UniProtKB - P26447 (S10A4_HUMAN)
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Protein
Protein S100-A4
Gene
S100A4
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 20 – 33 | 1; low affinityPROSITE-ProRule annotationAdd BLAST | 14 | |
Calcium bindingi | 63 – 74 | 2; high affinityPROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- actin binding Source: Ensembl
- calcium-dependent protein binding Source: Ensembl
- calcium ion binding Source: ProtInc
- identical protein binding Source: IntAct
- RAGE receptor binding Source: UniProtKB
- RNA binding Source: UniProtKB
- transition metal ion binding Source: InterPro
GO - Biological processi
- epithelial to mesenchymal transition Source: HGNC
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Keywordsi
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
SIGNORi | P26447. |
Names & Taxonomyi
Protein namesi | Recommended name: Protein S100-A4Alternative name(s): Calvasculin Metastasin Placental calcium-binding protein Protein Mts1 S100 calcium-binding protein A4 |
Gene namesi | Name:S100A4 Synonyms:CAPL, MTS1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000196154.11. |
HGNCi | HGNC:10494. S100A4. |
MIMi | 114210. gene. |
neXtProti | NX_P26447. |
Subcellular locationi
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 6275. |
OpenTargetsi | ENSG00000196154. |
PharmGKBi | PA34906. |
Chemistry databases
ChEMBLi | CHEMBL2362976. |
DrugBanki | DB00831. Trifluoperazine. |
Polymorphism and mutation databases
BioMutai | S100A4. |
DMDMi | 115601. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000143977 | 2 – 101 | Protein S100-A4Add BLAST | 100 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 7 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 35 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | P26447. |
MaxQBi | P26447. |
PaxDbi | P26447. |
PeptideAtlasi | P26447. |
PRIDEi | P26447. |
TopDownProteomicsi | P26447. |
2D gel databases
DOSAC-COBS-2DPAGEi | P26447. |
SWISS-2DPAGEi | P26447. |
PTM databases
iPTMneti | P26447. |
PhosphoSitePlusi | P26447. |
Expressioni
Tissue specificityi
Ubiquitously expressed.
Gene expression databases
Bgeei | ENSG00000196154. |
CleanExi | HS_S100A4. |
Genevisiblei | P26447. HS. |
Organism-specific databases
HPAi | CAB002618. CAB027387. CAB058698. CAB068227. CAB068228. HPA007973. |
Interactioni
Subunit structurei
Homodimer. Interacts with PPFIBP1 in a calcium-dependent mode.1 Publication
Binary interactionsi
GO - Molecular functioni
- actin binding Source: Ensembl
- calcium-dependent protein binding Source: Ensembl
- identical protein binding Source: IntAct
- RAGE receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 112183. 111 interactors. |
DIPi | DIP-44938N. |
IntActi | P26447. 42 interactors. |
MINTi | P26447. |
STRINGi | 9606.ENSP00000346294. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 4 – 20 | Combined sources | 17 | |
Beta strandi | 22 – 25 | Combined sources | 4 | |
Beta strandi | 26 – 30 | Combined sources | 5 | |
Helixi | 31 – 41 | Combined sources | 11 | |
Helixi | 43 – 45 | Combined sources | 3 | |
Helixi | 52 – 62 | Combined sources | 11 | |
Beta strandi | 64 – 66 | Combined sources | 3 | |
Beta strandi | 67 – 71 | Combined sources | 5 | |
Helixi | 72 – 86 | Combined sources | 15 | |
Turni | 89 – 91 | Combined sources | 3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1M31 | NMR | - | A/B | 1-101 | [»] | |
2LNK | NMR | - | A/B | 1-101 | [»] | |
2MRD | NMR | - | A/B | 1-101 | [»] | |
2Q91 | X-ray | 1.63 | A/B | 1-101 | [»] | |
3C1V | X-ray | 1.50 | A/B/C/D | 1-101 | [»] | |
3CGA | X-ray | 2.03 | A/B | 1-101 | [»] | |
3KO0 | X-ray | 2.30 | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T | 1-101 | [»] | |
3M0W | X-ray | 2.80 | A/B/C/D/E/F/G/H/I/J | 2-101 | [»] | |
3ZWH | X-ray | 1.94 | A/B | 1-101 | [»] | |
4CFQ | X-ray | 1.37 | A/B/C/D | 1-88 | [»] | |
4CFR | X-ray | 1.40 | A/B | 1-101 | [»] | |
4ETO | X-ray | 1.54 | A/B | 1-93 | [»] | |
4HSZ | X-ray | 2.25 | A/B/C/D | 1-93 | [»] | |
5LPU | X-ray | 2.10 | C/D | 1-101 | [»] | |
ProteinModelPortali | P26447. | |||||
SMRi | P26447. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P26447. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 47 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 50 – 85 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the S-100 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG410IYVZ. Eukaryota. ENOG4111DV3. LUCA. |
GeneTreei | ENSGT00760000119034. |
HOGENOMi | HOG000246968. |
HOVERGENi | HBG001479. |
InParanoidi | P26447. |
OMAi | FFEGCPD. |
OrthoDBi | EOG091G10JX. |
PhylomeDBi | P26447. |
TreeFami | TF332727. |
Family and domain databases
CDDi | cd00213. S-100. 1 hit. |
InterProi | View protein in InterPro IPR011992. EF-hand-dom_pair. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR034325. S-100_dom. IPR001751. S100/CaBP-9k_CS. IPR013787. S100_Ca-bd_sub. |
Pfami | View protein in Pfam PF01023. S_100. 1 hit. |
SMARTi | View protein in SMART SM00054. EFh. 1 hit. SM01394. S_100. 1 hit. |
SUPFAMi | SSF47473. SSF47473. 1 hit. |
PROSITEi | View protein in PROSITE PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 1 hit. PS00303. S100_CABP. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P26447-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MACPLEKALD VMVSTFHKYS GKEGDKFKLN KSELKELLTR ELPSFLGKRT
60 70 80 90 100
DEAAFQKLMS NLDSNRDNEV DFQEYCVFLS CIAMMCNEFF EGFPDKQPRK
K
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M80563 mRNA. Translation: AAA51920.1. Z18950 Genomic DNA. Translation: CAA79474.1. Z33457 Genomic DNA. Translation: CAA83880.1. CR450345 mRNA. Translation: CAG29341.1. AK292083 mRNA. Translation: BAF84772.1. BX470102 Genomic DNA. No translation available. CH471121 Genomic DNA. Translation: EAW53310.1. CH471121 Genomic DNA. Translation: EAW53311.1. CH471121 Genomic DNA. Translation: EAW53312.1. CH471121 Genomic DNA. Translation: EAW53313.1. CH471121 Genomic DNA. Translation: EAW53314.1. CH471121 Genomic DNA. Translation: EAW53315.1. BC000838 mRNA. Translation: AAH00838.1. BC016300 mRNA. Translation: AAH16300.1. |
CCDSi | CCDS1042.1. |
PIRi | A48219. |
RefSeqi | NP_002952.1. NM_002961.2. NP_062427.1. NM_019554.2. |
UniGenei | Hs.654444. |
Genome annotation databases
Ensembli | ENST00000354332; ENSP00000346294; ENSG00000196154. ENST00000368714; ENSP00000357703; ENSG00000196154. ENST00000368715; ENSP00000357704; ENSG00000196154. ENST00000368716; ENSP00000357705; ENSG00000196154. |
GeneIDi | 6275. |
KEGGi | hsa:6275. |
UCSCi | uc001fby.4. human. |
Similar proteinsi
Entry informationi
Entry namei | S10A4_HUMAN | |
Accessioni | P26447Primary (citable) accession number: P26447 Secondary accession number(s): A8K7R8, D3DV46, Q6ICP8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | August 1, 1992 | |
Last modified: | February 28, 2018 | |
This is version 180 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |