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P26441 (CNTF_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 146. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ciliary neurotrophic factor

Short name=CNTF
Gene names
Name:CNTF
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length200 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.

Subunit structure

Homodimer.

Subcellular location

Cytoplasm.

Tissue specificity

Nervous system.

Sequence similarities

Belongs to the CNTF family.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
   Cellular componentCytoplasm
   Coding sequence diversityPolymorphism
   Molecular functionDevelopmental protein
Growth factor
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processciliary neurotrophic factor-mediated signaling pathway

Inferred from direct assay PubMed 12643274. Source: BHF-UCL

growth

Inferred from electronic annotation. Source: InterPro

muscle organ morphogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron apoptotic process

Inferred from direct assay PubMed 10966616. Source: BHF-UCL

negative regulation of photoreceptor cell differentiation

Inferred from electronic annotation. Source: Ensembl

neuron development

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of tyrosine phosphorylation of Stat3 protein

Inferred from direct assay PubMed 12643274. Source: BHF-UCL

regulation of retinal cell programmed cell death

Inferred from electronic annotation. Source: Ensembl

signal transduction

Non-traceable author statement Ref.3. Source: ProtInc

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular space

Inferred by curator PubMed 12643274. Source: BHF-UCL

   Molecular_functionciliary neurotrophic factor receptor binding

Traceable author statement PubMed 1714745. Source: ProtInc

growth factor activity

Inferred from direct assay PubMed 12643274. Source: BHF-UCL

interleukin-6 receptor binding

Inferred from physical interaction PubMed 12643274. Source: BHF-UCL

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 200200Ciliary neurotrophic factor
PRO_0000149519

Natural variations

Natural variant491N → S.
Corresponds to variant rs17152779 [ dbSNP | Ensembl ].
VAR_033777
Natural variant1821H → R. Ref.10
Corresponds to variant rs6266 [ dbSNP | Ensembl ].
VAR_013924

Secondary structure

............. 200
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P26441 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: EDD9D895BDA6F35A

FASTA20022,931
        10         20         30         40         50         60 
MAFTEHSPLT PHRRDLCSRS IWLARKIRSD LTALTESYVK HQGLNKNINL DSADGMPVAS 

        70         80         90        100        110        120 
TDQWSELTEA ERLQENLQAY RTFHVLLARL LEDQQVHFTP TEGDFHQAIH TLLLQVAAFA 

       130        140        150        160        170        180 
YQIEELMILL EYKIPRNEAD GMPINVGDGG LFEKKLWGLK VLQELSQWTV RSIHDLRFIS 

       190        200 
SHQTGIPARG SHYIANNKKM 

« Hide

References

« Hide 'large scale' references
[1]"Recombinant human and rat ciliary neurotrophic factors."
Masiakowski P., Liu H., Radziejewski C., Lottspeich F., Oberthuer W., Wong V., Lindsay R.M., Furth M.E., Panayotatos N.
J. Neurochem. 57:1003-1012(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Cloning and expression of human ciliary neurotrophic factor."
Negro A., Tolosano E., Skaper S., Martini I., Callegaro L., Silengo L., Fiorini F., Altruda F.
Eur. J. Biochem. 201:289-294(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Sequence and structural organization of the human gene encoding ciliary neurotrophic factor."
Lam A., Fuller F., Miller J., Kloss J., Manthorpe M., Varon M., Cordell B.
Gene 102:271-276(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Lung.
[4]"Expression and characterization of recombinant human ciliary neurotrophic factor from Escherichia coli."
McDonald J.R., Ko C., Mismer D., Smith D.J., Collins F.
Biochim. Biophys. Acta 1090:70-80(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"A null mutation in the human CNTF gene is not causally related to neurological diseases."
Takahashi R., Yokoji H., Misawa H., Hayashi M., Hu J., Deguchi T.
Nat. Genet. 7:79-84(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Sciatic nerve.
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[9]"Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing."
McDonald N.Q., Panayotatos N., Hendrickson W.A.
EMBO J. 14:2689-2699(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-187.
[10]"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT ARG-182.
[11]Erratum
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.
Nat. Genet. 23:373-373(1999)
+Additional computationally mapped references.

Web resources

Wikipedia

Ciliary neurotrophic factor entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X60542 Genomic DNA. Translation: CAA43032.1.
X60477, X60478 Genomic DNA. Translation: CAA43009.1.
X55889, X55890 Genomic DNA. Translation: CAA39374.1.
AK314118 mRNA. Translation: BAG36809.1.
CH471076 Genomic DNA. Translation: EAW73819.1.
BC068030 mRNA. Translation: AAH68030.1.
BC074963 mRNA. Translation: AAH74963.1.
BC074964 mRNA. Translation: AAH74964.1.
PIRUNHUCF. JH0455.
RefSeqNP_000605.1. NM_000614.3.
UniGeneHs.524920.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1CNTX-ray2.401/2/3/41-187[»]
ProteinModelPortalP26441.
SMRP26441. Positions 11-187.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107670. 9 interactions.
DIPDIP-5776N.
MINTMINT-205057.
STRING9606.ENSP00000355370.

PTM databases

PhosphoSiteP26441.

Proteomic databases

PaxDbP26441.
PRIDEP26441.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000361987; ENSP00000355370; ENSG00000242689.
GeneID1270.
KEGGhsa:1270.
UCSCuc001nna.4. human.

Organism-specific databases

CTD1270.
GeneCardsGC11P058390.
HGNCHGNC:2169. CNTF.
HPAHPA019654.
MIM118945. gene.
neXtProtNX_P26441.
PharmGKBPA26683.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG114783.
HOGENOMHOG000059605.
HOVERGENHBG005362.
KOK05420.
OMAKLWGLKV.
OrthoDBEOG700893.
PhylomeDBP26441.
TreeFamTF336237.

Enzyme and pathway databases

SignaLinkP26441.

Gene expression databases

BgeeP26441.
CleanExHS_CNTF.
GenevestigatorP26441.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000151. Ciliary_neurotrophic_fac_CNTF.
[Graphical view]
PfamPF01110. CNTF. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP26441.
GeneWikiCiliary_neurotrophic_factor.
GenomeRNAi1270.
NextBio5143.
PROP26441.
SOURCESearch...

Entry information

Entry nameCNTF_HUMAN
AccessionPrimary (citable) accession number: P26441
Secondary accession number(s): B2RAB2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM