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Protein

ELAV-like protein 4

Gene

ELAVL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA.By similarity2 Publications

GO - Molecular functioni

  • AU-rich element binding Source: UniProtKB
  • mRNA 3'-UTR binding Source: ProtInc
  • RNA binding Source: ProtInc

GO - Biological processi

  • mRNA processing Source: ProtInc
  • RNA processing Source: ProtInc

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ELAV-like protein 4
Alternative name(s):
Hu-antigen D
Short name:
HuD
Paraneoplastic encephalomyelitis antigen HuD
Gene namesi
Name:ELAVL4
Synonyms:HUD, PNEM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162374.16.
HGNCiHGNC:3315. ELAVL4.

Pathology & Biotechi

Organism-specific databases

DisGeNETi1996.
OpenTargetsiENSG00000162374.
PharmGKBiPA27743.

Polymorphism and mutation databases

BioMutaiELAVL4.
DMDMi223590202.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815831 – 380ELAV-like protein 4Add BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33PhosphoserineBy similarity1
Modified residuei228PhosphoserineBy similarity1
Modified residuei243Omega-N-methylated arginine; by CARM11 Publication1

Post-translational modificationi

Methylation at Arg-243 by CARM1 weakens protective binding to the 3'-UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state. Methylation is inhibited by NGF, which facilitates neurite outgrowth (By similarity).By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiP26378.
PaxDbiP26378.
PeptideAtlasiP26378.
PRIDEiP26378.

PTM databases

iPTMnetiP26378.
PhosphoSitePlusiP26378.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSG00000162374.
CleanExiHS_ELAVL4.
ExpressionAtlasiP26378. baseline and differential.
GenevisibleiP26378. HS.

Organism-specific databases

HPAiCAB004442.

Interactioni

Subunit structurei

Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP.By similarity

Protein-protein interaction databases

BioGridi108311. 17 interactors.
IntActiP26378. 2 interactors.
MINTiMINT-1471928.
STRINGi9606.ENSP00000349594.

Structurei

Secondary structure

1380
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi46 – 52Combined sources7
Helixi59 – 67Combined sources9
Beta strandi72 – 79Combined sources8
Turni81 – 83Combined sources3
Beta strandi86 – 96Combined sources11
Helixi97 – 107Combined sources11
Beta strandi118 – 121Combined sources4
Helixi127 – 129Combined sources3
Beta strandi133 – 138Combined sources6
Helixi145 – 152Combined sources8
Helixi153 – 155Combined sources3
Beta strandi158 – 165Combined sources8
Turni167 – 169Combined sources3
Beta strandi172 – 182Combined sources11
Helixi183 – 193Combined sources11
Beta strandi206 – 209Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FXLX-ray1.80A44-210[»]
1G2EX-ray2.30A44-210[»]
ProteinModelPortaliP26378.
SMRiP26378.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26378.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 124RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini132 – 212RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini297 – 375RRM 3PROSITE-ProRule annotationAdd BLAST79

Sequence similaritiesi

Belongs to the RRM elav family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0145. Eukaryota.
ENOG410XP7S. LUCA.
GeneTreeiENSGT00760000118913.
HOGENOMiHOG000231162.
HOVERGENiHBG002295.
InParanoidiP26378.
KOiK13208.
PhylomeDBiP26378.
TreeFamiTF313377.

Family and domain databases

CDDicd12650. RRM1_Hu. 1 hit.
cd12656. RRM3_HuD. 1 hit.
InterProiView protein in InterPro
IPR006548. ELAD_HU_SF.
IPR034775. ELAV/Hu_RRM1.
IPR034918. HuD_RRM3.
IPR002343. Hud_Sxl_RNA.
IPR000504. RRM_dom.
PfamiView protein in Pfam
PF00076. RRM_1. 3 hits.
PRINTSiPR00961. HUDSXLRNA.
SMARTiView protein in SMART
SM00360. RRM. 3 hits.
SUPFAMiSSF54928. SSF54928. 3 hits.
TIGRFAMsiTIGR01661. ELAV_HUD_SF. 1 hit.
PROSITEiView protein in PROSITE
PS50102. RRM. 3 hits.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P26378-1) [UniParc]FASTAAdd to basket
Also known as: HUD1PRO

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVMIISTMEP QVSNGPTSNT SNGPSSNNRN CPSPMQTGAT TDDSKTNLIV
60 70 80 90 100
NYLPQNMTQE EFRSLFGSIG EIESCKLVRD KITGQSLGYG FVNYIDPKDA
110 120 130 140 150
EKAINTLNGL RLQTKTIKVS YARPSSASIR DANLYVSGLP KTMTQKELEQ
160 170 180 190 200
LFSQYGRIIT SRILVDQVTG VSRGVGFIRF DKRIEAEEAI KGLNGQKPSG
210 220 230 240 250
ATEPITVKFA NNPSQKSSQA LLSQLYQSPN RRYPGPLHHQ AQRFRLDNLL
260 270 280 290 300
NMAYGVKRLM SGPVPPSACP PRFSPITIDG MTSLVGMNIP GHTGTGWCIF
310 320 330 340 350
VYNLSPDSDE SVLWQLFGPF GAVNNVKVIR DFNTNKCKGF GFVTMTNYDE
360 370 380
AAMAIASLNG YRLGDRVLQV SFKTNKAHKS
Length:380
Mass (Da):41,770
Last modified:February 10, 2009 - v2
Checksum:i80E82D40FA5A05DE
GO
Isoform 2 (identifier: P26378-2) [UniParc]FASTAAdd to basket
Also known as: HUD1

The sequence of this isoform differs from the canonical sequence as follows:
     259-272: Missing.

Show »
Length:366
Mass (Da):40,379
Checksum:i9BB102A0AD7495F1
GO
Isoform 3 (identifier: P26378-3) [UniParc]FASTAAdd to basket
Also known as: HUD4

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MV → MRLLLLREIVINESRNCSF
     259-272: Missing.

Show »
Length:383
Mass (Da):42,437
Checksum:i4FA0B4DC38E805A2
GO
Isoform 4 (identifier: P26378-4) [UniParc]FASTAAdd to basket
Also known as: HUD3

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MVM → MEQ
     259-272: Missing.

Show »
Length:366
Mass (Da):40,406
Checksum:iB26D48737B9BCACB
GO
Isoform 5 (identifier: P26378-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MVM → MRLKNQ
     259-272: Missing.

Note: No experimental confirmation available.
Show »
Length:369
Mass (Da):40,788
Checksum:iD4A4DBCC6DF6A4DC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_058091166D → G1 PublicationCorresponds to variant dbSNP:rs17853533Ensembl.1
Natural variantiVAR_052204270P → S3 PublicationsCorresponds to variant dbSNP:rs2494876Ensembl.1
Natural variantiVAR_058092356A → T1 PublicationCorresponds to variant dbSNP:rs17853531Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0376081 – 3MVM → MEQ in isoform 4. 1 Publication3
Alternative sequenceiVSP_0434501 – 3MVM → MRLKNQ in isoform 5. 1 Publication3
Alternative sequenceiVSP_0141501 – 2MV → MRLLLLREIVINESRNCSF in isoform 3. 1 Publication2
Alternative sequenceiVSP_005791259 – 272Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 4 PublicationsAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62843 mRNA. Translation: AAA58396.1.
AY033995 mRNA. Translation: AAK57538.1.
AY033996 mRNA. Translation: AAK57539.1.
AY033997 mRNA. Translation: AAK57540.1.
AY033998 mRNA. Translation: AAK57541.1.
AK297338 mRNA. Translation: BAH12553.1.
AL583843, AL592182 Genomic DNA. Translation: CAI14634.1.
AL583843, AL592182 Genomic DNA. Translation: CAI14635.1.
AL583843, AL592182 Genomic DNA. Translation: CAI14636.1.
AL583843, AL592182 Genomic DNA. Translation: CAI14637.1.
AL592182, AL583843 Genomic DNA. Translation: CAI15788.1.
AL592182, AL583843 Genomic DNA. Translation: CAI15789.1.
AL592182, AL583843 Genomic DNA. Translation: CAI15790.1.
AL592182, AL583843 Genomic DNA. Translation: CAI15791.1.
AL645730 Genomic DNA. No translation available.
AL731870 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06845.1.
BC036071 mRNA. Translation: AAH36071.1.
CCDSiCCDS44138.1. [P26378-4]
CCDS44140.1. [P26378-2]
CCDS53315.1. [P26378-5]
CCDS553.1. [P26378-1]
PIRiA40348.
RefSeqiNP_001138246.1. NM_001144774.2. [P26378-2]
NP_001138247.2. NM_001144775.2.
NP_001138248.1. NM_001144776.2. [P26378-4]
NP_001138249.1. NM_001144777.2. [P26378-5]
NP_001281277.1. NM_001294348.1.
NP_068771.2. NM_021952.4. [P26378-1]
UniGeneiHs.213050.

Genome annotation databases

EnsembliENST00000371823; ENSP00000360888; ENSG00000162374. [P26378-1]
ENST00000371824; ENSP00000360889; ENSG00000162374. [P26378-2]
ENST00000371827; ENSP00000360892; ENSG00000162374. [P26378-4]
ENST00000448907; ENSP00000399939; ENSG00000162374. [P26378-5]
GeneIDi1996.
KEGGihsa:1996.
UCSCiuc001cry.3. human. [P26378-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiELAV4_HUMAN
AccessioniPrimary (citable) accession number: P26378
Secondary accession number(s): B1APY6
, B1APY7, B7Z4G7, Q8IYD4, Q96J74, Q96J75, Q9UD24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: February 10, 2009
Last modified: September 27, 2017
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families