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P26339 (CMGA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chromogranin-A

Short name=CgA

Cleaved into the following 3 chains:

  1. Pancreastatin
  2. Beta-granin
  3. WE-14
Gene names
Name:Chga
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length463 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.

Subunit structure

Interacts with SCG3; this interaction is optimal in conditions mimicking the lumenal milieu of the trans-Golgi network, i.e. pH 5.5 and 10 mM Ca(+2). Ref.3

Subcellular location

Cytoplasmic vesiclesecretory vesicle. Cytoplasmic vesiclesecretory vesicle membrane. Secreted. Note: Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions. Ref.3

Post-translational modification

CgA is O-glycosylated.

Miscellaneous

Binds calcium with a low-affinity.

Sequence similarities

Belongs to the chromogranin/secretogranin protein family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SOD1P004415EBI-990900,EBI-990792From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818
Chain19 – 463445Chromogranin-A
PRO_0000005422
Peptide19 – 151133Beta-granin By similarity
PRO_0000005423
Peptide276 – 32954Pancreastatin By similarity
PRO_0000005424
Peptide358 – 37114WE-14 By similarity
PRO_0000005425

Regions

Compositional bias103 – 11614Poly-Gln
Compositional bias236 – 24510Poly-Glu
Compositional bias340 – 3478Poly-Glu

Amino acid modifications

Modified residue1191Phosphoserine By similarity
Modified residue2201Phosphoserine By similarity
Modified residue3081Phosphoserine By similarity
Modified residue3291Glycine amide Probable
Modified residue3501Phosphoserine By similarity
Modified residue4101Phosphoserine By similarity
Modified residue4141Phosphoserine By similarity
Disulfide bond35 ↔ 56 By similarity

Sequences

Sequence LengthMass (Da)Tools
P26339 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 1AB3C5FF433C39E4

FASTA46351,789
        10         20         30         40         50         60 
MRSTAVLALL LCAGQVFALP VNSPMTKGDT KVMKCVLEVI SDSLSKPSPM PVSPECLETL 

        70         80         90        100        110        120 
QGDERILSIL RHQNLLKELQ DLALQGAKER AQQPLKQQQP PKQQQQQQQQ QQQEQQHSSF 

       130        140        150        160        170        180 
EDELSEVFEN QSPDAKHRDA AAEVPSRDTM EKRKDSDKGQ QDGFEATTEG PRPQAFPEPN 

       190        200        210        220        230        240 
QESPMMGDSE SPGEDTATNT QSPTSLPSQE HVDPQATGDS ERGLSAQQQA RKAKQEEKEE 

       250        260        270        280        290        300 
EEEEEAVARE KAGPEEVPTA ASSSHFHAGY KAIQKDDGQS DSQAVDGDGK TEASEALPSE 

       310        320        330        340        350        360 
GKGELEHSQQ EEDGEEAMVG TPQGLFPQGG KGRELEHKQE EEEEEEERLS REWEDKRWSR 

       370        380        390        400        410        420 
MDQLAKELTA EKRLEGEDDP DRSMKLSFRT RAYGFRDPGP QLRRGWRPSS REDSVEARSD 

       430        440        450        460 
FEEKKEEEGS ANRRAEDQEL ESLSAIEAEL EKVAHQLQAL RRG 

« Hide

References

« Hide 'large scale' references
[1]"Structure and function of the chromogranin A gene. Clues to evolution and tissue-specific expression."
Wu H.J., Rozansky D.J., Parmer R.J., Gill B.M., O'Connor D.T.
J. Biol. Chem. 266:13130-13134(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon.
[3]"Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells."
Hosaka M., Watanabe T., Sakai Y., Uchiyama Y., Takeuchi T.
Mol. Biol. Cell 13:3388-3399(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SCG3, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M64278 mRNA. Translation: AAA37457.1.
BC026554 mRNA. Translation: AAH26554.1.
CCDSCCDS26120.1.
PIRA39868.
RefSeqNP_031719.1. NM_007693.1.
UniGeneMm.4137.

3D structure databases

ProteinModelPortalP26339.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP26339. 3 interactions.
STRING10090.ENSMUSP00000021610.

PTM databases

PhosphoSiteP26339.

Proteomic databases

MaxQBP26339.
PaxDbP26339.
PRIDEP26339.

Protocols and materials databases

DNASU12652.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021610; ENSMUSP00000021610; ENSMUSG00000021194.
GeneID12652.
KEGGmmu:12652.
UCSCuc007oui.1. mouse.

Organism-specific databases

CTD1113.
MGIMGI:88394. Chga.

Phylogenomic databases

eggNOGNOG41926.
GeneTreeENSGT00730000111266.
HOGENOMHOG000111808.
HOVERGENHBG001272.
InParanoidP26339.
OMAVNSPMNK.
OrthoDBEOG7V766Z.
PhylomeDBP26339.
TreeFamTF336596.

Gene expression databases

BgeeP26339.
CleanExMM_CHGA.
GenevestigatorP26339.

Family and domain databases

InterProIPR001819. Chromogranin_AB.
IPR018054. Chromogranin_CS.
IPR001990. Granin.
[Graphical view]
PANTHERPTHR10583. PTHR10583. 1 hit.
PfamPF01271. Granin. 2 hits.
[Graphical view]
PRINTSPR00659. CHROMOGRANIN.
PROSITEPS00422. GRANINS_1. 1 hit.
PS00423. GRANINS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio281864.
PROP26339.
SOURCESearch...

Entry information

Entry nameCMGA_MOUSE
AccessionPrimary (citable) accession number: P26339
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot