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Protein

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

Gene

HSD3B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.

Catalytic activityi

A 3-beta-hydroxy-Delta(5)-steroid + NAD+ = a 3-oxo-Delta(5)-steroid + NADH.
A 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid.

Pathwayi: steroid biosynthesis

This protein is involved in the pathway steroid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway steroid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei154Proton acceptorBy similarity1
Binding sitei158NADBy similarity1

GO - Molecular functioni

  • 3-beta-hydroxy-delta5-steroid dehydrogenase activity Source: UniProtKB
  • steroid delta-isomerase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Oxidoreductase

Keywords - Biological processi

Steroidogenesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciMetaCyc:HS10943-MONOMER.
ZFISH:HS10943-MONOMER.
BRENDAi1.1.1.145. 2681.
5.3.3.1. 2681.
ReactomeiR-HSA-193048. Androgen biosynthesis.
R-HSA-193993. Mineralocorticoid biosynthesis.
R-HSA-194002. Glucocorticoid biosynthesis.
UniPathwayiUPA00062.

Chemistry databases

SwissLipidsiSLP:000001296.

Names & Taxonomyi

Protein namesi
Recommended name:
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
Alternative name(s):
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II
Short name:
3-beta-HSD II
3-beta-HSD adrenal and gonadal type
Including the following 2 domains:
3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC:1.1.1.145)
Alternative name(s):
3-beta-hydroxy-5-ene steroid dehydrogenase
Progesterone reductase
Steroid Delta-isomerase (EC:5.3.3.1)
Alternative name(s):
Delta-5-3-ketosteroid isomerase
Gene namesi
Name:HSD3B2
Synonyms:HSDB3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:5218. HSD3B2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum membrane Source: Reactome
  • integral component of membrane Source: UniProtKB
  • mitochondrial inner membrane Source: UniProtKB
  • mitochondrial intermembrane space Source: UniProtKB
  • mitochondrial membrane Source: UniProtKB
  • smooth endoplasmic reticulum membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Adrenal hyperplasia 2 (AH2)17 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: 'salt wasting' (SW, the most severe type), 'simple virilizing' (SV, less severely affected patients), with normal aldosterone biosynthesis, 'non-classic form' or late-onset (NC or LOAH) and 'cryptic' (asymptomatic). In AH2, virilization is much less marked or does not occur. AH2 is frequently lethal in early life.
See also OMIM:201810
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01051710A → E in AH2; activity abolished. 2 PublicationsCorresponds to variant rs28934880dbSNPEnsembl.1
Natural variantiVAR_01051810A → V in AH2; nonsalt-wasting form. 1 Publication1
Natural variantiVAR_01051915G → D in AH2; activity abolished. 2 Publications1
Natural variantiVAR_07002882A → P in AH2. 1 Publication1
Natural variantiVAR_01052082A → T in AH2. 2 PublicationsCorresponds to variant rs757033996dbSNPEnsembl.1
Natural variantiVAR_010521100N → S in AH2; nonsalt-wasting form. 2 Publications1
Natural variantiVAR_010522108L → W in AH2; activity abolished. 2 Publications1
Natural variantiVAR_010523129G → R in AH2; nonsalt-wasting form. 3 PublicationsCorresponds to variant rs587628683dbSNPEnsembl.1
Natural variantiVAR_000006142E → K in AH2; activity abolished. 3 PublicationsCorresponds to variant rs80358219dbSNPEnsembl.1
Natural variantiVAR_010524155P → L in AH2; nonsalt-wasting form. 1 PublicationCorresponds to variant rs779418168dbSNPEnsembl.1
Natural variantiVAR_010525167A → V in AH2; late onset; almost normal activity. 1 PublicationCorresponds to variant rs35486059dbSNPEnsembl.1
Natural variantiVAR_010526173L → R in AH2; nonsalt-wasting form. 2 PublicationsCorresponds to variant rs762479018dbSNPEnsembl.1
Natural variantiVAR_010527186P → L in AH2; activity abolished. 2 Publications1
Natural variantiVAR_000007205L → P in AH2. 2 Publications1
Natural variantiVAR_010528213S → G in AH2; late onset; partial loss of activity. 1 PublicationCorresponds to variant rs759422374dbSNPEnsembl.1
Natural variantiVAR_010529216K → E in AH2; late onset; partial loss of activity. 1 Publication1
Natural variantiVAR_010530222P → H in AH2; nonsalt-wasting form; activity abolished. 1 Publication1
Natural variantiVAR_010531222P → Q in AH2; activity abolished. 2 PublicationsCorresponds to variant rs765547422dbSNPEnsembl.1
Natural variantiVAR_015411222P → T in AH2. 1 PublicationCorresponds to variant rs80358220dbSNPEnsembl.1
Natural variantiVAR_010532231 – 238Missing in AH2; activity abolished. 8
Natural variantiVAR_010533236L → S in AH2; mild; 100% of activity. 2 PublicationsCorresponds to variant rs35887327dbSNPEnsembl.1
Natural variantiVAR_000008245A → P in AH2; loss of 88% of activity. 2 Publications1
Natural variantiVAR_000009253Y → N in AH2; activity abolished. 2 Publications1
Natural variantiVAR_000010254Y → D in AH2; activity abolished. 2 Publications1
Natural variantiVAR_010534259T → M in AH2; activity abolished. 2 PublicationsCorresponds to variant rs80358221dbSNPEnsembl.1
Natural variantiVAR_000011259T → R in AH2; activity abolished. 2 Publications1
Natural variantiVAR_010535294G → V in AH2; nonsalt-wasting form; activity abolished. 1 Publication1
Natural variantiVAR_065665341P → L in AH2; strongly reduced activity. 1 PublicationCorresponds to variant rs121964897dbSNPEnsembl.1

Mild HSD3B2 deficiency in hyperandrogenic females is associated with characteristic traits of polycystic ovary syndrome, such as insulin resistance and luteinizing hormone hypersecretion.

Keywords - Diseasei

Congenital adrenal hyperplasia, Disease mutation

Organism-specific databases

DisGeNETi3284.
MalaCardsiHSD3B2.
MIMi201810. phenotype.
OpenTargetsiENSG00000203859.
Orphaneti90791. Congenital adrenal hyperplasia due to 3-beta-hydroxysteroid dehydrogenase deficiency.
3185. Polycystic ovary syndrome.
PharmGKBiPA29487.

Chemistry databases

ChEMBLiCHEMBL3670.
DrugBankiDB01285. Corticotropin.
DB00603. Medroxyprogesterone Acetate.
DB01108. Trilostane.

Polymorphism and mutation databases

BioMutaiHSD3B2.
DMDMi112770.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000877751 – 3723 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2Add BLAST372

Proteomic databases

PaxDbiP26439.
PeptideAtlasiP26439.
PRIDEiP26439.

PTM databases

iPTMnetiP26439.
PhosphoSitePlusiP26439.

Expressioni

Tissue specificityi

Expressed in adrenal gland, testis and ovary.

Gene expression databases

BgeeiENSG00000203859.
CleanExiHS_HSD3B2.
ExpressionAtlasiP26439. baseline and differential.
GenevisibleiP26439. HS.

Organism-specific databases

HPAiHPA043261.
HPA043264.
HPA044028.

Interactioni

Protein-protein interaction databases

BioGridi109517. 20 interactors.
STRINGi9606.ENSP00000358424.

Chemistry databases

BindingDBiP26439.

Structurei

3D structure databases

ProteinModelPortaliP26439.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-beta-HSD family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1430. Eukaryota.
COG0451. LUCA.
GeneTreeiENSGT00550000074557.
HOVERGENiHBG000014.
KOiK00070.
OMAiACIQENV.
OrthoDBiEOG091G09QZ.
PhylomeDBiP26439.
TreeFamiTF343138.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR002225. 3Beta_OHSteriod_DH/Estase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01073. 3Beta_HSD. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P26439-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGWSCLVTGA GGLLGQRIVR LLVEEKELKE IRALDKAFRP ELREEFSKLQ
60 70 80 90 100
NRTKLTVLEG DILDEPFLKR ACQDVSVVIH TACIIDVFGV THRESIMNVN
110 120 130 140 150
VKGTQLLLEA CVQASVPVFI YTSSIEVAGP NSYKEIIQNG HEEEPLENTW
160 170 180 190 200
PTPYPYSKKL AEKAVLAANG WNLKNGDTLY TCALRPTYIY GEGGPFLSAS
210 220 230 240 250
INEALNNNGI LSSVGKFSTV NPVYVGNVAW AHILALRALR DPKKAPSVRG
260 270 280 290 300
QFYYISDDTP HQSYDNLNYI LSKEFGLRLD SRWSLPLTLM YWIGFLLEVV
310 320 330 340 350
SFLLSPIYSY QPPFNRHTVT LSNSVFTFSY KKAQRDLAYK PLYSWEEAKQ
360 370
KTVEWVGSLV DRHKETLKSK TQ
Length:372
Mass (Da):42,052
Last modified:January 23, 2007 - v2
Checksum:i8E0D933488988451
GO
Isoform 2 (identifier: P26439-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-222: GTQLLLEACV...SVGKFSTVNP → ELQNKIKLTV...FIDEKTRTEQ
     223-372: Missing.

