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UniProtKB - P26447 (S10A4_HUMAN)

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Protein

Protein S100-A4

Gene

S100A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331; low affinityPROSITE-ProRule annotationAdd BLAST14
Calcium bindingi63 – 742; high affinityPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • actin binding Source: Ensembl
  • calcium-dependent protein binding Source: Ensembl
  • calcium ion binding Source: ProtInc
  • identical protein binding Source: Ensembl
  • RAGE receptor binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • transition metal ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  • epithelial to mesenchymal transition Source: HGNC
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Complete GO annotation...

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A4
Alternative name(s):
Calvasculin
Metastasin
Placental calcium-binding protein
Protein Mts1
S100 calcium-binding protein A4
Gene namesi
Name:S100A4
Synonyms:CAPL, MTS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:10494. S100A4.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • neuron projection Source: Ensembl
  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi6275.
MalaCardsiS100A4.
OpenTargetsiENSG00000196154.
PharmGKBiPA34906.

Chemistry databases

ChEMBLiCHEMBL2362976.
DrugBankiDB00831. Trifluoperazine.

Polymorphism and mutation databases

BioMutaiS100A4.
DMDMi115601.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001439772 – 101Protein S100-A4Add BLAST100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei7N6-acetyllysineCombined sources1
Modified residuei35N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP26447.
MaxQBiP26447.
PaxDbiP26447.
PeptideAtlasiP26447.
PRIDEiP26447.
TopDownProteomicsiP26447.

2D gel databases

DOSAC-COBS-2DPAGEiP26447.
SWISS-2DPAGEiP26447.

PTM databases

iPTMnetiP26447.
PhosphoSitePlusiP26447.

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

BgeeiENSG00000196154.
CleanExiHS_S100A4.
GenevisibleiP26447. HS.

Organism-specific databases

HPAiCAB002618.
CAB027387.
CAB058698.
CAB068227.
CAB068228.
HPA007973.

Interactioni

Subunit structurei

Homodimer. Interacts with PPFIBP1 in a calcium-dependent mode.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Complete GO annotation...

Protein-protein interaction databases

BioGridi112183. 56 interactors.
DIPiDIP-44938N.
IntActiP26447. 42 interactors.
MINTiMINT-1372269.
STRINGi9606.ENSP00000346294.

Structurei

Secondary structure

1101
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 20Combined sources17
Beta strandi22 – 25Combined sources4
Beta strandi26 – 30Combined sources5
Helixi31 – 41Combined sources11
Helixi43 – 45Combined sources3
Helixi52 – 62Combined sources11
Beta strandi64 – 66Combined sources3
Beta strandi67 – 71Combined sources5
Helixi72 – 86Combined sources15
Turni89 – 91Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M31NMR-A/B1-101[»]
2LNKNMR-A/B1-101[»]
2MRDNMR-A/B1-101[»]
2Q91X-ray1.63A/B1-101[»]
3C1VX-ray1.50A/B/C/D1-101[»]
3CGAX-ray2.03A/B1-101[»]
3KO0X-ray2.30A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T1-101[»]
3M0WX-ray2.80A/B/C/D/E/F/G/H/I/J2-101[»]
3ZWHX-ray1.94A/B1-101[»]
4CFQX-ray1.37A/B/C/D1-88[»]
4CFRX-ray1.40A/B1-101[»]
4ETOX-ray1.54A/B1-93[»]
4HSZX-ray2.25A/B/C/D1-93[»]
ProteinModelPortaliP26447.
SMRiP26447.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26447.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IYVZ. Eukaryota.
ENOG4111DV3. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP26447.
OMAiFFEGCPD.
OrthoDBiEOG091G10JX.
PhylomeDBiP26447.
TreeFamiTF332727.

Family and domain databases

CDDicd00213. S-100. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR034325. S-100_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
PfamiView protein in Pfam
PF01023. S_100. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26447-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACPLEKALD VMVSTFHKYS GKEGDKFKLN KSELKELLTR ELPSFLGKRT 
        60         70         80         90        100
DEAAFQKLMS NLDSNRDNEV DFQEYCVFLS CIAMMCNEFF EGFPDKQPRK 

K
Length:101
Mass (Da):11,729
Last modified:August 1, 1992 - v1
Checksum:i286D2B7B07EDB562
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80563 mRNA. Translation: AAA51920.1.
Z18950 Genomic DNA. Translation: CAA79474.1.
Z33457 Genomic DNA. Translation: CAA83880.1.
CR450345 mRNA. Translation: CAG29341.1.
AK292083 mRNA. Translation: BAF84772.1.
BX470102 Genomic DNA. Translation: CAI14754.1.
CH471121 Genomic DNA. Translation: EAW53310.1.
CH471121 Genomic DNA. Translation: EAW53311.1.
CH471121 Genomic DNA. Translation: EAW53312.1.
CH471121 Genomic DNA. Translation: EAW53313.1.
CH471121 Genomic DNA. Translation: EAW53314.1.
CH471121 Genomic DNA. Translation: EAW53315.1.
BC000838 mRNA. Translation: AAH00838.1.
BC016300 mRNA. Translation: AAH16300.1.
CCDSiCCDS1042.1.
PIRiA48219.
RefSeqiNP_002952.1. NM_002961.2.
NP_062427.1. NM_019554.2.
UniGeneiHs.654444.

