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Protein

Maltoporin

Gene

lamB

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the transport of maltose and maltodextrins. Does not act as a receptor for phages.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei31Greasy slide, important in sugar transport1 Publication1
Sitei66Greasy slide, important in sugar transport1 Publication1
Sitei99Greasy slide, important in sugar transport1 Publication1
Sitei143Important in sugar transport1 Publication1
Sitei252Greasy slide, important in sugar transport1 Publication1
Sitei393Greasy slide, important in sugar transport1 Publication1
Sitei451Greasy slide, important in sugar transport1 Publication1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Sugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Maltoporin
Alternative name(s):
Maltose-inducible porin
Gene namesi
Name:lamB
Synonyms:malL1 Publication
Ordered Locus Names:STM4231
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26Periplasmic1 Publication1
Transmembranei27 – 35Beta stranded1 Publication9
Topological domaini36 – 64Extracellular1 PublicationAdd BLAST29
Transmembranei65 – 78Beta stranded1 PublicationAdd BLAST14
Topological domaini79 – 80Periplasmic1 Publication2
Transmembranei81 – 93Beta stranded1 PublicationAdd BLAST13
Topological domaini94 – 104Extracellular1 PublicationAdd BLAST11
Transmembranei105 – 115Beta stranded1 PublicationAdd BLAST11
Topological domaini116 – 122Periplasmic1 Publication7
Transmembranei123 – 130Beta stranded1 Publication8
Topological domaini131 – 148Extracellular1 PublicationAdd BLAST18
Transmembranei149 – 159Beta stranded1 PublicationAdd BLAST11
Topological domaini160 – 161Periplasmic1 Publication2
Transmembranei162 – 173Beta stranded1 PublicationAdd BLAST12
Topological domaini174 – 191Extracellular1 PublicationAdd BLAST18
Transmembranei192 – 205Beta stranded1 PublicationAdd BLAST14
Topological domaini206 – 209Periplasmic1 Publication4
Transmembranei210 – 222Beta stranded1 PublicationAdd BLAST13
Topological domaini223 – 234Extracellular1 PublicationAdd BLAST12
Transmembranei235 – 248Beta stranded1 PublicationAdd BLAST14
Topological domaini249 – 250Periplasmic1 Publication2
Transmembranei251 – 263Beta stranded1 PublicationAdd BLAST13
Topological domaini264 – 300Extracellular1 PublicationAdd BLAST37
Transmembranei301 – 315Beta stranded1 PublicationAdd BLAST15
Topological domaini316 – 317Periplasmic1 Publication2
Transmembranei318 – 333Beta stranded1 PublicationAdd BLAST16
Topological domaini334 – 336Extracellular1 Publication3
Transmembranei337 – 351Beta stranded1 PublicationAdd BLAST15
Topological domaini352 – 353Periplasmic1 Publication2
Transmembranei354 – 369Beta stranded1 PublicationAdd BLAST16
Topological domaini370 – 372Extracellular1 Publication3
Transmembranei373 – 388Beta stranded1 PublicationAdd BLAST16
Topological domaini389 – 395Periplasmic1 Publication7
Transmembranei396 – 410Beta stranded1 PublicationAdd BLAST15
Topological domaini411 – 436Extracellular1 PublicationAdd BLAST26
Transmembranei437 – 451Beta stranded1 PublicationAdd BLAST15
Topological domaini452Periplasmic1 Publication1

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Add BLAST25
ChainiPRO_000002518026 – 452MaltoporinAdd BLAST427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 631 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP26466.
PRIDEiP26466.

Expressioni

Inductioni

By maltose.Curated

Interactioni

Subunit structurei

Homotrimer formed of three 18-stranded antiparallel beta-barrels, containing three independent channels.1 Publication

Protein-protein interaction databases

STRINGi99287.STM4231.

Structurei

Secondary structure

1452
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 39Combined sources13
Beta strandi42 – 44Combined sources3
Beta strandi64 – 78Combined sources15
Beta strandi81 – 93Combined sources13
Beta strandi96 – 98Combined sources3
Beta strandi105 – 115Combined sources11
Beta strandi124 – 130Combined sources7
Beta strandi135 – 137Combined sources3
Helixi138 – 140Combined sources3
Beta strandi142 – 145Combined sources4
Beta strandi149 – 158Combined sources10
Beta strandi160 – 182Combined sources23
Beta strandi185 – 207Combined sources23
Beta strandi210 – 222Combined sources13
Beta strandi236 – 248Combined sources13
Beta strandi251 – 261Combined sources11
Helixi262 – 264Combined sources3
Turni265 – 267Combined sources3
Turni274 – 277Combined sources4
Beta strandi280 – 282Combined sources3
Beta strandi292 – 294Combined sources3
Beta strandi302 – 315Combined sources14
Turni316 – 318Combined sources3
Beta strandi319 – 332Combined sources14
Beta strandi338 – 352Combined sources15
Beta strandi355 – 368Combined sources14
Turni369 – 371Combined sources3
Beta strandi374 – 391Combined sources18
Beta strandi396 – 416Combined sources21
Beta strandi419 – 431Combined sources13
Beta strandi438 – 451Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MPRX-ray2.80A/B/C26-452[»]
2MPRX-ray2.40A/B/C26-452[»]
ProteinModelPortaliP26466.
SMRiP26466.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26466.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni134 – 143Substrate1 Publication10

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4108KDD. Bacteria.
COG4580. LUCA.
HOGENOMiHOG000218083.
KOiK02024.
OMAiYNKFVLQ.
PhylomeDBiP26466.

Family and domain databases

CDDicd01346. Maltoporin-like. 1 hit.
Gene3Di2.40.170.10. 1 hit.
HAMAPiMF_01301. LamB. 1 hit.
InterProiIPR023738. Maltoporin.
IPR003192. Porin_LamB.
[Graphical view]
PfamiPF02264. LamB. 1 hit.
[Graphical view]
ProDomiPD008788. Porin_LamB. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26466-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMITLRKLPL AVAVAAGVMS AQAMAVDFHG YARSGIGWTG SGGEQQCFQA
60 70 80 90 100
TGAQSKYRLG NECETYAELK LGQEVWKEGD KSFYFDTNVA YSVNQQNDWE
110 120 130 140 150
STDPAFREAN VQGKNLIEWL PGSTIWAGKR FYQRHDVHMI DFYYWDISGP
160 170 180 190 200
GAGIENIDLG FGKLSLAATR STEAGGSYTF SSQNIYDEVK DTANDVFDVR
210 220 230 240 250
LAGLQTNPDG VLELGVDYGR ANTTDGYKLA DGASKDGWMF TAEHTQSMLK
260 270 280 290 300
GYNKFVVQYA TDAMTTQGKG QARGSDGSSS FTEELSDGTK INYANKVINN
310 320 330 340 350
NGNMWRILDH GAISLGDKWD LMYVGMYQNI DWDNNLGTEW WTVGVRPMYK
360 370 380 390 400
WTPIMSTLLE VGYDNVKSQQ TGDRNNQYKI TLAQQWQAGD SIWSRPAIRI
410 420 430 440 450
FATYAKWDEK WGYIKDGDNI SRYAAATNSG ISTNSRGDSD EWTFGAQMEI

WW
Length:452
Mass (Da):50,549
Last modified:November 1, 1997 - v2
Checksum:iE5148050ECABF063
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54292 Genomic DNA. Translation: CAA38187.1.
AE006468 Genomic DNA. Translation: AAL23055.1.
PIRiA60177.
RefSeqiNP_463096.1. NC_003197.1.
WP_000973645.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL23055; AAL23055; STM4231.
GeneIDi1255757.
KEGGistm:STM4231.
PATRICi32387367. VBISalEnt20916_4451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54292 Genomic DNA. Translation: CAA38187.1.
AE006468 Genomic DNA. Translation: AAL23055.1.
PIRiA60177.
RefSeqiNP_463096.1. NC_003197.1.
WP_000973645.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MPRX-ray2.80A/B/C26-452[»]
2MPRX-ray2.40A/B/C26-452[»]
ProteinModelPortaliP26466.
SMRiP26466.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM4231.

Proteomic databases

PaxDbiP26466.
PRIDEiP26466.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL23055; AAL23055; STM4231.
GeneIDi1255757.
KEGGistm:STM4231.
PATRICi32387367. VBISalEnt20916_4451.

Phylogenomic databases

eggNOGiENOG4108KDD. Bacteria.
COG4580. LUCA.
HOGENOMiHOG000218083.
KOiK02024.
OMAiYNKFVLQ.
PhylomeDBiP26466.

Miscellaneous databases

EvolutionaryTraceiP26466.

Family and domain databases

CDDicd01346. Maltoporin-like. 1 hit.
Gene3Di2.40.170.10. 1 hit.
HAMAPiMF_01301. LamB. 1 hit.
InterProiIPR023738. Maltoporin.
IPR003192. Porin_LamB.
[Graphical view]
PfamiPF02264. LamB. 1 hit.
[Graphical view]
ProDomiPD008788. Porin_LamB. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiLAMB_SALTY
AccessioniPrimary (citable) accession number: P26466
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.