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Protein

Ciliary neurotrophic factor

Gene

CNTF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.

GO - Molecular functioni

  • ciliary neurotrophic factor receptor binding Source: ProtInc
  • cytokine activity Source: GO_Central
  • growth factor activity Source: BHF-UCL
  • interleukin-6 receptor binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-HSA-6788467. IL-6-type cytokine receptor ligand interactions.
SignaLinkiP26441.
SIGNORiP26441.

Names & Taxonomyi

Protein namesi
Recommended name:
Ciliary neurotrophic factor
Short name:
CNTF
Gene namesi
Name:CNTF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000242689.2.
HGNCiHGNC:2169. CNTF.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi1270.
OpenTargetsiENSG00000242689.
PharmGKBiPA26683.

Polymorphism and mutation databases

BioMutaiCNTF.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001495191 – 200Ciliary neurotrophic factorAdd BLAST200

Proteomic databases

EPDiP26441.
PaxDbiP26441.
PeptideAtlasiP26441.
PRIDEiP26441.

PTM databases

PhosphoSitePlusiP26441.

Expressioni

Tissue specificityi

Nervous system.

Gene expression databases

BgeeiENSG00000242689.
CleanExiHS_CNTF.
GenevisibleiP26441. HS.

Organism-specific databases

HPAiHPA019654.

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

Show more details

GO - Molecular functioni

  • ciliary neurotrophic factor receptor binding Source: ProtInc
  • cytokine activity Source: GO_Central
  • growth factor activity Source: BHF-UCL
  • interleukin-6 receptor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi107670. 16 interactors.
CORUMiP26441.
DIPiDIP-5776N.
IntActiP26441. 15 interactors.
MINTiMINT-205057.
STRINGi9606.ENSP00000355370.

Structurei

Secondary structure

1200
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi13 – 41Combined sources29
Helixi69 – 95Combined sources27
Turni96 – 98Combined sources3
Beta strandi99 – 101Combined sources3
Helixi104 – 129Combined sources26
Beta strandi138 – 140Combined sources3
Helixi152 – 180Combined sources29

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CNTX-ray2.401/2/3/41-187[»]
ProteinModelPortaliP26441.
SMRiP26441.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26441.

Family & Domainsi

Sequence similaritiesi

Belongs to the CNTF family.Curated

Phylogenomic databases

eggNOGiENOG410IGEN. Eukaryota.
ENOG410YYIH. LUCA.
GeneTreeiENSGT00420000029890.
HOGENOMiHOG000059605.
HOVERGENiHBG005362.
InParanoidiP26441.
KOiK05420.
OMAiKLWGLKV.
OrthoDBiEOG091G0R1O.
PhylomeDBiP26441.
TreeFamiTF336237.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR000151. Ciliary_neurotrophic_fac_CNTF.
PfamiView protein in Pfam
PF01110. CNTF. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

P26441-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFTEHSPLT PHRRDLCSRS IWLARKIRSD LTALTESYVK HQGLNKNINL
60 70 80 90 100
DSADGMPVAS TDQWSELTEA ERLQENLQAY RTFHVLLARL LEDQQVHFTP
110 120 130 140 150
TEGDFHQAIH TLLLQVAAFA YQIEELMILL EYKIPRNEAD GMPINVGDGG
160 170 180 190 200
LFEKKLWGLK VLQELSQWTV RSIHDLRFIS SHQTGIPARG SHYIANNKKM
Length:200
Mass (Da):22,931
Last modified:August 1, 1992 - v1
Checksum:iEDD9D895BDA6F35A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03377749N → S. Corresponds to variant dbSNP:rs17152779Ensembl.1
Natural variantiVAR_013924182H → R1 PublicationCorresponds to variant dbSNP:rs6266Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60542 Genomic DNA. Translation: CAA43032.1.
X60477, X60478 Genomic DNA. Translation: CAA43009.1.
X55889, X55890 Genomic DNA. Translation: CAA39374.1.
AK314118 mRNA. Translation: BAG36809.1.
CH471076 Genomic DNA. Translation: EAW73819.1.
BC068030 mRNA. Translation: AAH68030.1.
BC074963 mRNA. Translation: AAH74963.1.
BC074964 mRNA. Translation: AAH74964.1.
CCDSiCCDS31554.1.
PIRiJH0455. UNHUCF.
RefSeqiNP_000605.1. NM_000614.3.
UniGeneiHs.524920.

Genome annotation databases

EnsembliENST00000361987; ENSP00000355370; ENSG00000242689.
GeneIDi1270.
KEGGihsa:1270.
UCSCiuc001nna.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCNTF_HUMAN
AccessioniPrimary (citable) accession number: P26441
Secondary accession number(s): B2RAB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 27, 2017
This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families