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Protein

Sodium/bile acid cotransporter

Gene

Slc10a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.

GO - Molecular functioni

  • bile acid:sodium symporter activity Source: RGD
  • bile acid transmembrane transporter activity Source: RGD

GO - Biological processi

  • bile acid and bile salt transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-RNO-159418. Recycling of bile acids and salts.

Protein family/group databases

TCDBi2.A.28.1.1. the bile acid:na(+) symporter (bass) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/bile acid cotransporter
Alternative name(s):
Na(+)/bile acid cotransporter
Na(+)/taurocholate transport protein
Sodium/taurocholate cotransporting polypeptide
Solute carrier family 10 member 1
Gene namesi
Name:Slc10a1
Synonyms:Ntcp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi3681. Slc10a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 45HelicalSequence analysisAdd BLAST22
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei82 – 98HelicalSequence analysisAdd BLAST17
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Transmembranei190 – 211HelicalSequence analysisAdd BLAST22
Transmembranei228 – 244HelicalSequence analysisAdd BLAST17
Transmembranei285 – 306HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

  • basolateral plasma membrane Source: RGD
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4847.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000523371 – 362Sodium/bile acid cotransporterAdd BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Glycosylationi11N-linked (GlcNAc...)Sequence analysis1
Glycosylationi103N-linked (GlcNAc...)Sequence analysis1
Glycosylationi117N-linked (GlcNAc...)Sequence analysis1
Glycosylationi271N-linked (GlcNAc...)Sequence analysis1
Modified residuei330PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP26435.
PRIDEiP26435.

PTM databases

iPTMnetiP26435.
PhosphoSitePlusiP26435.

Expressioni

Tissue specificityi

Liver and kidney.

Gene expression databases

BgeeiENSRNOG00000005794.
GenevisibleiP26435. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007825.

Chemistry databases

BindingDBiP26435.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2718. Eukaryota.
COG0385. LUCA.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000234524.
HOVERGENiHBG101123.
InParanoidiP26435.
KOiK14341.
OMAiKIKAHFW.
OrthoDBiEOG091G0GT5.
PhylomeDBiP26435.
TreeFamiTF315811.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
IPR004710. Bilac:Na_transpt.
IPR030208. SLC10A1.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PTHR10361:SF40. PTHR10361:SF40. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00841. bass. 1 hit.

Sequencei

Sequence statusi: Complete.

P26435-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVHNVSAPF NFSLPPGFGH RATDKALSII LVLMLLLIML SLGCTMEFSK
60 70 80 90 100
IKAHLWKPKG VIVALVAQFG IMPLAAFLLG KIFHLSNIEA LAILICGCSP
110 120 130 140 150
GGNLSNLFTL AMKGDMNLSI VMTTCSSFSA LGMMPLLLYV YSKGIYDGDL
160 170 180 190 200
KDKVPYKGIM ISLVIVLIPC TIGIVLKSKR PHYVPYILKG GMIITFLLSV
210 220 230 240 250
AVTALSVINV GNSIMFVMTP HLLATSSLMP FSGFLMGYIL SALFQLNPSC
260 270 280 290 300
RRTISMETGF QNIQLCSTIL NVTFPPEVIG PLFFFPLLYM IFQLAEGLLI
310 320 330 340 350
IIIFRCYEKI KPPKDQTKIT YKAAATEDAT PAALEKGTHN GNIPPLQPGP
360
SPNGLNSGQM AN
Length:362
Mass (Da):39,295
Last modified:August 1, 1992 - v1
Checksum:iF0ABB76076A57550
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77479 mRNA. Translation: AAA42112.1.
BC091152 mRNA. Translation: AAH91152.1.
PIRiA41601.
RefSeqiNP_058743.1. NM_017047.1.
UniGeneiRn.9913.

Genome annotation databases

EnsembliENSRNOT00000007825; ENSRNOP00000007825; ENSRNOG00000005794.
GeneIDi24777.
KEGGirno:24777.
UCSCiRGD:3681. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77479 mRNA. Translation: AAA42112.1.
BC091152 mRNA. Translation: AAH91152.1.
PIRiA41601.
RefSeqiNP_058743.1. NM_017047.1.
UniGeneiRn.9913.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007825.

Chemistry databases

BindingDBiP26435.
ChEMBLiCHEMBL4847.

Protein family/group databases

TCDBi2.A.28.1.1. the bile acid:na(+) symporter (bass) family.

PTM databases

iPTMnetiP26435.
PhosphoSitePlusiP26435.

Proteomic databases

PaxDbiP26435.
PRIDEiP26435.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007825; ENSRNOP00000007825; ENSRNOG00000005794.
GeneIDi24777.
KEGGirno:24777.
UCSCiRGD:3681. rat.

Organism-specific databases

CTDi6554.
RGDi3681. Slc10a1.

Phylogenomic databases

eggNOGiKOG2718. Eukaryota.
COG0385. LUCA.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000234524.
HOVERGENiHBG101123.
InParanoidiP26435.
KOiK14341.
OMAiKIKAHFW.
OrthoDBiEOG091G0GT5.
PhylomeDBiP26435.
TreeFamiTF315811.

Enzyme and pathway databases

ReactomeiR-RNO-159418. Recycling of bile acids and salts.

Miscellaneous databases

PROiP26435.

Gene expression databases

BgeeiENSRNOG00000005794.
GenevisibleiP26435. RN.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
IPR004710. Bilac:Na_transpt.
IPR030208. SLC10A1.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PTHR10361:SF40. PTHR10361:SF40. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00841. bass. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNTCP_RAT
AccessioniPrimary (citable) accession number: P26435
Secondary accession number(s): Q5BK99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.