Acrosomal protein SP-10 precursor - Homo sapiens (Human)

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Names and origin

Protein names

Recommended name:
Acrosomal protein SP-10
Alternative name(s):
Acrosomal vesicle protein 1

Gene names

Name:

ACRV1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Subcellular location	Cytoplasmic vesicle › secretory vesicle › acrosome. Note: Nascent acrosomal vesicle of Golgi phase spermatids.
Tissue specificity	Testis.

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Ontologies

Keywords
Cellular component	Cytoplasmic vesicle
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	multicellular organismal development Ref.1 Traceable author statement. Source: ProtInc
Cellular component	acrosomal vesicle Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

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Alternative products

This entry describes 11 isoforms produced by alternative splicing. [Align] [Select] Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P26436-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P26436-2) The sequence of this isoform differs from the canonical sequence as follows: 166-184: Missing.

Isoform 3 (identifier: P26436-3) The sequence of this isoform differs from the canonical sequence as follows: 41-95: Missing.

Isoform 4 (identifier: P26436-4) The sequence of this isoform differs from the canonical sequence as follows: 41-110: Missing.

Isoform 5 (identifier: P26436-5) The sequence of this isoform differs from the canonical sequence as follows: 41-110: Missing. 166-184: Missing.

Isoform 6 (identifier: P26436-6) The sequence of this isoform differs from the canonical sequence as follows: 41-135: Missing.

Isoform 7 (identifier: P26436-7) The sequence of this isoform differs from the canonical sequence as follows: 41-95: Missing. 111-155: Missing.

Isoform 8 (identifier: P26436-8) The sequence of this isoform differs from the canonical sequence as follows: 41-110: Missing. 185-224: Missing.

Isoform 9 (identifier: P26436-9) The sequence of this isoform differs from the canonical sequence as follows: 41-110: Missing. 121-165: Missing.

Isoform 10 (identifier: P26436-10) The sequence of this isoform differs from the canonical sequence as follows: 41-184: Missing.

Isoform 11 (identifier: P26436-11) The sequence of this isoform differs from the canonical sequence as follows: 41-224: Missing.

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 21

21

Potential

Chain

22 – 265

244

Acrosomal protein SP-10

PRO_0000020760

Regions

Repeat

66 – 70

5

1-1

Repeat

71 – 75

5

1-2

Repeat

85 – 88

4

2-1

Repeat

91 – 95

5

1-3

Repeat

110 – 114

5

3-1

Repeat

115 – 119

5

3-2

Repeat

120 – 123

4

2-2

Repeat

125 – 129

5

3-3

Repeat

135 – 139

5

3-4

Repeat

140 – 144

5

3-5

Repeat

145 – 148

4

2-3

Repeat

150 – 154

5

3-6

Repeat

155 – 159

5

3-7

Repeat

160 – 164

5

3-8

Repeat

165 – 168

4

2-4

Repeat

170 – 174

5

3-9

Region

66 – 95

30

3 X 5 AA repeats of S-E-H-[GA]-S

Region

85 – 168

84

4 X 4 AA repeats of S-G-E-H

Region

110 – 174

65

9 X 5 AA repeats of [SV]-G-E-Q-[PSA]

Amino acid modifications

Glycosylation

258

1

N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence

41 – 224

184

Missing in isoform 11.

VSP_004124

Alternative sequence

41 – 184

144

Missing in isoform 10.

VSP_004123

Alternative sequence

41 – 135

95

Missing in isoform 6.

VSP_004122

Alternative sequence

41 – 110

70

Missing in isoform 4, isoform 5, isoform 8 and isoform 9.

VSP_004121

Alternative sequence

41 – 95

55

Missing in isoform 3 and isoform 7.

VSP_004120

Alternative sequence

111 – 155

45

Missing in isoform 7.

VSP_004125

Alternative sequence

121 – 165

45

Missing in isoform 9.

VSP_004126

Alternative sequence

166 – 184

19

Missing in isoform 2 and isoform 5.

VSP_004127

Alternative sequence

185 – 224

40

Missing in isoform 8.

VSP_004128

Natural variant

126

1

G → R: dbSNP rs34788353. Ref.3 Ref.4

VAR_050680

Experimental info

Sequence conflict

91

1

S → E AA sequence Ref.7

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Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified February 1, 1996. Version 2. Checksum: 318216453F20D68A Show »	FASTA	265	28,156
10 20 30 40 50 60 MNRFLLLMSL YLLGSARGTS SQPNELSGSI DHQTSVQQLP GEFFSLENPS DAEALYETSS 70 80 90 100 110 120 GLNTLSEHGS SEHGSSKHTV AEHTSGEHAE SEHASGEPAA TEHAEGEHTV GEQPSGEQPS 130 140 150 160 170 180 GEHLSGEQPL SELESGEQPS DEQPSGEHGS GEQPSGEQAS GEQPSGEHAS GEQASGAPIS 190 200 210 220 230 240 STSTGTILNC YTCAYMNDQG KCLRGEGTCI TQNSQQCMLK KIFEGGKLQF MVQGCENMCP 250 260 SMNLFSHGTR MQIICCRNQS FCNKI « Hide
Isoform 2. Checksum: 6FF8396ED844FA5F Show »	FASTA	246	26,401
10 20 30 40 50 60 MNRFLLLMSL YLLGSARGTS SQPNELSGSI DHQTSVQQLP GEFFSLENPS DAEALYETSS 70 80 90 100 110 120 GLNTLSEHGS SEHGSSKHTV AEHTSGEHAE SEHASGEPAA TEHAEGEHTV GEQPSGEQPS 130 140 150 160 170 180 GEHLSGEQPL SELESGEQPS DEQPSGEHGS GEQPSGEQAS GEQPSGTILN CYTCAYMNDQ 190 200 210 220 230 240 GKCLRGEGTC ITQNSQQCML KKIFEGGKLQ FMVQGCENMC PSMNLFSHGT RMQIICCRNQ SFCNKI « Hide
Isoform 3. Checksum: F0868BDCA5D5FC1D Show »	FASTA	210	22,375
10 20 30 40 50 60 MNRFLLLMSL YLLGSARGTS SQPNELSGSI DHQTSVQQLP GEPAATEHAE GEHTVGEQPS 70 80 90 100 110 120 GEQPSGEHLS GEQPLSELES GEQPSDEQPS GEHGSGEQPS GEQASGEQPS GEHASGEQAS 130 140 150 160 170 180 GAPISSTSTG TILNCYTCAY MNDQGKCLRG EGTCITQNSQ QCMLKKIFEG GKLQFMVQGC 190 200 210 ENMCPSMNLF SHGTRMQIIC CRNQSFCNKI « Hide
Isoform 4. Checksum: D8DC78EC5175A854 Show »	FASTA	195	20,858
10 20 30 40 50 60 MNRFLLLMSL YLLGSARGTS SQPNELSGSI DHQTSVQQLP GEQPSGEQPS GEHLSGEQPL 70 80 90 100 110 120 SELESGEQPS DEQPSGEHGS GEQPSGEQAS GEQPSGEHAS GEQASGAPIS STSTGTILNC 130 140 150 160 170 180 YTCAYMNDQG KCLRGEGTCI TQNSQQCMLK KIFEGGKLQF MVQGCENMCP SMNLFSHGTR 190 MQIICCRNQS FCNKI « Hide
Isoform 5. Checksum: C199FA046A09F327 Show »	FASTA	176	19,102
10 20 30 40 50 60 MNRFLLLMSL YLLGSARGTS SQPNELSGSI DHQTSVQQLP GEQPSGEQPS GEHLSGEQPL 70 80 90 100 110 120 SELESGEQPS DEQPSGEHGS GEQPSGEQAS GEQPSGTILN CYTCAYMNDQ GKCLRGEGTC 130 140 150 160 170 ITQNSQQCML KKIFEGGKLQ FMVQGCENMC PSMNLFSHGT RMQIICCRNQ SFCNKI « Hide
Isoform 6. Checksum: F87BD099E6105C97 Show »	FASTA	170	18,267
10 20 30 40 50 60 MNRFLLLMSL YLLGSARGTS SQPNELSGSI DHQTSVQQLP GEQPSDEQPS GEHGSGEQPS 70 80 90 100 110 120 GEQASGEQPS GEHASGEQAS GAPISSTSTG TILNCYTCAY MNDQGKCLRG EGTCITQNSQ 130 140 150 160 170 QCMLKKIFEG GKLQFMVQGC ENMCPSMNLF SHGTRMQIIC CRNQSFCNKI « Hide
Isoform 7. Checksum: 6ED6262433DCF9F1 Show »	FASTA	165	17,763
10 20 30 40 50 60 MNRFLLLMSL YLLGSARGTS SQPNELSGSI DHQTSVQQLP GEPAATEHAE GEHTVGEQAS 70 80 90 100 110 120 GEQPSGEHAS GEQASGAPIS STSTGTILNC YTCAYMNDQG KCLRGEGTCI TQNSQQCMLK 130 140 150 160 KIFEGGKLQF MVQGCENMCP SMNLFSHGTR MQIICCRNQS FCNKI « Hide
Isoform 8. Checksum: 25AAF9C235A9A588 Show »	FASTA	155	16,368
10 20 30 40 50 60 MNRFLLLMSL YLLGSARGTS SQPNELSGSI DHQTSVQQLP GEQPSGEQPS GEHLSGEQPL 70 80 90 100 110 120 SELESGEQPS DEQPSGEHGS GEQPSGEQAS GEQPSGEHAS GEQASGAPIS STSTGGKLQF 130 140 150 MVQGCENMCP SMNLFSHGTR MQIICCRNQS FCNKI « Hide
Isoform 9. Checksum: 67514BDD8C5C4A7B Show »	FASTA	150	16,272
10 20 30 40 50 60 MNRFLLLMSL YLLGSARGTS SQPNELSGSI DHQTSVQQLP GEQPSGEQPS GEHASGEQAS 70 80 90 100 110 120 GAPISSTSTG TILNCYTCAY MNDQGKCLRG EGTCITQNSQ QCMLKKIFEG GKLQFMVQGC 130 140 150 ENMCPSMNLF SHGTRMQIIC CRNQSFCNKI « Hide
Isoform 10. Checksum: 83A5DDCA9E7010C0 Show »	FASTA	121	13,520
10 20 30 40 50 60 MNRFLLLMSL YLLGSARGTS SQPNELSGSI DHQTSVQQLP GTILNCYTCA YMNDQGKCLR 70 80 90 100 110 120 GEGTCITQNS QQCMLKKIFE GGKLQFMVQG CENMCPSMNL FSHGTRMQII CCRNQSFCNK I « Hide
Isoform 11. Checksum: AD5DE4C5D83782B8 Show »	FASTA	81	9,030
10 20 30 40 50 60 MNRFLLLMSL YLLGSARGTS SQPNELSGSI DHQTSVQQLP GGKLQFMVQG CENMCPSMNL 70 80 FSHGTRMQII CCRNQSFCNK I « Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and sequencing of cDNAs coding for the human intra-acrosomal antigen SP-10." Wright R.M., John E., Klotz K., Flickinger C.J., Herr J.C. Biol. Reprod. 42:693-701(1990) [PubMed: 1693291] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	Erratum Wright R.M., John E., Klotz K., Flickinger C.J., Herr J.C. Biol. Reprod. 43:903-903(1990) Cited for: SEQUENCE REVISION.
[3]	"Cloning and characterization of the gene coding for the human acrosomal protein SP-10." Wright R.M., Suri A.K., Kornreich B., Flickinger C.J., Herr J.C. Biol. Reprod. 49:316-325(1993) [PubMed: 8373955] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-126.
[4]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-126. Tissue: Testis.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[6]	"Characterization of alternatively spliced human SP-10 mRNAs." Freemerman A.J., Flickinger C.J., Herr J.C. Mol. Reprod. Dev. 41:100-108(1995) [PubMed: 7619499] [Abstract] Cited for: ALTERNATIVE SPLICING. Tissue: Testis.
[7]	"Purification and microsequencing of the intra-acrosomal protein SP-10. Evidence that SP-10 heterogeneity results from endoproteolytic processes." Herr J.C., Klotz K., Shannon J., Wright R.M., Flickinger C.J. Biol. Reprod. 47:11-20(1992) [PubMed: 1637938] [Abstract] Cited for: PROTEIN SEQUENCE OF 78-100; 106-122 AND 127-151.

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Cross-references

Sequence databases
	M82967 mRNA. Translation: AAA36625.1. M82968 mRNA. Translation: AAA36626.1. S65583 , S65606, S65576, S65578 Genomic DNA. Translation: AAB28238.2. AK223335 mRNA. Translation: BAD97055.1. BC014588 mRNA. Translation: AAH14588.1.
IPI	IPI00032270. IPI00218531. IPI00218532. IPI00218533. IPI00218534. IPI00218535. IPI00218537. IPI00218538. IPI00219630. IPI00219631. IPI00333174.
PIR	A37225. B37225.
RefSeq	NP_001603.1. NP_064454.1. NP_064492.1. NP_064493.1. NP_064494.1. NP_064495.1. NP_064496.1. NP_064498.1. NP_064500.1.
UniGene	Hs.169222 Hs.596575
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P26436.
Proteomic databases
PRIDE	P26436.
Genome annotation databases
Ensembl	ENST00000315608; ENSP00000317684; ENSG00000134940; Homo sapiens. [Genome view]
GeneID	56.
KEGG	hsa:56.
UCSC	uc001qck.1. human. uc001qcl.1. human. uc001qcm.1. human. uc001qcn.1. human. uc001qco.1. human. uc001qcp.1. human. uc001qcq.1. human. uc001qcr.1. human. uc001qcs.1. human.
Organism-specific databases
CTD	56.
GeneCards	GC11M125047.
H-InvDB	HIX0010244.
HGNC	HGNC:127. ACRV1.
MIM	102525. gene.
PharmGKB	PA24454.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P26436.
OMA	EHTSGEH
OrthoDB	EOG94TRT3
Gene expression databases
ArrayExpress	P26436.
Bgee	P26436.
CleanEx	HS_ACRV1.
Genevestigator	P26436.
GermOnline	ENSG00000134940. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	225.
SOURCE	Search...

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Entry information

Entry name

ASPX_HUMAN

Accession

Primary (citable) accession number: P26436
Secondary accession number(s): Q53FF4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	February 1, 1996
Last modified:	November 24, 2009
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents