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Protein

Interferon-induced transmembrane protein 3

Gene

ifitm3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May inhibit early replication of influenza A virus, dengue virus, and West Nile virus.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiviral defense

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced transmembrane protein 3
Alternative name(s):
Dispanin subfamily A member 2b
Short name:
DSPA2b
Gene namesi
Name:ifitm3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5757CytoplasmicSequence analysisAdd
BLAST
Intramembranei58 – 7821HelicalSequence analysisAdd
BLAST
Topological domaini79 – 10931CytoplasmicSequence analysisAdd
BLAST
Transmembranei110 – 13021HelicalSequence analysisAdd
BLAST
Topological domaini131 – 1377ExtracellularSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 137137Interferon-induced transmembrane protein 3PRO_0000153730Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki24 – 24Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei27 – 271PhosphotyrosineBy similarity
Lipidationi71 – 711S-palmitoyl cysteineBy similarity
Lipidationi72 – 721S-palmitoyl cysteineBy similarity
Cross-linki83 – 83Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki88 – 88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki104 – 104Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Lipidationi105 – 1051S-palmitoyl cysteineBy similarity

Post-translational modificationi

Polyubiquitinated with both 'Lys-48' and 'Lys-63' linkages. Ubiqutination negatively regulates antiviral activity. Lys-24 is the most prevalent ubiquitination site (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP26376.
PRIDEiP26376.

PTM databases

iPTMnetiP26376.
PhosphoSiteiP26376.

Expressioni

Inductioni

By interferon beta.1 Publication

Gene expression databases

BgeeiENSRNOG00000015078.
GenevisibleiP26376. RN.

Interactioni

Protein-protein interaction databases

BioGridi262866. 1 interaction.
MINTiMINT-4996598.
STRINGi10116.ENSRNOP00000020265.

Family & Domainsi

Sequence similaritiesi

Belongs to the CD225/Dispanin family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2DU. Eukaryota.
ENOG4112C1U. LUCA.
GeneTreeiENSGT00390000003476.
HOGENOMiHOG000115781.
HOVERGENiHBG001182.
InParanoidiP26376.
KOiK06566.
OMAiEEHEVAT.
OrthoDBiEOG091G1143.
PhylomeDBiP26376.
TreeFamiTF334894.

Family and domain databases

InterProiIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamiPF04505. CD225. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHTSQAFVN AATGGQPPNY ERIKEEYEVS ELGAPHGSAS VRTTVINMPR
60 70 80 90 100
EVSVPDHVVW SLFNTLFMNF CCLGFIAYAY SVKSRDRKMV GDMTGAQAYA
110 120 130
STAKCLNISS LVLSILMVII TIVTVVIIAL NAPRLQT
Length:137
Mass (Da):14,971
Last modified:August 1, 1992 - v1
Checksum:i9D3F92264E0C0FC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61381 mRNA. Translation: CAA43655.1.
BC168774 mRNA. Translation: AAI68774.1.
CH473953 Genomic DNA. Translation: EDM11956.1.
PIRiJC1241.
RefSeqiNP_001129596.1. NM_001136124.1.
UniGeneiRn.145191.

Genome annotation databases

EnsembliENSRNOT00000020265; ENSRNOP00000020265; ENSRNOG00000015078.
GeneIDi361673.
KEGGirno:361673.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61381 mRNA. Translation: CAA43655.1.
BC168774 mRNA. Translation: AAI68774.1.
CH473953 Genomic DNA. Translation: EDM11956.1.
PIRiJC1241.
RefSeqiNP_001129596.1. NM_001136124.1.
UniGeneiRn.145191.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi262866. 1 interaction.
MINTiMINT-4996598.
STRINGi10116.ENSRNOP00000020265.

PTM databases

iPTMnetiP26376.
PhosphoSiteiP26376.

Proteomic databases

PaxDbiP26376.
PRIDEiP26376.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020265; ENSRNOP00000020265; ENSRNOG00000015078.
GeneIDi361673.
KEGGirno:361673.

Organism-specific databases

CTDi10410.

Phylogenomic databases

eggNOGiENOG410J2DU. Eukaryota.
ENOG4112C1U. LUCA.
GeneTreeiENSGT00390000003476.
HOGENOMiHOG000115781.
HOVERGENiHBG001182.
InParanoidiP26376.
KOiK06566.
OMAiEEHEVAT.
OrthoDBiEOG091G1143.
PhylomeDBiP26376.
TreeFamiTF334894.

Miscellaneous databases

PROiP26376.

Gene expression databases

BgeeiENSRNOG00000015078.
GenevisibleiP26376. RN.

Family and domain databases

InterProiIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamiPF04505. CD225. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIFM3_RAT
AccessioniPrimary (citable) accession number: P26376
Secondary accession number(s): B5DER6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.