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P26341

- MANB_SALTY

UniProt

P26341 - MANB_SALTY

Protein

Phosphomannomutase

Gene

manB

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (23 Jan 2002)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of the capsular polysaccharide colanic acid.

    Catalytic activityi

    Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

    Cofactori

    Binds 1 magnesium ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei98 – 981Phosphoserine intermediateBy similarity
    Metal bindingi98 – 981Magnesium; via phosphate groupBy similarity
    Metal bindingi245 – 2451MagnesiumBy similarity
    Metal bindingi247 – 2471MagnesiumBy similarity
    Metal bindingi249 – 2491MagnesiumBy similarity

    GO - Molecular functioni

    1. magnesium ion binding Source: InterPro
    2. phosphomannomutase activity Source: UniProtKB-EC

    GO - Biological processi

    1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
    2. lipopolysaccharide biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Capsule biogenesis/degradation, Lipopolysaccharide biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-2116-MONOMER.
    UniPathwayiUPA00126; UER00424.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphomannomutase (EC:5.4.2.8)
    Short name:
    PMM
    Gene namesi
    Name:manB
    Synonyms:cpsG, rfbL
    Ordered Locus Names:STM2104
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 456456PhosphomannomutasePRO_0000147822Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi99287.STM2104.

    Structurei

    Secondary structure

    1
    456
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 63
    Beta strandi9 – 168
    Turni17 – 193
    Helixi22 – 3615
    Beta strandi41 – 455
    Helixi51 – 6414
    Beta strandi68 – 747
    Helixi77 – 8610
    Beta strandi92 – 954
    Beta strandi104 – 1118
    Helixi123 – 13210
    Beta strandi140 – 1489
    Helixi152 – 16211
    Beta strandi167 – 1693
    Beta strandi171 – 1766
    Turni181 – 1855
    Helixi186 – 1938
    Beta strandi195 – 2017
    Beta strandi203 – 2064
    Helixi223 – 2264
    Helixi227 – 23610
    Beta strandi239 – 2446
    Beta strandi251 – 2555
    Helixi263 – 27715
    Beta strandi282 – 2854
    Helixi291 – 30010
    Beta strandi303 – 3064
    Helixi311 – 32111
    Beta strandi324 – 3274
    Beta strandi333 – 3353
    Helixi345 – 35713
    Turni362 – 3643
    Helixi365 – 3695
    Beta strandi379 – 3813
    Helixi388 – 3969
    Beta strandi401 – 4055
    Beta strandi407 – 4148
    Beta strandi417 – 4237
    Beta strandi425 – 4284
    Beta strandi430 – 4389
    Helixi439 – 45517

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1LLLmodel-A1-456[»]
    ProteinModelPortaliP26341.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phosphohexose mutase family.Curated

    Phylogenomic databases

    eggNOGiCOG1109.
    HOGENOMiHOG000268679.
    KOiK01840.
    OMAiVVGCDIR.
    OrthoDBiEOG6W9X55.
    PhylomeDBiP26341.

