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P26370 (UGA3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcriptional activator protein UGA3
Gene names
Name:UGA3
Ordered Locus Names:YDL170W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length528 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

GABA-dependent positive regulation of genes required for catabolism of GABA (UGA4, UGA1, and UGA2).

Subunit structure

UGA3 proteins associate in oligomers, at least in the presence of inducer.

Subcellular location

Nucleus.

Miscellaneous

Present with 1200 molecules/cell in log phase SD medium.

Sequence similarities

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 528528Transcriptional activator protein UGA3
PRO_0000114986

Regions

DNA binding17 – 4428Zn(2)-C6 fungal-type
Motif55 – 628Nuclear localization signal Potential

Experimental info

Mutagenesis2241G → R: Constitutive activity; when associated with R-451.
Mutagenesis4511G → R: Loss of activity. Constitutive activity; when associated with R-224.

Sequences

Sequence LengthMass (Da)Tools
P26370 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: DFA04DDE29937942

FASTA52861,224
        10         20         30         40         50         60 
MNYGVEKLKL KYSKHGCITC KIRKKRCSED KPVCRDCRRL SFPCIYISES VDKQSLKKIK 

        70         80         90        100        110        120 
ADIQHQLISK KRKHAPDSAQ KAAVATRTRR VGSDEQDNQV YLSKPLEDCI SQKLDSMGLQ 

       130        140        150        160        170        180 
LYNYYRSHLA NIISIAPMNQ NYYLNIFLPM AHENDGILFA ILAWSANHLS ISSSNELRKD 

       190        200        210        220        230        240 
EIFVNLANKY TYMSLSHLKT NEGSSACAKL GFLYSLAQIL ILCGSEICQG DVKFWKILLN 

       250        260        270        280        290        300 
IGKNLIENHV GKDVSRILTT TTEEPSLEER IIFPNFNSVV KYWLIVNFIY HDILNFNTTS 

       310        320        330        340        350        360 
FPIEQYEKFF QRDQNSLPSS ANFIESIDSP IEEIDPLIGI NKPILLLLGQ VTNLTRFLQT 

       370        380        390        400        410        420 
MEQEEMLEHG DKILSLQVEI YKLQPSLMAL EHLDDEKKFY YLELFEIMKI STLMFFQLTL 

       430        440        450        460        470        480 
LKIDKDSLEL QILRNKLDSK LDKVIGTFLE GSLCFPLFIY GVCIQVEDME KKIDLEAKFD 

       490        500        510        520 
DILKRYKCYN FQNARLLIRK IWQNEADGIS EHDLVHMIDE LDYNINFA 

« Hide

References

« Hide 'large scale' references
[1]"The UGA3 gene regulating the GABA catabolic pathway in Saccharomyces cerevisiae codes for a putative zinc-finger protein acting on RNA amount."
Andre B.
Mol. Gen. Genet. 220:269-276(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Sigma 1278B.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]Lindner Z.
Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 453-528.
Strain: ATCC 38626 / AH22 / NRRL Y-12843.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X51664 Genomic DNA. Translation: CAA35976.1.
Z67750 Genomic DNA. Translation: CAA91576.1.
Z74218 Genomic DNA. Translation: CAA98744.1.
X82846 Genomic DNA. Translation: CAA58049.1.
BK006938 Genomic DNA. Translation: DAA11691.1.
PIRS14944.
RefSeqNP_010111.1. NM_001180230.1.

3D structure databases

ProteinModelPortalP26370.
SMRP26370. Positions 16-47.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31895. 22 interactions.
MINTMINT-4479709.
STRING4932.YDL170W.

Proteomic databases

PaxDbP26370.
PeptideAtlasP26370.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYDL170W; YDL170W; YDL170W.
GeneID851384.
KEGGsce:YDL170W.

Organism-specific databases

CYGDYDL170w.
SGDS000002329. UGA3.

Phylogenomic databases

eggNOGNOG69028.
HOGENOMHOG000141818.
KOK09245.
OMACGAEICK.
OrthoDBEOG7GQZ4D.

Enzyme and pathway databases

BioCycYEAST:G3O-29561-MONOMER.

Gene expression databases

GenevestigatorP26370.

Family and domain databases

Gene3D4.10.240.10. 1 hit.
InterProIPR021858. DUF3468.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamPF11951. Fungal_trans_2. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMSSF57701. SSF57701. 1 hit.
PROSITEPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio968528.

Entry information

Entry nameUGA3_YEAST
AccessionPrimary (citable) accession number: P26370
Secondary accession number(s): D6VRI1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome IV

Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families