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P26436 (ASPX_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acrosomal protein SP-10
Alternative name(s):
Acrosomal vesicle protein 1
Gene names
Name:ACRV1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cytoplasmic vesiclesecretory vesicleacrosome. Note: Nascent acrosomal vesicle of Golgi phase spermatids.

Tissue specificity

Testis.

Ontologies

Keywords
   Cellular componentCytoplasmic vesicle
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Signal
   PTMGlycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentacrosomal vesicle

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 11 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P26436-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P26436-2)

The sequence of this isoform differs from the canonical sequence as follows:
     166-184: Missing.
Isoform 3 (identifier: P26436-3)

The sequence of this isoform differs from the canonical sequence as follows:
     41-95: Missing.
Isoform 4 (identifier: P26436-4)

The sequence of this isoform differs from the canonical sequence as follows:
     41-110: Missing.
Isoform 5 (identifier: P26436-5)

The sequence of this isoform differs from the canonical sequence as follows:
     41-110: Missing.
     166-184: Missing.
Isoform 6 (identifier: P26436-6)

The sequence of this isoform differs from the canonical sequence as follows:
     41-135: Missing.
Isoform 7 (identifier: P26436-7)

The sequence of this isoform differs from the canonical sequence as follows:
     41-95: Missing.
     111-155: Missing.
Isoform 8 (identifier: P26436-8)

The sequence of this isoform differs from the canonical sequence as follows:
     41-110: Missing.
     185-224: Missing.
Isoform 9 (identifier: P26436-9)

The sequence of this isoform differs from the canonical sequence as follows:
     41-110: Missing.
     121-165: Missing.
Isoform 10 (identifier: P26436-10)

The sequence of this isoform differs from the canonical sequence as follows:
     41-184: Missing.
Isoform 11 (identifier: P26436-11)

The sequence of this isoform differs from the canonical sequence as follows:
     41-224: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 265244Acrosomal protein SP-10
PRO_0000020760

Regions

Repeat66 – 7051-1
Repeat71 – 7551-2
Repeat85 – 8842-1
Repeat91 – 9551-3
Repeat110 – 11453-1
Repeat115 – 11953-2
Repeat120 – 12342-2
Repeat125 – 12953-3
Repeat135 – 13953-4
Repeat140 – 14453-5
Repeat145 – 14842-3
Repeat150 – 15453-6
Repeat155 – 15953-7
Repeat160 – 16453-8
Repeat165 – 16842-4
Repeat170 – 17453-9
Region66 – 95303 X 5 AA repeats of S-E-H-[GA]-S
Region85 – 168844 X 4 AA repeats of S-G-E-H
Region110 – 174659 X 5 AA repeats of [SV]-G-E-Q-[PSA]

Amino acid modifications

Glycosylation2581N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence41 – 224184Missing in isoform 11.
VSP_004124
Alternative sequence41 – 184144Missing in isoform 10.
VSP_004123
Alternative sequence41 – 13595Missing in isoform 6.
VSP_004122
Alternative sequence41 – 11070Missing in isoform 4, isoform 5, isoform 8 and isoform 9.
VSP_004121
Alternative sequence41 – 9555Missing in isoform 3 and isoform 7.
VSP_004120
Alternative sequence111 – 15545Missing in isoform 7.
VSP_004125
Alternative sequence121 – 16545Missing in isoform 9.
VSP_004126
Alternative sequence166 – 18419Missing in isoform 2 and isoform 5.
VSP_004127
Alternative sequence185 – 22440Missing in isoform 8.
VSP_004128
Natural variant1261G → R. Ref.3 Ref.4
Corresponds to variant rs34788353 [ dbSNP | Ensembl ].
VAR_050680

Experimental info

Sequence conflict911S → E AA sequence Ref.7

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: 318216453F20D68A

FASTA26528,156
        10         20         30         40         50         60 
MNRFLLLMSL YLLGSARGTS SQPNELSGSI DHQTSVQQLP GEFFSLENPS DAEALYETSS 

        70         80         90        100        110        120 
GLNTLSEHGS SEHGSSKHTV AEHTSGEHAE SEHASGEPAA TEHAEGEHTV GEQPSGEQPS 

       130        140        150        160        170        180 
GEHLSGEQPL SELESGEQPS DEQPSGEHGS GEQPSGEQAS GEQPSGEHAS GEQASGAPIS 

       190        200        210        220        230        240 
STSTGTILNC YTCAYMNDQG KCLRGEGTCI TQNSQQCMLK KIFEGGKLQF MVQGCENMCP 

       250        260 
SMNLFSHGTR MQIICCRNQS FCNKI 

« Hide

Isoform 2 [UniParc].

Checksum: 6FF8396ED844FA5F
Show »

FASTA24626,401
Isoform 3 [UniParc].

Checksum: F0868BDCA5D5FC1D
Show »

FASTA21022,375
Isoform 4 [UniParc].

Checksum: D8DC78EC5175A854
Show »

FASTA19520,858
Isoform 5 [UniParc].

Checksum: C199FA046A09F327
Show »

FASTA17619,102
Isoform 6 [UniParc].

Checksum: F87BD099E6105C97
Show »

FASTA17018,267
Isoform 7 [UniParc].

Checksum: 6ED6262433DCF9F1
Show »

FASTA16517,763
Isoform 8 [UniParc].

Checksum: 25AAF9C235A9A588
Show »

FASTA15516,368
Isoform 9 [UniParc].

Checksum: 67514BDD8C5C4A7B
Show »

FASTA15016,272
Isoform 10 [UniParc].

Checksum: 83A5DDCA9E7010C0
Show »

FASTA12113,520
Isoform 11 [UniParc].

Checksum: AD5DE4C5D83782B8
Show »

FASTA819,030

References

« Hide 'large scale' references
[1]"Cloning and sequencing of cDNAs coding for the human intra-acrosomal antigen SP-10."
Wright R.M., John E., Klotz K., Flickinger C.J., Herr J.C.
Biol. Reprod. 42:693-701(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]Erratum
Wright R.M., John E., Klotz K., Flickinger C.J., Herr J.C.
Biol. Reprod. 43:903-903(1990)
Cited for: SEQUENCE REVISION.
[3]"Cloning and characterization of the gene coding for the human acrosomal protein SP-10."
Wright R.M., Suri A.K., Kornreich B., Flickinger C.J., Herr J.C.
Biol. Reprod. 49:316-325(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-126.
[4]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-126.
Tissue: Testis.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[6]"Characterization of alternatively spliced human SP-10 mRNAs."
Freemerman A.J., Flickinger C.J., Herr J.C.
Mol. Reprod. Dev. 41:100-108(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING.
Tissue: Testis.
[7]"Purification and microsequencing of the intra-acrosomal protein SP-10. Evidence that SP-10 heterogeneity results from endoproteolytic processes."
Herr J.C., Klotz K., Shannon J., Wright R.M., Flickinger C.J.
Biol. Reprod. 47:11-20(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 78-100; 106-122 AND 127-151.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M82967 mRNA. Translation: AAA36625.1.
M82968 mRNA. Translation: AAA36626.1.
S65583 expand/collapse EMBL AC list , S65606, S65576, S65578 Genomic DNA. Translation: AAB28238.2.
AK223335 mRNA. Translation: BAD97055.1.
BC014588 mRNA. Translation: AAH14588.1.
PIRA37225.
B37225.
RefSeqNP_001603.1. NM_001612.5.
NP_064454.1. NM_020069.4.
NP_064492.1. NM_020107.4.
NP_064493.1. NM_020108.4.
UniGeneHs.169222.
Hs.596575.

3D structure databases

ProteinModelPortalP26436.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000317684.

Polymorphism databases

DMDM1351991.

Proteomic databases

PaxDbP26436.
PRIDEP26436.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000315608; ENSP00000317684; ENSG00000134940. [P26436-2]
ENST00000345274; ENSP00000257383; ENSG00000134940. [P26436-8]
ENST00000353070; ENSP00000257386; ENSG00000134940. [P26436-11]
ENST00000425431; ENSP00000395453; ENSG00000134940. [P26436-10]
ENST00000445562; ENSP00000412653; ENSG00000134940. [P26436-6]
ENST00000453509; ENSP00000397448; ENSG00000134940. [P26436-5]
ENST00000527795; ENSP00000436819; ENSG00000134940. [P26436-4]
ENST00000530048; ENSP00000433720; ENSG00000134940. [P26436-3]
ENST00000533904; ENSP00000432816; ENSG00000134940. [P26436-1]
GeneID56.
KEGGhsa:56.
UCSCuc001qcl.3. human. [P26436-4]
uc001qcn.3. human. [P26436-3]
uc001qcr.3. human. [P26436-2]
uc001qcs.3. human. [P26436-1]

Organism-specific databases

CTD56.
GeneCardsGC11M125576.
HGNCHGNC:127. ACRV1.
HPAHPA038718.
HPA038719.
MIM102525. gene.
neXtProtNX_P26436.
PharmGKBPA24454.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000034107.
HOVERGENHBG004291.
InParanoidP26436.
OMASGEHTSG.
OrthoDBEOG72JWKN.
PhylomeDBP26436.
TreeFamTF337781.

Gene expression databases

ArrayExpressP26436.
BgeeP26436.
CleanExHS_ACRV1.
GenevestigatorP26436.

Family and domain databases

ProtoNetSearch...

Other

GeneWikiACRV1.
GenomeRNAi56.
NextBio225.
PROP26436.
SOURCESearch...

Entry information

Entry nameASPX_HUMAN
AccessionPrimary (citable) accession number: P26436
Secondary accession number(s): Q53FF4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: February 1, 1996
Last modified: March 19, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM