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P26370

- UGA3_YEAST

UniProt

P26370 - UGA3_YEAST

Protein

Transcriptional activator protein UGA3

Gene

UGA3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    GABA-dependent positive regulation of genes required for catabolism of GABA (UGA4, UGA1, and UGA2).

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi17 – 4428Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: SGD
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: SGD
    3. sequence-specific DNA binding transcription factor recruiting transcription factor activity Source: SGD
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. gamma-aminobutyric acid catabolic process Source: SGD
    2. nitrogen catabolite activation of transcription from RNA polymerase II promoter Source: SGD
    3. nitrogen utilization Source: SGD
    4. positive regulation of transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29561-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional activator protein UGA3
    Gene namesi
    Name:UGA3
    Ordered Locus Names:YDL170W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IV

    Organism-specific databases

    CYGDiYDL170w.
    SGDiS000002329. UGA3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: SGD

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi224 – 2241G → R: Constitutive activity; when associated with R-451.
    Mutagenesisi451 – 4511G → R: Loss of activity. Constitutive activity; when associated with R-224.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 528528Transcriptional activator protein UGA3PRO_0000114986Add
    BLAST

    Proteomic databases

    MaxQBiP26370.
    PaxDbiP26370.
    PeptideAtlasiP26370.

    Expressioni

    Gene expression databases

    GenevestigatoriP26370.

    Interactioni

    Subunit structurei

    UGA3 proteins associate in oligomers, at least in the presence of inducer.

    Protein-protein interaction databases

    BioGridi31895. 22 interactions.
    MINTiMINT-4479709.
    STRINGi4932.YDL170W.

    Structurei

    3D structure databases

    ProteinModelPortaliP26370.
    SMRiP26370. Positions 16-47.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi55 – 628Nuclear localization signalSequence Analysis

    Sequence similaritiesi

    Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG69028.
    HOGENOMiHOG000141818.
    KOiK09245.
    OMAiCGAEICK.
    OrthoDBiEOG7GQZ4D.

    Family and domain databases

    Gene3Di4.10.240.10. 1 hit.
    InterProiIPR021858. DUF3468.
    IPR001138. Zn2-C6_fun-type_DNA-bd.
    [Graphical view]
    PfamiPF11951. Fungal_trans_2. 1 hit.
    PF00172. Zn_clus. 1 hit.
    [Graphical view]
    SMARTiSM00066. GAL4. 1 hit.
    [Graphical view]
    SUPFAMiSSF57701. SSF57701. 1 hit.
    PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
    PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P26370-1 [UniParc]FASTAAdd to Basket

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    MNYGVEKLKL KYSKHGCITC KIRKKRCSED KPVCRDCRRL SFPCIYISES    50
    VDKQSLKKIK ADIQHQLISK KRKHAPDSAQ KAAVATRTRR VGSDEQDNQV 100
    YLSKPLEDCI SQKLDSMGLQ LYNYYRSHLA NIISIAPMNQ NYYLNIFLPM 150
    AHENDGILFA ILAWSANHLS ISSSNELRKD EIFVNLANKY TYMSLSHLKT 200
    NEGSSACAKL GFLYSLAQIL ILCGSEICQG DVKFWKILLN IGKNLIENHV 250
    GKDVSRILTT TTEEPSLEER IIFPNFNSVV KYWLIVNFIY HDILNFNTTS 300
    FPIEQYEKFF QRDQNSLPSS ANFIESIDSP IEEIDPLIGI NKPILLLLGQ 350
    VTNLTRFLQT MEQEEMLEHG DKILSLQVEI YKLQPSLMAL EHLDDEKKFY 400
    YLELFEIMKI STLMFFQLTL LKIDKDSLEL QILRNKLDSK LDKVIGTFLE 450
    GSLCFPLFIY GVCIQVEDME KKIDLEAKFD DILKRYKCYN FQNARLLIRK 500
    IWQNEADGIS EHDLVHMIDE LDYNINFA 528
    Length:528
    Mass (Da):61,224
    Last modified:August 1, 1992 - v1
    Checksum:iDFA04DDE29937942
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51664 Genomic DNA. Translation: CAA35976.1.
    Z67750 Genomic DNA. Translation: CAA91576.1.
    Z74218 Genomic DNA. Translation: CAA98744.1.
    X82846 Genomic DNA. Translation: CAA58049.1.
    BK006938 Genomic DNA. Translation: DAA11691.1.
    PIRiS14944.
    RefSeqiNP_010111.1. NM_001180230.1.

    Genome annotation databases

    EnsemblFungiiYDL170W; YDL170W; YDL170W.
    GeneIDi851384.
    KEGGisce:YDL170W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51664 Genomic DNA. Translation: CAA35976.1 .
    Z67750 Genomic DNA. Translation: CAA91576.1 .
    Z74218 Genomic DNA. Translation: CAA98744.1 .
    X82846 Genomic DNA. Translation: CAA58049.1 .
    BK006938 Genomic DNA. Translation: DAA11691.1 .
    PIRi S14944.
    RefSeqi NP_010111.1. NM_001180230.1.

    3D structure databases

    ProteinModelPortali P26370.
    SMRi P26370. Positions 16-47.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31895. 22 interactions.
    MINTi MINT-4479709.
    STRINGi 4932.YDL170W.

    Proteomic databases

    MaxQBi P26370.
    PaxDbi P26370.
    PeptideAtlasi P26370.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YDL170W ; YDL170W ; YDL170W .
    GeneIDi 851384.
    KEGGi sce:YDL170W.

    Organism-specific databases

    CYGDi YDL170w.
    SGDi S000002329. UGA3.

    Phylogenomic databases

    eggNOGi NOG69028.
    HOGENOMi HOG000141818.
    KOi K09245.
    OMAi CGAEICK.
    OrthoDBi EOG7GQZ4D.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29561-MONOMER.

    Miscellaneous databases

    NextBioi 968528.

    Gene expression databases

    Genevestigatori P26370.

    Family and domain databases

    Gene3Di 4.10.240.10. 1 hit.
    InterProi IPR021858. DUF3468.
    IPR001138. Zn2-C6_fun-type_DNA-bd.
    [Graphical view ]
    Pfami PF11951. Fungal_trans_2. 1 hit.
    PF00172. Zn_clus. 1 hit.
    [Graphical view ]
    SMARTi SM00066. GAL4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57701. SSF57701. 1 hit.
    PROSITEi PS00463. ZN2_CY6_FUNGAL_1. 1 hit.
    PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The UGA3 gene regulating the GABA catabolic pathway in Saccharomyces cerevisiae codes for a putative zinc-finger protein acting on RNA amount."
      Andre B.
      Mol. Gen. Genet. 220:269-276(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Sigma 1278B.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
      Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
      , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
      Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Lindner Z.
      Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 453-528.
      Strain: ATCC 38626 / AH22 / NRRL Y-12843.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiUGA3_YEAST
    AccessioniPrimary (citable) accession number: P26370
    Secondary accession number(s): D6VRI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1200 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IV
      Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

    External Data

    Dasty 3