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P26436

- ASPX_HUMAN

UniProt

P26436 - ASPX_HUMAN

Protein

Acrosomal protein SP-10

Gene

ACRV1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. multicellular organismal development Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acrosomal protein SP-10
    Alternative name(s):
    Acrosomal vesicle protein 1
    Gene namesi
    Name:ACRV1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:127. ACRV1.

    Subcellular locationi

    Cytoplasmic vesiclesecretory vesicleacrosome
    Note: Nascent acrosomal vesicle of Golgi phase spermatids.

    GO - Cellular componenti

    1. acrosomal vesicle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24454.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 265244Acrosomal protein SP-10PRO_0000020760Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP26436.
    PRIDEiP26436.

    Expressioni

    Tissue specificityi

    Testis.

    Gene expression databases

    ArrayExpressiP26436.
    BgeeiP26436.
    CleanExiHS_ACRV1.
    GenevestigatoriP26436.

    Organism-specific databases

    HPAiHPA038718.
    HPA038719.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000317684.

    Structurei

    3D structure databases

    ProteinModelPortaliP26436.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati66 – 7051-1
    Repeati71 – 7551-2
    Repeati85 – 8842-1
    Repeati91 – 9551-3
    Repeati110 – 11453-1
    Repeati115 – 11953-2
    Repeati120 – 12342-2
    Repeati125 – 12953-3
    Repeati135 – 13953-4
    Repeati140 – 14453-5
    Repeati145 – 14842-3
    Repeati150 – 15453-6
    Repeati155 – 15953-7
    Repeati160 – 16453-8
    Repeati165 – 16842-4
    Repeati170 – 17453-9

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni66 – 95303 X 5 AA repeats of S-E-H-[GA]-SAdd
    BLAST
    Regioni85 – 168844 X 4 AA repeats of S-G-E-HAdd
    BLAST
    Regioni110 – 174659 X 5 AA repeats of [SV]-G-E-Q-[PSA]Add
    BLAST

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000034107.
    HOVERGENiHBG004291.
    InParanoidiP26436.
    OMAiSGEHTSG.
    OrthoDBiEOG72JWKN.
    PhylomeDBiP26436.
    TreeFamiTF337781.

    Family and domain databases

    InterProiIPR026787. Acrosomal_SP-10.
    [Graphical view]
    PANTHERiPTHR17571:SF31. PTHR17571:SF31. 1 hit.

    Sequences (11)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 11 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: P26436-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNRFLLLMSL YLLGSARGTS SQPNELSGSI DHQTSVQQLP GEFFSLENPS    50
    DAEALYETSS GLNTLSEHGS SEHGSSKHTV AEHTSGEHAE SEHASGEPAA 100
    TEHAEGEHTV GEQPSGEQPS GEHLSGEQPL SELESGEQPS DEQPSGEHGS 150
    GEQPSGEQAS GEQPSGEHAS GEQASGAPIS STSTGTILNC YTCAYMNDQG 200
    KCLRGEGTCI TQNSQQCMLK KIFEGGKLQF MVQGCENMCP SMNLFSHGTR 250
    MQIICCRNQS FCNKI 265
    Length:265
    Mass (Da):28,156
    Last modified:February 1, 1996 - v2
    Checksum:i318216453F20D68A
    GO
    Isoform 2 (identifier: P26436-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         166-184: Missing.

    Show »
    Length:246
    Mass (Da):26,401
    Checksum:i6FF8396ED844FA5F
    GO
    Isoform 3 (identifier: P26436-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         41-95: Missing.

    Show »
    Length:210
    Mass (Da):22,375
    Checksum:iF0868BDCA5D5FC1D
    GO
    Isoform 4 (identifier: P26436-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         41-110: Missing.

    Show »
    Length:195
    Mass (Da):20,858
    Checksum:iD8DC78EC5175A854
    GO
    Isoform 5 (identifier: P26436-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         41-110: Missing.
         166-184: Missing.

    Show »
    Length:176
    Mass (Da):19,102
    Checksum:iC199FA046A09F327
    GO
    Isoform 6 (identifier: P26436-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         41-135: Missing.

    Show »
    Length:170
    Mass (Da):18,267
    Checksum:iF87BD099E6105C97
    GO
    Isoform 7 (identifier: P26436-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         41-95: Missing.
         111-155: Missing.

    Show »
    Length:165
    Mass (Da):17,763
    Checksum:i6ED6262433DCF9F1
    GO
    Isoform 8 (identifier: P26436-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         41-110: Missing.
         185-224: Missing.

    Show »
    Length:155
    Mass (Da):16,368
    Checksum:i25AAF9C235A9A588
    GO
    Isoform 9 (identifier: P26436-9) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         41-110: Missing.
         121-165: Missing.

    Show »
    Length:150
    Mass (Da):16,272
    Checksum:i67514BDD8C5C4A7B
    GO
    Isoform 10 (identifier: P26436-10) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         41-184: Missing.

    Show »
    Length:121
    Mass (Da):13,520
    Checksum:i83A5DDCA9E7010C0
    GO
    Isoform 11 (identifier: P26436-11) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         41-224: Missing.

    Show »
    Length:81
    Mass (Da):9,030
    Checksum:iAD5DE4C5D83782B8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti91 – 911S → E AA sequence (PubMed:1637938)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti126 – 1261G → R.2 Publications
    Corresponds to variant rs34788353 [ dbSNP | Ensembl ].
    VAR_050680

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei41 – 224184Missing in isoform 11. CuratedVSP_004124Add
    BLAST
    Alternative sequencei41 – 184144Missing in isoform 10. CuratedVSP_004123Add
    BLAST
    Alternative sequencei41 – 13595Missing in isoform 6. CuratedVSP_004122Add
    BLAST
    Alternative sequencei41 – 11070Missing in isoform 4, isoform 5, isoform 8 and isoform 9. CuratedVSP_004121Add
    BLAST
    Alternative sequencei41 – 9555Missing in isoform 3 and isoform 7. CuratedVSP_004120Add
    BLAST
    Alternative sequencei111 – 15545Missing in isoform 7. CuratedVSP_004125Add
    BLAST
    Alternative sequencei121 – 16545Missing in isoform 9. CuratedVSP_004126Add
    BLAST
    Alternative sequencei166 – 18419Missing in isoform 2 and isoform 5. CuratedVSP_004127Add
    BLAST
    Alternative sequencei185 – 22440Missing in isoform 8. CuratedVSP_004128Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M82967 mRNA. Translation: AAA36625.1.
    M82968 mRNA. Translation: AAA36626.1.
    S65583
    , S65606, S65576, S65578 Genomic DNA. Translation: AAB28238.2.
    AK223335 mRNA. Translation: BAD97055.1.
    BC014588 mRNA. Translation: AAH14588.1.
    CCDSiCCDS44759.1. [P26436-2]
    CCDS44761.1. [P26436-4]
    CCDS8460.1. [P26436-1]
    CCDS8461.1. [P26436-3]
    PIRiA37225.
    B37225.
    RefSeqiNP_001603.1. NM_001612.5. [P26436-1]
    NP_064454.1. NM_020069.4. [P26436-2]
    NP_064492.1. NM_020107.4. [P26436-3]
    NP_064493.1. NM_020108.4. [P26436-4]
    UniGeneiHs.169222.
    Hs.596575.

    Genome annotation databases

    EnsembliENST00000315608; ENSP00000317684; ENSG00000134940. [P26436-2]
    ENST00000527795; ENSP00000436819; ENSG00000134940. [P26436-4]
    ENST00000530048; ENSP00000433720; ENSG00000134940. [P26436-3]
    ENST00000533904; ENSP00000432816; ENSG00000134940. [P26436-1]
    GeneIDi56.
    KEGGihsa:56.
    UCSCiuc001qcl.3. human. [P26436-4]
    uc001qcn.3. human. [P26436-3]
    uc001qcr.3. human. [P26436-2]
    uc001qcs.3. human. [P26436-1]

    Polymorphism databases

    DMDMi1351991.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M82967 mRNA. Translation: AAA36625.1 .
    M82968 mRNA. Translation: AAA36626.1 .
    S65583
    , S65606 , S65576 , S65578 Genomic DNA. Translation: AAB28238.2 .
    AK223335 mRNA. Translation: BAD97055.1 .
    BC014588 mRNA. Translation: AAH14588.1 .
    CCDSi CCDS44759.1. [P26436-2 ]
    CCDS44761.1. [P26436-4 ]
    CCDS8460.1. [P26436-1 ]
    CCDS8461.1. [P26436-3 ]
    PIRi A37225.
    B37225.
    RefSeqi NP_001603.1. NM_001612.5. [P26436-1 ]
    NP_064454.1. NM_020069.4. [P26436-2 ]
    NP_064492.1. NM_020107.4. [P26436-3 ]
    NP_064493.1. NM_020108.4. [P26436-4 ]
    UniGenei Hs.169222.
    Hs.596575.

    3D structure databases

    ProteinModelPortali P26436.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000317684.

    Polymorphism databases

    DMDMi 1351991.

    Proteomic databases

    PaxDbi P26436.
    PRIDEi P26436.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000315608 ; ENSP00000317684 ; ENSG00000134940 . [P26436-2 ]
    ENST00000527795 ; ENSP00000436819 ; ENSG00000134940 . [P26436-4 ]
    ENST00000530048 ; ENSP00000433720 ; ENSG00000134940 . [P26436-3 ]
    ENST00000533904 ; ENSP00000432816 ; ENSG00000134940 . [P26436-1 ]
    GeneIDi 56.
    KEGGi hsa:56.
    UCSCi uc001qcl.3. human. [P26436-4 ]
    uc001qcn.3. human. [P26436-3 ]
    uc001qcr.3. human. [P26436-2 ]
    uc001qcs.3. human. [P26436-1 ]

    Organism-specific databases

    CTDi 56.
    GeneCardsi GC11M125576.
    HGNCi HGNC:127. ACRV1.
    HPAi HPA038718.
    HPA038719.
    MIMi 102525. gene.
    neXtProti NX_P26436.
    PharmGKBi PA24454.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000034107.
    HOVERGENi HBG004291.
    InParanoidi P26436.
    OMAi SGEHTSG.
    OrthoDBi EOG72JWKN.
    PhylomeDBi P26436.
    TreeFami TF337781.

    Miscellaneous databases

    GeneWikii ACRV1.
    GenomeRNAii 56.
    NextBioi 225.
    PROi P26436.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P26436.
    Bgeei P26436.
    CleanExi HS_ACRV1.
    Genevestigatori P26436.

    Family and domain databases

    InterProi IPR026787. Acrosomal_SP-10.
    [Graphical view ]
    PANTHERi PTHR17571:SF31. PTHR17571:SF31. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of cDNAs coding for the human intra-acrosomal antigen SP-10."
      Wright R.M., John E., Klotz K., Flickinger C.J., Herr J.C.
      Biol. Reprod. 42:693-701(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. Erratum
      Wright R.M., John E., Klotz K., Flickinger C.J., Herr J.C.
      Biol. Reprod. 43:903-903(1990)
      Cited for: SEQUENCE REVISION.
    3. "Cloning and characterization of the gene coding for the human acrosomal protein SP-10."
      Wright R.M., Suri A.K., Kornreich B., Flickinger C.J., Herr J.C.
      Biol. Reprod. 49:316-325(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-126.
    4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-126.
      Tissue: Testis.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    6. "Characterization of alternatively spliced human SP-10 mRNAs."
      Freemerman A.J., Flickinger C.J., Herr J.C.
      Mol. Reprod. Dev. 41:100-108(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING.
      Tissue: Testis.
    7. "Purification and microsequencing of the intra-acrosomal protein SP-10. Evidence that SP-10 heterogeneity results from endoproteolytic processes."
      Herr J.C., Klotz K., Shannon J., Wright R.M., Flickinger C.J.
      Biol. Reprod. 47:11-20(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 78-100; 106-122 AND 127-151.

    Entry informationi

    Entry nameiASPX_HUMAN
    AccessioniPrimary (citable) accession number: P26436
    Secondary accession number(s): Q53FF4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3