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Protein

Keratin-associated protein 5-9

Gene

KRTAP5-9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

  • epidermis development Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 5-9
Alternative name(s):
Keratin, cuticle, ultrahigh sulfur 1
Keratin, ultra high-sulfur matrix protein A
Keratin-associated protein 5.9
UHS keratin A
Short name:
UHS KerA
Ultrahigh sulfur keratin-associated protein 5.9
Gene namesi
Name:KRTAP5-9
Synonyms:KAP5.9, KRN1, KRTAP5.9, UHSK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:23604. KRTAP5-9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134946701.

Polymorphism and mutation databases

BioMutaiKRTAP5-9.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 169169Keratin-associated protein 5-9PRO_0000184107Add
BLAST

Proteomic databases

PaxDbiP26371.
PRIDEiP26371.

PTM databases

iPTMnetiP26371.
PhosphoSiteiP26371.

Expressioni

Tissue specificityi

Restricted to hair root, not detected in any other tissues. Expressed in cuticle layers of differentiating hair follicles.1 Publication

Developmental stagei

At a late stage of fiber differentiation.

Gene expression databases

BgeeiENSG00000254997.
CleanExiHS_KRTAP5-9.
GenevisibleiP26371. HS.

Interactioni

Subunit structurei

Interacts with hair keratins.

