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P26341

- MANB_SALTY

UniProt

P26341 - MANB_SALTY

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Protein

Phosphomannomutase

Gene
manB, cpsG, rfbL, STM2104
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the capsular polysaccharide colanic acid.

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Cofactori

Binds 1 magnesium ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei98 – 981Phosphoserine intermediate By similarity
Metal bindingi98 – 981Magnesium; via phosphate group By similarity
Metal bindingi245 – 2451Magnesium By similarity
Metal bindingi247 – 2471Magnesium By similarity
Metal bindingi249 – 2491Magnesium By similarity

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. phosphomannomutase activity Source: UniProtKB-EC

GO - Biological processi

  1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
  2. lipopolysaccharide biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Capsule biogenesis/degradation, Lipopolysaccharide biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSENT99287:GCTI-2116-MONOMER.
UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase (EC:5.4.2.8)
Short name:
PMM
Gene namesi
Name:manB
Synonyms:cpsG, rfbL
Ordered Locus Names:STM2104
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456PhosphomannomutasePRO_0000147822Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi99287.STM2104.

Structurei

Secondary structure

1
456
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 63
Beta strandi9 – 168
Turni17 – 193
Helixi22 – 3615
Beta strandi41 – 455
Helixi51 – 6414
Beta strandi68 – 747
Helixi77 – 8610
Beta strandi92 – 954
Beta strandi104 – 1118
Helixi123 – 13210
Beta strandi140 – 1489
Helixi152 – 16211
Beta strandi167 – 1693
Beta strandi171 – 1766
Turni181 – 1855
Helixi186 – 1938
Beta strandi195 – 2017
Beta strandi203 – 2064
Helixi223 – 2264
Helixi227 – 23610
Beta strandi239 – 2446
Beta strandi251 – 2555
Helixi263 – 27715
Beta strandi282 – 2854
Helixi291 – 30010
Beta strandi303 – 3064
Helixi311 – 32111
Beta strandi324 – 3274
Beta strandi333 – 3353
Helixi345 – 35713
Turni362 – 3643
Helixi365 – 3695
Beta strandi379 – 3813
Helixi388 – 3969
Beta strandi401 – 4055
Beta strandi407 – 4148
Beta strandi417 – 4237
Beta strandi425 – 4284
Beta strandi430 – 4389
Helixi439 – 45517

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LLLmodel-A1-456[»]
ProteinModelPortaliP26341.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1109.
HOGENOMiHOG000268679.
KOiK01840.
OMAiVVGCDIR.
OrthoDBiEOG6W9X55.
PhylomeDBiP26341.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26341-1 [UniParc]FASTAAdd to Basket

« Hide

MTKLTCFKAY DIRGRLGEEL NEDIAWRIGR AYGEYLKPKT VVLGGDVRLT    50
SEALKLALAK GLQDAGVDVL DIGMSGTEEI YFATFHLGVD GGIEVTASHN 100
PMDYNGMKLV REGARPISGD TGLRDVQRLA EAGDFPPVNE AARGSYRQIS 150
LRDAYIDHLL GYISVNNLTP LKLVFNAGNG AAGPVIDAIE ARLKALGAPV 200
EFIKIHNTPD GTFPNGIPNP LLPECRDDTR KAVIEHGADM GIAFDGDFDR 250
CFLFDEKGQF IEGYYIVGLL AEAFLEKHPG AKIIHDPRLT WNTEAVVTAA 300
GGTPVMSKTG HAFIKERMRT EDAIYGGEMS AHHYFRDFAY CDSGMIPWLL 350
VAELVCLKRQ SLGELVRDRM AAFPASGEIN SRLAEPAAAI ARVEAHFAEE 400
AQAVDRTDGL SMSFADWRFN LRSSNTEPVV RLNVESRGDI PLMEARTRTL 450
LALLNQ 456
Length:456
Mass (Da):50,002
Last modified:January 23, 2002 - v2
Checksum:i6E32422242AF2CE2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 562KL → NV in CAA42541. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59886 Genomic DNA. Translation: CAA42541.1.
AE006468 Genomic DNA. Translation: AAL21008.1.
PIRiS16291.
RefSeqiNP_461049.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL21008; AAL21008; STM2104.
GeneIDi1253625.
KEGGistm:STM2104.
PATRICi32382791. VBISalEnt20916_2226.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59886 Genomic DNA. Translation: CAA42541.1 .
AE006468 Genomic DNA. Translation: AAL21008.1 .
PIRi S16291.
RefSeqi NP_461049.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1LLL model - A 1-456 [» ]
ProteinModelPortali P26341.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM2104.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL21008 ; AAL21008 ; STM2104 .
GeneIDi 1253625.
KEGGi stm:STM2104.
PATRICi 32382791. VBISalEnt20916_2226.

Phylogenomic databases

eggNOGi COG1109.
HOGENOMi HOG000268679.
KOi K01840.
OMAi VVGCDIR.
OrthoDBi EOG6W9X55.
PhylomeDBi P26341.

Enzyme and pathway databases

UniPathwayi UPA00126 ; UER00424 .
BioCyci SENT99287:GCTI-2116-MONOMER.

Family and domain databases

Gene3Di 3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProi IPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
[Graphical view ]
Pfami PF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view ]
PRINTSi PR00509. PGMPMM.
SUPFAMi SSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEi PS00710. PGM_PMM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The cps gene cluster of Salmonella strain LT2 includes a second mannose pathway: sequence of two genes and relationship to genes in the rfb gene cluster."
    Stevenson G., Lee S.J., Romana L.K., Reeves P.R.
    Mol. Gen. Genet. 227:173-180(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LT2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.
  3. "Structure of phosphomannomutase from Salmonella typhimurium."
    Sagajkar R., Muthuvel A., Reddy R.
    Submitted (APR-2003) to the PDB data bank
    Cited for: 3D-STRUCTURE MODELING.

Entry informationi

Entry nameiMANB_SALTY
AccessioniPrimary (citable) accession number: P26341
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: January 23, 2002
Last modified: July 9, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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