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P26441

- CNTF_HUMAN

UniProt

P26441 - CNTF_HUMAN

Protein

Ciliary neurotrophic factor

Gene

CNTF

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 149 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.

    GO - Molecular functioni

    1. ciliary neurotrophic factor receptor binding Source: ProtInc
    2. growth factor activity Source: BHF-UCL
    3. interleukin-6 receptor binding Source: BHF-UCL

    GO - Biological processi

    1. ciliary neurotrophic factor-mediated signaling pathway Source: BHF-UCL
    2. growth Source: InterPro
    3. muscle organ morphogenesis Source: Ensembl
    4. negative regulation of neuron apoptotic process Source: BHF-UCL
    5. negative regulation of photoreceptor cell differentiation Source: Ensembl
    6. neuron development Source: Ensembl
    7. positive regulation of cell proliferation Source: Ensembl
    8. positive regulation of tyrosine phosphorylation of Stat3 protein Source: BHF-UCL
    9. regulation of retinal cell programmed cell death Source: Ensembl
    10. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Developmental protein, Growth factor

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Enzyme and pathway databases

    SignaLinkiP26441.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ciliary neurotrophic factor
    Short name:
    CNTF
    Gene namesi
    Name:CNTF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:2169. CNTF.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular space Source: BHF-UCL

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26683.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 200200Ciliary neurotrophic factorPRO_0000149519Add
    BLAST

    Proteomic databases

    PaxDbiP26441.
    PRIDEiP26441.

    PTM databases

    PhosphoSiteiP26441.

    Expressioni

    Tissue specificityi

    Nervous system.

    Gene expression databases

    BgeeiP26441.
    CleanExiHS_CNTF.
    GenevestigatoriP26441.

    Organism-specific databases

    HPAiHPA019654.

    Interactioni

    Subunit structurei

    Homodimer.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EIF3EP602281EBI-1050897,EBI-347740
    EXT1Q163941EBI-1050897,EBI-1046007
    EXT2Q930631EBI-1050897,EBI-1047761
    ICA1Q050841EBI-1050897,EBI-1046751
    STK16O757161EBI-1050897,EBI-749295
    VHLP403371EBI-1050897,EBI-301246

    Protein-protein interaction databases

    BioGridi107670. 9 interactions.
    DIPiDIP-5776N.
    MINTiMINT-205057.
    STRINGi9606.ENSP00000355370.

    Structurei

    Secondary structure

    1
    200
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi13 – 4129
    Helixi69 – 9527
    Turni96 – 983
    Beta strandi99 – 1013
    Helixi104 – 12926
    Beta strandi138 – 1403
    Helixi152 – 18029

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1CNTX-ray2.401/2/3/41-187[»]
    ProteinModelPortaliP26441.
    SMRiP26441. Positions 11-187.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP26441.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CNTF family.Curated

    Phylogenomic databases

    eggNOGiNOG114783.
    HOGENOMiHOG000059605.
    HOVERGENiHBG005362.
    KOiK05420.
    OMAiQVAAFAY.
    OrthoDBiEOG700893.
    PhylomeDBiP26441.
    TreeFamiTF336237.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000151. Ciliary_neurotrophic_fac_CNTF.
    [Graphical view]
    PfamiPF01110. CNTF. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P26441-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFTEHSPLT PHRRDLCSRS IWLARKIRSD LTALTESYVK HQGLNKNINL    50
    DSADGMPVAS TDQWSELTEA ERLQENLQAY RTFHVLLARL LEDQQVHFTP 100
    TEGDFHQAIH TLLLQVAAFA YQIEELMILL EYKIPRNEAD GMPINVGDGG 150
    LFEKKLWGLK VLQELSQWTV RSIHDLRFIS SHQTGIPARG SHYIANNKKM 200
    Length:200
    Mass (Da):22,931
    Last modified:August 1, 1992 - v1
    Checksum:iEDD9D895BDA6F35A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti49 – 491N → S.
    Corresponds to variant rs17152779 [ dbSNP | Ensembl ].
    VAR_033777
    Natural varianti182 – 1821H → R.1 Publication
    Corresponds to variant rs6266 [ dbSNP | Ensembl ].
    VAR_013924

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60542 Genomic DNA. Translation: CAA43032.1.
    X60477, X60478 Genomic DNA. Translation: CAA43009.1.
    X55889, X55890 Genomic DNA. Translation: CAA39374.1.
    AK314118 mRNA. Translation: BAG36809.1.
    CH471076 Genomic DNA. Translation: EAW73819.1.
    BC068030 mRNA. Translation: AAH68030.1.
    BC074963 mRNA. Translation: AAH74963.1.
    BC074964 mRNA. Translation: AAH74964.1.
    CCDSiCCDS31554.1.
    PIRiJH0455. UNHUCF.
    RefSeqiNP_000605.1. NM_000614.3.
    UniGeneiHs.524920.

