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P26470 (WAAK_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipopolysaccharide 1,2-N-acetylglucosaminetransferase

EC=2.4.1.56
Gene names
Name:waaK
Synonyms:rfaK
Ordered Locus Names:STM3714
OrganismSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]
Taxonomic identifier99287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Adds the terminal N-acetyl-D-glucosamine group on the glucose(II) group of LPS.

Catalytic activity

UDP-N-acetyl-alpha-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-alpha-D-glucosaminyllipopolysaccharide.

Pathway

Bacterial outer membrane biogenesis; LPS core biosynthesis.

Subcellular location

Membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

Ontologies

Keywords
   Biological processLipopolysaccharide biosynthesis
   Cellular componentMembrane
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processlipopolysaccharide core region biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentmembrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionlipopolysaccharide N-acetylglucosaminyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 381381Lipopolysaccharide 1,2-N-acetylglucosaminetransferase
PRO_0000080306

Sequences

Sequence LengthMass (Da)Tools
P26470 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: F60F37FF175372C6

FASTA38143,152
        10         20         30         40         50         60 
MIKKIIFTVT PIFSIPPRGA AAVETWIYQV AKRLSIPNAI ACIKNAGYPE YNKINDNCDI 

        70         80         90        100        110        120 
HYIGFSKVYK RLFQKWTRLD PLPYSQRILN IRDKVTTQED SVIVIHNSMK LYRQIRERNP 

       130        140        150        160        170        180 
NAKLVMHMHN AFEPELPDND AKIIVPSQFL KAFYEERLPA AAVSIVPNGF CAETYKRNPQ 

       190        200        210        220        230        240 
DNLRQQLNIA EDATVLLYAG RISPDKGILL LLQAFKQLRT LRSNIKLVVV GDPYASRKGE 

       250        260        270        280        290        300 
KAEYQKKVLD AAKEIGTDCI MAGGQSPDQM HNFYHIADLV IVPSQVEEAF CMVAVEAMAA 

       310        320        330        340        350        360 
GKAVLASKKG GISEFVLDGI TGYHLAEPMS SDSIINDINR ALADKERHQI AEKAKSLVFS 

       370        380 
KYSWENVAQR FEEQMKNWFD K 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, characterization, and DNA sequence of the rfaLK region for lipopolysaccharide synthesis in Salmonella typhimurium LT2."
Maclachlan P.R., Kadam S.K., Sanderson K.E.
J. Bacteriol. 173:7151-7163(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: LT2.
[2]"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2."
McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. expand/collapse author list , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K.
Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M73826 Genomic DNA. Translation: AAA27207.1.
AE006468 Genomic DNA. Translation: AAL22573.1.
PIRC41317.
RefSeqNP_462614.1. NC_003197.1.

3D structure databases

ProteinModelPortalP26470.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING99287.STM3714.

Protein family/group databases

CAZyGT4. Glycosyltransferase Family 4.

Proteomic databases

PaxDbP26470.
PRIDEP26470.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL22573; AAL22573; STM3714.
GeneID1255238.
KEGGstm:STM3714.
PATRIC32386263. VBISalEnt20916_3928.

Phylogenomic databases

eggNOGCOG0438.
HOGENOMHOG000028248.
KOK03280.
OMASAIACIK.
OrthoDBEOG6677RB.
PhylomeDBP26470.

Enzyme and pathway databases

BioCycSENT99287:GCTI-3739-MONOMER.
UniPathwayUPA00958.

Family and domain databases

InterProIPR001296. Glyco_trans_1.
[Graphical view]
PfamPF00534. Glycos_transf_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameWAAK_SALTY
AccessionPrimary (citable) accession number: P26470
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways