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Protein

Maltoporin

Gene

lamB

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the transport of maltose and maltodextrins. Does not act as a receptor for phages.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei31 – 311Greasy slide, important in sugar transport1 Publication
Sitei66 – 661Greasy slide, important in sugar transport1 Publication
Sitei99 – 991Greasy slide, important in sugar transport1 Publication
Sitei143 – 1431Important in sugar transport1 Publication
Sitei252 – 2521Greasy slide, important in sugar transport1 Publication
Sitei393 – 3931Greasy slide, important in sugar transport1 Publication
Sitei451 – 4511Greasy slide, important in sugar transport1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Sugar transport, Transport

Enzyme and pathway databases

BioCyciSENT99287:GCTI-4262-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Maltoporin
Alternative name(s):
Maltose-inducible porin
Gene namesi
Name:lamB
Synonyms:malL1 Publication
Ordered Locus Names:STM4231
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 261Periplasmic1 Publication
Transmembranei27 – 359Beta stranded1 Publication
Topological domaini36 – 6429Extracellular1 PublicationAdd
BLAST
Transmembranei65 – 7814Beta stranded1 PublicationAdd
BLAST
Topological domaini79 – 802Periplasmic1 Publication
Transmembranei81 – 9313Beta stranded1 PublicationAdd
BLAST
Topological domaini94 – 10411Extracellular1 PublicationAdd
BLAST
Transmembranei105 – 11511Beta stranded1 PublicationAdd
BLAST
Topological domaini116 – 1227Periplasmic1 Publication
Transmembranei123 – 1308Beta stranded1 Publication
Topological domaini131 – 14818Extracellular1 PublicationAdd
BLAST
Transmembranei149 – 15911Beta stranded1 PublicationAdd
BLAST
Topological domaini160 – 1612Periplasmic1 Publication
Transmembranei162 – 17312Beta stranded1 PublicationAdd
BLAST
Topological domaini174 – 19118Extracellular1 PublicationAdd
BLAST
Transmembranei192 – 20514Beta stranded1 PublicationAdd
BLAST
Topological domaini206 – 2094Periplasmic1 Publication
Transmembranei210 – 22213Beta stranded1 PublicationAdd
BLAST
Topological domaini223 – 23412Extracellular1 PublicationAdd
BLAST
Transmembranei235 – 24814Beta stranded1 PublicationAdd
BLAST
Topological domaini249 – 2502Periplasmic1 Publication
Transmembranei251 – 26313Beta stranded1 PublicationAdd
BLAST
Topological domaini264 – 30037Extracellular1 PublicationAdd
BLAST
Transmembranei301 – 31515Beta stranded1 PublicationAdd
BLAST
Topological domaini316 – 3172Periplasmic1 Publication
Transmembranei318 – 33316Beta stranded1 PublicationAdd
BLAST
Topological domaini334 – 3363Extracellular1 Publication
Transmembranei337 – 35115Beta stranded1 PublicationAdd
BLAST
Topological domaini352 – 3532Periplasmic1 Publication
Transmembranei354 – 36916Beta stranded1 PublicationAdd
BLAST
Topological domaini370 – 3723Extracellular1 Publication
Transmembranei373 – 38816Beta stranded1 PublicationAdd
BLAST
Topological domaini389 – 3957Periplasmic1 Publication
Transmembranei396 – 41015Beta stranded1 PublicationAdd
BLAST
Topological domaini411 – 43626Extracellular1 PublicationAdd
BLAST
Transmembranei437 – 45115Beta stranded1 PublicationAdd
BLAST
Topological domaini452 – 4521Periplasmic1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Add
BLAST
Chaini26 – 452427MaltoporinPRO_0000025180Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 ↔ 631 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP26466.
PRIDEiP26466.

Expressioni

Inductioni

By maltose.Curated

Interactioni

Subunit structurei

Homotrimer formed of three 18-stranded antiparallel beta-barrels, containing three independent channels.1 Publication

Protein-protein interaction databases

STRINGi99287.STM4231.

Structurei

Secondary structure

1
452
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 3913Combined sources
Beta strandi42 – 443Combined sources
Beta strandi64 – 7815Combined sources
Beta strandi81 – 9313Combined sources
Beta strandi96 – 983Combined sources
Beta strandi105 – 11511Combined sources
Beta strandi124 – 1307Combined sources
Beta strandi135 – 1373Combined sources
Helixi138 – 1403Combined sources
Beta strandi142 – 1454Combined sources
Beta strandi149 – 15810Combined sources
Beta strandi160 – 18223Combined sources
Beta strandi185 – 20723Combined sources
Beta strandi210 – 22213Combined sources
Beta strandi236 – 24813Combined sources
Beta strandi251 – 26111Combined sources
Helixi262 – 2643Combined sources
Turni265 – 2673Combined sources
Turni274 – 2774Combined sources
Beta strandi280 – 2823Combined sources
Beta strandi292 – 2943Combined sources
Beta strandi302 – 31514Combined sources
Turni316 – 3183Combined sources
Beta strandi319 – 33214Combined sources
Beta strandi338 – 35215Combined sources
Beta strandi355 – 36814Combined sources
Turni369 – 3713Combined sources
Beta strandi374 – 39118Combined sources
Beta strandi396 – 41621Combined sources
Beta strandi419 – 43113Combined sources
Beta strandi438 – 45114Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MPRX-ray2.80A/B/C26-452[»]
2MPRX-ray2.40A/B/C26-452[»]
ProteinModelPortaliP26466.
SMRiP26466. Positions 26-452.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26466.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 14310Substrate1 Publication

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4108KDD. Bacteria.
COG4580. LUCA.
HOGENOMiHOG000218083.
KOiK02024.
OMAiYNKFVLQ.
OrthoDBiEOG63C0PN.
PhylomeDBiP26466.

Family and domain databases

Gene3Di2.40.170.10. 1 hit.
HAMAPiMF_01301. LamB.
InterProiIPR023738. Maltoporin.
IPR003192. Porin_LamB.
[Graphical view]
PfamiPF02264. LamB. 1 hit.
[Graphical view]
ProDomiPD008788. Porin_LamB. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26466-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMITLRKLPL AVAVAAGVMS AQAMAVDFHG YARSGIGWTG SGGEQQCFQA
60 70 80 90 100
TGAQSKYRLG NECETYAELK LGQEVWKEGD KSFYFDTNVA YSVNQQNDWE
110 120 130 140 150
STDPAFREAN VQGKNLIEWL PGSTIWAGKR FYQRHDVHMI DFYYWDISGP
160 170 180 190 200
GAGIENIDLG FGKLSLAATR STEAGGSYTF SSQNIYDEVK DTANDVFDVR
210 220 230 240 250
LAGLQTNPDG VLELGVDYGR ANTTDGYKLA DGASKDGWMF TAEHTQSMLK
260 270 280 290 300
GYNKFVVQYA TDAMTTQGKG QARGSDGSSS FTEELSDGTK INYANKVINN
310 320 330 340 350
NGNMWRILDH GAISLGDKWD LMYVGMYQNI DWDNNLGTEW WTVGVRPMYK
360 370 380 390 400
WTPIMSTLLE VGYDNVKSQQ TGDRNNQYKI TLAQQWQAGD SIWSRPAIRI
410 420 430 440 450
FATYAKWDEK WGYIKDGDNI SRYAAATNSG ISTNSRGDSD EWTFGAQMEI

WW
Length:452
Mass (Da):50,549
Last modified:November 1, 1997 - v2
Checksum:iE5148050ECABF063
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54292 Genomic DNA. Translation: CAA38187.1.
AE006468 Genomic DNA. Translation: AAL23055.1.
PIRiA60177.
RefSeqiNP_463096.1. NC_003197.1.
WP_000973645.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL23055; AAL23055; STM4231.
GeneIDi1255757.
KEGGistm:STM4231.
PATRICi32387367. VBISalEnt20916_4451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54292 Genomic DNA. Translation: CAA38187.1.
AE006468 Genomic DNA. Translation: AAL23055.1.
PIRiA60177.
RefSeqiNP_463096.1. NC_003197.1.
WP_000973645.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MPRX-ray2.80A/B/C26-452[»]
2MPRX-ray2.40A/B/C26-452[»]
ProteinModelPortaliP26466.
SMRiP26466. Positions 26-452.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM4231.

Proteomic databases

PaxDbiP26466.
PRIDEiP26466.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL23055; AAL23055; STM4231.
GeneIDi1255757.
KEGGistm:STM4231.
PATRICi32387367. VBISalEnt20916_4451.

Phylogenomic databases

eggNOGiENOG4108KDD. Bacteria.
COG4580. LUCA.
HOGENOMiHOG000218083.
KOiK02024.
OMAiYNKFVLQ.
OrthoDBiEOG63C0PN.
PhylomeDBiP26466.

Enzyme and pathway databases

BioCyciSENT99287:GCTI-4262-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP26466.

Family and domain databases

Gene3Di2.40.170.10. 1 hit.
HAMAPiMF_01301. LamB.
InterProiIPR023738. Maltoporin.
IPR003192. Porin_LamB.
[Graphical view]
PfamiPF02264. LamB. 1 hit.
[Graphical view]
ProDomiPD008788. Porin_LamB. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Completion of the nucleotide sequence of the 'maltose B' region in Salmonella typhimurium: the high conservation of the malM gene suggests a selected physiological role for its product."
    Schneider E., Francoz E., Dassa E.
    Biochim. Biophys. Acta 1129:223-227(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LT2.
  2. "The maltoporin of Salmonella typhimurium: sequence and folding model."
    Francoz E., Molla A., Dassa E., Saurin W., Hofnung M.
    Res. Microbiol. 141:1039-1059(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Strain: LT2.
  3. Dassa E.
    Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 427.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.
  5. "Structure of maltoporin from Salmonella typhimurium ligated with a nitrophenyl-maltotrioside."
    Meyer J.E.W., Hofnung M., Schulz G.E.
    J. Mol. Biol. 266:761-775(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 26-452 WITH AND WITHOUT SUBSTRATE, SUBUNIT, TOPOLOGY, DISULFIDE BOND.

Entry informationi

Entry nameiLAMB_SALTY
AccessioniPrimary (citable) accession number: P26466
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: November 1, 1997
Last modified: January 20, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.