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Protein

Interferon-induced transmembrane protein 3

Gene

ifitm3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May inhibit early replication of influenza A virus, dengue virus, and West Nile virus.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

ReactomeiR-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced transmembrane protein 3
Alternative name(s):
Dispanin subfamily A member 2b
Short name:
DSPA2b
Gene namesi
Name:ifitm3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57CytoplasmicSequence analysisAdd BLAST57
Intramembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 109CytoplasmicSequence analysisAdd BLAST31
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Topological domaini131 – 137ExtracellularSequence analysis7

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001537301 – 137Interferon-induced transmembrane protein 3Add BLAST137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki24Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei27PhosphotyrosineBy similarity1
Lipidationi71S-palmitoyl cysteineBy similarity1
Lipidationi72S-palmitoyl cysteineBy similarity1
Cross-linki83Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki104Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Lipidationi105S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Polyubiquitinated with both 'Lys-48' and 'Lys-63' linkages. Ubiquitination negatively regulates antiviral activity. Lys-24 is the most prevalent ubiquitination site (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP26376.
PRIDEiP26376.

PTM databases

iPTMnetiP26376.
PhosphoSitePlusiP26376.

Expressioni

Inductioni

By interferon beta.1 Publication

Gene expression databases

BgeeiENSRNOG00000015078.
GenevisibleiP26376. RN.

Interactioni

Protein-protein interaction databases

BioGridi262866. 1 interactor.
MINTiMINT-4996598.
STRINGi10116.ENSRNOP00000020265.

Family & Domainsi

Sequence similaritiesi

Belongs to the CD225/Dispanin family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2DU. Eukaryota.
ENOG4112C1U. LUCA.
GeneTreeiENSGT00390000003476.
HOGENOMiHOG000115781.
HOVERGENiHBG001182.
InParanoidiP26376.
KOiK06566.
OMAiEEHEVAT.
OrthoDBiEOG091G1143.
PhylomeDBiP26376.
TreeFamiTF334894.

Family and domain databases

InterProiIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamiPF04505. CD225. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHTSQAFVN AATGGQPPNY ERIKEEYEVS ELGAPHGSAS VRTTVINMPR
60 70 80 90 100
EVSVPDHVVW SLFNTLFMNF CCLGFIAYAY SVKSRDRKMV GDMTGAQAYA
110 120 130
STAKCLNISS LVLSILMVII TIVTVVIIAL NAPRLQT
Length:137
Mass (Da):14,971
Last modified:August 1, 1992 - v1
Checksum:i9D3F92264E0C0FC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61381 mRNA. Translation: CAA43655.1.
BC168774 mRNA. Translation: AAI68774.1.
CH473953 Genomic DNA. Translation: EDM11956.1.
PIRiJC1241.
RefSeqiNP_001129596.1. NM_001136124.1.
UniGeneiRn.145191.

Genome annotation databases

EnsembliENSRNOT00000020265; ENSRNOP00000020265; ENSRNOG00000015078.
GeneIDi361673.
KEGGirno:361673.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61381 mRNA. Translation: CAA43655.1.
BC168774 mRNA. Translation: AAI68774.1.
CH473953 Genomic DNA. Translation: EDM11956.1.
PIRiJC1241.
RefSeqiNP_001129596.1. NM_001136124.1.
UniGeneiRn.145191.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi262866. 1 interactor.
MINTiMINT-4996598.
STRINGi10116.ENSRNOP00000020265.

PTM databases

iPTMnetiP26376.
PhosphoSitePlusiP26376.

Proteomic databases

PaxDbiP26376.
PRIDEiP26376.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020265; ENSRNOP00000020265; ENSRNOG00000015078.
GeneIDi361673.
KEGGirno:361673.

Organism-specific databases

CTDi10410.

Phylogenomic databases

eggNOGiENOG410J2DU. Eukaryota.
ENOG4112C1U. LUCA.
GeneTreeiENSGT00390000003476.
HOGENOMiHOG000115781.
HOVERGENiHBG001182.
InParanoidiP26376.
KOiK06566.
OMAiEEHEVAT.
OrthoDBiEOG091G1143.
PhylomeDBiP26376.
TreeFamiTF334894.

Enzyme and pathway databases

ReactomeiR-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

PROiP26376.

Gene expression databases

BgeeiENSRNOG00000015078.
GenevisibleiP26376. RN.

Family and domain databases

InterProiIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamiPF04505. CD225. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIFM3_RAT
AccessioniPrimary (citable) accession number: P26376
Secondary accession number(s): B5DER6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.