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P26343

- DAL80_YEAST

UniProt

P26343 - DAL80_YEAST

Protein

Nitrogen regulatory protein DAL80

Gene

DAL80

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    Negative regulator of multiple nitrogen catabolic genes including the allantoin pathway genes.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri31 – 5525GATA-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: SGD
    2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: SGD
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. negative regulation of transcription from RNA polymerase II promoter Source: SGD
    2. nitrate assimilation Source: UniProtKB-KW
    3. nitrogen catabolite repression of transcription Source: SGD
    4. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Nitrate assimilation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32007-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nitrogen regulatory protein DAL80
    Alternative name(s):
    Regulatory protein UGA43
    Gene namesi
    Name:DAL80
    Synonyms:UGA43
    Ordered Locus Names:YKR034W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKR034w.
    SGDiS000001742. DAL80.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269Nitrogen regulatory protein DAL80PRO_0000083470Add
    BLAST

    Expressioni

    Inductioni

    Sensitive to nitrogen catabolite repression.

    Gene expression databases

    GenevestigatoriP26343.

    Interactioni

    Protein-protein interaction databases

    BioGridi34165. 57 interactions.
    DIPiDIP-2094N.
    IntActiP26343. 19 interactions.
    MINTiMINT-483456.
    STRINGi4932.YKR034W.

    Structurei

    3D structure databases

    ProteinModelPortaliP26343.
    SMRiP26343. Positions 30-70.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi79 – 10022Asn-richAdd
    BLAST
    Compositional biasi101 – 1088Arg/Lys-rich (basic)

    Sequence similaritiesi

    Contains 1 GATA-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri31 – 5525GATA-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5641.
    GeneTreeiENSGT00750000117454.
    KOiK09184.
    OMAiDVQCELP.
    OrthoDBiEOG7TQVCN.

    Family and domain databases

    Gene3Di3.30.50.10. 1 hit.
    InterProiIPR000679. Znf_GATA.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00320. GATA. 1 hit.
    [Graphical view]
    PRINTSiPR00619. GATAZNFINGER.
    SMARTiSM00401. ZnF_GATA. 1 hit.
    [Graphical view]
    PROSITEiPS00344. GATA_ZN_FINGER_1. 1 hit.
    PS50114. GATA_ZN_FINGER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P26343-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLSDSLKLP SPTLSAAAGV DDCDGEDHPT CQNCFTVKTP LWRRDEHGTV    50
    LCNACGLFLK LHGEPRPISL KTDTIKSRNR KKLNNNNVNT NANTHSNDPN 100
    KIFKRKKRLL TTGGGSLPTN NPKVSILEKF MVSGSIKPLL KPKETVPNTK 150
    ECSTQRGKFS LDPCEPSGKN YLYQINGSDI YTSNIELTRL PNLSTLLEPS 200
    PFSDSAVPEI ELTWKLHNEE EVIKLKTKIS ELELVTDLYK KHIFQLNEKC 250
    KQLEVELHSR ASVQSHPQH 269
    Length:269
    Mass (Da):30,166
    Last modified:May 1, 1992 - v1
    Checksum:iF37BEB10038599EC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61S → L in CAA42757. (PubMed:1525858)Curated
    Sequence conflicti207 – 2071V → I in CAA42757. (PubMed:1525858)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M77821 Genomic DNA. Translation: AAA34556.1.
    X60199 Genomic DNA. Translation: CAA42757.1.
    Z28259 Genomic DNA. Translation: CAA82107.1.
    Z28258 Genomic DNA. Translation: CAA82106.1.
    BK006944 Genomic DNA. Translation: DAA09187.1.
    PIRiS22781.
    RefSeqiNP_012959.1. NM_001179824.1.

    Genome annotation databases

    EnsemblFungiiYKR034W; YKR034W; YKR034W.
    GeneIDi853904.
    KEGGisce:YKR034W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M77821 Genomic DNA. Translation: AAA34556.1 .
    X60199 Genomic DNA. Translation: CAA42757.1 .
    Z28259 Genomic DNA. Translation: CAA82107.1 .
    Z28258 Genomic DNA. Translation: CAA82106.1 .
    BK006944 Genomic DNA. Translation: DAA09187.1 .
    PIRi S22781.
    RefSeqi NP_012959.1. NM_001179824.1.

    3D structure databases

    ProteinModelPortali P26343.
    SMRi P26343. Positions 30-70.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34165. 57 interactions.
    DIPi DIP-2094N.
    IntActi P26343. 19 interactions.
    MINTi MINT-483456.
    STRINGi 4932.YKR034W.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKR034W ; YKR034W ; YKR034W .
    GeneIDi 853904.
    KEGGi sce:YKR034W.

    Organism-specific databases

    CYGDi YKR034w.
    SGDi S000001742. DAL80.

    Phylogenomic databases

    eggNOGi COG5641.
    GeneTreei ENSGT00750000117454.
    KOi K09184.
    OMAi DVQCELP.
    OrthoDBi EOG7TQVCN.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32007-MONOMER.

    Miscellaneous databases

    NextBioi 975233.

    Gene expression databases

    Genevestigatori P26343.

    Family and domain databases

    Gene3Di 3.30.50.10. 1 hit.
    InterProi IPR000679. Znf_GATA.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00320. GATA. 1 hit.
    [Graphical view ]
    PRINTSi PR00619. GATAZNFINGER.
    SMARTi SM00401. ZnF_GATA. 1 hit.
    [Graphical view ]
    PROSITEi PS00344. GATA_ZN_FINGER_1. 1 hit.
    PS50114. GATA_ZN_FINGER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of the DAL80 gene, whose product is homologous to the GATA factors and is a negative regulator of multiple nitrogen catabolic genes in Saccharomyces cerevisiae, is sensitive to nitrogen catabolite repression."
      Cunningham T.S., Cooper T.G.
      Mol. Cell. Biol. 11:6205-6215(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Erratum
      Cunningham T.S., Cooper T.G.
      Mol. Cell. Biol. 12:2454-2454(1992) [PubMed] [Europe PMC] [Abstract]
    3. "The UGA43 negative regulatory gene of Saccharomyces cerevisiae contains both a GATA-1 type zinc finger and a putative leucine zipper."
      Coornaert D., Vissers S., Andre B., Grenson M.
      Curr. Genet. 21:301-307(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.

    Entry informationi

    Entry nameiDAL80_YEAST
    AccessioniPrimary (citable) accession number: P26343
    Secondary accession number(s): D6VX97
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3