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P26370

- UGA3_YEAST

UniProt

P26370 - UGA3_YEAST

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Protein

Transcriptional activator protein UGA3

Gene

UGA3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GABA-dependent positive regulation of genes required for catabolism of GABA (UGA4, UGA1, and UGA2).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi17 – 4428Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: SGD
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: SGD
  3. sequence-specific DNA binding transcription factor recruiting transcription factor activity Source: SGD
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. gamma-aminobutyric acid catabolic process Source: SGD
  2. nitrogen catabolite activation of transcription from RNA polymerase II promoter Source: SGD
  3. nitrogen utilization Source: SGD
  4. positive regulation of transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-29561-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator protein UGA3
Gene namesi
Name:UGA3
Ordered Locus Names:YDL170W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDL170w.
SGDiS000002329. UGA3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi224 – 2241G → R: Constitutive activity; when associated with R-451.
Mutagenesisi451 – 4511G → R: Loss of activity. Constitutive activity; when associated with R-224.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 528528Transcriptional activator protein UGA3PRO_0000114986Add
BLAST

Proteomic databases

MaxQBiP26370.
PaxDbiP26370.
PeptideAtlasiP26370.

Expressioni

Gene expression databases

GenevestigatoriP26370.

Interactioni

Subunit structurei

UGA3 proteins associate in oligomers, at least in the presence of inducer.

Protein-protein interaction databases

BioGridi31895. 23 interactions.
MINTiMINT-4479709.
STRINGi4932.YDL170W.

Structurei

3D structure databases

ProteinModelPortaliP26370.
SMRiP26370. Positions 16-47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi55 – 628Nuclear localization signalSequence Analysis

Sequence similaritiesi

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG69028.
HOGENOMiHOG000141818.
InParanoidiP26370.
KOiK09245.
OMAiCGAEICK.
OrthoDBiEOG7GQZ4D.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR021858. DUF3468.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF11951. Fungal_trans_2. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26370-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNYGVEKLKL KYSKHGCITC KIRKKRCSED KPVCRDCRRL SFPCIYISES
60 70 80 90 100
VDKQSLKKIK ADIQHQLISK KRKHAPDSAQ KAAVATRTRR VGSDEQDNQV
110 120 130 140 150
YLSKPLEDCI SQKLDSMGLQ LYNYYRSHLA NIISIAPMNQ NYYLNIFLPM
160 170 180 190 200
AHENDGILFA ILAWSANHLS ISSSNELRKD EIFVNLANKY TYMSLSHLKT
210 220 230 240 250
NEGSSACAKL GFLYSLAQIL ILCGSEICQG DVKFWKILLN IGKNLIENHV
260 270 280 290 300
GKDVSRILTT TTEEPSLEER IIFPNFNSVV KYWLIVNFIY HDILNFNTTS
310 320 330 340 350
FPIEQYEKFF QRDQNSLPSS ANFIESIDSP IEEIDPLIGI NKPILLLLGQ
360 370 380 390 400
VTNLTRFLQT MEQEEMLEHG DKILSLQVEI YKLQPSLMAL EHLDDEKKFY
410 420 430 440 450
YLELFEIMKI STLMFFQLTL LKIDKDSLEL QILRNKLDSK LDKVIGTFLE
460 470 480 490 500
GSLCFPLFIY GVCIQVEDME KKIDLEAKFD DILKRYKCYN FQNARLLIRK
510 520
IWQNEADGIS EHDLVHMIDE LDYNINFA
Length:528
Mass (Da):61,224
Last modified:August 1, 1992 - v1
Checksum:iDFA04DDE29937942
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51664 Genomic DNA. Translation: CAA35976.1.
Z67750 Genomic DNA. Translation: CAA91576.1.
Z74218 Genomic DNA. Translation: CAA98744.1.
X82846 Genomic DNA. Translation: CAA58049.1.
BK006938 Genomic DNA. Translation: DAA11691.1.
PIRiS14944.
RefSeqiNP_010111.1. NM_001180230.1.

Genome annotation databases

EnsemblFungiiYDL170W; YDL170W; YDL170W.
GeneIDi851384.
KEGGisce:YDL170W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51664 Genomic DNA. Translation: CAA35976.1 .
Z67750 Genomic DNA. Translation: CAA91576.1 .
Z74218 Genomic DNA. Translation: CAA98744.1 .
X82846 Genomic DNA. Translation: CAA58049.1 .
BK006938 Genomic DNA. Translation: DAA11691.1 .
PIRi S14944.
RefSeqi NP_010111.1. NM_001180230.1.

3D structure databases

ProteinModelPortali P26370.
SMRi P26370. Positions 16-47.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31895. 23 interactions.
MINTi MINT-4479709.
STRINGi 4932.YDL170W.

Proteomic databases

MaxQBi P26370.
PaxDbi P26370.
PeptideAtlasi P26370.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDL170W ; YDL170W ; YDL170W .
GeneIDi 851384.
KEGGi sce:YDL170W.

Organism-specific databases

CYGDi YDL170w.
SGDi S000002329. UGA3.

Phylogenomic databases

eggNOGi NOG69028.
HOGENOMi HOG000141818.
InParanoidi P26370.
KOi K09245.
OMAi CGAEICK.
OrthoDBi EOG7GQZ4D.

Enzyme and pathway databases

BioCyci YEAST:G3O-29561-MONOMER.

Miscellaneous databases

NextBioi 968528.

Gene expression databases

Genevestigatori P26370.

Family and domain databases

Gene3Di 4.10.240.10. 1 hit.
InterProi IPR021858. DUF3468.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view ]
Pfami PF11951. Fungal_trans_2. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view ]
SMARTi SM00066. GAL4. 1 hit.
[Graphical view ]
SUPFAMi SSF57701. SSF57701. 1 hit.
PROSITEi PS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The UGA3 gene regulating the GABA catabolic pathway in Saccharomyces cerevisiae codes for a putative zinc-finger protein acting on RNA amount."
    Andre B.
    Mol. Gen. Genet. 220:269-276(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sigma 1278B.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Lindner Z.
    Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 453-528.
    Strain: ATCC 38626 / AH22 / NRRL Y-12843.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUGA3_YEAST
AccessioniPrimary (citable) accession number: P26370
Secondary accession number(s): D6VRI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 29, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1200 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3