P26445 (TNFB_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lymphotoxin-alpha
Short name=LT-alpha

Alternative name(s):
TNF-beta
Tumor necrosis factor ligand superfamily member 1

Gene names

Name:	LTA
Synonyms:	TNFB, TNFSF1

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
Subunit structure	Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits By similarity.
Subcellular location	Secreted By similarity. Membrane By similarity. Note: The homotrimer is secreted By similarity. The heterotrimer is membrane-associated By similarity.
Sequence similarities	Belongs to the tumor necrosis factor family.

Ontologies

Keywords
Cellular component	Membrane Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to Gram-positive bacterium Inferred from electronic annotation. Source: Compara humoral immune response Inferred from sequence or structural similarity. Source: AgBase lymph node development Inferred from sequence or structural similarity. Source: AgBase negative regulation of growth of symbiont in host Inferred from electronic annotation. Source: Compara positive regulation of chronic inflammatory response to antigenic stimulus Inferred from electronic annotation. Source: Compara positive regulation of humoral immune response mediated by circulating immunoglobulin Inferred from electronic annotation. Source: Compara positive regulation of interferon-gamma production Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 33	33
	Chain	34 – 204	171	Lymphotoxin-alpha		PRO_0000034469
Amino acid modifications
	Glycosylation	95	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P26445 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: 81263187435E56AC	FASTA	204	21,960
	10 20 30 40 50 60 MTPPGRLYLR RVCSTPILLL LGLLLALPPE AQGLPGVGLP PSAAQPAHQH PPKHLARGTL 70 80 90 100 110 120 KPAAHLVGDP STPDSLRWRA NTDRAFLRHG FLLSNNSLLV PTSGLYFVYS QVVFSGEGCF 130 140 150 160 170 180 PKATPTPLYL AHEVQLFSSQ YPFHVPLLSA QKSVCPGPQG PWVRSVYQGA VFLLTQGDQL 190 200 STHTDGTPHL LLSPSSVFFG AFAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The porcine tumor necrosis factor-encoding genes: sequence and comparative analysis." Kuhnert P., Wuethrich C., Peterhans E., Pauli U. Gene 102:171-178(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Liver.
[2]	"Sequence of the swine major histocompatibility complex region containing all non-classical class I genes." Chardon P., Rogel-Gaillard C., Cattolico L., Duprat S., Vaiman M., Renard C. Tissue Antigens 57:55-65(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Large white. Tissue: Fibroblast.
[3]	Porcine genome sequencing project Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X54859 Genomic DNA. Translation: CAA38638.1. AJ251914 Genomic DNA. Translation: CAB63853.1. BX548169 Genomic DNA. Translation: CAN59690.1.
PIR	S17289.
RefSeq	NP_999618.1. NM_214453.1.
UniGene	Ssc.27595.
3D structure databases
ProteinModelPortal	P26445.
SMR	P26445. Positions 61-204.
ModBase	Search...
Protein-protein interaction databases
STRING	9823.ENSSSCP00000001490.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSSSCT00000001532; ENSSSCP00000001490; ENSSSCG00000001403. ENSSSCT00000034506; ENSSSCP00000028564; ENSSSCG00000001403.
GeneID	407742.
KEGG	ssc:407742.
Organism-specific databases
CTD	4049.
Phylogenomic databases
eggNOG	NOG41746.
GeneTree	ENSGT00530000062992.
HOGENOM	HOG000048729.
HOVERGEN	HBG012516.
KO	K05468.
OMA	QGPWVRS.
OrthoDB	EOG40P47W.
Gene expression databases
ArrayExpress	P26445.
Family and domain databases
Gene3D	2.60.120.40. 1 hit.
InterPro	IPR006052. TNF. IPR006053. TNF_a/b/c. IPR002960. TNF_beta. IPR021184. TNF_CS. IPR008983. Tumour_necrosis_fac-like_dom. [Graphical view]
Pfam	PF00229. TNF. 1 hit. [Graphical view]
PRINTS	PR01234. TNECROSISFCT. PR01236. TNFBETA.
SMART	SM00207. TNF. 1 hit. [Graphical view]
SUPFAM	SSF49842. TNF_like. 1 hit.
PROSITE	PS00251. TNF_1. 1 hit. PS50049. TNF_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TNFB_PIG

Accession

Primary (citable) accession number: P26445
Secondary accession number(s): A5D9N9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program