Genome annotation databases

EnsembliENST00000354332; ENSP00000346294; ENSG00000196154.
ENST00000368714; ENSP00000357703; ENSG00000196154.
ENST00000368715; ENSP00000357704; ENSG00000196154.
ENST00000368716; ENSP00000357705; ENSG00000196154.
GeneIDi6275.
KEGGihsa:6275.
UCSCiuc001fby.4. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80563 mRNA. Translation: AAA51920.1.
Z18950 Genomic DNA. Translation: CAA79474.1.
Z33457 Genomic DNA. Translation: CAA83880.1.
CR450345 mRNA. Translation: CAG29341.1.
AK292083 mRNA. Translation: BAF84772.1.
BX470102 Genomic DNA. Translation: CAI14754.1.
CH471121 Genomic DNA. Translation: EAW53310.1.
CH471121 Genomic DNA. Translation: EAW53311.1.
CH471121 Genomic DNA. Translation: EAW53312.1.
CH471121 Genomic DNA. Translation: EAW53313.1.
CH471121 Genomic DNA. Translation: EAW53314.1.
CH471121 Genomic DNA. Translation: EAW53315.1.
BC000838 mRNA. Translation: AAH00838.1.
BC016300 mRNA. Translation: AAH16300.1.
CCDSiCCDS1042.1.
PIRiA48219.
RefSeqiNP_002952.1. NM_002961.2.
NP_062427.1. NM_019554.2.
UniGeneiHs.654444.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M31NMR-A/B1-101[»]
2LNKNMR-A/B1-101[»]
2MRDNMR-A/B1-101[»]
2Q91X-ray1.63A/B1-101[»]
3C1VX-ray1.50A/B/C/D1-101[»]
3CGAX-ray2.03A/B1-101[»]
3KO0X-ray2.30A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T1-101[»]
3M0WX-ray2.80A/B/C/D/E/F/G/H/I/J2-101[»]
3ZWHX-ray1.94A/B1-101[»]
4CFQX-ray1.37A/B/C/D1-88[»]
4CFRX-ray1.40A/B1-101[»]
4ETOX-ray1.54A/B1-93[»]
4HSZX-ray2.25A/B/C/D1-93[»]
ProteinModelPortaliP26447.
SMRiP26447.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112183. 56 interactors.
DIPiDIP-44938N.
IntActiP26447. 42 interactors.
MINTiMINT-1372269.
STRINGi9606.ENSP00000346294.

Chemistry databases

ChEMBLiCHEMBL2362976.
DrugBankiDB00831. Trifluoperazine.

PTM databases

iPTMnetiP26447.
PhosphoSitePlusiP26447.

Polymorphism and mutation databases

BioMutaiS100A4.
DMDMi115601.

2D gel databases

DOSAC-COBS-2DPAGEiP26447.
SWISS-2DPAGEiP26447.

Proteomic databases

EPDiP26447.
MaxQBiP26447.
PaxDbiP26447.
PeptideAtlasiP26447.
PRIDEiP26447.
TopDownProteomicsiP26447.

Protocols and materials databases

DNASUi6275.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354332; ENSP00000346294; ENSG00000196154.
ENST00000368714; ENSP00000357703; ENSG00000196154.
ENST00000368715; ENSP00000357704; ENSG00000196154.
ENST00000368716; ENSP00000357705; ENSG00000196154.
GeneIDi6275.
KEGGihsa:6275.
UCSCiuc001fby.4. human.

Organism-specific databases

CTDi6275.
DisGeNETi6275.
GeneCardsiS100A4.
HGNCiHGNC:10494. S100A4.
HPAiCAB002618.
CAB027387.
CAB058698.
CAB068227.
CAB068228.
HPA007973.
MalaCardsiS100A4.
MIMi114210. gene.
neXtProtiNX_P26447.
OpenTargetsiENSG00000196154.
PharmGKBiPA34906.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYVZ. Eukaryota.
ENOG4111DV3. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP26447.
OMAiFFEGCPD.
OrthoDBiEOG091G10JX.
PhylomeDBiP26447.
TreeFamiTF332727.

Miscellaneous databases

ChiTaRSiS100A4. human.
EvolutionaryTraceiP26447.
GeneWikiiS100A4.
GenomeRNAii6275.
PROiPR:P26447.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196154.
CleanExiHS_S100A4.
GenevisibleiP26447. HS.

Family and domain databases

CDDicd00213. S-100. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR034325. S-100_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
PfamiView protein in Pfam
PF01023. S_100. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS10A4_HUMAN
AccessioniPrimary (citable) accession number: P26447
Secondary accession number(s): A8K7R8, D3DV46, Q6ICP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: May 10, 2017
This is version 175 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.