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P26361

- CFTR_MOUSE

UniProt

P26361 - CFTR_MOUSE

Protein

Cystic fibrosis transmembrane conductance regulator

Gene

Cftr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 149 (01 Oct 2014)
      Sequence version 2 (31 Jan 2002)
      Previous versions | rss
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    Functioni

    Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 By similarity. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.By similarity1 Publication

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi458 – 4658ATP 1PROSITE-ProRule annotation
    Nucleotide bindingi1240 – 12478ATP 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. bicarbonate transmembrane transporter activity Source: UniProtKB
    3. channel-conductance-controlling ATPase activity Source: UniProtKB-EC
    4. chloride channel activity Source: UniProtKB
    5. chloride channel inhibitor activity Source: UniProtKB
    6. chloride transmembrane transporter activity Source: UniProtKB
    7. protein binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to cAMP Source: UniProtKB
    2. cellular response to hormone stimulus Source: Ensembl
    3. chloride transmembrane transport Source: GOC
    4. chloride transport Source: MGI
    5. cholesterol biosynthetic process Source: MGI
    6. cholesterol transport Source: MGI
    7. intracellular pH elevation Source: UniProtKB
    8. iodide transport Source: Ensembl
    9. lung development Source: Ensembl
    10. membrane hyperpolarization Source: UniProtKB
    11. positive regulation of vasodilation Source: Ensembl
    12. response to cytokine Source: Ensembl
    13. response to drug Source: Ensembl
    14. response to estrogen Source: Ensembl
    15. response to peptide hormone Source: Ensembl
    16. sperm capacitation Source: UniProtKB
    17. transepithelial chloride transport Source: Ensembl
    18. vasodilation Source: Ensembl
    19. water transport Source: Ensembl

    Keywords - Molecular functioni

    Chloride channel, Hydrolase, Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    ATP-binding, Chloride, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi3.6.3.49. 3474.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cystic fibrosis transmembrane conductance regulator
    Short name:
    CFTR
    Alternative name(s):
    ATP-binding cassette sub-family C member 7
    Channel conductance-controlling ATPase (EC:3.6.3.49)
    cAMP-dependent chloride channel
    Gene namesi
    Name:Cftr
    Synonyms:Abcc7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:88388. Cftr.

    Subcellular locationi

    Early endosome membrane By similarity; Multi-pass membrane protein PROSITE-ProRule annotation. Cell membrane By similarity
    Note: In epithelial cells, detected on the apical side, but not associated with cilia.By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. basolateral plasma membrane Source: Ensembl
    3. cell surface Source: Ensembl
    4. chloride channel complex Source: UniProtKB-KW
    5. cytoplasmic vesicle membrane Source: Ensembl
    6. early endosome Source: UniProtKB
    7. early endosome membrane Source: UniProtKB-SubCell
    8. endoplasmic reticulum Sec complex Source: Ensembl
    9. microvillus Source: Ensembl
    10. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14761476Cystic fibrosis transmembrane conductance regulatorPRO_0000093424Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi524 – 5241S-palmitoyl cysteineBy similarity
    Modified residuei549 – 5491PhosphoserineBy similarity
    Modified residuei660 – 6601PhosphoserineBy similarity
    Modified residuei684 – 6841PhosphoserineBy similarity
    Modified residuei698 – 6981PhosphoserineBy similarity
    Modified residuei710 – 7101PhosphoserineBy similarity
    Modified residuei715 – 7151PhosphothreonineBy similarity
    Modified residuei732 – 7321PhosphoserineBy similarity
    Modified residuei763 – 7631PhosphoserineBy similarity
    Modified residuei785 – 7851PhosphoserineBy similarity
    Modified residuei790 – 7901PhosphoserineBy similarity
    Modified residuei808 – 8081PhosphoserineBy similarity
    Glycosylationi889 – 8891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi895 – 8951N-linked (GlcNAc...)Sequence Analysis
    Lipidationi1391 – 13911S-palmitoyl cysteineBy similarity
    Modified residuei1440 – 14401PhosphoserineBy similarity
    Modified residuei1452 – 14521PhosphoserineBy similarity

    Post-translational modificationi

    Ubiquitinated, leading to its degradation in the lysosome. Deubiquitination by USP10 in early endosomes, enhances its endocytic recycling. Ubiquitinated by RNF185 during ER stress By similarity.By similarity
    Phosphorylated; activates the channel. It is not clear whether PKC phosphorylation itself activates the channel or permits activation by phosphorylation at PKA sites. Phosphorylated by AMPK By similarity.By similarity

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiP26361.

    PTM databases

    PhosphoSiteiP26361.

    Expressioni

    Tissue specificityi

    Isoform 1 is expressed in a variety of epithelial tissues including colon, kidney, lung, small intestine and testis. Isoforms 2 and 3 are expressed only in testis.

    Gene expression databases

    ArrayExpressiP26361.
    BgeeiP26361.
    GenevestigatoriP26361.

    Interactioni

    Subunit structurei

    Interacts with MYO6 and GOPC. Interacts with SLC4A7 through SLC9A3R1. Interacts with SHANK2 By similarity. Found in a complex with MYO5B and RAB11A By similarity. Interacts with ANO1 By similarity. Interacts with SLC26A3, SLC26A6 and SLC9A3R1. Interacts with SLC26A8 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HSPA8P191205EBI-6115317,EBI-907802From a different organism.
    Slc26a3Q9WVC83EBI-6115317,EBI-6895537
    Slc26a6Q8CIW63EBI-6115317,EBI-6895517
    Slc9a3r1P704413EBI-6115317,EBI-1184085

    Protein-protein interaction databases

    BioGridi198687. 2 interactions.
    DIPiDIP-29618N.
    IntActiP26361. 9 interactions.
    MINTiMINT-2841263.

    Structurei

    Secondary structure

    1
    1476
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi392 – 4009
    Helixi405 – 4128
    Helixi423 – 4253
    Helixi430 – 4356
    Beta strandi439 – 44810
    Beta strandi453 – 4597
    Helixi464 – 4718
    Beta strandi478 – 4836
    Beta strandi488 – 4914
    Beta strandi499 – 5013
    Helixi502 – 5065
    Turni507 – 5093
    Helixi514 – 52310
    Helixi527 – 5304
    Helixi536 – 5383
    Helixi543 – 5453
    Helixi550 – 56314
    Beta strandi567 – 5737
    Helixi580 – 58910
    Helixi590 – 5945
    Turni595 – 5973
    Beta strandi598 – 6036
    Helixi607 – 6115
    Beta strandi614 – 6207
    Beta strandi623 – 6286
    Helixi630 – 6367
    Helixi638 – 6458
    Beta strandi647 – 6493
    Helixi650 – 6523
    Helixi655 – 66814

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1Q3HX-ray2.50A/B/C/D389-673[»]
    1R0WX-ray2.20A/B/C/D389-673[»]
    1R0XX-ray2.20A/B/C/D389-673[»]
    1R0YX-ray2.55A/B/C/D389-673[»]
    1R0ZX-ray2.35A/B/C/D389-673[»]
    1R10X-ray3.00A/B389-673[»]
    1XF9X-ray2.70A/B/C/D389-670[»]
    1XFAX-ray3.10A/B389-670[»]
    3SI7X-ray2.25A/B/C/D389-673[»]
    ProteinModelPortaliP26361.
    SMRiP26361. Positions 87-700, 943-1446.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP26361.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8080CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini104 – 11714ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini139 – 19456CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini216 – 2205ExtracellularSequence Analysis
    Topological domaini242 – 30766CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini329 – 3302ExtracellularSequence Analysis
    Topological domaini351 – 854504CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini876 – 90631ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini928 – 98558CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1007 – 10082ExtracellularSequence Analysis
    Topological domaini1030 – 109768CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1119 – 11235ExtracellularSequence Analysis
    Topological domaini1145 – 1476332CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei81 – 10323Helical; Name=1PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei118 – 13821Helical; Name=2PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei195 – 21521Helical; Name=3PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei221 – 24121Helical; Name=4PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei308 – 32821Helical; Name=5PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei331 – 35020Helical; Name=6PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei855 – 87521Helical; Name=7PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei907 – 92721Helical; Name=8PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei986 – 100621Helical; Name=9PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1009 – 102921Helical; Name=10PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1098 – 111821Helical; Name=11PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1124 – 114421Helical; Name=12PROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini81 – 365285ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini423 – 646224ABC transporter 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini854 – 1153300ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1208 – 1439232ABC transporter 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1474 – 14763PDZ-binding

    Domaini

    The PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, SLC9A3R1/EBP50 complex.By similarity

    Sequence similaritiesi

    Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
    Contains 2 ABC transporter domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1132.
    GeneTreeiENSGT00750000117627.
    HOGENOMiHOG000185880.
    HOVERGENiHBG004169.
    InParanoidiP26361.
    KOiK05031.
    OMAiTLAMNIM.
    OrthoDBiEOG7C2R0B.
    PhylomeDBiP26361.
    TreeFamiTF105200.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR005291. cAMP_cl_channel.
    IPR025837. CFTR_reg_dom.
    IPR009147. CysFib_conduc_TM.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    PF14396. CFTR_R. 1 hit.
    [Graphical view]
    PRINTSiPR01851. CYSFIBREGLTR.
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 3 hits.
    TIGRFAMsiTIGR01271. CFTR_protein. 1 hit.
    PROSITEiPS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P26361-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQKSPLEKAS FISKLFFSWT TPILRKGYRH HLELSDIYQA PSADSADHLS     50
    EKLEREWDRE QASKKNPQLI HALRRCFFWR FLFYGILLYL GEVTKAVQPV 100
    LLGRIIASYD PENKVERSIA IYLGIGLCLL FIVRTLLLHP AIFGLHRIGM 150
    QMRTAMFSLI YKKTLKLSSR VLDKISIGQL VSLLSNNLNK FDEGLALAHF 200
    IWIAPLQVTL LMGLLWDLLQ FSAFCGLGLL IILVIFQAIL GKMMVKYRDQ 250
    RAAKINERLV ITSEIIDNIY SVKAYCWESA MEKMIENLRE VELKMTRKAA 300
    YMRFFTSSAF FFSGFFVVFL SVLPYTVING IVLRKIFTTI SFCIVLRMSV 350
    TRQFPTAVQI WYDSFGMIRK IQDFLQKQEY KVLEYNLMTT GIIMENVTAF 400
    WEEGFGELLE KVQQSNGDRK HSSDENNVSF SHLCLVGNPV LKNINLNIEK 450
    GEMLAITGST GSGKTSLLML ILGELEASEG IIKHSGRVSF CSQFSWIMPG 500
    TIKENIIFGV SYDEYRYKSV VKACQLQQDI TKFAEQDNTV LGEGGVTLSG 550
    GQRARISLAR AVYKDADLYL LDSPFGYLDV FTEEQVFESC VCKLMANKTR 600
    ILVTSKMEHL RKADKILILH QGSSYFYGTF SELQSLRPDF SSKLMGYDTF 650
    DQFTEERRSS ILTETLRRFS VDDSSAPWSK PKQSFRQTGE VGEKRKNSIL 700
    NSFSSVRKIS IVQKTPLCID GESDDLQEKR LSLVPDSEQG EAALPRSNMI 750
    ATGPTFPGRR RQSVLDLMTF TPNSGSSNLQ RTRTSIRKIS LVPQISLNEV 800
    DVYSRRLSQD STLNITEEIN EEDLKECFLD DVIKIPPVTT WNTYLRYFTL 850
    HKGLLLVLIW CVLVFLVEVA ASLFVLWLLK NNPVNSGNNG TKISNSSYVV 900
    IITSTSFYYI FYIYVGVADT LLALSLFRGL PLVHTLITAS KILHRKMLHS 950
    ILHAPMSTIS KLKAGGILNR FSKDIAILDD FLPLTIFDFI QLVFIVIGAI 1000
    IVVSALQPYI FLATVPGLVV FILLRAYFLH TAQQLKQLES EGRSPIFTHL 1050
    VTSLKGLWTL RAFRRQTYFE TLFHKALNLH TANWFMYLAT LRWFQMRIDM 1100
    IFVLFFIVVT FISILTTGEG EGTAGIILTL AMNIMSTLQW AVNSSIDTDS 1150
    LMRSVSRVFK FIDIQTEESM YTQIIKELPR EGSSDVLVIK NEHVKKSDIW 1200
    PSGGEMVVKD LTVKYMDDGN AVLENISFSI SPGQRVGLLG RTGSGKSTLL 1250
    SAFLRMLNIK GDIEIDGVSW NSVTLQEWRK AFGVITQKVF IFSGTFRQNL 1300
    DPNGKWKDEE IWKVADEVGL KSVIEQFPGQ LNFTLVDGGY VLSHGHKQLM 1350
    CLARSVLSKA KIILLDEPSA HLDPITYQVI RRVLKQAFAG CTVILCEHRI 1400
    EAMLDCQRFL VIEESNVWQY DSLQALLSEK SIFQQAISSS EKMRFFQGRH 1450
    SSKHKPRTQI TALKEETEEE VQETRL 1476
    Length:1,476
    Mass (Da):167,870
    Last modified:January 31, 2002 - v2
    Checksum:i3D1B0BBDD80C1DA8
    GO
    Isoform 2 (identifier: P26361-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         561-576: AVYKDADLYLLDSPFG → FLICLQTKDKVSLFRN
         577-1476: Missing.

    Show »
    Length:576
    Mass (Da):65,799
    Checksum:i5EED7EC29AD39CFC
    GO
    Isoform 3 (identifier: P26361-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         561-600: AVYKDADLYL...VCKLMANKTR → QRTRSPYLEI...QYIKMLICTY
         601-1476: Missing.

    Show »
    Length:600
    Mass (Da):68,782
    Checksum:iC8E6AE26516811C4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti20 – 223TTP → STA in AAF30300. (PubMed:10655503)Curated
    Sequence conflicti30 – 301H → Q in AAF30300. (PubMed:10655503)Curated
    Sequence conflicti410 – 4123EKV → QKA in AAA37417. (PubMed:1712752)Curated
    Sequence conflicti462 – 4621S → L in AAA37417. (PubMed:1712752)Curated
    Sequence conflicti623 – 6231S → T in AAA37417. (PubMed:1712752)Curated
    Sequence conflicti639 – 6391D → S in AAA37417. (PubMed:1712752)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei561 – 60040AVYKD…ANKTR → QRTRSPYLEIRIFLCLFLYT RMKVCATTPEQYIKMLICTY in isoform 3. CuratedVSP_000064Add
    BLAST
    Alternative sequencei561 – 57616AVYKD…DSPFG → FLICLQTKDKVSLFRN in isoform 2. CuratedVSP_000062Add
    BLAST
    Alternative sequencei577 – 1476900Missing in isoform 2. CuratedVSP_000063Add
    BLAST
    Alternative sequencei601 – 1476876Missing in isoform 3. CuratedVSP_000065Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M69298 mRNA. Translation: AAA37417.1.
    M60493 mRNA. Translation: AAA18903.1.
    AF162137 Genomic DNA. Translation: AAF30300.1.
    L04873 Genomic DNA. Translation: AAA73562.1.
    S65942, S65940, S65941 Genomic DNA. Translation: AAB28393.1.
    S65942 Genomic DNA. Translation: AAB28391.1.
    S65941, S65940 Genomic DNA. Translation: AAB28392.1.
    CCDSiCCDS19930.1. [P26361-1]
    PIRiA39901.
    A40303.
    I49593.
    I58115.
    I78527.
    RefSeqiNP_066388.1. NM_021050.2. [P26361-1]
    XP_006505040.1. XM_006504977.1. [P26361-1]
    XP_006505041.1. XM_006504978.1. [P26361-1]
    UniGeneiMm.15621.

    Genome annotation databases

    EnsembliENSMUST00000045706; ENSMUSP00000049228; ENSMUSG00000041301. [P26361-1]
    ENSMUST00000115405; ENSMUSP00000111064; ENSMUSG00000041301. [P26361-3]
    ENSMUST00000140407; ENSMUSP00000116957; ENSMUSG00000041301. [P26361-2]
    GeneIDi12638.
    KEGGimmu:12638.
    UCSCiuc009bai.1. mouse. [P26361-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M69298 mRNA. Translation: AAA37417.1 .
    M60493 mRNA. Translation: AAA18903.1 .
    AF162137 Genomic DNA. Translation: AAF30300.1 .
    L04873 Genomic DNA. Translation: AAA73562.1 .
    S65942 , S65940 , S65941 Genomic DNA. Translation: AAB28393.1 .
    S65942 Genomic DNA. Translation: AAB28391.1 .
    S65941 , S65940 Genomic DNA. Translation: AAB28392.1 .
    CCDSi CCDS19930.1. [P26361-1 ]
    PIRi A39901.
    A40303.
    I49593.
    I58115.
    I78527.
    RefSeqi NP_066388.1. NM_021050.2. [P26361-1 ]
    XP_006505040.1. XM_006504977.1. [P26361-1 ]
    XP_006505041.1. XM_006504978.1. [P26361-1 ]
    UniGenei Mm.15621.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1Q3H X-ray 2.50 A/B/C/D 389-673 [» ]
    1R0W X-ray 2.20 A/B/C/D 389-673 [» ]
    1R0X X-ray 2.20 A/B/C/D 389-673 [» ]
    1R0Y X-ray 2.55 A/B/C/D 389-673 [» ]
    1R0Z X-ray 2.35 A/B/C/D 389-673 [» ]
    1R10 X-ray 3.00 A/B 389-673 [» ]
    1XF9 X-ray 2.70 A/B/C/D 389-670 [» ]
    1XFA X-ray 3.10 A/B 389-670 [» ]
    3SI7 X-ray 2.25 A/B/C/D 389-673 [» ]
    ProteinModelPortali P26361.
    SMRi P26361. Positions 87-700, 943-1446.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198687. 2 interactions.
    DIPi DIP-29618N.
    IntActi P26361. 9 interactions.
    MINTi MINT-2841263.

