Reviewed,
UniProtKB/Swiss-Prot P26460 (KCRB_SQUAC)
Last modified
March 3, 2009.
Version 50.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Creatine kinase B-type EC=2.7.3.2 Alternative name(s): Creatine kinase B chain B-CK |
| Organism | Squalus acanthias (Spiny dogfish) |
| Taxonomic identifier | 7797 [NCBI] |
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Chondrichthyes › Elasmobranchii › Squalea › Hypnosqualea › Squaliformes › Squaloidei › Squalidae › Squalus |
Protein attributes
| Sequence length | 52 AA. |
| Sequence status | Fragments. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. The isoform-specific function of B creatine kinase may be to provide a system for the rapid regeneration of metabolic energy for sodium transport. |
| Catalytic activity | ATP + creatine = ADP + phosphocreatine. |
| Subunit structure | Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain. |
| Subcellular location | Basal cell membrane. Note: Basal membrane of the sodium chloride-secreting epithelia. |
| Tissue specificity | Creatine kinase B is the major isoform present in the rectal gland. |
| Sequence similarities | Belongs to the ATP:guanido phosphotransferase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Coding sequence diversity | Polymorphism |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Cellular component | basal plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW creatine kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | ‹1 – ›52 | ›52 | Creatine kinase B-type | PRO_0000211972 | |||||
Sites | |||||||||
| Binding site | 13 | 1 | ATP By similarity | ||||||
| Binding site | 47 | 1 | ATP By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 3 | 1 | V → I | ||||||
| Natural variant | 5 | 1 | T → S | ||||||
| Natural variant | 10 | 1 | K → S | ||||||
| Natural variant | 13 | 1 | R → K | ||||||
| Natural variant | 16 | 1 | S → Q | ||||||
Experimental info | |||||||||
| Sequence uncertainty | 38 | 1 | |||||||
| Non-adjacent residues | 28 – 29 | 2 | |||||||
| Non-terminal residue | 1 | 1 | |||||||
| Non-terminal residue | 52 | 1 | |||||||
Sequences
References
| [1] | "Purification and localization of brain-type creatine kinase in sodium chloride transporting epithelia of the spiny dogfish, Squalus acanthias." Friedman D.L., Roberts R. J. Biol. Chem. 267:4270-4276(1992) [PubMed: 1310991] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Rectal gland. |
Cross-references
Sequence databases | |
|---|---|
| PIR | A42272. B42272. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1CRK based on UniProtKB P11009. |
| ModBase | Search... |
Phylogenomic databases | |
| HOVERGEN | P26460. |
Enzyme and pathway databases | |
| BRENDA | 2.7.3.2. 981. |
Family and domain databases | |
| InterPro | IPR000749. ATP-guanido_PTrfase. [Graphical view] |
| PANTHER | PTHR11547. ATP-gua_Ptrans. 1 hit. |
| Pfam | PF00217. ATP-gua_Ptrans. 1 hit. PF02807. ATP-gua_PtransN. 1 hit. [Graphical view] |
| PROSITE | PS00112. GUANIDO_KINASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | KCRB_SQUAC | ||||||||
| Accession | Primary (citable) accession number: P26460 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||

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