Binary interactionsi

WithEntry#Exp.IntActNotes
Q5BKY63EBI-3958099,EBI-10243533
Q9NWL93EBI-3958099,EBI-10315054
ADAMTSL4Q6UY14-35EBI-3958099,EBI-10173507
ALPPP051873EBI-3958099,EBI-1211484
ATG9AQ7Z3C63EBI-3958099,EBI-727146
BEX2Q9BXY83EBI-3958099,EBI-745073
BMP7A8K5713EBI-3958099,EBI-10174327
C10orf62Q5T6813EBI-3958099,EBI-744052
C11orf87Q6NUJ23EBI-3958099,EBI-6660291
CARKDQ8IW453EBI-3958099,EBI-8650724
CATSPER1Q8NEC53EBI-3958099,EBI-744545
CHIC2Q9UKJ53EBI-3958099,EBI-741528
CHRDQ9H2X03EBI-3958099,EBI-947551
CKS1BP610243EBI-3958099,EBI-456371
CNNM3Q8NE013EBI-3958099,EBI-741032
COMTP21964-23EBI-3958099,EBI-10200977
CRCT1Q9UGL93EBI-3958099,EBI-713677
CTSZQ9UBR24EBI-3958099,EBI-8636823
DHRS1Q96LJ73EBI-3958099,EBI-746300
DMRT3Q9NQL93EBI-3958099,EBI-9679045
DOCK2Q926083EBI-3958099,EBI-448771
FAHP169303EBI-3958099,EBI-4397076
FAM124BQ9H5Z63EBI-3958099,EBI-741626
FAM161AQ3B8203EBI-3958099,EBI-719941
FAM74A6Q5TZK33EBI-3958099,EBI-10247271
FAM76BQ5HYJ33EBI-3958099,EBI-751192
GLRX3O760035EBI-3958099,EBI-374781
GNEQ9Y2233EBI-3958099,EBI-4291090
HOXA1P496395EBI-3958099,EBI-740785
Hoxa1P090223EBI-3958099,EBI-3957603From a different organism.
HOXB9P174823EBI-3958099,EBI-745290
HPCAL1P372353EBI-3958099,EBI-749311
HSPD1P108093EBI-3958099,EBI-352528
JOSD1Q150403EBI-3958099,EBI-2510602
KLHL38Q2WGJ63EBI-3958099,EBI-6426443
KRTAP10-11P604123EBI-3958099,EBI-10217483
KRTAP10-5P603705EBI-3958099,EBI-10172150
KRTAP10-7P604095EBI-3958099,EBI-10172290
KRTAP10-8P604103EBI-3958099,EBI-10171774
KRTAP10-9P604113EBI-3958099,EBI-10172052
KRTAP12-1P599903EBI-3958099,EBI-10210845
KRTAP12-2P599913EBI-3958099,EBI-10176379
KRTAP4-11Q9BYQ63EBI-3958099,EBI-10302392
KRTAP4-12Q9BQ665EBI-3958099,EBI-739863
KRTAP4-2Q9BYR55EBI-3958099,EBI-10172511
KRTAP5-6Q6L8G93EBI-3958099,EBI-10250562
KRTAP9-2Q9BYQ43EBI-3958099,EBI-1044640
KRTAP9-4Q9BYQ23EBI-3958099,EBI-10185730
LCE1BQ5T7P33EBI-3958099,EBI-10245913
LCE2AQ5TA793EBI-3958099,EBI-10246607
LCE3CQ5T5A83EBI-3958099,EBI-10245291
LCE3EQ5T5B03EBI-3958099,EBI-10245456
LCE4AQ5TA783EBI-3958099,EBI-10246358
LY6HO947723EBI-3958099,EBI-724687
MAPKBP1O603363EBI-3958099,EBI-947402
MEOX2A4D1273EBI-3958099,EBI-10172134
MST065Q549C53EBI-3958099,EBI-10243297
NCLNQ969V3-23EBI-3958099,EBI-10281480
NECTIN2Q926923EBI-3958099,EBI-718419
NLKQ9UBE83EBI-3958099,EBI-366978
NMUP486453EBI-3958099,EBI-10210351
NOTCH2NLQ7Z3S93EBI-3958099,EBI-945833
NPBWR2P481463EBI-3958099,EBI-10210114
NPDC1Q9NQX53EBI-3958099,EBI-748927
NTMQ9P1213EBI-3958099,EBI-4315078
NTN4Q9HB63-33EBI-3958099,EBI-10310092
NUFIP2A1L3A75EBI-3958099,EBI-10172018
OTX1P322425EBI-3958099,EBI-740446
P2RX4Q995713EBI-3958099,EBI-2828248
PCSK5Q928243EBI-3958099,EBI-751290
PFKLP178583EBI-3958099,EBI-487243
PRKAB2O437413EBI-3958099,EBI-1053424
PSMA1P257863EBI-3958099,EBI-359352
PTPMT1Q8WUK03EBI-3958099,EBI-7199479
RAMP3O608963EBI-3958099,EBI-720447
RGS20O760813EBI-3958099,EBI-1052678
RGS20O76081-63EBI-3958099,EBI-10178530
RNF111Q6ZNA44EBI-3958099,EBI-2129175
RYDENQ9NUL53EBI-3958099,EBI-10313866
SCARB1Q8WTV03EBI-3958099,EBI-78657
SDC3A0A0S2Z4U33EBI-3958099,EBI-10204280
SDCBPO005603EBI-3958099,EBI-727004
SLC22A23A1A5C73EBI-3958099,EBI-10171756
SLC25A10Q9UBX33EBI-3958099,EBI-750394
SMCPP499015EBI-3958099,EBI-750494
SPINK2P201553EBI-3958099,EBI-10200479
SPRY2O435973EBI-3958099,EBI-742487
TBC1D10CQ8IV043EBI-3958099,EBI-10261452
TCEA2Q155603EBI-3958099,EBI-710310
TCEANCQ8N8B73EBI-3958099,EBI-954696
TYRO3Q064184EBI-3958099,EBI-3951628
WDYHV1Q96HA83EBI-3958099,EBI-741158
YIPF3Q9GZM53EBI-3958099,EBI-743787
ZBTB24O431673EBI-3958099,EBI-744471
ZFYVE21Q9BQ243EBI-3958099,EBI-2849569
ZNF124Q159733EBI-3958099,EBI-2555767
ZNF266Q145843EBI-3958099,EBI-7115319
ZNF417Q8TAU33EBI-3958099,EBI-740727
ZNF439Q8NDP43EBI-3958099,EBI-747580
ZNF581Q9P0T43EBI-3958099,EBI-745520
ZNF587Q96SQ53EBI-3958099,EBI-6427977

Protein-protein interaction databases

BioGridi110044. 108 interactions.
IntActiP26371. 104 interactions.
STRINGi9606.ENSP00000431443.

