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P26361

- CFTR_MOUSE

UniProt

P26361 - CFTR_MOUSE

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Protein

Cystic fibrosis transmembrane conductance regulator

Gene
Cftr, Abcc7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 By similarity. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi458 – 4658ATP 1 Reviewed prediction
Nucleotide bindingi1240 – 12478ATP 2 Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. bicarbonate transmembrane transporter activity Source: UniProtKB
  3. channel-conductance-controlling ATPase activity Source: UniProtKB-EC
  4. chloride channel activity Source: UniProtKB
  5. chloride channel inhibitor activity Source: UniProtKB
  6. chloride transmembrane transporter activity Source: UniProtKB
  7. protein binding Source: UniProtKB

GO - Biological processi

  1. cellular response to cAMP Source: UniProtKB
  2. cellular response to hormone stimulus Source: Ensembl
  3. chloride transmembrane transport Source: GOC
  4. chloride transport Source: MGI
  5. cholesterol biosynthetic process Source: MGI
  6. cholesterol transport Source: MGI
  7. intracellular pH elevation Source: UniProtKB
  8. iodide transport Source: Ensembl
  9. lung development Source: Ensembl
  10. membrane hyperpolarization Source: UniProtKB
  11. positive regulation of vasodilation Source: Ensembl
  12. response to cytokine Source: Ensembl
  13. response to drug Source: Ensembl
  14. response to estrogen Source: Ensembl
  15. response to peptide hormone Source: Ensembl
  16. sperm capacitation Source: UniProtKB
  17. transepithelial chloride transport Source: Ensembl
  18. vasodilation Source: Ensembl
  19. water transport Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Hydrolase, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

ATP-binding, Chloride, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.3.49. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystic fibrosis transmembrane conductance regulator
Short name:
CFTR
Alternative name(s):
ATP-binding cassette sub-family C member 7
Channel conductance-controlling ATPase (EC:3.6.3.49)
cAMP-dependent chloride channel
Gene namesi
Name:Cftr
Synonyms:Abcc7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:88388. Cftr.

Subcellular locationi

Early endosome membrane; Multi-pass membrane protein By similarity. Cell membrane By similarity
Note: In epithelial cells, detected on the apical side, but not associated with cilia By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8080Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei81 – 10323Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini104 – 11714Extracellular Reviewed predictionAdd
BLAST
Transmembranei118 – 13821Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini139 – 19456Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei195 – 21521Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini216 – 2205Extracellular Reviewed prediction
Transmembranei221 – 24121Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini242 – 30766Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei308 – 32821Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini329 – 3302Extracellular Reviewed prediction
Transmembranei331 – 35020Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini351 – 854504Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei855 – 87521Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini876 – 90631Extracellular Reviewed predictionAdd
BLAST
Transmembranei907 – 92721Helical; Name=8; Reviewed predictionAdd
BLAST
Topological domaini928 – 98558Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei986 – 100621Helical; Name=9; Reviewed predictionAdd
BLAST
Topological domaini1007 – 10082Extracellular Reviewed prediction
Transmembranei1009 – 102921Helical; Name=10; Reviewed predictionAdd
BLAST
Topological domaini1030 – 109768Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1098 – 111821Helical; Name=11; Reviewed predictionAdd
BLAST
Topological domaini1119 – 11235Extracellular Reviewed prediction
Transmembranei1124 – 114421Helical; Name=12; Reviewed predictionAdd
BLAST
Topological domaini1145 – 1476332Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. basolateral plasma membrane Source: Ensembl
  3. cell surface Source: Ensembl
  4. chloride channel complex Source: UniProtKB-KW
  5. cytoplasmic vesicle membrane Source: Ensembl
  6. early endosome Source: UniProtKB
  7. early endosome membrane Source: UniProtKB-SubCell
  8. endoplasmic reticulum Sec complex Source: Ensembl
  9. microvillus Source: Ensembl
  10. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14761476Cystic fibrosis transmembrane conductance regulatorPRO_0000093424Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi524 – 5241S-palmitoyl cysteine By similarity
Modified residuei549 – 5491Phosphoserine By similarity
Modified residuei660 – 6601Phosphoserine By similarity
Modified residuei684 – 6841Phosphoserine By similarity
Modified residuei698 – 6981Phosphoserine By similarity
Modified residuei710 – 7101Phosphoserine By similarity
Modified residuei715 – 7151Phosphothreonine By similarity
Modified residuei732 – 7321Phosphoserine By similarity
Modified residuei763 – 7631Phosphoserine By similarity
Modified residuei785 – 7851Phosphoserine By similarity
Modified residuei790 – 7901Phosphoserine By similarity
Modified residuei808 – 8081Phosphoserine By similarity
Glycosylationi889 – 8891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi895 – 8951N-linked (GlcNAc...) Reviewed prediction
Lipidationi1391 – 13911S-palmitoyl cysteine By similarity
Modified residuei1440 – 14401Phosphoserine By similarity
Modified residuei1452 – 14521Phosphoserine By similarity

Post-translational modificationi

Ubiquitinated, leading to its degradation in the lysosome. Deubiquitination by USP10 in early endosomes, enhances its endocytic recycling. Ubiquitinated by RNF185 during ER stress By similarity.
Phosphorylated; activates the channel. It is not clear whether PKC phosphorylation itself activates the channel or permits activation by phosphorylation at PKA sites. Phosphorylated by AMPK By similarity.

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiP26361.

PTM databases

PhosphoSiteiP26361.

Expressioni

Tissue specificityi

Isoform 1 is expressed in a variety of epithelial tissues including colon, kidney, lung, small intestine and testis. Isoforms 2 and 3 are expressed only in testis.

Gene expression databases

ArrayExpressiP26361.
BgeeiP26361.
GenevestigatoriP26361.

Interactioni

Subunit structurei

Interacts with MYO6 and GOPC. Interacts with SLC4A7 through SLC9A3R1. Interacts with SHANK2 By similarity. Found in a complex with MYO5B and RAB11A By similarity. Interacts with ANO1 By similarity. Interacts with SLC26A3, SLC26A6 and SLC9A3R1. Interacts with SLC26A8 By similarity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HSPA8P191205EBI-6115317,EBI-907802From a different organism.
Slc26a3Q9WVC83EBI-6115317,EBI-6895537
Slc26a6Q8CIW63EBI-6115317,EBI-6895517
Slc9a3r1P704413EBI-6115317,EBI-1184085

Protein-protein interaction databases

BioGridi198687. 2 interactions.
DIPiDIP-29618N.
IntActiP26361. 9 interactions.
MINTiMINT-2841263.

Structurei

Secondary structure

1
1476
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi392 – 4009
Helixi405 – 4128
Helixi423 – 4253
Helixi430 – 4356
Beta strandi439 – 44810
Beta strandi453 – 4597
Helixi464 – 4718
Beta strandi478 – 4836
Beta strandi488 – 4914
Beta strandi499 – 5013
Helixi502 – 5065
Turni507 – 5093
Helixi514 – 52310
Helixi527 – 5304
Helixi536 – 5383
Helixi543 – 5453
Helixi550 – 56314
Beta strandi567 – 5737
Helixi580 – 58910
Helixi590 – 5945
Turni595 – 5973
Beta strandi598 – 6036
Helixi607 – 6115
Beta strandi614 – 6207
Beta strandi623 – 6286
Helixi630 – 6367
Helixi638 – 6458
Beta strandi647 – 6493
Helixi650 – 6523
Helixi655 – 66814

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q3HX-ray2.50A/B/C/D389-673[»]
1R0WX-ray2.20A/B/C/D389-673[»]
1R0XX-ray2.20A/B/C/D389-673[»]
1R0YX-ray2.55A/B/C/D389-673[»]
1R0ZX-ray2.35A/B/C/D389-673[»]
1R10X-ray3.00A/B389-673[»]
1XF9X-ray2.70A/B/C/D389-670[»]
1XFAX-ray3.10A/B389-670[»]
3SI7X-ray2.25A/B/C/D389-673[»]
ProteinModelPortaliP26361.
SMRiP26361. Positions 87-700, 943-1446.

Miscellaneous databases

EvolutionaryTraceiP26361.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini81 – 365285ABC transmembrane type-1 1Add
BLAST
Domaini423 – 646224ABC transporter 1Add
BLAST
Domaini854 – 1153300ABC transmembrane type-1 2Add
BLAST
Domaini1208 – 1439232ABC transporter 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1474 – 14763PDZ-binding

Domaini

The PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, SLC9A3R1/EBP50 complex By similarity.

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
GeneTreeiENSGT00750000117627.
HOGENOMiHOG000185880.
HOVERGENiHBG004169.
InParanoidiP26361.
KOiK05031.
OMAiTLAMNIM.
OrthoDBiEOG7C2R0B.
PhylomeDBiP26361.
TreeFamiTF105200.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005291. cAMP_cl_channel.
IPR025837. CFTR_reg_dom.
IPR009147. CysFib_conduc_TM.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
PF14396. CFTR_R. 1 hit.
[Graphical view]
PRINTSiPR01851. CYSFIBREGLTR.
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
TIGRFAMsiTIGR01271. CFTR_protein. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P26361-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQKSPLEKAS FISKLFFSWT TPILRKGYRH HLELSDIYQA PSADSADHLS     50
EKLEREWDRE QASKKNPQLI HALRRCFFWR FLFYGILLYL GEVTKAVQPV 100
LLGRIIASYD PENKVERSIA IYLGIGLCLL FIVRTLLLHP AIFGLHRIGM 150
QMRTAMFSLI YKKTLKLSSR VLDKISIGQL VSLLSNNLNK FDEGLALAHF 200
IWIAPLQVTL LMGLLWDLLQ FSAFCGLGLL IILVIFQAIL GKMMVKYRDQ 250
RAAKINERLV ITSEIIDNIY SVKAYCWESA MEKMIENLRE VELKMTRKAA 300
YMRFFTSSAF FFSGFFVVFL SVLPYTVING IVLRKIFTTI SFCIVLRMSV 350
TRQFPTAVQI WYDSFGMIRK IQDFLQKQEY KVLEYNLMTT GIIMENVTAF 400
WEEGFGELLE KVQQSNGDRK HSSDENNVSF SHLCLVGNPV LKNINLNIEK 450
GEMLAITGST GSGKTSLLML ILGELEASEG IIKHSGRVSF CSQFSWIMPG 500
TIKENIIFGV SYDEYRYKSV VKACQLQQDI TKFAEQDNTV LGEGGVTLSG 550
GQRARISLAR AVYKDADLYL LDSPFGYLDV FTEEQVFESC VCKLMANKTR 600
ILVTSKMEHL RKADKILILH QGSSYFYGTF SELQSLRPDF SSKLMGYDTF 650
DQFTEERRSS ILTETLRRFS VDDSSAPWSK PKQSFRQTGE VGEKRKNSIL 700
NSFSSVRKIS IVQKTPLCID GESDDLQEKR LSLVPDSEQG EAALPRSNMI 750
ATGPTFPGRR RQSVLDLMTF TPNSGSSNLQ RTRTSIRKIS LVPQISLNEV 800
DVYSRRLSQD STLNITEEIN EEDLKECFLD DVIKIPPVTT WNTYLRYFTL 850
HKGLLLVLIW CVLVFLVEVA ASLFVLWLLK NNPVNSGNNG TKISNSSYVV 900
IITSTSFYYI FYIYVGVADT LLALSLFRGL PLVHTLITAS KILHRKMLHS 950
ILHAPMSTIS KLKAGGILNR FSKDIAILDD FLPLTIFDFI QLVFIVIGAI 1000
IVVSALQPYI FLATVPGLVV FILLRAYFLH TAQQLKQLES EGRSPIFTHL 1050
VTSLKGLWTL RAFRRQTYFE TLFHKALNLH TANWFMYLAT LRWFQMRIDM 1100
IFVLFFIVVT FISILTTGEG EGTAGIILTL AMNIMSTLQW AVNSSIDTDS 1150
LMRSVSRVFK FIDIQTEESM YTQIIKELPR EGSSDVLVIK NEHVKKSDIW 1200
PSGGEMVVKD LTVKYMDDGN AVLENISFSI SPGQRVGLLG RTGSGKSTLL 1250
SAFLRMLNIK GDIEIDGVSW NSVTLQEWRK AFGVITQKVF IFSGTFRQNL 1300
DPNGKWKDEE IWKVADEVGL KSVIEQFPGQ LNFTLVDGGY VLSHGHKQLM 1350
CLARSVLSKA KIILLDEPSA HLDPITYQVI RRVLKQAFAG CTVILCEHRI 1400
EAMLDCQRFL VIEESNVWQY DSLQALLSEK SIFQQAISSS EKMRFFQGRH 1450
SSKHKPRTQI TALKEETEEE VQETRL 1476
Length:1,476
Mass (Da):167,870
Last modified:January 31, 2002 - v2
Checksum:i3D1B0BBDD80C1DA8
GO
Isoform 2 (identifier: P26361-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     561-576: AVYKDADLYLLDSPFG → FLICLQTKDKVSLFRN
     577-1476: Missing.

Show »
Length:576
Mass (Da):65,799
Checksum:i5EED7EC29AD39CFC
GO
Isoform 3 (identifier: P26361-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     561-600: AVYKDADLYL...VCKLMANKTR → QRTRSPYLEI...QYIKMLICTY
     601-1476: Missing.

Show »
Length:600
Mass (Da):68,782
Checksum:iC8E6AE26516811C4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei561 – 60040AVYKD…ANKTR → QRTRSPYLEIRIFLCLFLYT RMKVCATTPEQYIKMLICTY in isoform 3. VSP_000064Add
BLAST
Alternative sequencei561 – 57616AVYKD…DSPFG → FLICLQTKDKVSLFRN in isoform 2. VSP_000062Add
BLAST
Alternative sequencei577 – 1476900Missing in isoform 2. VSP_000063Add
BLAST
Alternative sequencei601 – 1476876Missing in isoform 3. VSP_000065Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 223TTP → STA in AAF30300. 1 Publication
Sequence conflicti30 – 301H → Q in AAF30300. 1 Publication
Sequence conflicti410 – 4123EKV → QKA in AAA37417. 1 Publication
Sequence conflicti462 – 4621S → L in AAA37417. 1 Publication
Sequence conflicti623 – 6231S → T in AAA37417. 1 Publication
Sequence conflicti639 – 6391D → S in AAA37417. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M69298 mRNA. Translation: AAA37417.1.
M60493 mRNA. Translation: AAA18903.1.
AF162137 Genomic DNA. Translation: AAF30300.1.
L04873 Genomic DNA. Translation: AAA73562.1.
S65942, S65940, S65941 Genomic DNA. Translation: AAB28393.1.
S65942 Genomic DNA. Translation: AAB28391.1.
S65941, S65940 Genomic DNA. Translation: AAB28392.1.
CCDSiCCDS19930.1. [P26361-1]
PIRiA39901.
A40303.
I49593.
I58115.
I78527.
RefSeqiNP_066388.1. NM_021050.2. [P26361-1]
XP_006505040.1. XM_006504977.1. [P26361-1]
XP_006505041.1. XM_006504978.1. [P26361-1]
UniGeneiMm.15621.

Genome annotation databases

EnsembliENSMUST00000045706; ENSMUSP00000049228; ENSMUSG00000041301. [P26361-1]
ENSMUST00000115405; ENSMUSP00000111064; ENSMUSG00000041301. [P26361-3]
ENSMUST00000140407; ENSMUSP00000116957; ENSMUSG00000041301. [P26361-2]
GeneIDi12638.
KEGGimmu:12638.
UCSCiuc009bai.1. mouse. [P26361-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M69298 mRNA. Translation: AAA37417.1 .
M60493 mRNA. Translation: AAA18903.1 .
AF162137 Genomic DNA. Translation: AAF30300.1 .
L04873 Genomic DNA. Translation: AAA73562.1 .
S65942 , S65940 , S65941 Genomic DNA. Translation: AAB28393.1 .
S65942 Genomic DNA. Translation: AAB28391.1 .
S65941 , S65940 Genomic DNA. Translation: AAB28392.1 .
CCDSi CCDS19930.1. [P26361-1 ]
PIRi A39901.
A40303.
I49593.
I58115.
I78527.
RefSeqi NP_066388.1. NM_021050.2. [P26361-1 ]
XP_006505040.1. XM_006504977.1. [P26361-1 ]
XP_006505041.1. XM_006504978.1. [P26361-1 ]
UniGenei Mm.15621.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1Q3H X-ray 2.50 A/B/C/D 389-673 [» ]
1R0W X-ray 2.20 A/B/C/D 389-673 [» ]
1R0X X-ray 2.20 A/B/C/D 389-673 [» ]
1R0Y X-ray 2.55 A/B/C/D 389-673 [» ]
1R0Z X-ray 2.35 A/B/C/D 389-673 [» ]
1R10 X-ray 3.00 A/B 389-673 [» ]
1XF9 X-ray 2.70 A/B/C/D 389-670 [» ]
1XFA X-ray 3.10 A/B 389-670 [» ]
3SI7 X-ray 2.25 A/B/C/D 389-673 [» ]
ProteinModelPortali P26361.
SMRi P26361. Positions 87-700, 943-1446.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198687. 2 interactions.
DIPi DIP-29618N.
IntActi P26361. 9 interactions.
MINTi MINT-2841263.

PTM databases

PhosphoSitei P26361.

Proteomic databases

PRIDEi P26361.

Protocols and materials databases

DNASUi 12638.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000045706 ; ENSMUSP00000049228 ; ENSMUSG00000041301 . [P26361-1 ]
ENSMUST00000115405 ; ENSMUSP00000111064 ; ENSMUSG00000041301 . [P26361-3 ]
ENSMUST00000140407 ; ENSMUSP00000116957 ; ENSMUSG00000041301 . [P26361-2 ]
GeneIDi 12638.
KEGGi mmu:12638.
UCSCi uc009bai.1. mouse. [P26361-1 ]

Organism-specific databases

CTDi 1080.
MGIi MGI:88388. Cftr.

Phylogenomic databases

eggNOGi COG1132.
GeneTreei ENSGT00750000117627.
HOGENOMi HOG000185880.
HOVERGENi HBG004169.
InParanoidi P26361.
KOi K05031.
OMAi TLAMNIM.
OrthoDBi EOG7C2R0B.
PhylomeDBi P26361.
TreeFami TF105200.

Enzyme and pathway databases

BRENDAi 3.6.3.49. 3474.

Miscellaneous databases

EvolutionaryTracei P26361.
NextBioi 281830.
PROi P26361.
SOURCEi Search...

Gene expression databases

ArrayExpressi P26361.
Bgeei P26361.
Genevestigatori P26361.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005291. cAMP_cl_channel.
IPR025837. CFTR_reg_dom.
IPR009147. CysFib_conduc_TM.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
PF14396. CFTR_R. 1 hit.
[Graphical view ]
PRINTSi PR01851. CYSFIBREGLTR.
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
TIGRFAMsi TIGR01271. CFTR_protein. 1 hit.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning the mouse homolog of the human cystic fibrosis transmembrane conductance regulator gene."
    Tata F., Stanier P., Wicking C., Halford S., Kruyer H., Lench N.J., Scambler P.J., Hansen C., Braman J.C., Williamson R., Wainwright B.J.
    Genomics 10:301-307(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning and sequence analysis of the murine cDNA for the cystic fibrosis transmembrane conductance regulator."
    Yorifuji T., Lemna W.K., Ballard C.F., Rosenbloom C.L., Rozmahel R., Plavsic N., Tsui L.-C., Beaudet A.L.
    Genomics 10:547-550(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Analysis of the mouse and rat CFTR promoter regions."
    Denamur E., Chehab F.F.
    Hum. Mol. Genet. 3:1089-1094(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-17.
  5. "Cystic fibrosis transmembrane conductance regulator splice variants are not conserved and fail to produce chloride channels."
    Delaney S.J., Rich D.P., Thomson S.A., Hargrave M.R., Lovelock P.K., Welsh M.J., Wainwright B.J.
    Nat. Genet. 4:426-431(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 549-600, ALTERNATIVE SPLICING.
    Tissue: Testis.
  6. "Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation."
    Chavez J.C., Hernandez-Gonzalez E.O., Wertheimer E., Visconti P.E., Darszon A., Trevino C.L.
    Biol. Reprod. 86:1-14(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SLC26A3; SLC26A6 AND SLC9A3R1.

Entry informationi

Entry nameiCFTR_MOUSE
AccessioniPrimary (citable) accession number: P26361
Secondary accession number(s): Q63893, Q63894, Q9JKQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: January 31, 2002
Last modified: July 9, 2014
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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