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Protein

N-acetylmuramoyl-L-alanine amidase AmiB

Gene

amiB

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell-wall hydrolase involved in septum cleavage during cell division.By similarity

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-4402-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase AmiB (EC:3.5.1.28)
Gene namesi
Name:amiB
Ordered Locus Names:STM4358
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000646323 – 439N-acetylmuramoyl-L-alanine amidase AmiBAdd BLAST417

Proteomic databases

PaxDbiP26366
PRIDEiP26366

Interactioni

Protein-protein interaction databases

STRINGi99287.STM4358

Structurei

3D structure databases

ProteinModelPortaliP26366
SMRiP26366
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi130 – 135Poly-Pro6

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105C5C Bacteria
COG0860 LUCA
HOGENOMiHOG000263828
KOiK01448
OMAiQARITFS
PhylomeDBiP26366

Family and domain databases

CDDicd02696 MurNAc-LAA, 1 hit
InterProiView protein in InterPro
IPR002508 MurNAc-LAA_cat
PfamiView protein in Pfam
PF01520 Amidase_3, 1 hit
SMARTiView protein in SMART
SM00646 Ami_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYRIKNAVI AALILLCAQA GAASLSDIQV SNGEQQARIT LSFIGEPEYA
60 70 80 90 100
YSQDGKRTVA LDIRQTGVIQ GLPLQFSGNN LVKTIRAGTP KDAQSLRLLV
110 120 130 140 150
DLTENGKTEA VKRQNGGNYT VIFTINADVP PPPPPVVAKR VESAPRPTEP
160 170 180 190 200
ARNPFKSSDD RLTGVTSSNT VTRPAARASA GAGDKVVIAI DAGHGGQDPG
210 220 230 240 250
AIGPGGTREK NVTIAIARKL RTLLNNDPMF KGVLTRDGDY FISVMGRSDV
260 270 280 290 300
ARKQNANFLV SIHADAAPNR DATGASVWVL SNRRANSEMA NWLEQHEKQS
310 320 330 340 350
ELLGGAGDVL ANSQSDPYLS QAVLDLQFGH SQRVGYDVAT NVLSQLDGVG
360 370 380 390 400
SLHKRRPEHA SLGVLRSPDI PSILVETGFI SNHGEERLLA SDRYQQQIAD
410 420 430
AIYRGLRKYF AAHPIQSAPQ GGPGQTASTN QPGAITAAN
Length:439
Mass (Da):46,790
Last modified:December 19, 2001 - v2
Checksum:i01B2BEB753D34DE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA Translation: AAL23178.1
M29687 Genomic DNA No translation available.
RefSeqiNP_463219.1, NC_003197.2
WP_000640362.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL23178; AAL23178; STM4358
GeneIDi1255884
KEGGistm:STM4358
PATRICifig|99287.12.peg.4582

Similar proteinsi

Entry informationi

Entry nameiAMIB_SALTY
AccessioniPrimary (citable) accession number: P26366
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: December 19, 2001
Last modified: March 28, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health