Structurei

3D structure databases

ProteinModelPortaliP26371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati35 – 3841
Repeati41 – 4442
Repeati47 – 5043
Repeati82 – 8544
Repeati101 – 10445
Repeati130 – 13456
Repeati149 – 15247
Repeati159 – 16248

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni35 – 1621288 X 4 AA repeats of C-C-X-PAdd
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

OMAiPCCKDAP.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.

Sequencei

Sequence statusi: Complete.

P26371-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCCGCSGGC GSSCGGCDSS CGSCGSGCRG CGPSCCAPVY CCKPVCCCVP
60 70 80 90 100
ACSCSSCGKR GCGSCGGSKG GCGSCGCSQC SCCKPCCCSS GCGSSCCQCS
110 120 130 140 150
CCKPYCSQCS CCKPCCSSSG RGSSCCQSSC CKPCCSSSGC GSSCCQSSCC
160
KPCCSQSRCC VPVCYQCKI
Length:169
Mass (Da):16,276
Last modified:August 1, 1992 - v1
Checksum:i219B14FEEB49D4AB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81G → R.
Corresponds to variant rs34213141 [ dbSNP | Ensembl ].
VAR_053731
Natural varianti40 – 401Y → C.1 Publication
Corresponds to variant rs10792769 [ dbSNP | Ensembl ].
VAR_053732

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55293 Genomic DNA. Translation: CAA39005.1.
AJ006693 Genomic DNA. Translation: CAA07189.1.
X63755 mRNA. Translation: CAA45283.1.
AB126078 mRNA. Translation: BAD20205.1.
BC069531 mRNA. Translation: AAH69531.1.
BC101744 mRNA. Translation: AAI01745.2.
CCDSiCCDS53677.1.
PIRiS18946.
RefSeqiNP_005544.4. NM_005553.3.
UniGeneiHs.709220.

Genome annotation databases

EnsembliENST00000528743; ENSP00000431443; ENSG00000254997.
GeneIDi3846.
KEGGihsa:3846.
UCSCiuc001oqs.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55293 Genomic DNA. Translation: CAA39005.1.
AJ006693 Genomic DNA. Translation: CAA07189.1.
X63755 mRNA. Translation: CAA45283.1.
AB126078 mRNA. Translation: BAD20205.1.
BC069531 mRNA. Translation: AAH69531.1.
BC101744 mRNA. Translation: AAI01745.2.
CCDSiCCDS53677.1.
PIRiS18946.
RefSeqiNP_005544.4. NM_005553.3.
UniGeneiHs.709220.

3D structure databases

ProteinModelPortaliP26371.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110044. 108 interactions.
IntActiP26371. 104 interactions.
STRINGi9606.ENSP00000431443.

PTM databases

iPTMnetiP26371.
PhosphoSiteiP26371.

Polymorphism and mutation databases

BioMutaiKRTAP5-9.

Proteomic databases

PaxDbiP26371.
PRIDEiP26371.

Protocols and materials databases

DNASUi3846.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000528743; ENSP00000431443; ENSG00000254997.
GeneIDi3846.
KEGGihsa:3846.
UCSCiuc001oqs.2. human.

Organism-specific databases

CTDi3846.
GeneCardsiKRTAP5-9.
HGNCiHGNC:23604. KRTAP5-9.
MIMi148021. gene.
neXtProtiNX_P26371.
PharmGKBiPA134946701.
GenAtlasiSearch...

Phylogenomic databases

OMAiPCCKDAP.

Miscellaneous databases

GenomeRNAii3846.
PROiP26371.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000254997.
CleanExiHS_KRTAP5-9.
GenevisibleiP26371. HS.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKRA59_HUMAN
AccessioniPrimary (citable) accession number: P26371
Secondary accession number(s): Q14564, Q3MIP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.