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P26465

- FLII_SALTY

UniProt

P26465 - FLII_SALTY

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Protein

Flagellum-specific ATP synthase

Gene

fliI

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. May be involved in a specialized protein export pathway that proceeds without signal peptide cleavage.

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi182 – 1898ATPBy similarity

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP biosynthetic process Source: UniProtKB-KW
  2. bacterial-type flagellum assembly Source: InterPro
  3. bacterial-type flagellum-dependent cell motility Source: InterPro
  4. protein secretion by the type III secretion system Source: InterPro
  5. proton transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

ATP synthesis, Bacterial flagellum biogenesis, Bacterial flagellum protein export, Hydrogen ion transport, Ion transport, Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1982-MONOMER.

Protein family/group databases

TCDBi3.A.6.2.1. the type iii (virulence-related) secretory pathway (iiisp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellum-specific ATP synthase (EC:3.6.3.14)
Gene namesi
Name:fliI
Synonyms:fla AIII, flaC
Ordered Locus Names:STM1972
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. type III protein secretion system complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi188 – 1881K → E: Loss of flagellum. 1 Publication
Mutagenesisi188 – 1881K → I: Loss of flagellum. 1 Publication
Mutagenesisi272 – 2721D → N: Loss of flagellum. 1 Publication
Mutagenesisi363 – 3631Y → S: Loss of flagellum. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Flagellum-specific ATP synthasePRO_0000144695Add
BLAST

Proteomic databases

PaxDbiP26465.
PRIDEiP26465.

Interactioni

Protein-protein interaction databases

DIPiDIP-59076N.
IntActiP26465. 1 interaction.
STRINGi99287.STM1972.

Structurei

Secondary structure

1
456
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi29 – 335Combined sources
Beta strandi35 – 439Combined sources
Beta strandi51 – 566Combined sources
Beta strandi63 – 719Combined sources
Beta strandi77 – 837Combined sources
Beta strandi92 – 965Combined sources
Beta strandi109 – 1113Combined sources
Helixi114 – 1163Combined sources
Beta strandi119 – 1213Combined sources
Beta strandi127 – 1315Combined sources
Beta strandi139 – 1424Combined sources
Helixi164 – 1696Combined sources
Beta strandi177 – 1826Combined sources
Helixi188 – 19811Combined sources
Beta strandi202 – 2109Combined sources
Helixi213 – 2219Combined sources
Turni222 – 2243Combined sources
Helixi225 – 2306Combined sources
Beta strandi232 – 2376Combined sources
Helixi243 – 26119Combined sources
Turni262 – 2643Combined sources
Beta strandi266 – 2727Combined sources
Helixi274 – 28714Combined sources
Beta strandi294 – 2963Combined sources
Helixi301 – 3099Combined sources
Beta strandi321 – 3299Combined sources
Beta strandi331 – 3333Combined sources
Helixi338 – 3469Combined sources
Beta strandi347 – 3537Combined sources
Helixi355 – 3595Combined sources
Beta strandi366 – 3738Combined sources
Helixi376 – 3794Combined sources
Helixi382 – 40019Combined sources
Helixi401 – 4033Combined sources
Beta strandi405 – 4084Combined sources
Helixi416 – 4227Combined sources
Helixi425 – 4328Combined sources
Helixi442 – 45211Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DPYX-ray2.40A/B19-456[»]
ProteinModelPortaliP26465.
SMRiP26465. Positions 23-456.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26465.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

eggNOGiCOG1157.
HOGENOMiHOG000257876.
KOiK02412.
OMAiQRTPITD.
OrthoDBiEOG6W9X53.
PhylomeDBiP26465.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR020003. ATPase_a/bsu_AS.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR005714. ATPase_T3SS_FliI/YscN.
IPR020005. FliI_clade1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR15184:SF9. PTHR15184:SF9. 1 hit.
PfamiPF00006. ATP-synt_ab. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03496. FliI_clade1. 1 hit.
TIGR01026. fliI_yscN. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26465-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTRLTRWLT ALDNFEAKMA LLPAVRRYGR LTRATGLVLE ATGLQLPLGA
60 70 80 90 100
TCIIERQDGP ETKEVESEVV GFNGQRLFLM PLEEVEGILP GARVYARNGH
110 120 130 140 150
GDGLQSGKQL PLGPALLGRV LDGGGKPLDG LPAPDTLETG ALITPPFNPL
160 170 180 190 200
QRTPIEHVLD TGVRAINALL TVGRGQRMGL FAGSGVGKSV LLGMMARYTR
210 220 230 240 250
ADVIVVGLIG ERGREVKDFI ENILGPDGRA RSVVIAAPAD VSPLLRMQGA
260 270 280 290 300
AYATRIAEDF RDRGQHVLLI MDSLTRYAMA QREIALAIGE PPATKGYPPS
310 320 330 340 350
VFAKLPALVE RAGNGIHGGG SITAFYTVLT EGDDQQDPIA DSARAILDGH
360 370 380 390 400
IVLSRRLAEA GHYPAIDIEA SISRAMTALI TEQHYARVRL FKQLLSSFQR
410 420 430 440 450
NRDLVSVGAY AKGSDPMLDK AITLWPQLEA FLQQGIFERA DWEDSLQALD

LIFPTV
Length:456
Mass (Da):49,265
Last modified:August 1, 1992 - v1
Checksum:i830867B657592BF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62408 Genomic DNA. Translation: AAA27101.1.
AE006468 Genomic DNA. Translation: AAL20884.1.
PIRiC42364.
RefSeqiNP_460925.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20884; AAL20884; STM1972.
GeneIDi1253493.
KEGGistm:STM1972.
PATRICi32382507. VBISalEnt20916_2089.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62408 Genomic DNA. Translation: AAA27101.1 .
AE006468 Genomic DNA. Translation: AAL20884.1 .
PIRi C42364.
RefSeqi NP_460925.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DPY X-ray 2.40 A/B 19-456 [» ]
ProteinModelPortali P26465.
SMRi P26465. Positions 23-456.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-59076N.
IntActi P26465. 1 interaction.
STRINGi 99287.STM1972.

Protein family/group databases

TCDBi 3.A.6.2.1. the type iii (virulence-related) secretory pathway (iiisp) family.

Proteomic databases

PaxDbi P26465.
PRIDEi P26465.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL20884 ; AAL20884 ; STM1972 .
GeneIDi 1253493.
KEGGi stm:STM1972.
PATRICi 32382507. VBISalEnt20916_2089.

Phylogenomic databases

eggNOGi COG1157.
HOGENOMi HOG000257876.
KOi K02412.
OMAi QRTPITD.
OrthoDBi EOG6W9X53.
PhylomeDBi P26465.

Enzyme and pathway databases

BioCyci SENT99287:GCTI-1982-MONOMER.

Miscellaneous databases

EvolutionaryTracei P26465.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR020003. ATPase_a/bsu_AS.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR005714. ATPase_T3SS_FliI/YscN.
IPR020005. FliI_clade1.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR15184:SF9. PTHR15184:SF9. 1 hit.
Pfami PF00006. ATP-synt_ab. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR03496. FliI_clade1. 1 hit.
TIGR01026. fliI_yscN. 1 hit.
PROSITEi PS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Salmonella typhimurium mutants defective in flagellar filament regrowth and sequence similarity of FliI to F0F1, vacuolar, and archaebacterial ATPase subunits."
    Vogler A.P., Homma M., Irikura V.M., Macnab R.M.
    J. Bacteriol. 173:3564-3572(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.
  3. "Genetic and biochemical analysis of Salmonella typhimurium FliI, a flagellar protein related to the catalytic subunit of the F0F1 ATPase and to virulence proteins of mammalian and plant pathogens."
    Dreyfus G., Williams A.W., Kawagishi I., Macnab R.M.
    J. Bacteriol. 175:3131-3138(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, MUTAGENESIS.

Entry informationi

Entry nameiFLII_SALTY
AccessioniPrimary (citable) accession number: P26465
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 26, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3