Ciliary neurotrophic factor - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot P26441 (CNTF_HUMAN)

Last modified June 16, 2009. Version 98. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Ciliary neurotrophic factor
Short name=CNTF

Gene names

Name:

CNTF

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
Subunit structure	Homodimer.
Subcellular location	Cytoplasm.
Tissue specificity	Nervous system.
Sequence similarities	Belongs to the CNTF family.

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Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Molecular function	Developmental protein Growth factor
Technical term	3D-structure Pharmaceutical
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW ciliary neurotrophic factor-mediated signaling pathway Inferred from direct assay. Source: UniProtKB growth Inferred from electronic annotation. Source: InterPro nervous system development Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of tyrosine phosphorylation of Stat3 protein Inferred from direct assay. Source: UniProtKB
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular space Inferred by curator. Source: UniProtKB
Molecular function	ciliary neurotrophic factor receptor binding Traceable author statement. Source: ProtInc interleukin-6 receptor binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct
EIF3E	P60228	1	EBI-1050897,EBI-347740
EXT1	Q16394	1	EBI-1050897,EBI-1046007
EXT2	Q93063	1	EBI-1050897,EBI-1047761
ICA1	Q05084	1	EBI-1050897,EBI-1046751
STK16	O75716	1	EBI-1050897,EBI-1046308
VHL	P40337	1	EBI-1050897,EBI-301246

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 200

200

Ciliary neurotrophic factor

PRO_0000149519

Natural variations

Natural variant

N → S: dbSNP rs17152779.

VAR_033777

Natural variant

182

H → R: dbSNP rs6266. Ref.8

VAR_013924

Secondary structure

200

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

P26441-1 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: EDD9D895BDA6F35A
Show »

FASTA

200

22,931

        10         20         30         40         50         60 
MAFTEHSPLT PHRRDLCSRS IWLARKIRSD LTALTESYVK HQGLNKNINL DSADGMPVAS 

        70         80         90        100        110        120 
TDQWSELTEA ERLQENLQAY RTFHVLLARL LEDQQVHFTP TEGDFHQAIH TLLLQVAAFA 

       130        140        150        160        170        180 
YQIEELMILL EYKIPRNEAD GMPINVGDGG LFEKKLWGLK VLQELSQWTV RSIHDLRFIS 

       190        200 
SHQTGIPARG SHYIANNKKM

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Recombinant human and rat ciliary neurotrophic factors." Masiakowski P., Liu H., Radziejewski C., Lottspeich F., Oberthuer W., Wong V., Lindsay R.M., Furth M.E., Panayotatos N. J. Neurochem. 57:1003-1012(1991) [PubMed: 1861138] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Cloning and expression of human ciliary neurotrophic factor." Negro A., Tolosano E., Skaper S., Martini I., Callegaro L., Silengo L., Fiorini F., Altruda F. Eur. J. Biochem. 201:289-294(1991) [PubMed: 1915374] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Sequence and structural organization of the human gene encoding ciliary neurotrophic factor." Lam A., Fuller F., Miller J., Kloss J., Manthorpe M., Varon M., Cordell B. Gene 102:271-276(1991) [PubMed: 1840538] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Lung.
[4]	"Expression and characterization of recombinant human ciliary neurotrophic factor from Escherichia coli." McDonald J.R., Ko C., Mismer D., Smith D.J., Collins F. Biochim. Biophys. Acta 1090:70-80(1991) [PubMed: 1883844] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"A null mutation in the human CNTF gene is not causally related to neurological diseases." Takahashi R., Yokoji H., Misawa H., Hayashi M., Hu J., Deguchi T. Nat. Genet. 7:79-84(1994) [PubMed: 8075647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Sciatic nerve.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[7]	"Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing." McDonald N.Q., Panayotatos N., Hendrickson W.A. EMBO J. 14:2689-2699(1995) [PubMed: 7796798] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-187.
[8]	"Characterization of single-nucleotide polymorphisms in coding regions of human genes." Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S. Nat. Genet. 22:231-238(1999) [PubMed: 10391209] [Abstract] Cited for: VARIANT ARG-182.
[9]	Erratum Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S. Nat. Genet. 23:373-373(1999)
+	Additional computationally mapped references.

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Web resources

Wikipedia

Ciliary neurotrophic factor entry

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Cross-references

Sequence databases

X60542 Genomic DNA. Translation: CAA43032.1.
X60477, X60478 Genomic DNA. Translation: CAA43009.1.
X55889, X55890 Genomic DNA. Translation: CAA39374.1.
BC068030 mRNA. Translation: AAH68030.1.
BC074963 mRNA. Translation: AAH74963.1.
BC074964 mRNA. Translation: AAH74964.1.

IPI

IPI00032298.

PIR

UNHUCF. JH0455.

RefSeq

NP_000605.1.

UniGene

Hs.524920

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1CNT	X-ray	2.40	1/2/3/4	1-187	[»]

ModBase

Search...

Protein-protein interaction databases

DIP

DIP:5776N.

IntAct

P26441. 6 interactions.

Proteomic databases

PRIDE

P26441.

Genome annotation databases

Ensembl

ENSG00000186660. Homo sapiens. [Contig view]

GeneID

1270.

KEGG

hsa:1270.

Organism-specific databases

GeneCards

GC11P058103.
GC11P058146.

H-InvDB

HIX0009648.

HGNC

HGNC:2169. CNTF.

MIM

118945. gene.

PharmGKB

PA26683.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

P26441.

HOVERGEN

P26441.

OMA

P26441. EKKLWGL.

Gene expression databases

ArrayExpress

P26441.

Bgee

P26441.

CleanEx

HS_CNTF.

GermOnline

ENSG00000205003. Homo sapiens.

Family and domain databases

InterPro

IPR012351. 4_helix_cytokine_core.
IPR000151. Ciliary_neurotrophic_fac_CNTF.
[Graphical view]

Gene3D

G3DSA:1.20.1250.10. 4_helix_cytokine_core. 1 hit.

Pfam

PF01110. CNTF. 1 hit.
[Graphical view]

ProDom

PD011041. Cil_neuro_factor. 1 hit.
[Graphical view] [Entries sharing at least one domain]

ProtoNet

Search...

Other Resources

NextBio

5143.

SOURCE

Search...

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Entry information

Entry name

CNTF_HUMAN

Accession

Primary (citable) accession number: P26441

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	June 16, 2009
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Natural variations

Secondary structure

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents