Prothymosin alpha - Mus musculus (Mouse)

Contribute

Read comments (?) or add your own

P26350 (PTMA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 98. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

text xml rdf/xml gff fasta

to top of page

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

to top of page

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Prothymosin alpha

Cleaved into the following chain:

Thymosin alpha

Gene names

Name:

Ptma

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	111 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
Subcellular location	Nucleus.
Post-translational modification	Covalently linked to a small RNA of about 20 nucleotides.
Sequence similarities	Belongs to the pro/parathymosin family.

Ontologies

Keywords
Cellular component	Nucleus
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

Removed Ref.4

Chain

110

Prothymosin alpha

PRO_0000299251

Peptide

28

Thymosin alpha

PRO_0000029866

Regions

Compositional bias

60

Asp/Glu-rich (acidic)

Amino acid modifications

Modified residue

1

N-acetylserine By similarity

Modified residue

1

Phosphoserine By similarity

Modified residue

1

Phosphothreonine By similarity

Modified residue

1

Phosphoserine By similarity

Modified residue

1

Phosphoserine By similarity

Modified residue

1

Phosphothreonine By similarity

Modified residue

1

Phosphothreonine By similarity

Modified residue

1

N6-acetyllysine By similarity

Modified residue

1

Phosphothreonine By similarity

Modified residue

1

Phosphothreonine By similarity

Experimental info

Sequence conflict

1

K → KK AA sequence Ref.4

Secondary structure

1

.

.

.

111

Helix Strand Turn

Sequences

Sequence

Length

Mass (Da)

Tools

P26350 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 345FACE953A3E8FA
Show »

111

12,254

        10         20         30         40         50         60 
MSDAAVDTSS EITTKDLKEK KEVVEEAENG RDAPANGNAQ NEENGEQEAD NEVDEEEEEG 

        70         80         90        100        110 
GEEEEEEEEG DGEEEDGDED EEAEAPTGKR VAEDDEDDDV DTKKQKTEED D

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of the murine prothymosin alpha cDNA and its deduced primary and secondary protein structure." Schmidt G., Werner D. Biochim. Biophys. Acta 1088:442-444(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J and NOD. Tissue: Eye and Thymus.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain and Limb.
[4]	"Depression of prothymosin alpha production in murine thymus correlates with staphylococcal enterotoxin-B-induced immunosuppression." Low T.L.K., Pan T.L., Lin Y.S. FEBS Lett. 273:1-5(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-111.
[5]	"Prothymosin alpha is an evolutionary conserved protein covalently linked to a small RNA." Makarova T., Grebenshikov N., Egorov C., Vartapetian A., Bogdanov A. FEBS Lett. 257:247-250(1989) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 15-18; 22-68 AND 91-103.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X56135 mRNA. Translation: CAA39601.1.
AK037980 mRNA. Translation: BAC29913.1.
AK084218 mRNA. Translation: BAC39141.1.
AK132003 mRNA. Translation: BAE20932.1.
AK142076 mRNA. Translation: BAE24932.1.
AK145650 mRNA. Translation: BAE26566.1.
AK153953 mRNA. Translation: BAE32276.1.
BC081453 mRNA. Translation: AAH81453.1.
BC083135 mRNA. Translation: AAH83135.1.

IPI

IPI00224784.

PIR

RefSeq

NP_032998.1. NM_008972.2.

UniGene

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2Z32	X-ray	2.00	B	39-54	[»]

ProteinModelPortal

SMR

P26350. Positions 2-29.

ModBase

PTM databases

PhosphoSite

Proteomic databases

PaxDb

PRIDE

Protocols and materials databases

StructuralBiologyKnowledgebase

Genome annotation databases

Ensembl

ENSMUST00000045897; ENSMUSP00000044188; ENSMUSG00000026238.

GeneID

KEGG

Organism-specific databases

CTD

MGI

MGI:97803. Ptma.

Phylogenomic databases

eggNOG

HOVERGEN

InParanoid

KO

OMA

OrthoDB

Gene expression databases

ArrayExpress

Bgee

CleanEx

Genevestigator

Family and domain databases

InterPro

IPR004931. Pro/parathymosin.
[Graphical view]

PANTHER

PTHR22745. PTHR22745. 1 hit.

Pfam

PF03247. Prothymosin. 1 hit.
[Graphical view]

ProtoNet

Other

ChiTaRS

PTMA. mouse.

EvolutionaryTrace

NextBio

PMAP-CutDB

SOURCE

Entry information

Entry name

PTMA_MOUSE

Accession

Primary (citable) accession number: P26350
Secondary accession number(s): Q3UQV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of page

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents