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Protein

60S ribosomal protein L13

Gene

RPL13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: ProtInc
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L13
Alternative name(s):
Breast basic conserved protein 1
Gene namesi
Name:RPL13
Synonyms:BBC1
ORF Names:OK/SW-cl.46
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:10303. RPL13.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • cytosolic large ribosomal subunit Source: UniProtKB
  • cytosolic ribosome Source: ProtInc
  • membrane Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34670.

Polymorphism and mutation databases

BioMutaiRPL13.
DMDMi21903462.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21121160S ribosomal protein L13PRO_0000192919Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161N6-acetyllysineCombined sources
Modified residuei52 – 521PhosphoserineCombined sources
Modified residuei77 – 771PhosphoserineCombined sources
Modified residuei106 – 1061PhosphoserineCombined sources
Cross-linki174 – 174Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei177 – 1771N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP26373.
MaxQBiP26373.
PaxDbiP26373.
PeptideAtlasiP26373.
PRIDEiP26373.
TopDownProteomicsiP26373-1. [P26373-1]
P26373-2. [P26373-2]

PTM databases

iPTMnetiP26373.
PhosphoSiteiP26373.
SwissPalmiP26373.

Miscellaneous databases

PMAP-CutDBP26373.

Expressioni

Tissue specificityi

Higher levels of expression in benign breast lesions than in carcinomas.

Gene expression databases

BgeeiENSG00000167526.
CleanExiHS_RPL13.
ExpressionAtlasiP26373. baseline and differential.
GenevisibleiP26373. HS.

Organism-specific databases

HPAiHPA051702.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP70Q8NHQ13EBI-356849,EBI-739624
LRRK2Q5S0072EBI-356849,EBI-5323863
NCK1P163332EBI-356849,EBI-389883
PIK3R1P279862EBI-356849,EBI-79464
TERF2Q155542EBI-356849,EBI-706637

Protein-protein interaction databases

BioGridi112057. 213 interactions.
IntActiP26373. 48 interactions.
MINTiMINT-1148895.
STRINGi9606.ENSP00000307889.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LL1-211[»]
4V6Xelectron microscopy5.00CL1-211[»]
5AJ0electron microscopy3.50AL1-211[»]
ProteinModelPortaliP26373.
SMRiP26373. Positions 2-211.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L13e family.Curated

Phylogenomic databases

eggNOGiKOG3295. Eukaryota.
COG4352. LUCA.
GeneTreeiENSGT00390000007818.
HOGENOMiHOG000170452.
HOVERGENiHBG001156.
InParanoidiP26373.
KOiK02873.
OMAiFPRRAKK.
OrthoDBiEOG091G0KGO.
PhylomeDBiP26373.
TreeFamiTF300073.

Family and domain databases

InterProiIPR001380. Ribosomal_L13e.
IPR018256. Ribosomal_L13e_CS.
[Graphical view]
PANTHERiPTHR11722. PTHR11722. 1 hit.
PfamiPF01294. Ribosomal_L13e. 1 hit.
[Graphical view]
PROSITEiPS01104. RIBOSOMAL_L13E. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P26373-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPSRNGMVL KPHFHKDWQR RVATWFNQPA RKIRRRKARQ AKARRIAPRP
60 70 80 90 100
ASGPIRPIVR CPTVRYHTKV RAGRGFSLEE LRVAGIHKKV ARTIGISVDP
110 120 130 140 150
RRRNKSTESL QANVQRLKEY RSKLILFPRK PSAPKKGDSS AEELKLATQL
160 170 180 190 200
TGPVMPVRNV YKKEKARVIT EEEKNFKAFA SLRMARANAR LFGIRAKRAK
210
EAAEQDVEKK K
Length:211
Mass (Da):24,261
Last modified:January 23, 2007 - v4
Checksum:iDB9FC57768E6BEDE
GO
Isoform 2 (identifier: P26373-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-134: Missing.

Note: No experimental confirmation available.
Show »
Length:164
Mass (Da):18,845
Checksum:iF631C531204EEFAC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91V → A in BAG59685 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti112 – 1121A → T.2 Publications
Corresponds to variant rs9930567 [ dbSNP | Ensembl ].
VAR_051801
Natural varianti170 – 1701T → P.
Corresponds to variant rs16965839 [ dbSNP | Ensembl ].
VAR_051802

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei88 – 13447Missing in isoform 2. 1 PublicationVSP_046028Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64707 mRNA. Translation: CAA45963.1.
AB062392 mRNA. Translation: BAB93479.1.
AK297198 mRNA. Translation: BAG59685.1.
AC092123 Genomic DNA. No translation available.
BC004954 mRNA. Translation: AAH04954.1.
BC007345 mRNA. Translation: AAH07345.1.
BC007563 mRNA. Translation: AAH07563.1.
BC007805 mRNA. Translation: AAH07805.1.
BC010994 mRNA. Translation: AAH10994.1.
BC013078 mRNA. Translation: AAH13078.1.
BC014167 mRNA. Translation: AAH14167.1.
BC020804 mRNA. Translation: AAH20804.1.
BC027463 mRNA. Translation: AAH27463.1.
BC063378 mRNA. Translation: AAH63378.1.
BC093063 mRNA. Translation: AAH93063.1.
BC106058 mRNA. Translation: AAI06059.1.
CCDSiCCDS10979.1. [P26373-1]
CCDS58492.1. [P26373-2]
PIRiS23753.
RefSeqiNP_000968.2. NM_000977.3. [P26373-1]
NP_001230059.1. NM_001243130.1.
NP_001230060.1. NM_001243131.1. [P26373-2]
NP_150254.1. NM_033251.2. [P26373-1]
UniGeneiHs.410817.

Genome annotation databases

EnsembliENST00000311528; ENSP00000307889; ENSG00000167526. [P26373-1]
ENST00000393099; ENSP00000376811; ENSG00000167526. [P26373-1]
ENST00000452368; ENSP00000438959; ENSG00000167526. [P26373-2]
ENST00000567815; ENSP00000455009; ENSG00000167526. [P26373-1]
GeneIDi6137.
KEGGihsa:6137.
UCSCiuc002fnm.3. human. [P26373-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64707 mRNA. Translation: CAA45963.1.
AB062392 mRNA. Translation: BAB93479.1.
AK297198 mRNA. Translation: BAG59685.1.
AC092123 Genomic DNA. No translation available.
BC004954 mRNA. Translation: AAH04954.1.
BC007345 mRNA. Translation: AAH07345.1.
BC007563 mRNA. Translation: AAH07563.1.
BC007805 mRNA. Translation: AAH07805.1.
BC010994 mRNA. Translation: AAH10994.1.
BC013078 mRNA. Translation: AAH13078.1.
BC014167 mRNA. Translation: AAH14167.1.
BC020804 mRNA. Translation: AAH20804.1.
BC027463 mRNA. Translation: AAH27463.1.
BC063378 mRNA. Translation: AAH63378.1.
BC093063 mRNA. Translation: AAH93063.1.
BC106058 mRNA. Translation: AAI06059.1.
CCDSiCCDS10979.1. [P26373-1]
CCDS58492.1. [P26373-2]
PIRiS23753.
RefSeqiNP_000968.2. NM_000977.3. [P26373-1]
NP_001230059.1. NM_001243130.1.
NP_001230060.1. NM_001243131.1. [P26373-2]
NP_150254.1. NM_033251.2. [P26373-1]
UniGeneiHs.410817.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LL1-211[»]
4V6Xelectron microscopy5.00CL1-211[»]
5AJ0electron microscopy3.50AL1-211[»]
ProteinModelPortaliP26373.
SMRiP26373. Positions 2-211.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112057. 213 interactions.
IntActiP26373. 48 interactions.
MINTiMINT-1148895.
STRINGi9606.ENSP00000307889.

PTM databases

iPTMnetiP26373.
PhosphoSiteiP26373.
SwissPalmiP26373.

Polymorphism and mutation databases

BioMutaiRPL13.
DMDMi21903462.

Proteomic databases

EPDiP26373.
MaxQBiP26373.
PaxDbiP26373.
PeptideAtlasiP26373.
PRIDEiP26373.
TopDownProteomicsiP26373-1. [P26373-1]
P26373-2. [P26373-2]

Protocols and materials databases

DNASUi6137.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311528; ENSP00000307889; ENSG00000167526. [P26373-1]
ENST00000393099; ENSP00000376811; ENSG00000167526. [P26373-1]
ENST00000452368; ENSP00000438959; ENSG00000167526. [P26373-2]
ENST00000567815; ENSP00000455009; ENSG00000167526. [P26373-1]
GeneIDi6137.
KEGGihsa:6137.
UCSCiuc002fnm.3. human. [P26373-1]

Organism-specific databases

CTDi6137.
GeneCardsiRPL13.
HGNCiHGNC:10303. RPL13.
HPAiHPA051702.
MIMi113703. gene.
neXtProtiNX_P26373.
PharmGKBiPA34670.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3295. Eukaryota.
COG4352. LUCA.
GeneTreeiENSGT00390000007818.
HOGENOMiHOG000170452.
HOVERGENiHBG001156.
InParanoidiP26373.
KOiK02873.
OMAiFPRRAKK.
OrthoDBiEOG091G0KGO.
PhylomeDBiP26373.
TreeFamiTF300073.

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRPL13. human.
GeneWikiiRPL13.
GenomeRNAii6137.
PMAP-CutDBP26373.
PROiP26373.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167526.
CleanExiHS_RPL13.
ExpressionAtlasiP26373. baseline and differential.
GenevisibleiP26373. HS.

Family and domain databases

InterProiIPR001380. Ribosomal_L13e.
IPR018256. Ribosomal_L13e_CS.
[Graphical view]
PANTHERiPTHR11722. PTHR11722. 1 hit.
PfamiPF01294. Ribosomal_L13e. 1 hit.
[Graphical view]
PROSITEiPS01104. RIBOSOMAL_L13E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL13_HUMAN
AccessioniPrimary (citable) accession number: P26373
Secondary accession number(s): B4DLX3
, F5H1S2, Q3KQT8, Q567Q8, Q9BPX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 162 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.