P26340 (MANC_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannose-1-phosphate guanylyltransferase manC
EC=2.7.7.13

Alternative name(s):
GDP-mannose pyrophosphorylase
Short name=GMP
Short name=GMPP

Gene names

Name:	manC
Synonyms:	cpsB
Ordered Locus Names:	STM2105

Organism

Salmonella typhimurium

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	480 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of the capsular polysaccharide colanic acid.
Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.
Sequence similarities	Belongs to the mannose-6-phosphate isomerase type 2 family.

Ontologies

Keywords
Biological process	Capsule biogenesis/degradation Lipopolysaccharide biosynthesis
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipopolysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 480	480	Mannose-1-phosphate guanylyltransferase manC		PRO_0000194257

Sequences

	Sequence		Length	Mass (Da)
	P26340 [UniParc]. Last modified May 1, 1992. Version 1. Checksum: C1F09C66B04CDBD6	FASTA	480	53,370
	10 20 30 40 50 60 MIMRQTKLYP VVMAGGSGSR LWPLSRVLYP KQFLCLKGDL TMLQTTICRL NGVECESPLV 70 80 90 100 110 120 ICNEQHRFIV AEQLRQLNKL TENIILEPAG RNTAPAIALA ALAATRQHTD CDPLMLVLAA 130 140 150 160 170 180 DHAIANEEAF RDAVRGAMPY ADAGKLVTFG IVPDLPETGY GYIRRGDVVP GATDAVAFEV 190 200 210 220 230 240 AQFVEKPGLE TAQAYVASGD YYWNSGMFLF RAGRYLEELK KFRPDILAAC EQAMRGVDPD 250 260 270 280 290 300 LDFIRVDEEA FLACPEESID YAVMERTADA VVMPMDAGWS DVGSWSSLWE ISAHTPEGNV 310 320 330 340 350 360 HHGDVISHKT ENSYVYAESG LVTTVGVKDL VVVQTKDAVL IADRHAVQDV KKVVEKIKAD 370 380 390 400 410 420 GRHEHHMHRE VYRPWGKYDS IDAGERYQVK RITVKPGEGL SVQMHHHRAE HWVVVAGTAR 430 440 450 460 470 480 VTINGEVKLL GENESIYIPL GATHCLENPG KIPLDLIEVR SGSYLEEDDV VRFEDRYGRV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The cps gene cluster of Salmonella strain LT2 includes a second mannose pathway: sequence of two genes and relationship to genes in the rfb gene cluster." Stevenson G., Lee S.J., Romana L.K., Reeves P.R. Mol. Gen. Genet. 227:173-180(1991) [PubMed: 1712067] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LT2.
[2]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X59886 Genomic DNA. Translation: CAA42540.1. AE006468 Genomic DNA. Translation: AAL21009.1.
PIR	S16290.
3D structure databases
ProteinModelPortal	P26340.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GenomeReviews	Gene locus STM2105 in contig AE006468_GR.
NMPDR	fig|99287.1.peg.2030.
PATRIC	32382793. VBISalEnt20916_2227.
Phylogenomic databases
HOGENOM	HBG422488.
OMA	HHIHREV.
ProtClustDB	PRK15460.
Enzyme and pathway databases
BioCyc	STYP99287:STM2105-MONOMER.
Family and domain databases
InterPro	IPR011051. Cupin_RmlC_type. IPR006375. Man1P_GuaTrfase/Man6P_Isoase. IPR001538. Man6P_isomerase-2_C. IPR005835. NTP_transferase. IPR014710. RmlC-like_jellyroll. [Graphical view]
Gene3D	G3DSA:2.60.120.10. RmlC-like_jellyroll. 1 hit.
Pfam	PF01050. MannoseP_isomer. 1 hit. PF00483. NTP_transferase. 1 hit. [Graphical view]
SUPFAM	SSF51182. RmlC_like_cupin. 1 hit.
TIGRFAMs	TIGR01479. GMP_PMI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MANC_SALTY

Accession

Primary (citable) accession number: P26340

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	May 1, 1992
Last modified:	January 25, 2012
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program