Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P26471 (RFAL_SALTY)

Last modified January 19, 2010. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    O-antigen ligase
Gene names
Name: rfaL
Synonyms: rfbT, waaL
Ordered Locus Names: STM3713
OrganismSalmonella typhimurium [Complete proteome] [HAMAP]
Taxonomic identifier90371 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Adds the O-antigen on the glucose(II) group of LPS.

Pathway

Bacterial outer membrane biogenesis; LPS core biosynthesis.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the O-antigen polymerase family.

Ontologies

Keywords
   Biological processLipopolysaccharide biosynthesis
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processlipopolysaccharide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionligase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 404404O-antigen ligase
PRO_0000208067

Regions

Transmembrane66 – 8419 Potential
Transmembrane184 – 20320 Potential
Transmembrane227 – 24418 Potential

Sequences

Sequence LengthMass (Da)Tools
P26471-1 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 1B84F7B3C757D2AB

FASTA40446,034
        10         20         30         40         50         60 
MLTTSLTLNK EKWKPIWNKA LVFLFVATYF LDGITRYKHL IIILMVITAI YQVSRSPKSF 

        70         80         90        100        110        120 
PPLFKNSVFY SVAVLSLILV YSILISPDMK ESFKEFENTV LEGFLLYTLL IPVLLKDETK 

       130        140        150        160        170        180 
ETVAKIVLFS FLTSLGLRCL AESILYIEDY NKGIMPFISY AHRHMSDSMV FLFPALLNIW 

       190        200        210        220        230        240 
LFRKNAIKLV FLVLSAIYLF FILGTLSRGA WLAVLIVGVL WAILNRQWKL IGVGAILLAI 

       250        260        270        280        290        300 
IGALVITQHN NKPDPEHLLY KLQQTDSSYR YTNGTQGTAW ILIQENPIKG YGYGNDVYDG 

       310        320        330        340        350        360 
VYNKRVVDYP TWTFKESIGP HNTILYIWFS AGILGLASLV YLYGAIIRET ASSTLRKVEI 

       370        380        390        400 
SPYNAHLLLF LSFVGFYIVR GNFEQVDIAQ IGIITGFLLA LRNR 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, characterization, and DNA sequence of the rfaLK region for lipopolysaccharide synthesis in Salmonella typhimurium LT2."
Maclachlan P.R., Kadam S.K., Sanderson K.E.
J. Bacteriol. 173:7151-7163(1991) [PubMed: 1657881] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: LT2.
[2]"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2."
McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. expand/collapse author list , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K.
Nature 413:852-856(2001) [PubMed: 11677609] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M73826 Genomic DNA. Translation: AAA27206.1.
AE006468 Genomic DNA. Translation: AAL22572.1.
PIRB41317.
RefSeqNP_462613.1.

3D structure databases

ModBaseSearch...

Proteomic databases

PRIDEP26471.

Genome annotation databases

GeneID1255237.
GenomeReviewsGene locus STM3713 in contig AE006468_GR.
KEGGstm:STM3713.
NMPDRfig|99287.1.peg.3589.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG467985.
OMANDVYDSV.

Enzyme and pathway databases

BioCycSTYP99287:STM3713-MONOMER.

Family and domain databases

InterProIPR007016. O-antigen_ligase-related.
[Graphical view]
PfamPF04932. Wzy_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRFAL_SALTY
AccessionPrimary (citable) accession number: P26471
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: January 19, 2010
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents