Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hydrogenase transcriptional regulatory protein hupR1

Gene

hupR1

Organism
Rhodobacter capsulatus (Rhodopseudomonas capsulata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable member of the two-component regulatory system involved in the regulation of the [NiFe] hydrogenase activity. HupR1 is probably phosphorylated by the sensory component and then acts in conjunction with sigma-54 as a transcriptional activator.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi193 – 200ATPPROSITE-ProRule annotation8
Nucleotide bindingi255 – 264ATPPROSITE-ProRule annotation10
DNA bindingi452 – 471H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Two-component regulatory system
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hydrogenase transcriptional regulatory protein hupR1
Gene namesi
Name:hupR1
OrganismiRhodobacter capsulatus (Rhodopseudomonas capsulata)
Taxonomic identifieri1061 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000811111 – 492Hydrogenase transcriptional regulatory protein hupR1Add BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei554-aspartylphosphatePROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Interactioni

GO - Molecular functioni

Structurei

Secondary structure

1492
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 11Combined sources5
Helixi15 – 25Combined sources11
Turni26 – 28Combined sources3
Beta strandi31 – 36Combined sources6
Helixi37 – 46Combined sources10
Beta strandi49 – 56Combined sources8
Beta strandi59 – 61Combined sources3
Helixi63 – 73Combined sources11
Beta strandi77 – 84Combined sources8
Helixi89 – 97Combined sources9
Beta strandi102 – 107Combined sources6
Helixi110 – 140Combined sources31

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JK1X-ray2.10A5-140[»]
2VUHX-ray2.50B5-140[»]
2VUIX-ray2.90B5-140[»]
ProteinModelPortaliP26408.
SMRiP26408.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26408.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 121Response regulatoryPROSITE-ProRule annotationAdd BLAST115
Domaini164 – 393Sigma-54 factor interactionPROSITE-ProRule annotationAdd BLAST230

Phylogenomic databases

eggNOGiENOG4105C1W. Bacteria.
COG2204. LUCA.
HOGENOMiHOG000058489.

Family and domain databases

CDDicd00156. REC. 1 hit.
InterProiView protein in InterPro
IPR011006. CheY-like_superfamily.
IPR009057. Homeobox-like.
IPR002197. HTH_Fis.
IPR027417. P-loop_NTPase.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR002078. Sigma_54_int.
IPR025944. Sigma_54_int_dom_CS.
PfamiView protein in Pfam
PF02954. HTH_8. 1 hit.
PF00072. Response_reg. 1 hit.
PF00158. Sigma54_activat. 1 hit.
PRINTSiPR01590. HTHFIS.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS50110. RESPONSE_REGULATORY. 1 hit.
PS00688. SIGMA54_INTERACT_3. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.

Sequencei

Sequence statusi: Complete.

P26408-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASAPAILL VDDEPHSLAA MKLALEDDFD VLTAQGAEAA IAILEEEWVQ
60 70 80 90 100
VIICDQRMPG RTGVDFLTEV RERWPETVRI IITGYTDSAS MMAAINDAGI
110 120 130 140 150
HQFLTKPWHP EQLLSSARNA ARMFTLAREN ERLSLEMRLL NSTSESRVEK
160 170 180 190 200
RRRALREGMG FETILRTPNS AMTGAIALAR QFASFDVPVL LRGEPGSGRA
210 220 230 240 250
QLARAMHYVS LRSDKPFYEI NLAGLPEDLA MIELFGARRG VLPGGVAKIG
260 270 280 290 300
LAQKADRGTL FVAGVEAASP ALQLALLRML ADGAITPLGG QETASTNLRL
310 320 330 340 350
ITGAAADLRA MVAEGRFRAD LYYALSAGEI ALPPLRARRG DVALLAQSML
360 370 380 390 400
AEAAVRHGKQ ALGFDAAALE FLENYDWPGN LRELHNEVTR MLIFAQDNVL
410 420 430 440 450
GAELISRHIL QAAPSESGAD RSAEEVMTAD GTLKDRIELI EMRILRETLT
460 470 480 490
RNRWNKSRAA AELGLSRVGL RAKLDRYGIE HPAGRVQEEE ED
Length:492
Mass (Da):53,838
Last modified:August 1, 1992 - v1
Checksum:i5BCF1ADCFE83A28A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63670 Genomic DNA. Translation: AAA26104.1.
X61007 Genomic DNA. Translation: CAA43327.1.
M55089 Genomic DNA. Translation: AAA72927.1.
PIRiS32951.

Genome annotation databases

GeneIDi31489720.

Similar proteinsi

Entry informationi

Entry nameiHUPR_RHOCA
AccessioniPrimary (citable) accession number: P26408
Secondary accession number(s): Q6LDK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: August 30, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references