    PTM databases

    PhosphoSitei P26361.

    Proteomic databases

    PRIDEi P26361.

    Protocols and materials databases

    DNASUi 12638.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000045706 ; ENSMUSP00000049228 ; ENSMUSG00000041301 . [P26361-1 ]
    ENSMUST00000115405 ; ENSMUSP00000111064 ; ENSMUSG00000041301 . [P26361-3 ]
    ENSMUST00000140407 ; ENSMUSP00000116957 ; ENSMUSG00000041301 . [P26361-2 ]
    GeneIDi 12638.
    KEGGi mmu:12638.
    UCSCi uc009bai.1. mouse. [P26361-1 ]

    Organism-specific databases

    CTDi 1080.
    MGIi MGI:88388. Cftr.

    Phylogenomic databases

    eggNOGi COG1132.
    GeneTreei ENSGT00750000117627.
    HOGENOMi HOG000185880.
    HOVERGENi HBG004169.
    InParanoidi P26361.
    KOi K05031.
    OMAi TLAMNIM.
    OrthoDBi EOG7C2R0B.
    PhylomeDBi P26361.
    TreeFami TF105200.

    Enzyme and pathway databases

    BRENDAi 3.6.3.49. 3474.

    Miscellaneous databases

    EvolutionaryTracei P26361.
    NextBioi 281830.
    PROi P26361.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P26361.
    Bgeei P26361.
    Genevestigatori P26361.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR005291. cAMP_cl_channel.
    IPR025837. CFTR_reg_dom.
    IPR009147. CysFib_conduc_TM.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    PF14396. CFTR_R. 1 hit.
    [Graphical view ]
    PRINTSi PR01851. CYSFIBREGLTR.
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 3 hits.
    TIGRFAMsi TIGR01271. CFTR_protein. 1 hit.
    PROSITEi PS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning the mouse homolog of the human cystic fibrosis transmembrane conductance regulator gene."
      Tata F., Stanier P., Wicking C., Halford S., Kruyer H., Lench N.J., Scambler P.J., Hansen C., Braman J.C., Williamson R., Wainwright B.J.
      Genomics 10:301-307(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning and sequence analysis of the murine cDNA for the cystic fibrosis transmembrane conductance regulator."
      Yorifuji T., Lemna W.K., Ballard C.F., Rosenbloom C.L., Rozmahel R., Plavsic N., Tsui L.-C., Beaudet A.L.
      Genomics 10:547-550(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Analysis of the mouse and rat CFTR promoter regions."
      Denamur E., Chehab F.F.
      Hum. Mol. Genet. 3:1089-1094(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-17.
    5. "Cystic fibrosis transmembrane conductance regulator splice variants are not conserved and fail to produce chloride channels."
      Delaney S.J., Rich D.P., Thomson S.A., Hargrave M.R., Lovelock P.K., Welsh M.J., Wainwright B.J.
      Nat. Genet. 4:426-431(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 549-600, ALTERNATIVE SPLICING.
      Tissue: Testis.
    6. "Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation."
      Chavez J.C., Hernandez-Gonzalez E.O., Wertheimer E., Visconti P.E., Darszon A., Trevino C.L.
      Biol. Reprod. 86:1-14(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH SLC26A3; SLC26A6 AND SLC9A3R1.

    Entry informationi

    Entry nameiCFTR_MOUSE
    AccessioniPrimary (citable) accession number: P26361
    Secondary accession number(s): Q63893, Q63894, Q9JKQ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: January 31, 2002
    Last modified: October 1, 2014
    This is version 149 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3