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Protein

Transcriptional activator protein UGA3

Gene

UGA3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GABA-dependent positive regulation of genes required for catabolism of GABA (UGA4, UGA1, and UGA2).

Miscellaneous

Present with 1200 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi17 – 44Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST28

GO - Molecular functioni

GO - Biological processi

  • gamma-aminobutyric acid catabolic process Source: SGD
  • nitrogen catabolite activation of transcription from RNA polymerase II promoter Source: SGD
  • nitrogen utilization Source: SGD

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-29561-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator protein UGA3
Gene namesi
Name:UGA3
Ordered Locus Names:YDL170W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL170W
SGDiS000002329 UGA3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi224G → R: Constitutive activity; when associated with R-451. 1
Mutagenesisi451G → R: Loss of activity. Constitutive activity; when associated with R-224. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001149861 – 528Transcriptional activator protein UGA3Add BLAST528

Proteomic databases

MaxQBiP26370
PaxDbiP26370
PRIDEiP26370

Interactioni

Subunit structurei

UGA3 proteins associate in oligomers, at least in the presence of inducer.

Protein-protein interaction databases

BioGridi31895, 67 interactors
STRINGi4932.YDL170W

Structurei

3D structure databases

ProteinModelPortaliP26370
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi55 – 62Nuclear localization signalSequence analysis8

Phylogenomic databases

HOGENOMiHOG000141818
InParanoidiP26370
KOiK09245
OMAiENNCFLS
OrthoDBiEOG092C1J6X

Family and domain databases

CDDicd00067 GAL4, 1 hit
Gene3Di4.10.240.10, 1 hit
InterProiView protein in InterPro
IPR021858 Fun_TF
IPR001138 Zn2-C6_fun-type_DNA-bd
IPR036864 Zn2-C6_fun-type_DNA-bd_sf
PfamiView protein in Pfam
PF11951 Fungal_trans_2, 1 hit
PF00172 Zn_clus, 1 hit
SMARTiView protein in SMART
SM00066 GAL4, 1 hit
SUPFAMiSSF57701 SSF57701, 1 hit
PROSITEiView protein in PROSITE
PS00463 ZN2_CY6_FUNGAL_1, 1 hit
PS50048 ZN2_CY6_FUNGAL_2, 1 hit

Sequencei

Sequence statusi: Complete.

P26370-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYGVEKLKL KYSKHGCITC KIRKKRCSED KPVCRDCRRL SFPCIYISES
60 70 80 90 100
VDKQSLKKIK ADIQHQLISK KRKHAPDSAQ KAAVATRTRR VGSDEQDNQV
110 120 130 140 150
YLSKPLEDCI SQKLDSMGLQ LYNYYRSHLA NIISIAPMNQ NYYLNIFLPM
160 170 180 190 200
AHENDGILFA ILAWSANHLS ISSSNELRKD EIFVNLANKY TYMSLSHLKT
210 220 230 240 250
NEGSSACAKL GFLYSLAQIL ILCGSEICQG DVKFWKILLN IGKNLIENHV
260 270 280 290 300
GKDVSRILTT TTEEPSLEER IIFPNFNSVV KYWLIVNFIY HDILNFNTTS
310 320 330 340 350
FPIEQYEKFF QRDQNSLPSS ANFIESIDSP IEEIDPLIGI NKPILLLLGQ
360 370 380 390 400
VTNLTRFLQT MEQEEMLEHG DKILSLQVEI YKLQPSLMAL EHLDDEKKFY
410 420 430 440 450
YLELFEIMKI STLMFFQLTL LKIDKDSLEL QILRNKLDSK LDKVIGTFLE
460 470 480 490 500
GSLCFPLFIY GVCIQVEDME KKIDLEAKFD DILKRYKCYN FQNARLLIRK
510 520
IWQNEADGIS EHDLVHMIDE LDYNINFA
Length:528
Mass (Da):61,224
Last modified:August 1, 1992 - v1
Checksum:iDFA04DDE29937942
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51664 Genomic DNA Translation: CAA35976.1
Z67750 Genomic DNA Translation: CAA91576.1
Z74218 Genomic DNA Translation: CAA98744.1
X82846 Genomic DNA Translation: CAA58049.1
BK006938 Genomic DNA Translation: DAA11691.1
PIRiS14944
RefSeqiNP_010111.1, NM_001180230.1

Genome annotation databases

EnsemblFungiiYDL170W; YDL170W; YDL170W
GeneIDi851384
KEGGisce:YDL170W

Similar proteinsi

Entry informationi

Entry nameiUGA3_YEAST
AccessioniPrimary (citable) accession number: P26370
Secondary accession number(s): D6VRI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: May 23, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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