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Protein

Lipopolysaccharide 1,2-N-acetylglucosaminetransferase

Gene

waaK

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Adds the terminal N-acetyl-D-glucosamine group on the glucose(II) group of LPS.

Catalytic activityi

UDP-N-acetyl-alpha-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-alpha-D-glucosaminyllipopolysaccharide.

Pathway:iLPS core biosynthesis

This protein is involved in the pathway LPS core biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway LPS core biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciSENT99287:GCTI-3739-MONOMER.
UniPathwayiUPA00958.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipopolysaccharide 1,2-N-acetylglucosaminetransferase (EC:2.4.1.56)
Gene namesi
Name:waaK
Synonyms:rfaK
Ordered Locus Names:STM3714
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381Lipopolysaccharide 1,2-N-acetylglucosaminetransferasePRO_0000080306Add
BLAST

Proteomic databases

PaxDbiP26470.
PRIDEiP26470.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM3714.

Structurei

3D structure databases

ProteinModelPortaliP26470.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0438.
HOGENOMiHOG000028248.
KOiK03280.
OMAiSAIACIK.
OrthoDBiEOG6677RB.
PhylomeDBiP26470.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
[Graphical view]
PfamiPF00534. Glycos_transf_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26470-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKKIIFTVT PIFSIPPRGA AAVETWIYQV AKRLSIPNAI ACIKNAGYPE
60 70 80 90 100
YNKINDNCDI HYIGFSKVYK RLFQKWTRLD PLPYSQRILN IRDKVTTQED
110 120 130 140 150
SVIVIHNSMK LYRQIRERNP NAKLVMHMHN AFEPELPDND AKIIVPSQFL
160 170 180 190 200
KAFYEERLPA AAVSIVPNGF CAETYKRNPQ DNLRQQLNIA EDATVLLYAG
210 220 230 240 250
RISPDKGILL LLQAFKQLRT LRSNIKLVVV GDPYASRKGE KAEYQKKVLD
260 270 280 290 300
AAKEIGTDCI MAGGQSPDQM HNFYHIADLV IVPSQVEEAF CMVAVEAMAA
310 320 330 340 350
GKAVLASKKG GISEFVLDGI TGYHLAEPMS SDSIINDINR ALADKERHQI
360 370 380
AEKAKSLVFS KYSWENVAQR FEEQMKNWFD K
Length:381
Mass (Da):43,152
Last modified:August 1, 1992 - v1
Checksum:iF60F37FF175372C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73826 Genomic DNA. Translation: AAA27207.1.
AE006468 Genomic DNA. Translation: AAL22573.1.
PIRiC41317.
RefSeqiNP_462614.1. NC_003197.1.
WP_000591818.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL22573; AAL22573; STM3714.
GeneIDi1255238.
KEGGistm:STM3714.
PATRICi32386263. VBISalEnt20916_3928.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73826 Genomic DNA. Translation: AAA27207.1.
AE006468 Genomic DNA. Translation: AAL22573.1.
PIRiC41317.
RefSeqiNP_462614.1. NC_003197.1.
WP_000591818.1. NC_003197.1.

3D structure databases

ProteinModelPortaliP26470.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM3714.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Proteomic databases

PaxDbiP26470.
PRIDEiP26470.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL22573; AAL22573; STM3714.
GeneIDi1255238.
KEGGistm:STM3714.
PATRICi32386263. VBISalEnt20916_3928.

Phylogenomic databases

eggNOGiCOG0438.
HOGENOMiHOG000028248.
KOiK03280.
OMAiSAIACIK.
OrthoDBiEOG6677RB.
PhylomeDBiP26470.

Enzyme and pathway databases

UniPathwayiUPA00958.
BioCyciSENT99287:GCTI-3739-MONOMER.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
[Graphical view]
PfamiPF00534. Glycos_transf_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, characterization, and DNA sequence of the rfaLK region for lipopolysaccharide synthesis in Salmonella typhimurium LT2."
    Maclachlan P.R., Kadam S.K., Sanderson K.E.
    J. Bacteriol. 173:7151-7163(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LT2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiWAAK_SALTY
AccessioniPrimary (citable) accession number: P26470
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: May 27, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.