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Protein

Prothymosin alpha

Gene

Ptma

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.

GO - Molecular functioni

  • histone binding Source: MGI

GO - Biological processi

  • histone exchange Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Prothymosin alpha
Cleaved into the following 2 chains:
Gene namesi
Name:Ptma
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:97803. Ptma.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 111111Prothymosin alphaPRO_0000423256Add
BLAST
Initiator methionineiRemoved; alternateCombined sources1 Publication
Chaini2 – 111110Prothymosin alpha, N-terminally processedPRO_0000299251Add
BLAST
Peptidei2 – 2928Thymosin alphaPRO_0000029866Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei2 – 21N-acetylserine; in Prothymosin alpha, N-terminally processedCombined sources
Modified residuei2 – 21PhosphoserineBy similarity
Modified residuei8 – 81PhosphothreonineBy similarity
Modified residuei9 – 91PhosphoserineBy similarity
Modified residuei10 – 101PhosphoserineBy similarity
Modified residuei13 – 131PhosphothreonineBy similarity
Modified residuei14 – 141PhosphothreonineBy similarity
Modified residuei15 – 151N6-acetyllysine; alternateCombined sources
Modified residuei15 – 151N6-succinyllysine; alternateCombined sources
Modified residuei102 – 1021PhosphothreonineBy similarity
Modified residuei103 – 1031N6-acetyllysineCombined sources
Modified residuei107 – 1071PhosphothreonineBy similarity

Post-translational modificationi

Covalently linked to a small RNA of about 20 nucleotides.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP26350.
PaxDbiP26350.
PeptideAtlasiP26350.
PRIDEiP26350.
TopDownProteomicsiP26350.

PTM databases

iPTMnetiP26350.
PhosphoSiteiP26350.

Miscellaneous databases

PMAP-CutDBP26350.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026238.
CleanExiMM_PTMA.
ExpressionAtlasiP26350. baseline.
GenevisibleiP26350. MM.

Interactioni

GO - Molecular functioni

  • histone binding Source: MGI

Protein-protein interaction databases

BioGridi202469. 4 interactions.
STRINGi10090.ENSMUSP00000044188.

Structurei

Secondary structure

1
111
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni42 – 443Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Z32X-ray2.00B39-54[»]
ProteinModelPortaliP26350.
SMRiP26350. Positions 2-29.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26350.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi42 – 10160Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the pro/parathymosin family.Curated

Phylogenomic databases

eggNOGiENOG410J563. Eukaryota.
ENOG410ZA5I. LUCA.
HOVERGENiHBG078507.
InParanoidiP26350.
KOiK13784.
OMAiANWNDNE.
TreeFamiTF350357.

Family and domain databases

InterProiIPR004931. Pro/parathymosin.
[Graphical view]
PANTHERiPTHR22745. PTHR22745. 1 hit.
PfamiPF03247. Prothymosin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26350-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDAAVDTSS EITTKDLKEK KEVVEEAENG RDAPANGNAQ NEENGEQEAD
60 70 80 90 100
NEVDEEEEEG GEEEEEEEEG DGEEEDGDED EEAEAPTGKR VAEDDEDDDV
110
DTKKQKTEED D
Length:111
Mass (Da):12,254
Last modified:January 23, 2007 - v2
Checksum:i345FACE953A3E8FA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti106 – 1061K → KK AA sequence (PubMed:2226839).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56135 mRNA. Translation: CAA39601.1.
AK037980 mRNA. Translation: BAC29913.1.
AK084218 mRNA. Translation: BAC39141.1.
AK132003 mRNA. Translation: BAE20932.1.
AK142076 mRNA. Translation: BAE24932.1.
AK145650 mRNA. Translation: BAE26566.1.
AK153953 mRNA. Translation: BAE32276.1.
BC081453 mRNA. Translation: AAH81453.1.
BC083135 mRNA. Translation: AAH83135.1.
CCDSiCCDS35649.1.
PIRiS15073.
RefSeqiNP_032998.1. NM_008972.2.
UniGeneiMm.19187.

Genome annotation databases

EnsembliENSMUST00000045897; ENSMUSP00000044188; ENSMUSG00000026238.
GeneIDi19231.
KEGGimmu:19231.
UCSCiuc007bvp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56135 mRNA. Translation: CAA39601.1.
AK037980 mRNA. Translation: BAC29913.1.
AK084218 mRNA. Translation: BAC39141.1.
AK132003 mRNA. Translation: BAE20932.1.
AK142076 mRNA. Translation: BAE24932.1.
AK145650 mRNA. Translation: BAE26566.1.
AK153953 mRNA. Translation: BAE32276.1.
BC081453 mRNA. Translation: AAH81453.1.
BC083135 mRNA. Translation: AAH83135.1.
CCDSiCCDS35649.1.
PIRiS15073.
RefSeqiNP_032998.1. NM_008972.2.
UniGeneiMm.19187.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Z32X-ray2.00B39-54[»]
ProteinModelPortaliP26350.
SMRiP26350. Positions 2-29.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202469. 4 interactions.
STRINGi10090.ENSMUSP00000044188.

PTM databases

iPTMnetiP26350.
PhosphoSiteiP26350.

Proteomic databases

EPDiP26350.
PaxDbiP26350.
PeptideAtlasiP26350.
PRIDEiP26350.
TopDownProteomicsiP26350.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045897; ENSMUSP00000044188; ENSMUSG00000026238.
GeneIDi19231.
KEGGimmu:19231.
UCSCiuc007bvp.1. mouse.

Organism-specific databases

CTDi5757.
MGIiMGI:97803. Ptma.

Phylogenomic databases

eggNOGiENOG410J563. Eukaryota.
ENOG410ZA5I. LUCA.
HOVERGENiHBG078507.
InParanoidiP26350.
KOiK13784.
OMAiANWNDNE.
TreeFamiTF350357.

Miscellaneous databases

ChiTaRSiPtma. mouse.
EvolutionaryTraceiP26350.
PMAP-CutDBP26350.
PROiP26350.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026238.
CleanExiMM_PTMA.
ExpressionAtlasiP26350. baseline.
GenevisibleiP26350. MM.

Family and domain databases

InterProiIPR004931. Pro/parathymosin.
[Graphical view]
PANTHERiPTHR22745. PTHR22745. 1 hit.
PfamiPF03247. Prothymosin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTMA_MOUSE
AccessioniPrimary (citable) accession number: P26350
Secondary accession number(s): Q3UQV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.