P26442 (AMFR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Autocrine motility factor receptor, isoform 1
Short name=AMF receptor, isoform 1

Gene names

Name:

AMFR

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Specific receptor for the autocrine motility factor.
Subcellular location	Membrane; Single-pass type I membrane protein.
Post-translational modification	Phosphorylated in the presence of AMF. O-glycosylated.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular component movement Traceable author statement. Source: ProtInc signal transduction Traceable author statement. Source: ProtInc
Cellular component	integral to membrane Non-traceable author statement Ref.1. Source: UniProtKB
Molecular function	receptor activity Inferred from physical interaction Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P26442-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UKV5-1)

The sequence of this isoform can be found in the external entry Q9UKV5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 323	306	Autocrine motility factor receptor, isoform 1		PRO_0000020700
Regions
	Topological domain	18 – 110	93	Extracellular Potential
	Transmembrane	111 – 137	27	Helical; Potential
	Topological domain	138 – 323	186	Cytoplasmic Potential
Amino acid modifications
	Modified residue	194	1	Phosphoserine Potential
	Glycosylation	24	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	181	1	I → V. Corresponds to variant rs4924 [ dbSNP | Ensembl ].		VAR_014809

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: 0A7AF4DCF90A8700	FASTA	323	34,325
	10 20 30 40 50 60 MRDSACWSQR KDELLQQARK RFLNKSSEDD AASESFLPSE GASSDPVTLR RRMLAAARNG 70 80 90 100 110 120 GFRSSRPPSA PLPSSAASCA LCPTDWRRPV PILPLHGKAG LTALPLYKAC GLIVFGQLIN 130 140 150 160 170 180 LILLCNTFYV TFLFPLETLQ ILTVGMISSG VDWTAWGGGR SGGSEPVACL QQAASTPASC 190 200 210 220 230 240 IRPTNAGVLS TTPSGKSVGE AHSVSPPPRR GVTSVIKLLS LLWKHVDCAR ARPTGSCTPE 250 260 270 280 290 300 QQGILEKELL VRYLEQRRGK SRAIGCDEVT PFCPTTSGTD FPSLQSKAGL ISVNSGAPAS 310 320 HECAPWVPSP LSISLSRLDL GSG
	Isoform 2 [UniParc]. See Q9UKV5.		–	–

References

[1]	"Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor." Watanabe H., Carmi P., Hogan V., Raz T., Silletti S., Nabi I.R., Raz A. J. Biol. Chem. 266:13442-13448(1991) [PubMed: 1649192] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Identification of an upstream region that controls the transcription of the human autocrine motility factor receptor." Huang B., Xie Y., Raz A. Biochem. Biophys. Res. Commun. 212:727-742(1995) [PubMed: 7626106] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M63175 mRNA. Translation: AAA36671.1. L35233 mRNA. Translation: AAA79362.1.
IPI	IPI00435690.
PIR	A39877.
UniGene	Hs.295137.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P26442. 6 interactions.
STRING	P26442.
Polymorphism databases
DMDM	113707.
Proteomic databases
PRIDE	P26442.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000314566; ENSP00000313137; ENSG00000159461.
Organism-specific databases
GeneCards	GC16M056447.
HGNC	HGNC:463. AMFR.
HPA	CAB026381.
MIM	603243. gene.
neXtProt	NX_P26442.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG16152.
GeneTree	ENSGT00530000062938.
Gene expression databases
ArrayExpress	P26442.
Bgee	P26442.
CleanEx	HS_AMFR.
Genevestigator	P26442.
GermOnline	ENSG00000159461. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

AMFR1_HUMAN

Accession

Primary (citable) accession number: P26442

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	January 25, 2012
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.