P26364 (KAD2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate kinase 2
Short name=AK 2
EC=2.7.4.3

Alternative name(s):
ATP-AMP transphosphorylase 2

Gene names

Name:	ADK2
Synonyms:	PAK3
Ordered Locus Names:	YER170W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This small ubiquitous enzyme is essential for maintenance and cell growth.
Catalytic activity	ATP + AMP = 2 ADP.
Subcellular location	Mitochondrion.
Miscellaneous	Present with 704 molecules/cell in log phase SD medium. Ref.6
Sequence similarities	Belongs to the adenylate kinase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	mitochondrial inner membrane Inferred from direct assay. Source: SGD
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from direct assay. Source: SGD nucleoside triphosphate adenylate kinase activity Inferred from direct assay. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 225	225	Adenylate kinase 2		PRO_0000158907
Regions
	Nucleotide binding	21 – 29	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P26364 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: 3B192BE2535BF91F	FASTA	225	25,194
	10 20 30 40 50 60 MKADAKQITH LLKPLRLLLL GAPGSGKGTQ TSRLLKQIPQ LSSISSGDIL RQEIKSESTL 70 80 90 100 110 120 GREATTYIAQ GKLLPDDLIT RLITFRLSAL GWLKPSAMWL LDGFPRTTAQ ASALDELLKQ 130 140 150 160 170 180 HDASLNLVVE LDVPESTILE RIENRYVHVP SGRVYNLQYN PPKVPGLDDI TGEPLTKRLD 190 200 210 220 DTAEVFKKRL EEYKKTNEPL KDYYKKSGIF GTVSGETSDI IFRNY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A putative second adenylate kinase-encoding gene from the yeast Saccharomyces cerevisiae." Cooper A.J., Friedberg E.C. Gene 114:145-148(1992) [PubMed: 1587477] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"A new member of the adenylate kinase family in yeast: PAK3 is highly homologous to mammalian AK3 and is targeted to mitochondria." Schricker R., Magdolen V., Bandlow W. Mol. Gen. Genet. 233:363-371(1992) [PubMed: 1620094] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: DL-1.
[3]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W. Nature 387:78-81(1997) [PubMed: 9169868] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[4]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[5]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M77757 Genomic DNA. Translation: AAA34418.1. X65126 Genomic DNA. Translation: CAA46254.1. U18922 Genomic DNA. Translation: AAB64697.1. AY558457 Genomic DNA. Translation: AAS56783.1. BK006939 Genomic DNA. Translation: DAA07832.1.
PIR	S23568.
RefSeq	NP_011097.1. NM_001179060.1.
3D structure databases
ProteinModelPortal	P26364.
SMR	P26364. Positions 11-224.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4877N.
MINT	MINT-517522.
STRING	P26364.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YER170W; YER170W; YER170W.
GeneID	856917.
KEGG	sce:YER170W.
NMPDR	fig|4932.3.peg.2183.
Organism-specific databases
CYGD	YER170w.
SGD	S000000972. ADK2.
Phylogenomic databases
eggNOG	fuNOG08516.
HOGENOM	HBG630208.
OMA	LLRDNML.
OrthoDB	EOG4CG3JM.
Gene expression databases
ArrayExpress	P26364.
Genevestigator	P26364.
GermOnline	YER170W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_lid-dom. [Graphical view]
KO	K00939.
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
TIGRFAMs	TIGR01351. Adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	983371.

Entry information

Entry name

KAD2_YEAST

Accession

Primary (citable) accession number: P26364
Secondary accession number(s): D3DM78

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	December 14, 2011
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program