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Protein

Transforming growth factor beta receptor type 3

Gene

Tgfbr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.

GO - Molecular functioni

  • activin binding Source: RGD
  • coreceptor activity Source: Ensembl
  • fibroblast growth factor binding Source: RGD
  • glycosaminoglycan binding Source: BHF-UCL
  • heparin binding Source: BHF-UCL
  • SMAD binding Source: Ensembl
  • transforming growth factor beta-activated receptor activity Source: RGD
  • transforming growth factor beta binding Source: BHF-UCL
  • transforming growth factor beta receptor activity, type III Source: BHF-UCL
  • transforming growth factor beta receptor binding Source: BHF-UCL
  • type II transforming growth factor beta receptor binding Source: Ensembl

GO - Biological processi

  • animal organ regeneration Source: RGD
  • BMP signaling pathway Source: Ensembl
  • cardiac epithelial to mesenchymal transition Source: Ensembl
  • immune response Source: Ensembl
  • intracellular signal transduction Source: Ensembl
  • negative regulation of cellular component movement Source: Ensembl
  • negative regulation of transforming growth factor beta receptor signaling pathway Source: RGD
  • pathway-restricted SMAD protein phosphorylation Source: Ensembl
  • positive regulation of transforming growth factor beta receptor signaling pathway Source: RGD
  • protein-containing complex assembly Source: RGD
  • regulation of protein binding Source: RGD
  • response to follicle-stimulating hormone Source: Ensembl
  • response to hypoxia Source: RGD
  • response to luteinizing hormone Source: Ensembl
  • response to prostaglandin E Source: Ensembl
  • signal transduction Source: BHF-UCL
  • transforming growth factor beta receptor complex assembly Source: RGD
  • transforming growth factor beta receptor signaling pathway Source: RGD

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming growth factor beta receptor type 3
Short name:
TGF-beta receptor type 3
Short name:
TGFR-3
Alternative name(s):
Betaglycan
Transforming growth factor beta receptor III
Short name:
TGF-beta receptor type III
Gene namesi
Name:Tgfbr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi61821 Tgfbr3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 789ExtracellularSequence analysisAdd BLAST766
Transmembranei790 – 811HelicalSequence analysisAdd BLAST22
Topological domaini812 – 853CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000004166624 – 853Transforming growth factor beta receptor type 3Add BLAST830

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi493N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi535O-linked (Xyl...) (glycosaminoglycan) serineBy similarity1
Glycosylationi546O-linked (Xyl...) (glycosaminoglycan) serineBy similarity1
Glycosylationi572N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi591N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi640 ↔ 7061 Publication
Disulfide bondi661 ↔ 7301 Publication
Glycosylationi698N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi711 ↔ 723By similarity

Post-translational modificationi

Extensively modified by glycosaminoglycan groups (GAG).

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiP26342
PRIDEiP26342

PTM databases

iPTMnetiP26342
PhosphoSitePlusiP26342

Expressioni

Gene expression databases

BgeeiENSRNOG00000002093
GenevisibleiP26342 RN

Interactioni

Subunit structurei

Interacts with TCTEX1D4.By similarity

GO - Molecular functioni

  • fibroblast growth factor binding Source: RGD
  • SMAD binding Source: Ensembl
  • transforming growth factor beta binding Source: BHF-UCL
  • transforming growth factor beta receptor binding Source: BHF-UCL
  • type II transforming growth factor beta receptor binding Source: Ensembl

Protein-protein interaction databases

DIPiDIP-6248N
STRINGi10116.ENSRNOP00000002867

Structurei

Secondary structure

1853
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi592 – 601Combined sources10
Beta strandi610 – 614Combined sources5
Beta strandi619 – 629Combined sources11
Beta strandi633 – 644Combined sources12
Beta strandi655 – 658Combined sources4
Beta strandi668 – 677Combined sources10
Turni678 – 681Combined sources4
Beta strandi682 – 692Combined sources11
Beta strandi700 – 717Combined sources18
Helixi726 – 731Combined sources6
Beta strandi746 – 754Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QW9X-ray2.00A/B591-763[»]
SMRiP26342
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26342

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini456 – 730ZPPROSITE-ProRule annotationAdd BLAST275

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni737 – 751Interaction with TGF-beta ligandBy similarityAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi772 – 778Poly-Pro7

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK7K Eukaryota
ENOG410XSMK LUCA
GeneTreeiENSGT00530000063861
HOGENOMiHOG000090193
HOVERGENiHBG057515
InParanoidiP26342
KOiK05843
OMAiIIENICP
OrthoDBiEOG091G030O
PhylomeDBiP26342
TreeFamiTF337375

Family and domain databases

InterProiView protein in InterPro
IPR001507 ZP_dom
IPR017977 ZP_dom_CS
PfamiView protein in Pfam
PF00100 Zona_pellucida, 1 hit
PRINTSiPR00023 ZPELLUCIDA
SMARTiView protein in SMART
SM00241 ZP, 1 hit
PROSITEiView protein in PROSITE
PS00682 ZP_1, 1 hit
PS51034 ZP_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26342-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVTSHHMIP VMVVLMSACL ATAGPEPSTR CELSPINASH PVQALMESFT
60 70 80 90 100
VLSGCASRGT TGLPREVHVL NLRSTDQGPG QRQREVTLHL NPIASVHTHH
110 120 130 140 150
KPIVFLLNSP QPLVWHLKTE RLAAGVPRLF LVSEGSVVQF PSGNFSLTAE
160 170 180 190 200
TEERNFPQEN EHLLRWAQKE YGAVTSFTEL KIARNIYIKV GEDQVFPPTC
210 220 230 240 250
NIGKNFLSLN YLAEYLQPKA AEGCVLPSQP HEKEVHIIEL ITPSSNPYSA
260 270 280 290 300
FQVDIIVDIR PAQEDPEVVK NLVLILKCKK SVNWVIKSFD VKGNLKVIAP
310 320 330 340 350
NSIGFGKESE RSMTMTKLVR DDIPSTQENL MKWALDNGYR PVTSYTMAPV
360 370 380 390 400
ANRFHLRLEN NEEMRDEEVH TIPPELRILL DPDHPPALDN PLFPGEGSPN
410 420 430 440 450
GGLPFPFPDI PRRGWKEGED RIPRPKQPIV PSVQLLPDHR EPEEVQGGVD
460 470 480 490 500
IALSVKCDHE KMVVAVDKDS FQTNGYSGME LTLLDPSCKA KMNGTHFVLE
510 520 530 540 550
SPLNGCGTRH RRSTPDGVVY YNSIVVQAPS PGDSSGWPDG YEDLESGDNG
560 570 580 590 600
FPGDGDEGET APLSRAGVVV FNCSLRQLRN PSGFQGQLDG NATFNMELYN
610 620 630 640 650
TDLFLVPSPG VFSVAENEHV YVEVSVTKAD QDLGFAIQTC FLSPYSNPDR
660 670 680 690 700
MSDYTIIENI CPKDDSVKFY SSKRVHFPIP HAEVDKKRFS FLFKSVFNTS
710 720 730 740 750
LLFLHCELTL CSRKKGSLKL PRCVTPDDAC TSLDATMIWT MMQNKKTFTK
760 770 780 790 800
PLAVVLQVDY KENVPSTKDS SPIPPPPPQI FHGLDTLTVM GIAFAAFVIG
810 820 830 840 850
ALLTGALWYI YSHTGETARR QQVPTSPPAS ENSSAAHSIG STQSTPCSSS

STA
Length:853
Mass (Da):94,103
Last modified:May 1, 1992 - v1
Checksum:iAF7078599560A928
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti164L → V in AAA42236 (PubMed:1657407).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77809 mRNA Translation: AAA40813.1
M80784 mRNA Translation: AAA42236.1
PIRiA41220
RefSeqiNP_058952.1, NM_017256.1
UniGeneiRn.9953

Genome annotation databases

EnsembliENSRNOT00000002867; ENSRNOP00000002867; ENSRNOG00000002093
GeneIDi29610
KEGGirno:29610
UCSCiRGD:61821 rat

Similar proteinsi

Entry informationi

Entry nameiTGBR3_RAT
AccessioniPrimary (citable) accession number: P26342
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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