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Protein

Acrosomal protein SP-10

Gene

ACRV1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • multicellular organism development Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134940-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acrosomal protein SP-10
Alternative name(s):
Acrosomal vesicle protein 1
Gene namesi
Name:ACRV1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:127. ACRV1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

DisGeNETi56.
OpenTargetsiENSG00000134940.
PharmGKBiPA24454.

Polymorphism and mutation databases

BioMutaiACRV1.
DMDMi1351991.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002076022 – 265Acrosomal protein SP-10Add BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi258N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP26436.
PeptideAtlasiP26436.
PRIDEiP26436.

Expressioni

Tissue specificityi

Testis.

Gene expression databases

BgeeiENSG00000134940.
CleanExiHS_ACRV1.
GenevisibleiP26436. HS.

Organism-specific databases

HPAiHPA038718.
HPA038719.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000432816.

Structurei

3D structure databases

ProteinModelPortaliP26436.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati66 – 701-15
Repeati71 – 751-25
Repeati85 – 882-14
Repeati91 – 951-35
Repeati110 – 1143-15
Repeati115 – 1193-25
Repeati120 – 1232-24
Repeati125 – 1293-35
Repeati135 – 1393-45
Repeati140 – 1443-55
Repeati145 – 1482-34
Repeati150 – 1543-65
Repeati155 – 1593-75
Repeati160 – 1643-85
Repeati165 – 1682-44
Repeati170 – 1743-95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni66 – 953 X 5 AA repeats of S-E-H-[GA]-SAdd BLAST30
Regioni85 – 1684 X 4 AA repeats of S-G-E-HAdd BLAST84
Regioni110 – 1749 X 5 AA repeats of [SV]-G-E-Q-[PSA]Add BLAST65

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J414. Eukaryota.
ENOG41127AD. LUCA.
GeneTreeiENSGT00730000111437.
HOGENOMiHOG000034107.
HOVERGENiHBG004291.
InParanoidiP26436.
OMAiCHTCAYM.
OrthoDBiEOG091G1600.
PhylomeDBiP26436.
TreeFamiTF337781.

Sequences (11)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 11 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P26436-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNRFLLLMSL YLLGSARGTS SQPNELSGSI DHQTSVQQLP GEFFSLENPS
60 70 80 90 100
DAEALYETSS GLNTLSEHGS SEHGSSKHTV AEHTSGEHAE SEHASGEPAA
110 120 130 140 150
TEHAEGEHTV GEQPSGEQPS GEHLSGEQPL SELESGEQPS DEQPSGEHGS
160 170 180 190 200
GEQPSGEQAS GEQPSGEHAS GEQASGAPIS STSTGTILNC YTCAYMNDQG
210 220 230 240 250
KCLRGEGTCI TQNSQQCMLK KIFEGGKLQF MVQGCENMCP SMNLFSHGTR
260
MQIICCRNQS FCNKI
Length:265
Mass (Da):28,156
Last modified:February 1, 1996 - v2
Checksum:i318216453F20D68A
GO
Isoform 2 (identifier: P26436-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     166-184: Missing.

Show »
Length:246
Mass (Da):26,401
Checksum:i6FF8396ED844FA5F
GO
Isoform 3 (identifier: P26436-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-95: Missing.

Show »
Length:210
Mass (Da):22,375
Checksum:iF0868BDCA5D5FC1D
GO
Isoform 4 (identifier: P26436-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-110: Missing.

Show »
Length:195
Mass (Da):20,858
Checksum:iD8DC78EC5175A854
GO
Isoform 5 (identifier: P26436-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-110: Missing.
     166-184: Missing.

Show »
Length:176
Mass (Da):19,102
Checksum:iC199FA046A09F327
GO
Isoform 6 (identifier: P26436-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-135: Missing.

Show »
Length:170
Mass (Da):18,267
Checksum:iF87BD099E6105C97
GO
Isoform 7 (identifier: P26436-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-95: Missing.
     111-155: Missing.

Show »
Length:165
Mass (Da):17,763
Checksum:i6ED6262433DCF9F1
GO
Isoform 8 (identifier: P26436-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-110: Missing.
     185-224: Missing.

Show »
Length:155
Mass (Da):16,368
Checksum:i25AAF9C235A9A588
GO
Isoform 9 (identifier: P26436-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-110: Missing.
     121-165: Missing.

Show »
Length:150
Mass (Da):16,272
Checksum:i67514BDD8C5C4A7B
GO
Isoform 10 (identifier: P26436-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-184: Missing.

Show »
Length:121
Mass (Da):13,520
Checksum:i83A5DDCA9E7010C0
GO
Isoform 11 (identifier: P26436-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-224: Missing.

Show »
Length:81
Mass (Da):9,030
Checksum:iAD5DE4C5D83782B8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91S → E AA sequence (PubMed:1637938).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050680126G → R.2 PublicationsCorresponds to variant rs34788353dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00412441 – 224Missing in isoform 11. CuratedAdd BLAST184
Alternative sequenceiVSP_00412341 – 184Missing in isoform 10. CuratedAdd BLAST144
Alternative sequenceiVSP_00412241 – 135Missing in isoform 6. CuratedAdd BLAST95
Alternative sequenceiVSP_00412141 – 110Missing in isoform 4, isoform 5, isoform 8 and isoform 9. CuratedAdd BLAST70
Alternative sequenceiVSP_00412041 – 95Missing in isoform 3 and isoform 7. CuratedAdd BLAST55
Alternative sequenceiVSP_004125111 – 155Missing in isoform 7. CuratedAdd BLAST45
Alternative sequenceiVSP_004126121 – 165Missing in isoform 9. CuratedAdd BLAST45
Alternative sequenceiVSP_004127166 – 184Missing in isoform 2 and isoform 5. CuratedAdd BLAST19
Alternative sequenceiVSP_004128185 – 224Missing in isoform 8. CuratedAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M82967 mRNA. Translation: AAA36625.1.
M82968 mRNA. Translation: AAA36626.1.
S65583
, S65606, S65576, S65578 Genomic DNA. Translation: AAB28238.2.
AK223335 mRNA. Translation: BAD97055.1.
BC014588 mRNA. Translation: AAH14588.1.
CCDSiCCDS44759.1. [P26436-2]
CCDS44761.1. [P26436-4]
CCDS8460.1. [P26436-1]
CCDS8461.1. [P26436-3]
PIRiA37225.
B37225.
RefSeqiNP_001603.1. NM_001612.5. [P26436-1]
NP_064454.1. NM_020069.4. [P26436-2]
NP_064492.1. NM_020107.4. [P26436-3]
NP_064493.1. NM_020108.4. [P26436-4]
UniGeneiHs.169222.
Hs.596575.

Genome annotation databases

EnsembliENST00000315608; ENSP00000317684; ENSG00000134940. [P26436-2]
ENST00000527795; ENSP00000436819; ENSG00000134940. [P26436-4]
ENST00000530048; ENSP00000433720; ENSG00000134940. [P26436-3]
ENST00000533904; ENSP00000432816; ENSG00000134940. [P26436-1]
GeneIDi56.
KEGGihsa:56.
UCSCiuc001qcl.4. human. [P26436-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M82967 mRNA. Translation: AAA36625.1.
M82968 mRNA. Translation: AAA36626.1.
S65583
, S65606, S65576, S65578 Genomic DNA. Translation: AAB28238.2.
AK223335 mRNA. Translation: BAD97055.1.
BC014588 mRNA. Translation: AAH14588.1.
CCDSiCCDS44759.1. [P26436-2]
CCDS44761.1. [P26436-4]
CCDS8460.1. [P26436-1]
CCDS8461.1. [P26436-3]
PIRiA37225.
B37225.
RefSeqiNP_001603.1. NM_001612.5. [P26436-1]
NP_064454.1. NM_020069.4. [P26436-2]
NP_064492.1. NM_020107.4. [P26436-3]
NP_064493.1. NM_020108.4. [P26436-4]
UniGeneiHs.169222.
Hs.596575.

3D structure databases

ProteinModelPortaliP26436.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000432816.

Polymorphism and mutation databases

BioMutaiACRV1.
DMDMi1351991.

Proteomic databases

PaxDbiP26436.
PeptideAtlasiP26436.
PRIDEiP26436.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315608; ENSP00000317684; ENSG00000134940. [P26436-2]
ENST00000527795; ENSP00000436819; ENSG00000134940. [P26436-4]
ENST00000530048; ENSP00000433720; ENSG00000134940. [P26436-3]
ENST00000533904; ENSP00000432816; ENSG00000134940. [P26436-1]
GeneIDi56.
KEGGihsa:56.
UCSCiuc001qcl.4. human. [P26436-1]

Organism-specific databases

CTDi56.
DisGeNETi56.
GeneCardsiACRV1.
HGNCiHGNC:127. ACRV1.
HPAiHPA038718.
HPA038719.
MIMi102525. gene.
neXtProtiNX_P26436.
OpenTargetsiENSG00000134940.
PharmGKBiPA24454.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J414. Eukaryota.
ENOG41127AD. LUCA.
GeneTreeiENSGT00730000111437.
HOGENOMiHOG000034107.
HOVERGENiHBG004291.
InParanoidiP26436.
OMAiCHTCAYM.
OrthoDBiEOG091G1600.
PhylomeDBiP26436.
TreeFamiTF337781.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134940-MONOMER.

Miscellaneous databases

GeneWikiiACRV1.
GenomeRNAii56.
PROiP26436.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134940.
CleanExiHS_ACRV1.
GenevisibleiP26436. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiASPX_HUMAN
AccessioniPrimary (citable) accession number: P26436
Secondary accession number(s): Q53FF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.