Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P26323

- FLI1_MOUSE

UniProt

P26323 - FLI1_MOUSE

Protein

Friend leukemia integration 1 transcription factor

Gene

Fli1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi281 – 36181ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    4. RNA polymerase II distal enhancer sequence-specific DNA binding Source: MGI
    5. sequence-specific DNA binding Source: MGI
    6. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

    GO - Biological processi

    1. blood circulation Source: MGI
    2. cellular process Source: MGI
    3. megakaryocyte development Source: MGI
    4. organ morphogenesis Source: MGI
    5. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    6. regulation of transcription, DNA-templated Source: MGI
    7. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    8. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Friend leukemia integration 1 transcription factor
    Alternative name(s):
    Retroviral integration site protein Fli-1
    Gene namesi
    Name:Fli1
    Synonyms:Fli-1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:95554. Fli1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Involved in erythroleukemia induction by Friend murine leukemia virus (F-MULV).

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 452452Friend leukemia integration 1 transcription factorPRO_0000204125Add
    BLAST

    Proteomic databases

    MaxQBiP26323.
    PaxDbiP26323.
    PRIDEiP26323.

    PTM databases

    PhosphoSiteiP26323.

    Miscellaneous databases

    PMAP-CutDBP26323.

    Expressioni

    Tissue specificityi

    Expressed in both hematopoietic and nonhematopoietic tissues.

    Inductioni

    Specifically up-regulated in leukemic clones with F-MuLV insertions up-stream of the FLI-1 locus.

    Gene expression databases

    ArrayExpressiP26323.
    BgeeiP26323.
    CleanExiMM_FLI1.
    GenevestigatoriP26323.

    Interactioni

    Subunit structurei

    Can form homodimers or heterodimers with ETV6/TEL1.By similarity

    Protein-protein interaction databases

    BioGridi199702. 1 interaction.
    IntActiP26323. 2 interactions.
    MINTiMINT-1578124.

    Structurei

    3D structure databases

    ProteinModelPortaliP26323.
    SMRiP26323. Positions 114-254, 276-373.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini112 – 19887PNTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ETS family.Curated
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG242679.
    HOGENOMiHOG000290658.
    HOVERGENiHBG001553.
    InParanoidiP26323.
    KOiK09436.
    OMAiKNGPPPN.
    OrthoDBiEOG73V6K8.
    PhylomeDBiP26323.
    TreeFamiTF350537.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00178. Ets. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view]
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P26323-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGTIKEALS VVSDDQSLFD SAYGAAAHLP KADMTASGSP DYGQPHKINP    50
    LPPQQEWINQ PVRVNVKREY DHMNGSRESP VDCSVSKCNK LVGGGEANPM 100
    NYNSYMDEKN GPPPPNMTTN ERRVIVPADP TLWTQEHVRQ WLEWAIKEYG 150
    LMEIDTSFFQ NMDGKELCKM NKEDFLRATS AYNTEVLLSH LSYLRESSLL 200
    AYNTTSHTDQ SSRLNVKEDP SYDSVRRGAW NNNMNSGLNK SPLLGGSQTM 250
    GKNTEQRPQP DPYQILGPTS SRLANPGSGQ IQLWQFLLEL LSDSANASCI 300
    TWEGTNGEFK MTDPDEVARR WGERKSKPNM NYDKLSRALR YYYDKNIMTK 350
    VHGKRYAYKF DFHGIAQALQ PHPTETSMYK YPSDISYMPS YHAHQQKVNF 400
    VPSHPSSMPV TSSSFFGAAS QYWTSPTAGI YPNPSVPRHP NTHVPSHLGS 450
    YY 452
    Length:452
    Mass (Da):51,002
    Last modified:May 1, 1992 - v1
    Checksum:i1F9A06C6893FE2AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59421 mRNA. Translation: CAA42055.1.
    CCDSiCCDS40571.1.
    PIRiS17403.
    RefSeqiNP_032052.1. NM_008026.4.
    UniGeneiMm.258908.

    Genome annotation databases

    EnsembliENSMUST00000016231; ENSMUSP00000016231; ENSMUSG00000016087.
    GeneIDi14247.
    KEGGimmu:14247.
    UCSCiuc009orz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59421 mRNA. Translation: CAA42055.1 .
    CCDSi CCDS40571.1.
    PIRi S17403.
    RefSeqi NP_032052.1. NM_008026.4.
    UniGenei Mm.258908.

    3D structure databases

    ProteinModelPortali P26323.
    SMRi P26323. Positions 114-254, 276-373.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199702. 1 interaction.
    IntActi P26323. 2 interactions.
    MINTi MINT-1578124.

    PTM databases

    PhosphoSitei P26323.

    Proteomic databases

    MaxQBi P26323.
    PaxDbi P26323.
    PRIDEi P26323.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000016231 ; ENSMUSP00000016231 ; ENSMUSG00000016087 .
    GeneIDi 14247.
    KEGGi mmu:14247.
    UCSCi uc009orz.1. mouse.

    Organism-specific databases

    CTDi 2313.
    MGIi MGI:95554. Fli1.

    Phylogenomic databases

    eggNOGi NOG242679.
    HOGENOMi HOG000290658.
    HOVERGENi HBG001553.
    InParanoidi P26323.
    KOi K09436.
    OMAi KNGPPPN.
    OrthoDBi EOG73V6K8.
    PhylomeDBi P26323.
    TreeFami TF350537.

    Miscellaneous databases

    ChiTaRSi FLI1. mouse.
    NextBioi 285561.
    PMAP-CutDB P26323.
    PROi P26323.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P26323.
    Bgeei P26323.
    CleanExi MM_FLI1.
    Genevestigatori P26323.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00178. Ets. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view ]
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Erythroleukemia induction by Friend murine leukemia virus: insertional activation of a new member of the ets gene family, Fli-1, closely linked to c-ets-1."
      Ben-David Y., Giddens E.B., Letwin K., Bernstein A.
      Genes Dev. 5:908-918(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Spleen.
    2. "The Fli-1 proto-oncogene, involved in erythroleukemia and Ewing's sarcoma, encodes a transcriptional activator with DNA-binding specificities distinct from other Ets family members."
      Zhang L., Lemarchandel V., Romeo P.-H., Ben-David Y., Greer P., Bernstein A.
      Oncogene 8:1621-1630(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.

    Entry informationi

    Entry nameiFLI1_MOUSE
    AccessioniPrimary (citable) accession number: P26323
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3