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Protein

Flagellum-specific ATP synthase

Gene

fliI

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. May be involved in a specialized protein export pathway that proceeds without signal peptide cleavage.

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi182 – 189ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

ATP synthesis, Bacterial flagellum biogenesis, Bacterial flagellum protein export, Hydrogen ion transport, Ion transport, Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Protein family/group databases

TCDBi3.A.6.2.1. the type iii (virulence-related) secretory pathway (iiisp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellum-specific ATP synthase (EC:3.6.3.14)
Gene namesi
Name:fliI
Synonyms:fla AIII, flaC
Ordered Locus Names:STM1972
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi188K → E: Loss of flagellum. 1 Publication1
Mutagenesisi188K → I: Loss of flagellum. 1 Publication1
Mutagenesisi272D → N: Loss of flagellum. 1 Publication1
Mutagenesisi363Y → S: Loss of flagellum. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001446951 – 456Flagellum-specific ATP synthaseAdd BLAST456

Proteomic databases

PaxDbiP26465.
PRIDEiP26465.

Interactioni

Protein-protein interaction databases

DIPiDIP-59076N.
IntActiP26465. 1 interactor.
STRINGi99287.STM1972.

Structurei

Secondary structure

1456
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 19Combined sources17
Beta strandi29 – 33Combined sources5
Beta strandi35 – 43Combined sources9
Beta strandi51 – 56Combined sources6
Beta strandi63 – 71Combined sources9
Beta strandi77 – 83Combined sources7
Beta strandi92 – 96Combined sources5
Turni99 – 102Combined sources4
Beta strandi109 – 111Combined sources3
Helixi114 – 116Combined sources3
Beta strandi119 – 121Combined sources3
Beta strandi127 – 131Combined sources5
Beta strandi139 – 142Combined sources4
Helixi149 – 151Combined sources3
Helixi164 – 169Combined sources6
Beta strandi177 – 182Combined sources6
Helixi188 – 198Combined sources11
Beta strandi202 – 210Combined sources9
Helixi213 – 221Combined sources9
Turni222 – 224Combined sources3
Helixi225 – 230Combined sources6
Beta strandi232 – 237Combined sources6
Beta strandi239 – 241Combined sources3
Helixi243 – 261Combined sources19
Turni262 – 264Combined sources3
Beta strandi266 – 272Combined sources7
Helixi274 – 287Combined sources14
Beta strandi294 – 296Combined sources3
Helixi301 – 309Combined sources9
Beta strandi321 – 329Combined sources9
Beta strandi331 – 333Combined sources3
Helixi338 – 346Combined sources9
Beta strandi347 – 353Combined sources7
Helixi355 – 359Combined sources5
Beta strandi366 – 373Combined sources8
Helixi376 – 379Combined sources4
Helixi382 – 400Combined sources19
Helixi401 – 403Combined sources3
Beta strandi405 – 408Combined sources4
Helixi416 – 422Combined sources7
Helixi425 – 432Combined sources8
Helixi442 – 452Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DPYX-ray2.40A/B19-456[»]
5B0OX-ray3.00A/B/C/D1-456[»]
5KP0NMR-A1-25[»]
ProteinModelPortaliP26465.
SMRiP26465.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26465.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

eggNOGiENOG4108JIR. Bacteria.
COG1157. LUCA.
HOGENOMiHOG000257876.
KOiK02412.
OMAiQAQKFKQ.
PhylomeDBiP26465.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR020003. ATPase_a/bsu_AS.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR032463. ATPase_T3SS_FliI.
IPR005714. ATPase_T3SS_FliI/YscN.
IPR020005. FliI_clade1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR15184:SF9. PTHR15184:SF9. 1 hit.
PfamiPF00006. ATP-synt_ab. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03496. FliI_clade1. 1 hit.
TIGR01026. fliI_yscN. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26465-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTRLTRWLT ALDNFEAKMA LLPAVRRYGR LTRATGLVLE ATGLQLPLGA
60 70 80 90 100
TCIIERQDGP ETKEVESEVV GFNGQRLFLM PLEEVEGILP GARVYARNGH
110 120 130 140 150
GDGLQSGKQL PLGPALLGRV LDGGGKPLDG LPAPDTLETG ALITPPFNPL
160 170 180 190 200
QRTPIEHVLD TGVRAINALL TVGRGQRMGL FAGSGVGKSV LLGMMARYTR
210 220 230 240 250
ADVIVVGLIG ERGREVKDFI ENILGPDGRA RSVVIAAPAD VSPLLRMQGA
260 270 280 290 300
AYATRIAEDF RDRGQHVLLI MDSLTRYAMA QREIALAIGE PPATKGYPPS
310 320 330 340 350
VFAKLPALVE RAGNGIHGGG SITAFYTVLT EGDDQQDPIA DSARAILDGH
360 370 380 390 400
IVLSRRLAEA GHYPAIDIEA SISRAMTALI TEQHYARVRL FKQLLSSFQR
410 420 430 440 450
NRDLVSVGAY AKGSDPMLDK AITLWPQLEA FLQQGIFERA DWEDSLQALD

LIFPTV
Length:456
Mass (Da):49,265
Last modified:August 1, 1992 - v1
Checksum:i830867B657592BF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62408 Genomic DNA. Translation: AAA27101.1.
AE006468 Genomic DNA. Translation: AAL20884.1.
PIRiC42364.
RefSeqiNP_460925.1. NC_003197.1.
WP_000213257.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20884; AAL20884; STM1972.
GeneIDi1253493.
KEGGistm:STM1972.
PATRICi32382507. VBISalEnt20916_2089.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62408 Genomic DNA. Translation: AAA27101.1.
AE006468 Genomic DNA. Translation: AAL20884.1.
PIRiC42364.
RefSeqiNP_460925.1. NC_003197.1.
WP_000213257.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DPYX-ray2.40A/B19-456[»]
5B0OX-ray3.00A/B/C/D1-456[»]
5KP0NMR-A1-25[»]
ProteinModelPortaliP26465.
SMRiP26465.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59076N.
IntActiP26465. 1 interactor.
STRINGi99287.STM1972.

Protein family/group databases

TCDBi3.A.6.2.1. the type iii (virulence-related) secretory pathway (iiisp) family.

Proteomic databases

PaxDbiP26465.
PRIDEiP26465.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL20884; AAL20884; STM1972.
GeneIDi1253493.
KEGGistm:STM1972.
PATRICi32382507. VBISalEnt20916_2089.

Phylogenomic databases

eggNOGiENOG4108JIR. Bacteria.
COG1157. LUCA.
HOGENOMiHOG000257876.
KOiK02412.
OMAiQAQKFKQ.
PhylomeDBiP26465.

Miscellaneous databases

EvolutionaryTraceiP26465.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR020003. ATPase_a/bsu_AS.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR032463. ATPase_T3SS_FliI.
IPR005714. ATPase_T3SS_FliI/YscN.
IPR020005. FliI_clade1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR15184:SF9. PTHR15184:SF9. 1 hit.
PfamiPF00006. ATP-synt_ab. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03496. FliI_clade1. 1 hit.
TIGR01026. fliI_yscN. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFLII_SALTY
AccessioniPrimary (citable) accession number: P26465
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 2, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.