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Protein

Ciliary neurotrophic factor

Gene

CNTF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.

GO - Molecular functioni

  1. ciliary neurotrophic factor receptor binding Source: ProtInc
  2. growth factor activity Source: BHF-UCL
  3. interleukin-6 receptor binding Source: BHF-UCL

GO - Biological processi

  1. ciliary neurotrophic factor-mediated signaling pathway Source: BHF-UCL
  2. growth Source: InterPro
  3. muscle organ morphogenesis Source: Ensembl
  4. negative regulation of neuron apoptotic process Source: BHF-UCL
  5. negative regulation of photoreceptor cell differentiation Source: Ensembl
  6. neuron development Source: Ensembl
  7. positive regulation of cell proliferation Source: Ensembl
  8. positive regulation of tyrosine phosphorylation of Stat3 protein Source: BHF-UCL
  9. regulation of retinal cell programmed cell death Source: Ensembl
  10. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

SignaLinkiP26441.

Names & Taxonomyi

Protein namesi
Recommended name:
Ciliary neurotrophic factor
Short name:
CNTF
Gene namesi
Name:CNTF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:2169. CNTF.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular space Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26683.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200Ciliary neurotrophic factorPRO_0000149519Add
BLAST

Proteomic databases

PaxDbiP26441.
PRIDEiP26441.

PTM databases

PhosphoSiteiP26441.

Expressioni

Tissue specificityi

Nervous system.

Gene expression databases

BgeeiP26441.
CleanExiHS_CNTF.
GenevestigatoriP26441.

Organism-specific databases

HPAiHPA019654.

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF3EP602281EBI-1050897,EBI-347740
EXT1Q163941EBI-1050897,EBI-1046007
EXT2Q930631EBI-1050897,EBI-1047761
ICA1Q050841EBI-1050897,EBI-1046751
STK16O757161EBI-1050897,EBI-749295
VHLP403371EBI-1050897,EBI-301246

Protein-protein interaction databases

BioGridi107670. 11 interactions.
DIPiDIP-5776N.
MINTiMINT-205057.
STRINGi9606.ENSP00000355370.

Structurei

Secondary structure

1
200
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi13 – 4129Combined sources
Helixi69 – 9527Combined sources
Turni96 – 983Combined sources
Beta strandi99 – 1013Combined sources
Helixi104 – 12926Combined sources
Beta strandi138 – 1403Combined sources
Helixi152 – 18029Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CNTX-ray2.401/2/3/41-187[»]
ProteinModelPortaliP26441.
SMRiP26441. Positions 11-187.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26441.

Family & Domainsi

Sequence similaritiesi

Belongs to the CNTF family.Curated

Phylogenomic databases

eggNOGiNOG114783.
GeneTreeiENSGT00420000029890.
HOGENOMiHOG000059605.
HOVERGENiHBG005362.
InParanoidiP26441.
KOiK05420.
OMAiKLWGLKV.
OrthoDBiEOG700893.
PhylomeDBiP26441.
TreeFamiTF336237.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000151. Ciliary_neurotrophic_fac_CNTF.
[Graphical view]
PfamiPF01110. CNTF. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

P26441-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFTEHSPLT PHRRDLCSRS IWLARKIRSD LTALTESYVK HQGLNKNINL
60 70 80 90 100
DSADGMPVAS TDQWSELTEA ERLQENLQAY RTFHVLLARL LEDQQVHFTP
110 120 130 140 150
TEGDFHQAIH TLLLQVAAFA YQIEELMILL EYKIPRNEAD GMPINVGDGG
160 170 180 190 200
LFEKKLWGLK VLQELSQWTV RSIHDLRFIS SHQTGIPARG SHYIANNKKM
Length:200
Mass (Da):22,931
Last modified:July 31, 1992 - v1
Checksum:iEDD9D895BDA6F35A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti49 – 491N → S.
Corresponds to variant rs17152779 [ dbSNP | Ensembl ].
VAR_033777
Natural varianti182 – 1821H → R.1 Publication
Corresponds to variant rs6266 [ dbSNP | Ensembl ].
VAR_013924

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60542 Genomic DNA. Translation: CAA43032.1.
X60477, X60478 Genomic DNA. Translation: CAA43009.1.
X55889, X55890 Genomic DNA. Translation: CAA39374.1.
AK314118 mRNA. Translation: BAG36809.1.
CH471076 Genomic DNA. Translation: EAW73819.1.
BC068030 mRNA. Translation: AAH68030.1.
BC074963 mRNA. Translation: AAH74963.1.
BC074964 mRNA. Translation: AAH74964.1.
CCDSiCCDS31554.1.
PIRiJH0455. UNHUCF.
RefSeqiNP_000605.1. NM_000614.3.
UniGeneiHs.524920.

Genome annotation databases

EnsembliENST00000361987; ENSP00000355370; ENSG00000242689.
GeneIDi1270.
KEGGihsa:1270.
UCSCiuc001nna.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Ciliary neurotrophic factor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60542 Genomic DNA. Translation: CAA43032.1.
X60477, X60478 Genomic DNA. Translation: CAA43009.1.
X55889, X55890 Genomic DNA. Translation: CAA39374.1.
AK314118 mRNA. Translation: BAG36809.1.
CH471076 Genomic DNA. Translation: EAW73819.1.
BC068030 mRNA. Translation: AAH68030.1.
BC074963 mRNA. Translation: AAH74963.1.
BC074964 mRNA. Translation: AAH74964.1.
CCDSiCCDS31554.1.
PIRiJH0455. UNHUCF.
RefSeqiNP_000605.1. NM_000614.3.
UniGeneiHs.524920.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CNTX-ray2.401/2/3/41-187[»]
ProteinModelPortaliP26441.
SMRiP26441. Positions 11-187.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107670. 11 interactions.
DIPiDIP-5776N.
MINTiMINT-205057.
STRINGi9606.ENSP00000355370.

PTM databases

PhosphoSiteiP26441.

Proteomic databases

PaxDbiP26441.
PRIDEiP26441.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361987; ENSP00000355370; ENSG00000242689.
GeneIDi1270.
KEGGihsa:1270.
UCSCiuc001nna.4. human.

Organism-specific databases

CTDi1270.
GeneCardsiGC11P058390.
HGNCiHGNC:2169. CNTF.
HPAiHPA019654.
MIMi118945. gene.
neXtProtiNX_P26441.
PharmGKBiPA26683.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG114783.
GeneTreeiENSGT00420000029890.
HOGENOMiHOG000059605.
HOVERGENiHBG005362.
InParanoidiP26441.
KOiK05420.
OMAiKLWGLKV.
OrthoDBiEOG700893.
PhylomeDBiP26441.
TreeFamiTF336237.

Enzyme and pathway databases

SignaLinkiP26441.

Miscellaneous databases

EvolutionaryTraceiP26441.
GeneWikiiCiliary_neurotrophic_factor.
GenomeRNAii1270.
NextBioi5143.
PROiP26441.
SOURCEiSearch...

Gene expression databases

BgeeiP26441.
CleanExiHS_CNTF.
GenevestigatoriP26441.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000151. Ciliary_neurotrophic_fac_CNTF.
[Graphical view]
PfamiPF01110. CNTF. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Sequence and structural organization of the human gene encoding ciliary neurotrophic factor."
    Lam A., Fuller F., Miller J., Kloss J., Manthorpe M., Varon M., Cordell B.
    Gene 102:271-276(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Lung.
  4. "Expression and characterization of recombinant human ciliary neurotrophic factor from Escherichia coli."
    McDonald J.R., Ko C., Mismer D., Smith D.J., Collins F.
    Biochim. Biophys. Acta 1090:70-80(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "A null mutation in the human CNTF gene is not causally related to neurological diseases."
    Takahashi R., Yokoji H., Misawa H., Hayashi M., Hu J., Deguchi T.
    Nat. Genet. 7:79-84(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Sciatic nerve.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  9. "Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing."
    McDonald N.Q., Panayotatos N., Hendrickson W.A.
    EMBO J. 14:2689-2699(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-187.
  10. Cited for: VARIANT ARG-182.

Entry informationi

Entry nameiCNTF_HUMAN
AccessioniPrimary (citable) accession number: P26441
Secondary accession number(s): B2RAB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 31, 1992
Last sequence update: July 31, 1992
Last modified: February 3, 2015
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.