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P26405

- RFBK_SALTY

UniProt

P26405 - RFBK_SALTY

Protein

Phosphomannomutase

Gene

rfbK

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS group B O antigen.

    Catalytic activityi

    Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

    Cofactori

    Binds 1 magnesium ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei111 – 1111Phosphoserine intermediateBy similarity
    Metal bindingi111 – 1111Magnesium; via phosphate groupBy similarity
    Metal bindingi245 – 2451MagnesiumBy similarity
    Metal bindingi247 – 2471MagnesiumBy similarity
    Metal bindingi249 – 2491MagnesiumBy similarity

    GO - Molecular functioni

    1. magnesium ion binding Source: InterPro
    2. phosphomannomutase activity Source: UniProtKB-EC

    GO - Biological processi

    1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
    2. O antigen biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Lipopolysaccharide biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-2095-MONOMER.
    UniPathwayiUPA00126; UER00424.
    UPA00281.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphomannomutase (EC:5.4.2.8)
    Short name:
    PMM
    Gene namesi
    Name:rfbK
    Ordered Locus Names:STM2083
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 477477PhosphomannomutasePRO_0000147826Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP26405.
    PRIDEiP26405.

    Interactioni

    Protein-protein interaction databases

    STRINGi99287.STM2083.

    Structurei

    3D structure databases

    ProteinModelPortaliP26405.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 4617HelicalSequence AnalysisAdd
    BLAST
    Transmembranei265 – 28420HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phosphohexose mutase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1109.
    HOGENOMiHOG000066295.
    KOiK01840.
    OMAiRCYVEAS.
    OrthoDBiEOG6TFCNH.
    PhylomeDBiP26405.

    Family and domain databases

    Gene3Di3.30.310.50. 1 hit.
    3.40.120.10. 1 hit.
    InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
    IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
    IPR005845. A-D-PHexomutase_a/b/a-II.
    IPR005846. A-D-PHexomutase_a/b/a-III.
    IPR005843. A-D-PHexomutase_C.
    IPR016066. A-D-PHexomutase_CS.
    [Graphical view]
    PfamiPF02878. PGM_PMM_I. 1 hit.
    PF02879. PGM_PMM_II. 1 hit.
    PF02880. PGM_PMM_III. 1 hit.
    PF00408. PGM_PMM_IV. 1 hit.
    [Graphical view]
    SUPFAMiSSF53738. SSF53738. 3 hits.
    SSF55957. SSF55957. 1 hit.
    PROSITEiPS00710. PGM_PMM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P26405-1 [UniParc]FASTAAdd to Basket

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    MNVVNNSRDV IYSSGIVFGT SGARGLVKDF TPQVCAAFTV SFVAVMQEHF    50
    SFDTVALAID NRPSSYGMAQ ACAAALADKG VNCIFYGVVP TPALAFQSMS 100
    DNMPAIMVTG SHIPFERNGL KFYRPDGEIT KHDEAAILSV EDTCSHLELK 150
    ELIVSEMAAV NYISRYTSLF STPFLKNKRI GIYEHSSAGR DLYKPLFIAL 200
    GAEVVSLGRS DNFVPIDTEA VSKEDREKAR SWAKEFDLDA IFSTDGDGDR 250
    PLIADEAGEW LRGDILGLLC SLALDAEAVA IPVSCNSIIS SGRFFKHVKL 300
    TKIGSPYVIE AFNELSRSYS RIVGFEANGG FLLGSDICIN EQNLHALPTR 350
    DAVLPAIMLL YKSRNTSISA LVNELPTRYT HSDRLQGITT DKSQSLISMG 400
    RENLSNLLSY IGLENEGAIS TDMTDGMRIT LRDGCIVHLR ASGNAPELRC 450
    YAEANLLNRA QDLVNTTLAN IKKRCLL 477
    Length:477
    Mass (Da):52,086
    Last modified:August 1, 1992 - v1
    Checksum:iBA6BF851AB931915
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56793 Genomic DNA. Translation: CAA40129.1.
    AE006468 Genomic DNA. Translation: AAL20987.1.
    PIRiS15313.
    RefSeqiNP_461028.1. NC_003197.1.
    WP_001103643.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL20987; AAL20987; STM2083.
    GeneIDi1253604.
    KEGGistm:STM2083.
    PATRICi32382749. VBISalEnt20916_2205.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56793 Genomic DNA. Translation: CAA40129.1 .
    AE006468 Genomic DNA. Translation: AAL20987.1 .
    PIRi S15313.
    RefSeqi NP_461028.1. NC_003197.1.
    WP_001103643.1. NC_003197.1.

    3D structure databases

    ProteinModelPortali P26405.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM2083.

    Proteomic databases

    PaxDbi P26405.
    PRIDEi P26405.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL20987 ; AAL20987 ; STM2083 .
    GeneIDi 1253604.
    KEGGi stm:STM2083.
    PATRICi 32382749. VBISalEnt20916_2205.

    Phylogenomic databases

    eggNOGi COG1109.
    HOGENOMi HOG000066295.
    KOi K01840.
    OMAi RCYVEAS.
    OrthoDBi EOG6TFCNH.
    PhylomeDBi P26405.

    Enzyme and pathway databases

    UniPathwayi UPA00126 ; UER00424 .
    UPA00281 .
    BioCyci SENT99287:GCTI-2095-MONOMER.

    Family and domain databases

    Gene3Di 3.30.310.50. 1 hit.
    3.40.120.10. 1 hit.
    InterProi IPR005844. A-D-PHexomutase_a/b/a-I.
    IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
    IPR005845. A-D-PHexomutase_a/b/a-II.
    IPR005846. A-D-PHexomutase_a/b/a-III.
    IPR005843. A-D-PHexomutase_C.
    IPR016066. A-D-PHexomutase_CS.
    [Graphical view ]
    Pfami PF02878. PGM_PMM_I. 1 hit.
    PF02879. PGM_PMM_II. 1 hit.
    PF02880. PGM_PMM_III. 1 hit.
    PF00408. PGM_PMM_IV. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53738. SSF53738. 3 hits.
    SSF55957. SSF55957. 1 hit.
    PROSITEi PS00710. PGM_PMM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and sequence of the rfb (O antigen) gene cluster of Salmonella serovar typhimurium (strain LT2)."
      Jiang X.-M., Neal B., Santiago F., Lee S.J., Romana L.K., Reeves P.R.
      Mol. Microbiol. 5:695-713(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: LT2.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.

    Entry informationi

    Entry nameiRFBK_SALTY
    AccessioniPrimary (citable) accession number: P26405
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3