Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Basigin

Gene

Bsg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.1 Publication

GO - Molecular functioni

GO - Biological processi

  • decidualization Source: RGD
  • embryo implantation Source: RGD
  • odontogenesis of dentin-containing tooth Source: RGD
  • protein targeting to plasma membrane Source: UniProtKB
  • response to cAMP Source: RGD
  • response to mercury ion Source: RGD
  • response to peptide hormone Source: RGD
Complete GO annotation...

Keywords - Ligandi

Lectin, Mannose-binding

Enzyme and pathway databases

ReactomeiR-RNO-1474228. Degradation of the extracellular matrix.
R-RNO-210991. Basigin interactions.
R-RNO-216083. Integrin cell surface interactions.
R-RNO-433692. Proton-coupled monocarboxylate transport.
R-RNO-70268. Pyruvate metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Basigin
Alternative name(s):
Glycoprotein CE9
OX-47 antigen
CD_antigen: CD147
Gene namesi
Name:Bsg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi2220. Bsg.

Subcellular locationi

  • Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
  • Melanosome By similarity

  • Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV (By similarity). In spermatozoa, localized on the principal piece of caput and in the middle piece during transit in the corpus and cauda epididymides (By similarity).By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 324ExtracellularSequence analysisAdd BLAST303
Transmembranei325 – 348HelicalSequence analysisAdd BLAST24
Topological domaini349 – 388CytoplasmicSequence analysisAdd BLAST40

GO - Cellular componenti

  • acrosomal membrane Source: Ensembl
  • cell-cell adherens junction Source: Ensembl
  • extracellular exosome Source: Ensembl
  • focal adhesion Source: Ensembl
  • integral component of plasma membrane Source: UniProtKB
  • melanosome Source: UniProtKB-SubCell
  • membrane raft Source: RGD
  • mitochondrion Source: RGD
  • sarcolemma Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001452122 – 388BasiginAdd BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi157 ↔ 203PROSITE-ProRule annotation
Glycosylationi160N-linked (GlcNAc...)By similarity1
Disulfide bondi242 ↔ 304PROSITE-ProRule annotation
Glycosylationi269N-linked (GlcNAc...)By similarity1
Glycosylationi305N-linked (GlcNAc...)Sequence analysis1
Modified residuei357PhosphothreonineCombined sources1
Modified residuei371PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP26453.
PRIDEiP26453.

PTM databases

iPTMnetiP26453.
PhosphoSitePlusiP26453.
SwissPalmiP26453.
UniCarbKBiP26453.

Expressioni

Tissue specificityi

Essentially found in lymphocytes. Also present in various immature cells, endothelia and cells with excitable membranes.

Developmental stagei

In uterus during peri-implantation period strongly expressed in the luminal epithelium on day 1 of pregnancy and gradually decreased to a basal concentration from day 3 to day 5 of pregnancy. Strongly expressed in the implanting blastocyst and primary decidua on day 6 of pregnancy.1 Publication

Inductioni

By activation of lymphocytes by mitogens. By estrogen in the uterine epithelium of ovariectomized animals.1 Publication

Gene expression databases

BgeeiENSRNOG00000008414.
ExpressionAtlasiP26453. baseline and differential.
GenevisibleiP26453. RN.

Interactioni

Subunit structurei

Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms a complex with MMP1 at the tumor cell surface (By similarity). Interacts with AJAP1, ATP1B2, MAG and L1CAM (By similarity). Interacts with SLC16A1, SLC16A7 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with PPIL2; regulates BSG transport to the cell membrane.By similarity2 Publications

Protein-protein interaction databases

IntActiP26453. 1 interactor.
MINTiMINT-4996604.
STRINGi10116.ENSRNOP00000011275.

Structurei

3D structure databases

ProteinModelPortaliP26453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini138 – 219Ig-like C2-typeAdd BLAST82
Domaini221 – 320Ig-like V-typeAdd BLAST100

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJET. Eukaryota.
ENOG4111V1Q. LUCA.
GeneTreeiENSGT00390000010516.
HOGENOMiHOG000263411.
HOVERGENiHBG008120.
InParanoidiP26453.
KOiK06535.
OMAiQANVFVI.
OrthoDBiEOG091G07LY.
PhylomeDBiP26453.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR009151. Basigin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10075:SF12. PTHR10075:SF12. 1 hit.
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P26453-1) [UniParc]FASTAAdd to basket
Also known as: Basigin-2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAALLLALA FTFLSGQGAC AAAGFLKAPM SQEQWAGGSV VLHCEAVGSP
60 70 80 90 100
MPEIQWWFEG NEPNDSCSQL WDGARLDRVH IHATYRQHAA STLSVDGLAA
110 120 130 140 150
EDTGTYECRA SSDPDRNHLT RPPRVKWVRA QASVVVLEPG TIVTSVQEVD
160 170 180 190 200
SKTQLTCFLN SSGIDIVGHR WMRGGKVLQE DTLPDLQMKY TVDADDRSGE
210 220 230 240 250
YSCIFLPEPV GRGNINVEGP PRIKVGKKSE HASEGEFVKL ICKSEASHPP
260 270 280 290 300
VDEWVWFKTS DTGDQTISNG TEANSKYVII STPELSELII SDLDMNVDPG
310 320 330 340 350
TYVCNATNSQ GSARETISLR VRSRLAALWP FLGIVAEVLV LVTIIFIYEK
360 370 380
RRKPDQTLDE DDPGAAPLKG SGSHLNDKDK NVRQRNAT
Length:388
Mass (Da):42,436
Last modified:August 31, 2004 - v2
Checksum:i3D655169F537E3D4
GO
Isoform 2 (identifier: P26453-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-140: Missing.

Show »
Length:272
Mass (Da):29,585
Checksum:iAB2B589ABEAB0B0D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01150325 – 140Missing in isoform 2. 2 PublicationsAdd BLAST116

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54640 mRNA. Translation: CAA38452.1.
X67215 mRNA. Translation: CAA47655.1.
AY120888 mRNA. Translation: AAM81604.1.
PIRiS15674.
RefSeqiNP_001103352.1. NM_001109882.1. [P26453-1]
NP_036915.1. NM_012783.3. [P26453-2]
UniGeneiRn.2269.

Genome annotation databases

EnsembliENSRNOT00000011275; ENSRNOP00000011275; ENSRNOG00000008414. [P26453-1]
ENSRNOT00000044275; ENSRNOP00000050252; ENSRNOG00000008414. [P26453-2]
GeneIDi25246.
KEGGirno:25246.
UCSCiRGD:2220. rat. [P26453-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54640 mRNA. Translation: CAA38452.1.
X67215 mRNA. Translation: CAA47655.1.
AY120888 mRNA. Translation: AAM81604.1.
PIRiS15674.
RefSeqiNP_001103352.1. NM_001109882.1. [P26453-1]
NP_036915.1. NM_012783.3. [P26453-2]
UniGeneiRn.2269.

3D structure databases

ProteinModelPortaliP26453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP26453. 1 interactor.
MINTiMINT-4996604.
STRINGi10116.ENSRNOP00000011275.

PTM databases

iPTMnetiP26453.
PhosphoSitePlusiP26453.
SwissPalmiP26453.
UniCarbKBiP26453.

Proteomic databases

PaxDbiP26453.
PRIDEiP26453.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011275; ENSRNOP00000011275; ENSRNOG00000008414. [P26453-1]
ENSRNOT00000044275; ENSRNOP00000050252; ENSRNOG00000008414. [P26453-2]
GeneIDi25246.
KEGGirno:25246.
UCSCiRGD:2220. rat. [P26453-1]

Organism-specific databases

CTDi682.
RGDi2220. Bsg.

Phylogenomic databases

eggNOGiENOG410IJET. Eukaryota.
ENOG4111V1Q. LUCA.
GeneTreeiENSGT00390000010516.
HOGENOMiHOG000263411.
HOVERGENiHBG008120.
InParanoidiP26453.
KOiK06535.
OMAiQANVFVI.
OrthoDBiEOG091G07LY.
PhylomeDBiP26453.

Enzyme and pathway databases

ReactomeiR-RNO-1474228. Degradation of the extracellular matrix.
R-RNO-210991. Basigin interactions.
R-RNO-216083. Integrin cell surface interactions.
R-RNO-433692. Proton-coupled monocarboxylate transport.
R-RNO-70268. Pyruvate metabolism.

Miscellaneous databases

PROiP26453.

Gene expression databases

BgeeiENSRNOG00000008414.
ExpressionAtlasiP26453. baseline and differential.
GenevisibleiP26453. RN.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR009151. Basigin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10075:SF12. PTHR10075:SF12. 1 hit.
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBASI_RAT
AccessioniPrimary (citable) accession number: P26453
Secondary accession number(s): Q7TNP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 31, 2004
Last modified: November 30, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.