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Protein

N-acetylmuramoyl-L-alanine amidase AmiB

Gene

amiB

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cell-wall hydrolase involved in septum cleavage during cell division.By similarity

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Cell wall biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase AmiB (EC:3.5.1.28)
Gene namesi
Name:amiB
Ordered Locus Names:STM4358
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000646323 – 439N-acetylmuramoyl-L-alanine amidase AmiBAdd BLAST417

Proteomic databases

PaxDbiP26366.
PRIDEiP26366.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM4358.

Structurei

3D structure databases

ProteinModelPortaliP26366.
SMRiP26366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi130 – 135Poly-Pro6

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105C5C. Bacteria.
COG0860. LUCA.
HOGENOMiHOG000263828.
KOiK01448.
OMAiMTRDGDY.
PhylomeDBiP26366.

Family and domain databases

CDDicd02696. MurNAc-LAA. 1 hit.
Gene3Di3.40.630.40. 2 hits.
InterProiIPR002508. MurNAc-LAA_cat.
[Graphical view]
PfamiPF01520. Amidase_3. 1 hit.
[Graphical view]
SMARTiSM00646. Ami_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYRIKNAVI AALILLCAQA GAASLSDIQV SNGEQQARIT LSFIGEPEYA
60 70 80 90 100
YSQDGKRTVA LDIRQTGVIQ GLPLQFSGNN LVKTIRAGTP KDAQSLRLLV
110 120 130 140 150
DLTENGKTEA VKRQNGGNYT VIFTINADVP PPPPPVVAKR VESAPRPTEP
160 170 180 190 200
ARNPFKSSDD RLTGVTSSNT VTRPAARASA GAGDKVVIAI DAGHGGQDPG
210 220 230 240 250
AIGPGGTREK NVTIAIARKL RTLLNNDPMF KGVLTRDGDY FISVMGRSDV
260 270 280 290 300
ARKQNANFLV SIHADAAPNR DATGASVWVL SNRRANSEMA NWLEQHEKQS
310 320 330 340 350
ELLGGAGDVL ANSQSDPYLS QAVLDLQFGH SQRVGYDVAT NVLSQLDGVG
360 370 380 390 400
SLHKRRPEHA SLGVLRSPDI PSILVETGFI SNHGEERLLA SDRYQQQIAD
410 420 430
AIYRGLRKYF AAHPIQSAPQ GGPGQTASTN QPGAITAAN
Length:439
Mass (Da):46,790
Last modified:December 19, 2001 - v2
Checksum:i01B2BEB753D34DE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL23178.1.
M29687 Genomic DNA. No translation available.
RefSeqiNP_463219.1. NC_003197.1.
WP_000640362.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL23178; AAL23178; STM4358.
GeneIDi1255884.
KEGGistm:STM4358.
PATRICi32387637. VBISalEnt20916_4582.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL23178.1.
M29687 Genomic DNA. No translation available.
RefSeqiNP_463219.1. NC_003197.1.
WP_000640362.1. NC_003197.1.

3D structure databases

ProteinModelPortaliP26366.
SMRiP26366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM4358.

Proteomic databases

PaxDbiP26366.
PRIDEiP26366.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL23178; AAL23178; STM4358.
GeneIDi1255884.
KEGGistm:STM4358.
PATRICi32387637. VBISalEnt20916_4582.

Phylogenomic databases

eggNOGiENOG4105C5C. Bacteria.
COG0860. LUCA.
HOGENOMiHOG000263828.
KOiK01448.
OMAiMTRDGDY.
PhylomeDBiP26366.

Family and domain databases

CDDicd02696. MurNAc-LAA. 1 hit.
Gene3Di3.40.630.40. 2 hits.
InterProiIPR002508. MurNAc-LAA_cat.
[Graphical view]
PfamiPF01520. Amidase_3. 1 hit.
[Graphical view]
SMARTiSM00646. Ami_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAMIB_SALTY
AccessioniPrimary (citable) accession number: P26366
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: December 19, 2001
Last modified: November 2, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.