    Genome annotation databases

    EnsembliENST00000361987; ENSP00000355370; ENSG00000242689.
    GeneIDi1270.
    KEGGihsa:1270.
    UCSCiuc001nna.4. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Ciliary neurotrophic factor entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60542 Genomic DNA. Translation: CAA43032.1 .
    X60477 , X60478 Genomic DNA. Translation: CAA43009.1 .
    X55889 , X55890 Genomic DNA. Translation: CAA39374.1 .
    AK314118 mRNA. Translation: BAG36809.1 .
    CH471076 Genomic DNA. Translation: EAW73819.1 .
    BC068030 mRNA. Translation: AAH68030.1 .
    BC074963 mRNA. Translation: AAH74963.1 .
    BC074964 mRNA. Translation: AAH74964.1 .
    CCDSi CCDS31554.1.
    PIRi JH0455. UNHUCF.
    RefSeqi NP_000605.1. NM_000614.3.
    UniGenei Hs.524920.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1CNT X-ray 2.40 1/2/3/4 1-187 [» ]
    ProteinModelPortali P26441.
    SMRi P26441. Positions 11-187.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107670. 9 interactions.
    DIPi DIP-5776N.
    MINTi MINT-205057.
    STRINGi 9606.ENSP00000355370.

    PTM databases

    PhosphoSitei P26441.

    Proteomic databases

    PaxDbi P26441.
    PRIDEi P26441.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361987 ; ENSP00000355370 ; ENSG00000242689 .
    GeneIDi 1270.
    KEGGi hsa:1270.
    UCSCi uc001nna.4. human.

    Organism-specific databases

    CTDi 1270.
    GeneCardsi GC11P058390.
    HGNCi HGNC:2169. CNTF.
    HPAi HPA019654.
    MIMi 118945. gene.
    neXtProti NX_P26441.
    PharmGKBi PA26683.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG114783.
    HOGENOMi HOG000059605.
    HOVERGENi HBG005362.
    KOi K05420.
    OMAi QVAAFAY.
    OrthoDBi EOG700893.
    PhylomeDBi P26441.
    TreeFami TF336237.

    Enzyme and pathway databases

    SignaLinki P26441.

    Miscellaneous databases

    EvolutionaryTracei P26441.
    GeneWikii Ciliary_neurotrophic_factor.
    GenomeRNAii 1270.
    NextBioi 5143.
    PROi P26441.
    SOURCEi Search...

    Gene expression databases

    Bgeei P26441.
    CleanExi HS_CNTF.
    Genevestigatori P26441.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000151. Ciliary_neurotrophic_fac_CNTF.
    [Graphical view ]
    Pfami PF01110. CNTF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Sequence and structural organization of the human gene encoding ciliary neurotrophic factor."
      Lam A., Fuller F., Miller J., Kloss J., Manthorpe M., Varon M., Cordell B.
      Gene 102:271-276(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Lung.
    4. "Expression and characterization of recombinant human ciliary neurotrophic factor from Escherichia coli."
      McDonald J.R., Ko C., Mismer D., Smith D.J., Collins F.
      Biochim. Biophys. Acta 1090:70-80(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "A null mutation in the human CNTF gene is not causally related to neurological diseases."
      Takahashi R., Yokoji H., Misawa H., Hayashi M., Hu J., Deguchi T.
      Nat. Genet. 7:79-84(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Sciatic nerve.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    9. "Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing."
      McDonald N.Q., Panayotatos N., Hendrickson W.A.
      EMBO J. 14:2689-2699(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-187.
    10. Cited for: VARIANT ARG-182.

    Entry informationi

    Entry nameiCNTF_HUMAN
    AccessioniPrimary (citable) accession number: P26441
    Secondary accession number(s): B2RAB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 149 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3