Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P26448 (BUB2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitotic check point protein BUB2
Alternative name(s):
Cell cycle arrest protein BUB2
Gene names
Name:BUB2
Ordered Locus Names:YMR055C
ORF Names:YM9796.08C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Part of a checkpoint which monitors spindle integrity and prevents premature exit from mitosis. This cell-cycle arrest depends upon inhibition of the GTP-binding protein TEM1 by the BFA1/BUB2 complex.

Subunit structure

Interacts with BFA1.

Subcellular location

Cytoplasmcytoskeletonspindle pole.

Sequence similarities

Belongs to the BUB2 family.

Contains 1 Rab-GAP TBC domain.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306Mitotic check point protein BUB2
PRO_0000208008

Regions

Domain37 – 235199Rab-GAP TBC

Sequences

Sequence LengthMass (Da)Tools
P26448 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: A1DDBFB548E81EA3

FASTA30635,028
        10         20         30         40         50         60 
MTSIEDLISN PPLLLHSSLS QLRYLILSEG LPISEDKQQQ RTRCYVWTVL SQTSMEASTQ 

        70         80         90        100        110        120 
RYLALLKLGP PSTTIYQKIK NDTSRTFQTD PNFRNRVSED ALIRCLSCFA WQTQQRRQKT 

       130        140        150        160        170        180 
RFGRIPVSTY VQGMNVLLAP LLYSCPSEPM AYQLFTKLCY EMIPTYLTKN LNGAQNGAKL 

       190        200        210        220        230        240 
LDISLRIIDP KLSKFLSDNL LTAEIYGMPS ILTLSSCNKP LDQVIKLWDF MFAYGFHMNI 

       250        260        270        280        290        300 
LFVVAFLVKM RSKVFKSDSP VNLLRQFPDF DADEIIRLGV GFIAKIPAQI YDLLVDHLTD 


PDIYIP 

« Hide

References

« Hide 'large scale' references
[1]"S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function."
Hoyt M.A., Totis L., Roberts B.T.
Cell 66:507-517(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"The Bub2-dependent mitotic pathway in yeast acts every cell cycle and regulates cytokinesis."
Lee S.E., Jensen S., Frenz L.M., Johnson A.L., Fesquet D., Johnston L.H.
J. Cell Sci. 114:2345-2354(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M64706 Genomic DNA. Translation: AAA16885.1.
Z49703 Genomic DNA. Translation: CAA89765.1.
BK006946 Genomic DNA. Translation: DAA09954.1.
PIRA39654.
RefSeqNP_013771.1. NM_001182553.1.

3D structure databases

ProteinModelPortalP26448.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35231. 133 interactions.
DIPDIP-1215N.
IntActP26448. 33 interactions.
MINTMINT-395099.
STRING4932.YMR055C.

Proteomic databases

MaxQBP26448.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYMR055C; YMR055C; YMR055C.
GeneID855077.
KEGGsce:YMR055C.

Organism-specific databases

CYGDYMR055c.
SGDS000004659. BUB2.

Phylogenomic databases

eggNOGCOG5210.
HOGENOMHOG000212290.
KOK02179.
OMARLNDAHE.
OrthoDBEOG7WQ83F.

Enzyme and pathway databases

BioCycYEAST:G3O-32760-MONOMER.

Gene expression databases

GenevestigatorP26448.

Family and domain databases

InterProIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMSSF47923. SSF47923. 2 hits.
PROSITEPS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio978357.
PROP26448.

Entry information

Entry nameBUB2_YEAST
AccessionPrimary (citable) accession number: P26448
Secondary accession number(s): D6VZN0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: June 11, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families