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P26465

- FLII_SALTY

UniProt

P26465 - FLII_SALTY

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Protein
Flagellum-specific ATP synthase
Gene
fliI, fla AIII, flaC, STM1972
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. May be involved in a specialized protein export pathway that proceeds without signal peptide cleavage.

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi182 – 1898ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. ATP biosynthetic process Source: UniProtKB-KW
  2. bacterial-type flagellum assembly Source: InterPro
  3. bacterial-type flagellum-dependent cell motility Source: InterPro
  4. protein secretion by the type III secretion system Source: InterPro
  5. proton transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

ATP synthesis, Bacterial flagellum biogenesis, Bacterial flagellum protein export, Hydrogen ion transport, Ion transport, Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1982-MONOMER.

Protein family/group databases

TCDBi3.A.6.2.1. the type iii (virulence-related) secretory pathway (iiisp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellum-specific ATP synthase (EC:3.6.3.14)
Gene namesi
Name:fliI
Synonyms:fla AIII, flaC
Ordered Locus Names:STM1972
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. type III protein secretion system complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi188 – 1881K → E: Loss of flagellum.
Mutagenesisi188 – 1881K → I: Loss of flagellum.
Mutagenesisi272 – 2721D → N: Loss of flagellum.
Mutagenesisi363 – 3631Y → S: Loss of flagellum.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Flagellum-specific ATP synthase
PRO_0000144695Add
BLAST

Proteomic databases

PaxDbiP26465.
PRIDEiP26465.

Interactioni

Protein-protein interaction databases

DIPiDIP-59076N.
IntActiP26465. 1 interaction.
STRINGi99287.STM1972.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi29 – 335
Beta strandi35 – 439
Beta strandi51 – 566
Beta strandi63 – 719
Beta strandi77 – 837
Beta strandi92 – 965
Beta strandi109 – 1113
Helixi114 – 1163
Beta strandi119 – 1213
Beta strandi127 – 1315
Beta strandi139 – 1424
Helixi164 – 1696
Beta strandi177 – 1826
Helixi188 – 19811
Beta strandi202 – 2109
Helixi213 – 2219
Turni222 – 2243
Helixi225 – 2306
Beta strandi232 – 2376
Helixi243 – 26119
Turni262 – 2643
Beta strandi266 – 2727
Helixi274 – 28714
Beta strandi294 – 2963
Helixi301 – 3099
Beta strandi321 – 3299
Beta strandi331 – 3333
Helixi338 – 3469
Beta strandi347 – 3537
Helixi355 – 3595
Beta strandi366 – 3738
Helixi376 – 3794
Helixi382 – 40019
Helixi401 – 4033
Beta strandi405 – 4084
Helixi416 – 4227
Helixi425 – 4328
Helixi442 – 45211

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DPYX-ray2.40A/B19-456[»]
ProteinModelPortaliP26465.
SMRiP26465. Positions 23-456.

Miscellaneous databases

EvolutionaryTraceiP26465.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1157.
HOGENOMiHOG000257876.
KOiK02412.
OMAiQRTPITD.
OrthoDBiEOG6W9X53.
PhylomeDBiP26465.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR020003. ATPase_a/bsu_AS.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR005714. ATPase_T3SS_FliI/YscN.
IPR020005. FliI_clade1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR15184:SF9. PTHR15184:SF9. 1 hit.
PfamiPF00006. ATP-synt_ab. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03496. FliI_clade1. 1 hit.
TIGR01026. fliI_yscN. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26465-1 [UniParc]FASTAAdd to Basket

« Hide

MTTRLTRWLT ALDNFEAKMA LLPAVRRYGR LTRATGLVLE ATGLQLPLGA    50
TCIIERQDGP ETKEVESEVV GFNGQRLFLM PLEEVEGILP GARVYARNGH 100
GDGLQSGKQL PLGPALLGRV LDGGGKPLDG LPAPDTLETG ALITPPFNPL 150
QRTPIEHVLD TGVRAINALL TVGRGQRMGL FAGSGVGKSV LLGMMARYTR 200
ADVIVVGLIG ERGREVKDFI ENILGPDGRA RSVVIAAPAD VSPLLRMQGA 250
AYATRIAEDF RDRGQHVLLI MDSLTRYAMA QREIALAIGE PPATKGYPPS 300
VFAKLPALVE RAGNGIHGGG SITAFYTVLT EGDDQQDPIA DSARAILDGH 350
IVLSRRLAEA GHYPAIDIEA SISRAMTALI TEQHYARVRL FKQLLSSFQR 400
NRDLVSVGAY AKGSDPMLDK AITLWPQLEA FLQQGIFERA DWEDSLQALD 450
LIFPTV 456
Length:456
Mass (Da):49,265
Last modified:August 1, 1992 - v1
Checksum:i830867B657592BF1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M62408 Genomic DNA. Translation: AAA27101.1.
AE006468 Genomic DNA. Translation: AAL20884.1.
PIRiC42364.
RefSeqiNP_460925.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20884; AAL20884; STM1972.
GeneIDi1253493.
KEGGistm:STM1972.
PATRICi32382507. VBISalEnt20916_2089.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M62408 Genomic DNA. Translation: AAA27101.1 .
AE006468 Genomic DNA. Translation: AAL20884.1 .
PIRi C42364.
RefSeqi NP_460925.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DPY X-ray 2.40 A/B 19-456 [» ]
ProteinModelPortali P26465.
SMRi P26465. Positions 23-456.
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-59076N.
IntActi P26465. 1 interaction.
STRINGi 99287.STM1972.

Protein family/group databases

TCDBi 3.A.6.2.1. the type iii (virulence-related) secretory pathway (iiisp) family.

Proteomic databases

PaxDbi P26465.
PRIDEi P26465.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL20884 ; AAL20884 ; STM1972 .
GeneIDi 1253493.
KEGGi stm:STM1972.
PATRICi 32382507. VBISalEnt20916_2089.

Phylogenomic databases

eggNOGi COG1157.
HOGENOMi HOG000257876.
KOi K02412.
OMAi QRTPITD.
OrthoDBi EOG6W9X53.
PhylomeDBi P26465.

Enzyme and pathway databases

BioCyci SENT99287:GCTI-1982-MONOMER.

Miscellaneous databases

EvolutionaryTracei P26465.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR020003. ATPase_a/bsu_AS.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR005714. ATPase_T3SS_FliI/YscN.
IPR020005. FliI_clade1.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR15184:SF9. PTHR15184:SF9. 1 hit.
Pfami PF00006. ATP-synt_ab. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR03496. FliI_clade1. 1 hit.
TIGR01026. fliI_yscN. 1 hit.
PROSITEi PS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Salmonella typhimurium mutants defective in flagellar filament regrowth and sequence similarity of FliI to F0F1, vacuolar, and archaebacterial ATPase subunits."
    Vogler A.P., Homma M., Irikura V.M., Macnab R.M.
    J. Bacteriol. 173:3564-3572(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.
  3. "Genetic and biochemical analysis of Salmonella typhimurium FliI, a flagellar protein related to the catalytic subunit of the F0F1 ATPase and to virulence proteins of mammalian and plant pathogens."
    Dreyfus G., Williams A.W., Kawagishi I., Macnab R.M.
    J. Bacteriol. 175:3131-3138(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, MUTAGENESIS.

Entry informationi

Entry nameiFLII_SALTY
AccessioniPrimary (citable) accession number: P26465
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 3, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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