    Family and domain databases

    Gene3Di3.30.310.50. 1 hit.
    3.40.120.10. 3 hits.
    InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
    IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
    IPR005845. A-D-PHexomutase_a/b/a-II.
    IPR005846. A-D-PHexomutase_a/b/a-III.
    IPR005843. A-D-PHexomutase_C.
    IPR016066. A-D-PHexomutase_CS.
    IPR005841. Alpha-D-phosphohexomutase_SF.
    [Graphical view]
    PfamiPF02878. PGM_PMM_I. 1 hit.
    PF02879. PGM_PMM_II. 1 hit.
    PF02880. PGM_PMM_III. 1 hit.
    PF00408. PGM_PMM_IV. 1 hit.
    [Graphical view]
    PRINTSiPR00509. PGMPMM.
    SUPFAMiSSF53738. SSF53738. 3 hits.
    SSF55957. SSF55957. 1 hit.
    PROSITEiPS00710. PGM_PMM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P26341-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKLTCFKAY DIRGRLGEEL NEDIAWRIGR AYGEYLKPKT VVLGGDVRLT    50
    SEALKLALAK GLQDAGVDVL DIGMSGTEEI YFATFHLGVD GGIEVTASHN 100
    PMDYNGMKLV REGARPISGD TGLRDVQRLA EAGDFPPVNE AARGSYRQIS 150
    LRDAYIDHLL GYISVNNLTP LKLVFNAGNG AAGPVIDAIE ARLKALGAPV 200
    EFIKIHNTPD GTFPNGIPNP LLPECRDDTR KAVIEHGADM GIAFDGDFDR 250
    CFLFDEKGQF IEGYYIVGLL AEAFLEKHPG AKIIHDPRLT WNTEAVVTAA 300
    GGTPVMSKTG HAFIKERMRT EDAIYGGEMS AHHYFRDFAY CDSGMIPWLL 350
    VAELVCLKRQ SLGELVRDRM AAFPASGEIN SRLAEPAAAI ARVEAHFAEE 400
    AQAVDRTDGL SMSFADWRFN LRSSNTEPVV RLNVESRGDI PLMEARTRTL 450
    LALLNQ 456
    Length:456
    Mass (Da):50,002
    Last modified:January 23, 2002 - v2
    Checksum:i6E32422242AF2CE2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti55 – 562KL → NV in CAA42541. (PubMed:1712067)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59886 Genomic DNA. Translation: CAA42541.1.
    AE006468 Genomic DNA. Translation: AAL21008.1.
    PIRiS16291.
    RefSeqiNP_461049.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL21008; AAL21008; STM2104.
    GeneIDi1253625.
    KEGGistm:STM2104.
    PATRICi32382791. VBISalEnt20916_2226.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59886 Genomic DNA. Translation: CAA42541.1 .
    AE006468 Genomic DNA. Translation: AAL21008.1 .
    PIRi S16291.
    RefSeqi NP_461049.1. NC_003197.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1LLL model - A 1-456 [» ]
    ProteinModelPortali P26341.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM2104.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL21008 ; AAL21008 ; STM2104 .
    GeneIDi 1253625.
    KEGGi stm:STM2104.
    PATRICi 32382791. VBISalEnt20916_2226.

    Phylogenomic databases

    eggNOGi COG1109.
    HOGENOMi HOG000268679.
    KOi K01840.
    OMAi VVGCDIR.
    OrthoDBi EOG6W9X55.
    PhylomeDBi P26341.

    Enzyme and pathway databases

    UniPathwayi UPA00126 ; UER00424 .
    BioCyci SENT99287:GCTI-2116-MONOMER.

    Family and domain databases

    Gene3Di 3.30.310.50. 1 hit.
    3.40.120.10. 3 hits.
    InterProi IPR005844. A-D-PHexomutase_a/b/a-I.
    IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
    IPR005845. A-D-PHexomutase_a/b/a-II.
    IPR005846. A-D-PHexomutase_a/b/a-III.
    IPR005843. A-D-PHexomutase_C.
    IPR016066. A-D-PHexomutase_CS.
    IPR005841. Alpha-D-phosphohexomutase_SF.
    [Graphical view ]
    Pfami PF02878. PGM_PMM_I. 1 hit.
    PF02879. PGM_PMM_II. 1 hit.
    PF02880. PGM_PMM_III. 1 hit.
    PF00408. PGM_PMM_IV. 1 hit.
    [Graphical view ]
    PRINTSi PR00509. PGMPMM.
    SUPFAMi SSF53738. SSF53738. 3 hits.
    SSF55957. SSF55957. 1 hit.
    PROSITEi PS00710. PGM_PMM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The cps gene cluster of Salmonella strain LT2 includes a second mannose pathway: sequence of two genes and relationship to genes in the rfb gene cluster."
      Stevenson G., Lee S.J., Romana L.K., Reeves P.R.
      Mol. Gen. Genet. 227:173-180(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: LT2.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.
    3. "Structure of phosphomannomutase from Salmonella typhimurium."
      Sagajkar R., Muthuvel A., Reddy R.
      Submitted (APR-2003) to the PDB data bank
      Cited for: 3D-STRUCTURE MODELING.

    Entry informationi

    Entry nameiMANB_SALTY
    AccessioniPrimary (citable) accession number: P26341
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: January 23, 2002
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3