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Protein

CDP-glucose 4,6-dehydratase

Gene

rfbG

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

CDP-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O.

Cofactori

Pathwayi: CDP-3,6-dideoxy-D-mannose biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glucose-1-phosphate cytidylyltransferase (rfbF)
  2. CDP-glucose 4,6-dehydratase (rfbG)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway CDP-3,6-dideoxy-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-3,6-dideoxy-D-mannose from CTP and alpha-D-glucose 1-phosphate, the pathway CDP-3,6-dideoxy-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

Pathwayi: LPS O-antigen biosynthesis

This protein is involved in the pathway LPS O-antigen biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway LPS O-antigen biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSENT99287:GCTI-2103-MONOMER.
UniPathwayiUPA00055; UER00512.
UPA00281.

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-glucose 4,6-dehydratase (EC:4.2.1.45)
Gene namesi
Name:rfbG
Ordered Locus Names:STM2091
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359CDP-glucose 4,6-dehydratasePRO_0000097294Add
BLAST

Proteomic databases

PaxDbiP26397.
PRIDEiP26397.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM2091.

Structurei

Secondary structure

1
359
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 74Combined sources
Beta strandi11 – 155Combined sources
Turni16 – 183Combined sources
Helixi20 – 3112Combined sources
Beta strandi35 – 428Combined sources
Beta strandi44 – 474Combined sources
Helixi49 – 524Combined sources
Helixi55 – 573Combined sources
Beta strandi59 – 635Combined sources
Helixi69 – 7911Combined sources
Beta strandi82 – 865Combined sources
Helixi93 – 986Combined sources
Helixi100 – 12122Combined sources
Beta strandi126 – 1305Combined sources
Helixi133 – 1353Combined sources
Beta strandi141 – 1433Combined sources
Helixi156 – 17520Combined sources
Helixi178 – 1803Combined sources
Helixi181 – 1844Combined sources
Beta strandi187 – 1937Combined sources
Beta strandi195 – 1973Combined sources
Helixi207 – 21610Combined sources
Beta strandi221 – 2244Combined sources
Beta strandi232 – 2343Combined sources
Helixi236 – 25116Combined sources
Helixi253 – 2564Combined sources
Beta strandi258 – 2625Combined sources
Helixi266 – 2683Combined sources
Helixi272 – 28312Combined sources
Beta strandi289 – 2913Combined sources
Helixi308 – 3136Combined sources
Helixi322 – 33716Combined sources
Helixi342 – 35514Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WVGX-ray1.80A/B2-359[»]
ProteinModelPortaliP26397.
SMRiP26397. Positions 2-356.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26397.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105FAW. Bacteria.
COG0451. LUCA.
HOGENOMiHOG000167999.
KOiK01709.
OMAiKCYENRE.
PhylomeDBiP26397.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR013445. CDP_4_6_deHydtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF16363. GDP_Man_Dehyd. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR02622. CDP_4_6_dhtase. 1 hit.

Sequencei

Sequence statusi: Complete.

P26397-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDKNFWQGK RVFVTGHTGF KGSWLSLWLT EMGAIVKGYA LDAPTVPSLF
60 70 80 90 100
EIVRLNDLME SHIGDIRDFE KLRNSIAEFK PEIVFHMAAQ PLVRLSYEQP
110 120 130 140 150
IETYSTNVMG TVHLLETVKQ VGNIKAVVNI TSDKCYDNRE WVWGYRENEP
160 170 180 190 200
MGGYDPYSNS KGCAELVASA FRNSFFNPAN YEQHGVGLAS VRAGNVIGGG
210 220 230 240 250
DWAKDRLIPD ILRSFENNQQ VIIRNPYSIR PWQHVLEPLS GYIVVAQRLY
260 270 280 290 300
TEGAKFSEGW NFGPRDEDAK TVEFIVDKMV TLWGDDASWL LDGENHPHEA
310 320 330 340 350
HYLKLDCSKA NMQLGWHPRW GLTETLGRIV KWHKAWIRGE DMLICSKREI

SDYMSATTR
Length:359
Mass (Da):41,022
Last modified:August 1, 1992 - v1
Checksum:iD6EB7B3D36B2F9FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56793 Genomic DNA. Translation: CAA40121.1.
AE006468 Genomic DNA. Translation: AAL20995.1.
PIRiS15305.
RefSeqiNP_461036.1. NC_003197.1.
WP_000565905.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20995; AAL20995; STM2091.
GeneIDi1253612.
KEGGistm:STM2091.
PATRICi32382765. VBISalEnt20916_2213.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56793 Genomic DNA. Translation: CAA40121.1.
AE006468 Genomic DNA. Translation: AAL20995.1.
PIRiS15305.
RefSeqiNP_461036.1. NC_003197.1.
WP_000565905.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WVGX-ray1.80A/B2-359[»]
ProteinModelPortaliP26397.
SMRiP26397. Positions 2-356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM2091.

Proteomic databases

PaxDbiP26397.
PRIDEiP26397.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL20995; AAL20995; STM2091.
GeneIDi1253612.
KEGGistm:STM2091.
PATRICi32382765. VBISalEnt20916_2213.

Phylogenomic databases

eggNOGiENOG4105FAW. Bacteria.
COG0451. LUCA.
HOGENOMiHOG000167999.
KOiK01709.
OMAiKCYENRE.
PhylomeDBiP26397.

Enzyme and pathway databases

UniPathwayiUPA00055; UER00512.
UPA00281.
BioCyciSENT99287:GCTI-2103-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP26397.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR013445. CDP_4_6_deHydtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF16363. GDP_Man_Dehyd. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR02622. CDP_4_6_dhtase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRFBG_SALTY
AccessioniPrimary (citable) accession number: P26397
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.