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P26448

- BUB2_YEAST

UniProt

P26448 - BUB2_YEAST

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Protein
Mitotic check point protein BUB2
Gene
BUB2, YMR055C, YM9796.08C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Part of a checkpoint which monitors spindle integrity and prevents premature exit from mitosis. This cell-cycle arrest depends upon inhibition of the GTP-binding protein TEM1 by the BFA1/BUB2 complex.

GO - Molecular functioni

  1. GTPase activator activity Source: SGD
  2. Rab GTPase activator activity Source: InterPro
  3. protein binding Source: IntAct

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
  2. mitotic spindle orientation checkpoint Source: SGD
  3. positive regulation of GTPase activity Source: GOC
  4. regulation of exit from mitosis Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-32760-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitotic check point protein BUB2
Alternative name(s):
Cell cycle arrest protein BUB2
Gene namesi
Name:BUB2
Ordered Locus Names:YMR055C
ORF Names:YM9796.08C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR055c.
SGDiS000004659. BUB2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. spindle pole body Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Mitotic check point protein BUB2
PRO_0000208008Add
BLAST

Proteomic databases

MaxQBiP26448.

Expressioni

Gene expression databases

GenevestigatoriP26448.

Interactioni

Subunit structurei

Interacts with BFA1.

Binary interactionsi

WithEntry#Exp.IntActNotes
BFA1P471135EBI-3824,EBI-3586
GIC1P387855EBI-3824,EBI-7575
TEM1P389872EBI-3824,EBI-19113

Protein-protein interaction databases

BioGridi35231. 135 interactions.
DIPiDIP-1215N.
IntActiP26448. 33 interactions.
MINTiMINT-395099.
STRINGi4932.YMR055C.

Structurei

3D structure databases

ProteinModelPortaliP26448.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 235199Rab-GAP TBC
Add
BLAST

Sequence similaritiesi

Belongs to the BUB2 family.
Contains 1 Rab-GAP TBC domain.

Phylogenomic databases

eggNOGiCOG5210.
HOGENOMiHOG000212290.
KOiK02179.
OMAiRLNDAHE.
OrthoDBiEOG7WQ83F.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26448-1 [UniParc]FASTAAdd to Basket

« Hide

MTSIEDLISN PPLLLHSSLS QLRYLILSEG LPISEDKQQQ RTRCYVWTVL    50
SQTSMEASTQ RYLALLKLGP PSTTIYQKIK NDTSRTFQTD PNFRNRVSED 100
ALIRCLSCFA WQTQQRRQKT RFGRIPVSTY VQGMNVLLAP LLYSCPSEPM 150
AYQLFTKLCY EMIPTYLTKN LNGAQNGAKL LDISLRIIDP KLSKFLSDNL 200
LTAEIYGMPS ILTLSSCNKP LDQVIKLWDF MFAYGFHMNI LFVVAFLVKM 250
RSKVFKSDSP VNLLRQFPDF DADEIIRLGV GFIAKIPAQI YDLLVDHLTD 300
PDIYIP 306
Length:306
Mass (Da):35,028
Last modified:August 1, 1992 - v1
Checksum:iA1DDBFB548E81EA3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64706 Genomic DNA. Translation: AAA16885.1.
Z49703 Genomic DNA. Translation: CAA89765.1.
BK006946 Genomic DNA. Translation: DAA09954.1.
PIRiA39654.
RefSeqiNP_013771.1. NM_001182553.1.

Genome annotation databases

EnsemblFungiiYMR055C; YMR055C; YMR055C.
GeneIDi855077.
KEGGisce:YMR055C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64706 Genomic DNA. Translation: AAA16885.1 .
Z49703 Genomic DNA. Translation: CAA89765.1 .
BK006946 Genomic DNA. Translation: DAA09954.1 .
PIRi A39654.
RefSeqi NP_013771.1. NM_001182553.1.

3D structure databases

ProteinModelPortali P26448.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35231. 135 interactions.
DIPi DIP-1215N.
IntActi P26448. 33 interactions.
MINTi MINT-395099.
STRINGi 4932.YMR055C.

Proteomic databases

MaxQBi P26448.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR055C ; YMR055C ; YMR055C .
GeneIDi 855077.
KEGGi sce:YMR055C.

Organism-specific databases

CYGDi YMR055c.
SGDi S000004659. BUB2.

Phylogenomic databases

eggNOGi COG5210.
HOGENOMi HOG000212290.
KOi K02179.
OMAi RLNDAHE.
OrthoDBi EOG7WQ83F.

Enzyme and pathway databases

BioCyci YEAST:G3O-32760-MONOMER.

Miscellaneous databases

NextBioi 978357.
PROi P26448.

Gene expression databases

Genevestigatori P26448.

Family and domain databases

InterProi IPR000195. Rab-GTPase-TBC_dom.
[Graphical view ]
Pfami PF00566. RabGAP-TBC. 1 hit.
[Graphical view ]
SMARTi SM00164. TBC. 1 hit.
[Graphical view ]
SUPFAMi SSF47923. SSF47923. 2 hits.
PROSITEi PS50086. TBC_RABGAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function."
    Hoyt M.A., Totis L., Roberts B.T.
    Cell 66:507-517(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "The Bub2-dependent mitotic pathway in yeast acts every cell cycle and regulates cytokinesis."
    Lee S.E., Jensen S., Frenz L.M., Johnson A.L., Fesquet D., Johnston L.H.
    J. Cell Sci. 114:2345-2354(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiBUB2_YEAST
AccessioniPrimary (citable) accession number: P26448
Secondary accession number(s): D6VZN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 3, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

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