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Protein

Chromogranin-A

Gene

Chga

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas.
Catestatin: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines.By similarity
Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation (PubMed:21436258). Pyroglutaminated (pGlu)-serpinin exerts an antiapoptotic effect on cells exposed to oxidative stress (PubMed:21537909).2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-MMU-6803157. Antimicrobial peptides.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromogranin-A
Short name:
CgA
Cleaved into the following 8 chains:
Serpinin2 Publications
Alternative name(s):
AL261 Publication
p-Glu serpinin precursor1 Publication
Gene namesi
Name:Chga
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:88394. Chga.

Subcellular locationi

Serpinin :

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000000542219 – 463Chromogranin-AAdd BLAST445
PeptideiPRO_000000542319 – 151Beta-graninBy similarityAdd BLAST133
PeptideiPRO_0000005424276 – 329PancreastatinBy similarityAdd BLAST54
PeptideiPRO_0000005425358 – 371WE-14By similarityAdd BLAST14
PeptideiPRO_0000432687382 – 402CatestatinBy similarityAdd BLAST21
PeptideiPRO_0000432688405 – 423GE-25By similarityAdd BLAST19
PeptideiPRO_0000432689435 – 463Serpinin-RRGBy similarityAdd BLAST29
PeptideiPRO_0000432690435 – 460Serpinin2 PublicationsAdd BLAST26
PeptideiPRO_0000432691438 – 460p-Glu serpinin precursor1 PublicationAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 56By similarity
Modified residuei119PhosphoserineBy similarity1
Modified residuei220PhosphoserineBy similarity1
Modified residuei282PhosphoserineCombined sources1
Modified residuei308PhosphoserineBy similarity1
Modified residuei329Glycine amideCurated1
Modified residuei350PhosphoserineBy similarity1
Modified residuei383PhosphoserineBy similarity1
Modified residuei384Methionine sulfoxideBy similarity1
Modified residuei410PhosphoserineBy similarity1
Modified residuei414PhosphoserineBy similarity1
Modified residuei430PhosphoserineBy similarity1
Modified residuei438Pyrrolidone carboxylic acid1 Publication1
Modified residuei444PhosphoserineBy similarity1

Post-translational modificationi

CgA is O-glycosylated.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Oxidation, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiP26339.
PaxDbiP26339.
PeptideAtlasiP26339.
PRIDEiP26339.

PTM databases

iPTMnetiP26339.
PhosphoSitePlusiP26339.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021194.
CleanExiMM_CHGA.
GenevisibleiP26339. MM.

Interactioni

Subunit structurei

Interacts with SCG3; this interaction is optimal in conditions mimicking the lumenal milieu of the trans-Golgi network, i.e. pH 5.5 and 10 mM Ca(+2).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SOD1P004415EBI-990900,EBI-990792From a different organism.

Protein-protein interaction databases

IntActiP26339. 3 interactors.
STRINGi10090.ENSMUSP00000021610.

Structurei

3D structure databases

ProteinModelPortaliP26339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi103 – 116Poly-GlnAdd BLAST14
Compositional biasi236 – 245Poly-Glu10
Compositional biasi340 – 347Poly-Glu8

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II3Z. Eukaryota.
ENOG410YGBX. LUCA.
GeneTreeiENSGT00730000111266.
HOGENOMiHOG000111808.
HOVERGENiHBG001272.
InParanoidiP26339.
KOiK19990.
OMAiVNSPMNK.
OrthoDBiEOG091G0I4D.
PhylomeDBiP26339.
TreeFamiTF336596.

Family and domain databases

InterProiIPR001819. Chromogranin_AB.
IPR018054. Chromogranin_CS.
IPR001990. Granin.
[Graphical view]
PANTHERiPTHR10583. PTHR10583. 1 hit.
PfamiPF01271. Granin. 2 hits.
[Graphical view]
PRINTSiPR00659. CHROMOGRANIN.
PROSITEiPS00422. GRANINS_1. 1 hit.
PS00423. GRANINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26339-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSTAVLALL LCAGQVFALP VNSPMTKGDT KVMKCVLEVI SDSLSKPSPM
60 70 80 90 100
PVSPECLETL QGDERILSIL RHQNLLKELQ DLALQGAKER AQQPLKQQQP
110 120 130 140 150
PKQQQQQQQQ QQQEQQHSSF EDELSEVFEN QSPDAKHRDA AAEVPSRDTM
160 170 180 190 200
EKRKDSDKGQ QDGFEATTEG PRPQAFPEPN QESPMMGDSE SPGEDTATNT
210 220 230 240 250
QSPTSLPSQE HVDPQATGDS ERGLSAQQQA RKAKQEEKEE EEEEEAVARE
260 270 280 290 300
KAGPEEVPTA ASSSHFHAGY KAIQKDDGQS DSQAVDGDGK TEASEALPSE
310 320 330 340 350
GKGELEHSQQ EEDGEEAMVG TPQGLFPQGG KGRELEHKQE EEEEEEERLS
360 370 380 390 400
REWEDKRWSR MDQLAKELTA EKRLEGEDDP DRSMKLSFRT RAYGFRDPGP
410 420 430 440 450
QLRRGWRPSS REDSVEARSD FEEKKEEEGS ANRRAEDQEL ESLSAIEAEL
460
EKVAHQLQAL RRG
Length:463
Mass (Da):51,789
Last modified:May 1, 1992 - v1
Checksum:i1AB3C5FF433C39E4
GO

Mass spectrometryi

Molecular mass is 3020.6 Da from positions 434 - 460. Determined by MALDI. 1 Publication
Molecular mass is 2864.4 Da from positions 435 - 460. Determined by MALDI. 1 Publication
Molecular mass is 2864.5 Da from positions 435 - 460. Determined by MALDI. 1 Publication
Molecular mass is 2644.4 Da from positions 437 - 460. Determined by MALDI. 1 Publication
Molecular mass is 2532.4 Da from positions 438 - 460. Determined by MALDI. With pyrrolidone carboxylic acid at Gln-438.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64278 mRNA. Translation: AAA37457.1.
BC026554 mRNA. Translation: AAH26554.1.
CCDSiCCDS26120.1.
PIRiA39868.
RefSeqiNP_031719.1. NM_007693.2.
UniGeneiMm.4137.

Genome annotation databases

EnsembliENSMUST00000021610; ENSMUSP00000021610; ENSMUSG00000021194.
GeneIDi12652.
KEGGimmu:12652.
UCSCiuc007oui.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64278 mRNA. Translation: AAA37457.1.
BC026554 mRNA. Translation: AAH26554.1.
CCDSiCCDS26120.1.
PIRiA39868.
RefSeqiNP_031719.1. NM_007693.2.
UniGeneiMm.4137.

3D structure databases

ProteinModelPortaliP26339.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP26339. 3 interactors.
STRINGi10090.ENSMUSP00000021610.

PTM databases

iPTMnetiP26339.
PhosphoSitePlusiP26339.

Proteomic databases

MaxQBiP26339.
PaxDbiP26339.
PeptideAtlasiP26339.
PRIDEiP26339.

Protocols and materials databases

DNASUi12652.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021610; ENSMUSP00000021610; ENSMUSG00000021194.
GeneIDi12652.
KEGGimmu:12652.
UCSCiuc007oui.1. mouse.

Organism-specific databases

CTDi1113.
MGIiMGI:88394. Chga.

Phylogenomic databases

eggNOGiENOG410II3Z. Eukaryota.
ENOG410YGBX. LUCA.
GeneTreeiENSGT00730000111266.
HOGENOMiHOG000111808.
HOVERGENiHBG001272.
InParanoidiP26339.
KOiK19990.
OMAiVNSPMNK.
OrthoDBiEOG091G0I4D.
PhylomeDBiP26339.
TreeFamiTF336596.

Enzyme and pathway databases

ReactomeiR-MMU-6803157. Antimicrobial peptides.

Miscellaneous databases

PROiP26339.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021194.
CleanExiMM_CHGA.
GenevisibleiP26339. MM.

Family and domain databases

InterProiIPR001819. Chromogranin_AB.
IPR018054. Chromogranin_CS.
IPR001990. Granin.
[Graphical view]
PANTHERiPTHR10583. PTHR10583. 1 hit.
PfamiPF01271. Granin. 2 hits.
[Graphical view]
PRINTSiPR00659. CHROMOGRANIN.
PROSITEiPS00422. GRANINS_1. 1 hit.
PS00423. GRANINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCMGA_MOUSE
AccessioniPrimary (citable) accession number: P26339
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds calcium with a low-affinity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.