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P26341 (MANB_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphomannomutase
Short name=PMM
EC=5.4.2.8
Gene names
Name:manB
Synonyms:cpsG, rfbL
Ordered Locus Names:STM2104
OrganismSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]
Taxonomic identifier99287 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella ›

Protein attributes

Sequence length456 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the capsular polysaccharide colanic acid.

Catalytic activity

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.

Sequence similarities

Belongs to the phosphohexose mutase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 456456Phosphomannomutase
PRO_0000147822

Sites

Active site981Phosphoserine intermediate By similarity
Metal binding981Magnesium; via phosphate group By similarity
Metal binding2451Magnesium By similarity
Metal binding2471Magnesium By similarity
Metal binding2491Magnesium By similarity

Experimental info

Sequence conflict55 – 562KL → NV in CAA42541. Ref.1

Secondary structure

1 .............................................................................. 456
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P26341 [UniParc].

Last modified January 23, 2002. Version 2.
Checksum: 6E32422242AF2CE2

FASTA45650,002
        10         20         30         40         50         60 
MTKLTCFKAY DIRGRLGEEL NEDIAWRIGR AYGEYLKPKT VVLGGDVRLT SEALKLALAK 

        70         80         90        100        110        120 
GLQDAGVDVL DIGMSGTEEI YFATFHLGVD GGIEVTASHN PMDYNGMKLV REGARPISGD 

       130        140        150        160        170        180 
TGLRDVQRLA EAGDFPPVNE AARGSYRQIS LRDAYIDHLL GYISVNNLTP LKLVFNAGNG 

       190        200        210        220        230        240 
AAGPVIDAIE ARLKALGAPV EFIKIHNTPD GTFPNGIPNP LLPECRDDTR KAVIEHGADM 

       250        260        270        280        290        300 
GIAFDGDFDR CFLFDEKGQF IEGYYIVGLL AEAFLEKHPG AKIIHDPRLT WNTEAVVTAA 

       310        320        330        340        350        360 
GGTPVMSKTG HAFIKERMRT EDAIYGGEMS AHHYFRDFAY CDSGMIPWLL VAELVCLKRQ 

       370        380        390        400        410        420 
SLGELVRDRM AAFPASGEIN SRLAEPAAAI ARVEAHFAEE AQAVDRTDGL SMSFADWRFN 

       430        440        450 
LRSSNTEPVV RLNVESRGDI PLMEARTRTL LALLNQ

« Hide

References

« Hide 'large scale' references
[1]"The cps gene cluster of Salmonella strain LT2 includes a second mannose pathway: sequence of two genes and relationship to genes in the rfb gene cluster."
Stevenson G., Lee S.J., Romana L.K., Reeves P.R.
Mol. Gen. Genet. 227:173-180(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: LT2.
[2]"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2."
McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. expand/collapse author list , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K.
Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LT2 / SGSC1412 / ATCC 700720.
[3]"Structure of phosphomannomutase from Salmonella typhimurium."
Sagajkar R., Muthuvel A., Reddy R.
Submitted (APR-2003) to the PDB data bank
Cited for: 3D-STRUCTURE MODELING.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X59886 Genomic DNA. Translation: CAA42541.1.
AE006468 Genomic DNA. Translation: AAL21008.1.
PIRS16291.
RefSeqNP_461049.1. NC_003197.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1LLLmodel-A1-456[»]
ProteinModelPortalP26341.
ModBaseSearch...

Protein-protein interaction databases

STRING99287.STM2104.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL21008; AAL21008; STM2104.
GeneID1253625.
KEGGstm:STM2104.
PATRIC32382791. VBISalEnt20916_2226.

Phylogenomic databases

eggNOGCOG1109.
HOGENOMHOG000268679.
KOK01840.
OMARDAYIGH.
ProtClustDBPRK15414.

Enzyme and pathway databases

UniPathwayUPA00126; UER00424.

Family and domain databases

Gene3D3.40.120.10. 3 hits.
InterProIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view]
PfamPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSPR00509. PGMPMM.
SUPFAMSSF53738. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
PROSITEPS00710. PGM_PMM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMANB_SALTY
AccessionPrimary (citable) accession number: P26341
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: January 23, 2002
Last modified: May 1, 2013
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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