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P26465

- FLII_SALTY

UniProt

P26465 - FLII_SALTY

Protein

Flagellum-specific ATP synthase

Gene

fliI

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. May be involved in a specialized protein export pathway that proceeds without signal peptide cleavage.

    Catalytic activityi

    ATP + H2O + H+(In) = ADP + phosphate + H+(Out).PROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi182 – 1898ATPBy similarity

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. ATP biosynthetic process Source: UniProtKB-KW
    2. bacterial-type flagellum assembly Source: InterPro
    3. bacterial-type flagellum-dependent cell motility Source: InterPro
    4. protein secretion by the type III secretion system Source: InterPro
    5. proton transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    ATP synthesis, Bacterial flagellum biogenesis, Bacterial flagellum protein export, Hydrogen ion transport, Ion transport, Protein transport, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-1982-MONOMER.

    Protein family/group databases

    TCDBi3.A.6.2.1. the type iii (virulence-related) secretory pathway (iiisp) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Flagellum-specific ATP synthase (EC:3.6.3.14)
    Gene namesi
    Name:fliI
    Synonyms:fla AIII, flaC
    Ordered Locus Names:STM1972
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. type III protein secretion system complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi188 – 1881K → E: Loss of flagellum. 1 Publication
    Mutagenesisi188 – 1881K → I: Loss of flagellum. 1 Publication
    Mutagenesisi272 – 2721D → N: Loss of flagellum. 1 Publication
    Mutagenesisi363 – 3631Y → S: Loss of flagellum. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 456456Flagellum-specific ATP synthasePRO_0000144695Add
    BLAST

    Proteomic databases

    PaxDbiP26465.
    PRIDEiP26465.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-59076N.
    IntActiP26465. 1 interaction.
    STRINGi99287.STM1972.

    Structurei

    Secondary structure

    1
    456
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi29 – 335
    Beta strandi35 – 439
    Beta strandi51 – 566
    Beta strandi63 – 719
    Beta strandi77 – 837
    Beta strandi92 – 965
    Beta strandi109 – 1113
    Helixi114 – 1163
    Beta strandi119 – 1213
    Beta strandi127 – 1315
    Beta strandi139 – 1424
    Helixi164 – 1696
    Beta strandi177 – 1826
    Helixi188 – 19811
    Beta strandi202 – 2109
    Helixi213 – 2219
    Turni222 – 2243
    Helixi225 – 2306
    Beta strandi232 – 2376
    Helixi243 – 26119
    Turni262 – 2643
    Beta strandi266 – 2727
    Helixi274 – 28714
    Beta strandi294 – 2963
    Helixi301 – 3099
    Beta strandi321 – 3299
    Beta strandi331 – 3333
    Helixi338 – 3469
    Beta strandi347 – 3537
    Helixi355 – 3595
    Beta strandi366 – 3738
    Helixi376 – 3794
    Helixi382 – 40019
    Helixi401 – 4033
    Beta strandi405 – 4084
    Helixi416 – 4227
    Helixi425 – 4328
    Helixi442 – 45211

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DPYX-ray2.40A/B19-456[»]
    ProteinModelPortaliP26465.
    SMRiP26465. Positions 23-456.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP26465.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATPase alpha/beta chains family.Curated