Show »
Length:222
Mass (Da):24,987
Checksum:i48A60A9900F0C500
GO

Sequence cautioni

The sequence AAC60600 differs from that shown. Reason: Frameshift at position 186. The frameshift is caused by a single nucleotide insertion which is found in AH2.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52 – 53RT → KI in AAD14329 (PubMed:7588414).Curated2
Sequence conflicti92 – 94HRE → RRQ in AAD14329 (PubMed:7588414).Curated3
Sequence conflicti232H → L in BAD96717 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01051710A → E in AH2; activity abolished. 2 PublicationsCorresponds to variant rs28934880dbSNPEnsembl.1
Natural variantiVAR_01051810A → V in AH2; nonsalt-wasting form. 1 Publication1
Natural variantiVAR_01051915G → D in AH2; activity abolished. 2 Publications1
Natural variantiVAR_04809974D → N.Corresponds to variant rs4986954dbSNPEnsembl.1
Natural variantiVAR_07002882A → P in AH2. 1 Publication1
Natural variantiVAR_01052082A → T in AH2. 2 PublicationsCorresponds to variant rs757033996dbSNPEnsembl.1
Natural variantiVAR_01481894E → Q.1 PublicationCorresponds to variant rs6211dbSNPEnsembl.1
Natural variantiVAR_010521100N → S in AH2; nonsalt-wasting form. 2 Publications1
Natural variantiVAR_010522108L → W in AH2; activity abolished. 2 Publications1
Natural variantiVAR_010523129G → R in AH2; nonsalt-wasting form. 3 PublicationsCorresponds to variant rs587628683dbSNPEnsembl.1
Natural variantiVAR_000006142E → K in AH2; activity abolished. 3 PublicationsCorresponds to variant rs80358219dbSNPEnsembl.1
Natural variantiVAR_010524155P → L in AH2; nonsalt-wasting form. 1 PublicationCorresponds to variant rs779418168dbSNPEnsembl.1
Natural variantiVAR_010525167A → V in AH2; late onset; almost normal activity. 1 PublicationCorresponds to variant rs35486059dbSNPEnsembl.1
Natural variantiVAR_010526173L → R in AH2; nonsalt-wasting form. 2 PublicationsCorresponds to variant rs762479018dbSNPEnsembl.1
Natural variantiVAR_010527186P → L in AH2; activity abolished. 2 Publications1
Natural variantiVAR_000007205L → P in AH2. 2 Publications1
Natural variantiVAR_010528213S → G in AH2; late onset; partial loss of activity. 1 PublicationCorresponds to variant rs759422374dbSNPEnsembl.1
Natural variantiVAR_010529216K → E in AH2; late onset; partial loss of activity. 1 Publication1
Natural variantiVAR_010530222P → H in AH2; nonsalt-wasting form; activity abolished. 1 Publication1
Natural variantiVAR_010531222P → Q in AH2; activity abolished. 2 PublicationsCorresponds to variant rs765547422dbSNPEnsembl.1
Natural variantiVAR_015411222P → T in AH2. 1 PublicationCorresponds to variant rs80358220dbSNPEnsembl.1
Natural variantiVAR_010532231 – 238Missing in AH2; activity abolished. 8
Natural variantiVAR_010533236L → S in AH2; mild; 100% of activity. 2 PublicationsCorresponds to variant rs35887327dbSNPEnsembl.1
Natural variantiVAR_000008245A → P in AH2; loss of 88% of activity. 2 Publications1
Natural variantiVAR_000009253Y → N in AH2; activity abolished. 2 Publications1
Natural variantiVAR_000010254Y → D in AH2; activity abolished. 2 Publications1
Natural variantiVAR_010534259T → M in AH2; activity abolished. 2 PublicationsCorresponds to variant rs80358221dbSNPEnsembl.1
Natural variantiVAR_000011259T → R in AH2; activity abolished. 2 Publications1
Natural variantiVAR_010535294G → V in AH2; nonsalt-wasting form; activity abolished. 1 Publication1
Natural variantiVAR_065665341P → L in AH2; strongly reduced activity. 1 PublicationCorresponds to variant rs121964897dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_037399103 – 222GTQLL…STVNP → ELQNKIKLTVLEGDILDEPF LKRACQDVSVVIHTACIIDV FGVTHRQSIMNVNVKGRVAW GGDKARWGNEDQKEGQEGKR SLSIEHLLCSGPSDFADHYQ LGELKAAIFSFIDEKTRTEQ in isoform 2. 1 PublicationAdd BLAST120
Alternative sequenceiVSP_037400223 – 372Missing in isoform 2. 1 PublicationAdd BLAST150

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77144 Genomic DNA. Translation: AAA36014.1.
M67466 mRNA. Translation: AAA36016.1.
CR627415 mRNA. Translation: CAH10504.1.
AK222997 mRNA. Translation: BAD96717.1.
AL359553 Genomic DNA. Translation: CAC19799.1.
CH471122 Genomic DNA. Translation: EAW56700.1.
BC038419 mRNA. Translation: AAH38419.1.
BC131488 mRNA. Translation: AAI31489.1.
S80140 Genomic DNA. Translation: AAD14329.1.
S60309 Genomic DNA. Translation: AAC60599.1.
S60310 Genomic DNA. Translation: AAC60600.1. Frameshift.
CCDSiCCDS902.1. [P26439-1]
PIRiA39488. DEHUH2.
RefSeqiNP_000189.1. NM_000198.3. [P26439-1]
NP_001159592.1. NM_001166120.1. [P26439-1]
UniGeneiHs.654399.

Genome annotation databases

EnsembliENST00000369416; ENSP00000358424; ENSG00000203859. [P26439-1]
ENST00000543831; ENSP00000445122; ENSG00000203859. [P26439-1]
GeneIDi3284.
KEGGihsa:3284.
UCSCiuc001eht.4. human. [P26439-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77144 Genomic DNA. Translation: AAA36014.1.
M67466 mRNA. Translation: AAA36016.1.
CR627415 mRNA. Translation: CAH10504.1.
AK222997 mRNA. Translation: BAD96717.1.
AL359553 Genomic DNA. Translation: CAC19799.1.
CH471122 Genomic DNA. Translation: EAW56700.1.
BC038419 mRNA. Translation: AAH38419.1.
BC131488 mRNA. Translation: AAI31489.1.
S80140 Genomic DNA. Translation: AAD14329.1.
S60309 Genomic DNA. Translation: AAC60599.1.
S60310 Genomic DNA. Translation: AAC60600.1. Frameshift.
CCDSiCCDS902.1. [P26439-1]
PIRiA39488. DEHUH2.
RefSeqiNP_000189.1. NM_000198.3. [P26439-1]
NP_001159592.1. NM_001166120.1. [P26439-1]
UniGeneiHs.654399.

3D structure databases

ProteinModelPortaliP26439.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109517. 20 interactors.
STRINGi9606.ENSP00000358424.

Chemistry databases

BindingDBiP26439.
ChEMBLiCHEMBL3670.
DrugBankiDB01285. Corticotropin.
DB00603. Medroxyprogesterone Acetate.
DB01108. Trilostane.
SwissLipidsiSLP:000001296.

PTM databases

iPTMnetiP26439.
PhosphoSitePlusiP26439.

Polymorphism and mutation databases

BioMutaiHSD3B2.
DMDMi112770.

Proteomic databases

PaxDbiP26439.
PeptideAtlasiP26439.
PRIDEiP26439.

Protocols and materials databases

DNASUi3284.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369416; ENSP00000358424; ENSG00000203859. [P26439-1]
ENST00000543831; ENSP00000445122; ENSG00000203859. [P26439-1]
GeneIDi3284.
KEGGihsa:3284.
UCSCiuc001eht.4. human. [P26439-1]

Organism-specific databases

CTDi3284.
DisGeNETi3284.
GeneCardsiHSD3B2.
HGNCiHGNC:5218. HSD3B2.
HPAiHPA043261.
HPA043264.
HPA044028.
MalaCardsiHSD3B2.
MIMi201810. phenotype.
613890. gene.
neXtProtiNX_P26439.
OpenTargetsiENSG00000203859.
Orphaneti90791. Congenital adrenal hyperplasia due to 3-beta-hydroxysteroid dehydrogenase deficiency.
3185. Polycystic ovary syndrome.
PharmGKBiPA29487.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1430. Eukaryota.
COG0451. LUCA.
GeneTreeiENSGT00550000074557.
HOVERGENiHBG000014.
KOiK00070.
OMAiACIQENV.
OrthoDBiEOG091G09QZ.
PhylomeDBiP26439.
TreeFamiTF343138.

Enzyme and pathway databases

UniPathwayiUPA00062.
BioCyciMetaCyc:HS10943-MONOMER.
ZFISH:HS10943-MONOMER.
BRENDAi1.1.1.145. 2681.
5.3.3.1. 2681.
ReactomeiR-HSA-193048. Androgen biosynthesis.
R-HSA-193993. Mineralocorticoid biosynthesis.
R-HSA-194002. Glucocorticoid biosynthesis.

Miscellaneous databases

GeneWikiiHSD3B2.
GenomeRNAii3284.
PROiP26439.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000203859.
CleanExiHS_HSD3B2.
ExpressionAtlasiP26439. baseline and differential.
GenevisibleiP26439. HS.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR002225. 3Beta_OHSteriod_DH/Estase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01073. 3Beta_HSD. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry namei3BHS2_HUMAN
AccessioniPrimary (citable) accession number: P26439
Secondary accession number(s): A2RRA5
, Q16010, Q53GD4, Q6AI10, Q6LDB9, Q99890, Q9UD08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 177 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.