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Protein

Alcohol dehydrogenase 1

Gene
N/A
Organism
Gadus morhua subsp. callarias (Baltic cod) (Gadus callarias)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi46 – 461Zinc 1; catalytic
Metal bindingi68 – 681Zinc 1; catalytic
Metal bindingi98 – 981Zinc 2
Metal bindingi101 – 1011Zinc 2
Metal bindingi104 – 1041Zinc 2
Metal bindingi112 – 1121Zinc 2
Metal bindingi175 – 1751Zinc 1; catalytic
Binding sitei224 – 2241NAD
Binding sitei229 – 2291NAD
Binding sitei369 – 3691NAD

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi200 – 2056NAD
Nucleotide bindingi293 – 2953NAD

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
OrganismiGadus morhua subsp. callarias (Baltic cod) (Gadus callarias)
Taxonomic identifieri8053 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataZeiogadariaGadariaeGadiformesGadoideiGadidaeGadus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Alcohol dehydrogenase 1PRO_0000160679Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Homodimer.

Structurei

Secondary structure

1
375
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 148Combined sources
Beta strandi22 – 287Combined sources
Beta strandi35 – 4410Combined sources
Helixi47 – 548Combined sources
Beta strandi63 – 653Combined sources
Beta strandi70 – 778Combined sources
Beta strandi89 – 924Combined sources
Beta strandi99 – 1013Combined sources
Helixi102 – 1054Combined sources
Helixi116 – 1183Combined sources
Turni121 – 1244Combined sources
Beta strandi131 – 1333Combined sources
Beta strandi136 – 1405Combined sources
Helixi141 – 1433Combined sources
Beta strandi147 – 1548Combined sources
Helixi155 – 1573Combined sources
Beta strandi158 – 1603Combined sources
Helixi167 – 1704Combined sources
Helixi171 – 1744Combined sources
Helixi176 – 18510Combined sources
Turni186 – 1883Combined sources
Beta strandi195 – 1995Combined sources
Helixi203 – 21412Combined sources
Beta strandi218 – 2236Combined sources
Helixi227 – 2293Combined sources
Helixi230 – 2356Combined sources
Beta strandi240 – 2423Combined sources
Helixi244 – 2463Combined sources
Helixi251 – 2599Combined sources
Beta strandi263 – 2686Combined sources
Helixi273 – 2819Combined sources
Turni285 – 2873Combined sources
Beta strandi289 – 2924Combined sources
Beta strandi297 – 2993Combined sources
Beta strandi301 – 3033Combined sources
Helixi305 – 3095Combined sources
Beta strandi313 – 3164Combined sources
Helixi319 – 3213Combined sources
Helixi324 – 33613Combined sources
Helixi343 – 3453Combined sources
Beta strandi346 – 3516Combined sources
Helixi352 – 3543Combined sources
Helixi355 – 3639Combined sources
Beta strandi368 – 3736Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CDOX-ray2.05A/B1-374[»]
ProteinModelPortaliP26325.
SMRiP26325. Positions 1-374.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26325.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG000195.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 2 hits.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ATVGKVIKCK AAVAWEANKP LVIEEIEVDV PHANEIRIKI IATGVCHTDL
60 70 80 90 100
YHLFEGKHKD GFPVVLGHEG AGIVESVGPG VTEFQPGEKV IPLFISQCGE
110 120 130 140 150
CRFCQSPKTN QCVKGWANES PDVMSPKETR FTCKGRKVLQ FLGTSTFSQY
160 170 180 190 200
TVVNQIAVAK IDPSAPLDTV CLLGCGVSTG FGAAVNTAKV EPGSTCAVFG
210 220 230 240 250
LGAVGLAAVM GCHSAGAKRI IAVDLNPDKF EKAKVFGATD FVNPNDHSEP
260 270 280 290 300
ISQVLSKMTN GGVDFSLECV GNVGVMRNAL ESCLKGWGVS VLVGWTDLHD
310 320 330 340 350
VATRPIQLIA GRTWKGSMFG GFKGKDGVPK MVKAYLDKKV KLDEFITHRM
360 370
PLESVNDAID LMKHGKCIRT VLSLE
Length:375
Mass (Da):40,128
Last modified:May 1, 1992 - v1
Checksum:i0A8BDEAA0C9BCEAD
GO

Sequence databases

PIRiA42343.

Cross-referencesi

Sequence databases

PIRiA42343.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CDOX-ray2.05A/B1-374[»]
ProteinModelPortaliP26325.
SMRiP26325. Positions 1-374.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000195.

Miscellaneous databases

EvolutionaryTraceiP26325.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 2 hits.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADH1_GADMC
AccessioniPrimary (citable) accession number: P26325
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 11, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Functionally related to class-I mammalian enzymes, but structurally related to class-III.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.