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P26436

- ASPX_HUMAN

UniProt

P26436 - ASPX_HUMAN

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Protein

Acrosomal protein SP-10

Gene

ACRV1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. multicellular organismal development Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Acrosomal protein SP-10
Alternative name(s):
Acrosomal vesicle protein 1
Gene namesi
Name:ACRV1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:127. ACRV1.

Subcellular locationi

Cytoplasmic vesiclesecretory vesicleacrosome
Note: Nascent acrosomal vesicle of Golgi phase spermatids.

GO - Cellular componenti

  1. acrosomal vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24454.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 265244Acrosomal protein SP-10PRO_0000020760Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP26436.
PRIDEiP26436.

Expressioni

Tissue specificityi

Testis.

Gene expression databases

BgeeiP26436.
CleanExiHS_ACRV1.
ExpressionAtlasiP26436. baseline and differential.
GenevestigatoriP26436.

Organism-specific databases

HPAiHPA038718.
HPA038719.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000317684.

Structurei

3D structure databases

ProteinModelPortaliP26436.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati66 – 7051-1
Repeati71 – 7551-2
Repeati85 – 8842-1
Repeati91 – 9551-3
Repeati110 – 11453-1
Repeati115 – 11953-2
Repeati120 – 12342-2
Repeati125 – 12953-3
Repeati135 – 13953-4
Repeati140 – 14453-5
Repeati145 – 14842-3
Repeati150 – 15453-6
Repeati155 – 15953-7
Repeati160 – 16453-8
Repeati165 – 16842-4
Repeati170 – 17453-9

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni66 – 95303 X 5 AA repeats of S-E-H-[GA]-SAdd
BLAST
Regioni85 – 168844 X 4 AA repeats of S-G-E-HAdd
BLAST
Regioni110 – 174659 X 5 AA repeats of [SV]-G-E-Q-[PSA]Add
BLAST

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00730000111437.
HOGENOMiHOG000034107.
HOVERGENiHBG004291.
InParanoidiP26436.
OMAiSGEHTSG.
OrthoDBiEOG72JWKN.
PhylomeDBiP26436.
TreeFamiTF337781.

Family and domain databases

InterProiIPR026787. Acrosomal_SP-10.
[Graphical view]
PANTHERiPTHR17571:SF31. PTHR17571:SF31. 1 hit.

Sequences (11)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 11 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P26436-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNRFLLLMSL YLLGSARGTS SQPNELSGSI DHQTSVQQLP GEFFSLENPS
60 70 80 90 100
DAEALYETSS GLNTLSEHGS SEHGSSKHTV AEHTSGEHAE SEHASGEPAA
110 120 130 140 150
TEHAEGEHTV GEQPSGEQPS GEHLSGEQPL SELESGEQPS DEQPSGEHGS
160 170 180 190 200
GEQPSGEQAS GEQPSGEHAS GEQASGAPIS STSTGTILNC YTCAYMNDQG
210 220 230 240 250
KCLRGEGTCI TQNSQQCMLK KIFEGGKLQF MVQGCENMCP SMNLFSHGTR
260
MQIICCRNQS FCNKI
Length:265
Mass (Da):28,156
Last modified:February 1, 1996 - v2
Checksum:i318216453F20D68A
GO
Isoform 2 (identifier: P26436-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     166-184: Missing.

Show »
Length:246
Mass (Da):26,401
Checksum:i6FF8396ED844FA5F
GO
Isoform 3 (identifier: P26436-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-95: Missing.

Show »
Length:210
Mass (Da):22,375
Checksum:iF0868BDCA5D5FC1D
GO
Isoform 4 (identifier: P26436-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-110: Missing.

Show »
Length:195
Mass (Da):20,858
Checksum:iD8DC78EC5175A854
GO
Isoform 5 (identifier: P26436-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-110: Missing.
     166-184: Missing.

Show »
Length:176
Mass (Da):19,102
Checksum:iC199FA046A09F327
GO
Isoform 6 (identifier: P26436-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-135: Missing.

Show »
Length:170
Mass (Da):18,267
Checksum:iF87BD099E6105C97
GO
Isoform 7 (identifier: P26436-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-95: Missing.
     111-155: Missing.

Show »
Length:165
Mass (Da):17,763
Checksum:i6ED6262433DCF9F1
GO
Isoform 8 (identifier: P26436-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-110: Missing.
     185-224: Missing.

Show »
Length:155
Mass (Da):16,368
Checksum:i25AAF9C235A9A588
GO
Isoform 9 (identifier: P26436-9) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-110: Missing.
     121-165: Missing.

Show »
Length:150
Mass (Da):16,272
Checksum:i67514BDD8C5C4A7B
GO
Isoform 10 (identifier: P26436-10) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-184: Missing.

Show »
Length:121
Mass (Da):13,520
Checksum:i83A5DDCA9E7010C0
GO
Isoform 11 (identifier: P26436-11) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-224: Missing.

Show »
Length:81
Mass (Da):9,030
Checksum:iAD5DE4C5D83782B8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 911S → E AA sequence (PubMed:1637938)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti126 – 1261G → R.2 Publications
Corresponds to variant rs34788353 [ dbSNP | Ensembl ].
VAR_050680

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei41 – 224184Missing in isoform 11. CuratedVSP_004124Add
BLAST
Alternative sequencei41 – 184144Missing in isoform 10. CuratedVSP_004123Add
BLAST
Alternative sequencei41 – 13595Missing in isoform 6. CuratedVSP_004122Add
BLAST
Alternative sequencei41 – 11070Missing in isoform 4, isoform 5, isoform 8 and isoform 9. CuratedVSP_004121Add
BLAST
Alternative sequencei41 – 9555Missing in isoform 3 and isoform 7. CuratedVSP_004120Add
BLAST
Alternative sequencei111 – 15545Missing in isoform 7. CuratedVSP_004125Add
BLAST
Alternative sequencei121 – 16545Missing in isoform 9. CuratedVSP_004126Add
BLAST
Alternative sequencei166 – 18419Missing in isoform 2 and isoform 5. CuratedVSP_004127Add
BLAST
Alternative sequencei185 – 22440Missing in isoform 8. CuratedVSP_004128Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M82967 mRNA. Translation: AAA36625.1.
M82968 mRNA. Translation: AAA36626.1.
S65583
, S65606, S65576, S65578 Genomic DNA. Translation: AAB28238.2.
AK223335 mRNA. Translation: BAD97055.1.
BC014588 mRNA. Translation: AAH14588.1.
CCDSiCCDS44759.1. [P26436-2]
CCDS44761.1. [P26436-4]
CCDS8460.1. [P26436-1]
CCDS8461.1. [P26436-3]
PIRiA37225.
B37225.
RefSeqiNP_001603.1. NM_001612.5. [P26436-1]
NP_064454.1. NM_020069.4. [P26436-2]
NP_064492.1. NM_020107.4. [P26436-3]
NP_064493.1. NM_020108.4. [P26436-4]
UniGeneiHs.169222.
Hs.596575.

Genome annotation databases

EnsembliENST00000315608; ENSP00000317684; ENSG00000134940. [P26436-2]
ENST00000527795; ENSP00000436819; ENSG00000134940. [P26436-4]
ENST00000530048; ENSP00000433720; ENSG00000134940. [P26436-3]
ENST00000533904; ENSP00000432816; ENSG00000134940. [P26436-1]
GeneIDi56.
KEGGihsa:56.
UCSCiuc001qcl.3. human. [P26436-4]
uc001qcn.3. human. [P26436-3]
uc001qcr.3. human. [P26436-2]
uc001qcs.3. human. [P26436-1]

Polymorphism databases

DMDMi1351991.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M82967 mRNA. Translation: AAA36625.1 .
M82968 mRNA. Translation: AAA36626.1 .
S65583
, S65606 , S65576 , S65578 Genomic DNA. Translation: AAB28238.2 .
AK223335 mRNA. Translation: BAD97055.1 .
BC014588 mRNA. Translation: AAH14588.1 .
CCDSi CCDS44759.1. [P26436-2 ]
CCDS44761.1. [P26436-4 ]
CCDS8460.1. [P26436-1 ]
CCDS8461.1. [P26436-3 ]
PIRi A37225.
B37225.
RefSeqi NP_001603.1. NM_001612.5. [P26436-1 ]
NP_064454.1. NM_020069.4. [P26436-2 ]
NP_064492.1. NM_020107.4. [P26436-3 ]
NP_064493.1. NM_020108.4. [P26436-4 ]
UniGenei Hs.169222.
Hs.596575.

3D structure databases

ProteinModelPortali P26436.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000317684.

Polymorphism databases

DMDMi 1351991.

Proteomic databases

PaxDbi P26436.
PRIDEi P26436.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000315608 ; ENSP00000317684 ; ENSG00000134940 . [P26436-2 ]
ENST00000527795 ; ENSP00000436819 ; ENSG00000134940 . [P26436-4 ]
ENST00000530048 ; ENSP00000433720 ; ENSG00000134940 . [P26436-3 ]
ENST00000533904 ; ENSP00000432816 ; ENSG00000134940 . [P26436-1 ]
GeneIDi 56.
KEGGi hsa:56.
UCSCi uc001qcl.3. human. [P26436-4 ]
uc001qcn.3. human. [P26436-3 ]
uc001qcr.3. human. [P26436-2 ]
uc001qcs.3. human. [P26436-1 ]

Organism-specific databases

CTDi 56.
GeneCardsi GC11M125576.
HGNCi HGNC:127. ACRV1.
HPAi HPA038718.
HPA038719.
MIMi 102525. gene.
neXtProti NX_P26436.
PharmGKBi PA24454.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00730000111437.
HOGENOMi HOG000034107.
HOVERGENi HBG004291.
InParanoidi P26436.
OMAi SGEHTSG.
OrthoDBi EOG72JWKN.
PhylomeDBi P26436.
TreeFami TF337781.

Miscellaneous databases

GeneWikii ACRV1.
GenomeRNAii 56.
NextBioi 225.
PROi P26436.
SOURCEi Search...

Gene expression databases

Bgeei P26436.
CleanExi HS_ACRV1.
ExpressionAtlasi P26436. baseline and differential.
Genevestigatori P26436.

Family and domain databases

InterProi IPR026787. Acrosomal_SP-10.
[Graphical view ]
PANTHERi PTHR17571:SF31. PTHR17571:SF31. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of cDNAs coding for the human intra-acrosomal antigen SP-10."
    Wright R.M., John E., Klotz K., Flickinger C.J., Herr J.C.
    Biol. Reprod. 42:693-701(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. Erratum
    Wright R.M., John E., Klotz K., Flickinger C.J., Herr J.C.
    Biol. Reprod. 43:903-903(1990)
    Cited for: SEQUENCE REVISION.
  3. "Cloning and characterization of the gene coding for the human acrosomal protein SP-10."
    Wright R.M., Suri A.K., Kornreich B., Flickinger C.J., Herr J.C.
    Biol. Reprod. 49:316-325(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-126.
  4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-126.
    Tissue: Testis.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  6. "Characterization of alternatively spliced human SP-10 mRNAs."
    Freemerman A.J., Flickinger C.J., Herr J.C.
    Mol. Reprod. Dev. 41:100-108(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING.
    Tissue: Testis.
  7. "Purification and microsequencing of the intra-acrosomal protein SP-10. Evidence that SP-10 heterogeneity results from endoproteolytic processes."
    Herr J.C., Klotz K., Shannon J., Wright R.M., Flickinger C.J.
    Biol. Reprod. 47:11-20(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 78-100; 106-122 AND 127-151.

Entry informationi

Entry nameiASPX_HUMAN
AccessioniPrimary (citable) accession number: P26436
Secondary accession number(s): Q53FF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3