Reviewed, UniProtKB/Swiss-Prot P26338 (CYAA_TRYEQ)

Names and origin

Protein names

Recommended name:
    Receptor-type adenylate cyclase
    EC=4.6.1.1
Alternative name(s):
    ATP pyrophosphate-lyase
    Adenylyl cyclase

Gene names

Name:

ESAG4C

Organism

Trypanosoma equiperdum

Taxonomic identifier

5694 [NCBI]

Taxonomic lineage

Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma

Protein attributes

Sequence length	469 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Could act as a receptor for a unknown ligand.
Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the adenylyl cyclase class-3 family. Contains 1 guanylate cyclase domain.

Ontologies

Keywords
Biological process	cAMP biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Lyase Receptor
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	cAMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW intracellular signaling cascade Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate cyclase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 469	›469	Receptor-type adenylate cyclase		PRO_0000195741
Regions
	Topological domain	‹1 – 59	›59	Extracellular Potential
	Transmembrane	60 – 80	21	Potential
	Topological domain	81 – 469	389	Cytoplasmic Potential
	Domain	103 – 257	155	Guanylate cyclase
Sites
	Metal binding	108	1	Magnesium By similarity
	Metal binding	151	1	Magnesium By similarity
Amino acid modifications
	Glycosylation	31	1	N-linked (GlcNAc...) Potential
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P26338-1 [UniParc]. Last modified May 1, 1992. Version 1. Checksum: F87638C3152DEA3A	FASTA	469	50,819
	10 20 30 40 50 60 VDTAEKLSKN GCASNYGATQ ISVWSMARAL NASIPPLTNP MTPSMTFRNS NAGRISGVAL 70 80 90 100 110 120 VGVIIGGALA LFLVVALGVV PYFFLHNTRD NNLAPKELTD PVTLIFTDIE SSTALWAAHP 130 140 150 160 170 180 ELMPDAVATH HRLIRSLIGR YGCYEVKTVG DSFMIASKSP FAAVQLAQEL QLCFLHHDWG 190 200 210 220 230 240 TNAIDESYQQ LEQQRAEEDA KYTPPTARLD LKVYSRLWNG LRVRVGIHTG LCDIRRDEVT 250 260 270 280 290 300 KGYDYYGRTS NMAARTESVG NGGQVLMTTA AYMSLSAEER EQIDVTALGD VPLRGVAKPV 310 320 330 340 350 360 EMYQLNAVPG RTFAGLRLEH ELLNDDEDQT TTSCSDHSSS RTDLSVAAQT IAASLQSLLG 370 380 390 400 410 420 TFTPAQRQKA LIPFCERWRV PLPQKVGNVW DNDGCQEAIR RVAAKVGRVM DFGTRKASSS 430 440 450 460 VTSLERGGSL FSAGGATVAT VASSSNFSCV DGRCGTVQLI DLENDSTTS

References

[1]

"The trypanosome VSG expression site encodes adenylate cyclase and a leucine-rich putative regulatory gene." Ross D.T., Raibaud A., Florent I.C., Sather S., Gross M.K., Storm D.R., Eisen H. EMBO J. 10:2047-2053(1991) [PubMed: 2065652] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: CL.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X59386 Genomic DNA. Translation: CAA42029.1.
PIR	S16359.
3D structure databases
HSSP	HSSP built from PDB template 1FX2 based on UniProtKB Q99279.
SMR	P26338. Positions 90-324.
ModBase	Search...
Enzyme and pathway databases
BRENDA	4.6.1.1. 2307.
Family and domain databases
InterPro	IPR001054. A/G_cyclase. [Graphical view]
Gene3D	G3DSA:3.30.70.1230. A/G_cyclase. 1 hit.
Pfam	PF00211. Guanylate_cyc. 1 hit. [Graphical view]
SMART	SM00044. CYCc. 1 hit. [Graphical view]
PROSITE	PS50125. GUANYLATE_CYCLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYAA_TRYEQ

Accession

Primary (citable) accession number: P26338

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	May 1, 1992
Last modified:	June 16, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)