST
    Transmembranei184 – 20320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei227 – 24418HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the O-antigen polymerase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG3307.
    HOGENOMiHOG000028346.
    KOiK02847.
    OMAiNDVYDSV.
    OrthoDBiEOG6G4VRD.

    Sequencei

    Sequence statusi: Complete.

    P26471-1 [UniParc]FASTAAdd to Basket

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    MLTTSLTLNK EKWKPIWNKA LVFLFVATYF LDGITRYKHL IIILMVITAI    50
    YQVSRSPKSF PPLFKNSVFY SVAVLSLILV YSILISPDMK ESFKEFENTV 100
    LEGFLLYTLL IPVLLKDETK ETVAKIVLFS FLTSLGLRCL AESILYIEDY 150
    NKGIMPFISY AHRHMSDSMV FLFPALLNIW LFRKNAIKLV FLVLSAIYLF 200
    FILGTLSRGA WLAVLIVGVL WAILNRQWKL IGVGAILLAI IGALVITQHN 250
    NKPDPEHLLY KLQQTDSSYR YTNGTQGTAW ILIQENPIKG YGYGNDVYDG 300
    VYNKRVVDYP TWTFKESIGP HNTILYIWFS AGILGLASLV YLYGAIIRET 350
    ASSTLRKVEI SPYNAHLLLF LSFVGFYIVR GNFEQVDIAQ IGIITGFLLA 400
    LRNR 404
    Length:404
    Mass (Da):46,034
    Last modified:August 1, 1992 - v1
    Checksum:i1B84F7B3C757D2AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73826 Genomic DNA. Translation: AAA27206.1.
    AE006468 Genomic DNA. Translation: AAL22572.1.
    PIRiB41317.
    RefSeqiNP_462613.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL22572; AAL22572; STM3713.
    GeneIDi1255237.
    KEGGistm:STM3713.
    PATRICi32386261. VBISalEnt20916_3927.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73826 Genomic DNA. Translation: AAA27206.1 .
    AE006468 Genomic DNA. Translation: AAL22572.1 .
    PIRi B41317.
    RefSeqi NP_462613.1. NC_003197.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM3713.

    Proteomic databases

    PaxDbi P26471.
    PRIDEi P26471.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL22572 ; AAL22572 ; STM3713 .
    GeneIDi 1255237.
    KEGGi stm:STM3713.
    PATRICi 32386261. VBISalEnt20916_3927.

    Phylogenomic databases

    eggNOGi COG3307.
    HOGENOMi HOG000028346.
    KOi K02847.
    OMAi NDVYDSV.
    OrthoDBi EOG6G4VRD.

    Enzyme and pathway databases

    UniPathwayi UPA00958 .
    BioCyci SENT99287:GCTI-3738-MONOMER.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Cloning, characterization, and DNA sequence of the rfaLK region for lipopolysaccharide synthesis in Salmonella typhimurium LT2."
      Maclachlan P.R., Kadam S.K., Sanderson K.E.
      J. Bacteriol. 173:7151-7163(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: LT2.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.

    Entry informationi

    Entry nameiRFAL_SALTY
    AccessioniPrimary (citable) accession number: P26471
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3