    Phylogenomic databases

    eggNOGiCOG1157.
    HOGENOMiHOG000257876.
    KOiK02412.
    OMAiQRTPITD.
    OrthoDBiEOG6W9X53.
    PhylomeDBiP26465.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR020003. ATPase_a/bsu_AS.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR005714. ATPase_T3SS_FliI/YscN.
    IPR020005. FliI_clade1.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR15184:SF9. PTHR15184:SF9. 1 hit.
    PfamiPF00006. ATP-synt_ab. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR03496. FliI_clade1. 1 hit.
    TIGR01026. fliI_yscN. 1 hit.
    PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P26465-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTRLTRWLT ALDNFEAKMA LLPAVRRYGR LTRATGLVLE ATGLQLPLGA    50
    TCIIERQDGP ETKEVESEVV GFNGQRLFLM PLEEVEGILP GARVYARNGH 100
    GDGLQSGKQL PLGPALLGRV LDGGGKPLDG LPAPDTLETG ALITPPFNPL 150
    QRTPIEHVLD TGVRAINALL TVGRGQRMGL FAGSGVGKSV LLGMMARYTR 200
    ADVIVVGLIG ERGREVKDFI ENILGPDGRA RSVVIAAPAD VSPLLRMQGA 250
    AYATRIAEDF RDRGQHVLLI MDSLTRYAMA QREIALAIGE PPATKGYPPS 300
    VFAKLPALVE RAGNGIHGGG SITAFYTVLT EGDDQQDPIA DSARAILDGH 350
    IVLSRRLAEA GHYPAIDIEA SISRAMTALI TEQHYARVRL FKQLLSSFQR 400
    NRDLVSVGAY AKGSDPMLDK AITLWPQLEA FLQQGIFERA DWEDSLQALD 450
    LIFPTV 456
    Length:456
    Mass (Da):49,265
    Last modified:August 1, 1992 - v1
    Checksum:i830867B657592BF1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62408 Genomic DNA. Translation: AAA27101.1.
    AE006468 Genomic DNA. Translation: AAL20884.1.
    PIRiC42364.
    RefSeqiNP_460925.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL20884; AAL20884; STM1972.
    GeneIDi1253493.
    KEGGistm:STM1972.
    PATRICi32382507. VBISalEnt20916_2089.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62408 Genomic DNA. Translation: AAA27101.1 .
    AE006468 Genomic DNA. Translation: AAL20884.1 .
    PIRi C42364.
    RefSeqi NP_460925.1. NC_003197.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DPY X-ray 2.40 A/B 19-456 [» ]
    ProteinModelPortali P26465.
    SMRi P26465. Positions 23-456.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-59076N.
    IntActi P26465. 1 interaction.
    STRINGi 99287.STM1972.

    Protein family/group databases

    TCDBi 3.A.6.2.1. the type iii (virulence-related) secretory pathway (iiisp) family.

    Proteomic databases

    PaxDbi P26465.
    PRIDEi P26465.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL20884 ; AAL20884 ; STM1972 .
    GeneIDi 1253493.
    KEGGi stm:STM1972.
    PATRICi 32382507. VBISalEnt20916_2089.

    Phylogenomic databases

    eggNOGi COG1157.
    HOGENOMi HOG000257876.
    KOi K02412.
    OMAi QRTPITD.
    OrthoDBi EOG6W9X53.
    PhylomeDBi P26465.

    Enzyme and pathway databases

    BioCyci SENT99287:GCTI-1982-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P26465.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR020003. ATPase_a/bsu_AS.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR005714. ATPase_T3SS_FliI/YscN.
    IPR020005. FliI_clade1.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR15184:SF9. PTHR15184:SF9. 1 hit.
    Pfami PF00006. ATP-synt_ab. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR03496. FliI_clade1. 1 hit.
    TIGR01026. fliI_yscN. 1 hit.
    PROSITEi PS00152. ATPASE_ALPHA_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Salmonella typhimurium mutants defective in flagellar filament regrowth and sequence similarity of FliI to F0F1, vacuolar, and archaebacterial ATPase subunits."
      Vogler A.P., Homma M., Irikura V.M., Macnab R.M.
      J. Bacteriol. 173:3564-3572(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.
    3. "Genetic and biochemical analysis of Salmonella typhimurium FliI, a flagellar protein related to the catalytic subunit of the F0F1 ATPase and to virulence proteins of mammalian and plant pathogens."
      Dreyfus G., Williams A.W., Kawagishi I., Macnab R.M.
      J. Bacteriol. 175:3131-3138(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, MUTAGENESIS.

    Entry informationi

    Entry nameiFLII_SALTY
    AccessioniPrimary (citable) accession number: P26465
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3