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Protein

Friend leukemia integration 1 transcription factor

Gene

Fli1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi281 – 36181ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  4. RNA polymerase II distal enhancer sequence-specific DNA binding Source: MGI
  5. sequence-specific DNA binding Source: MGI
  6. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: GO_Central

GO - Biological processi

  1. blood circulation Source: MGI
  2. cellular process Source: MGI
  3. megakaryocyte development Source: MGI
  4. organ morphogenesis Source: MGI
  5. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  6. regulation of transcription, DNA-templated Source: MGI
  7. regulation of transcription from RNA polymerase II promoter Source: GO_Central
  8. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Friend leukemia integration 1 transcription factor
Alternative name(s):
Retroviral integration site protein Fli-1
Gene namesi
Name:Fli1
Synonyms:Fli-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:95554. Fli1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Involved in erythroleukemia induction by Friend murine leukemia virus (F-MULV).

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Friend leukemia integration 1 transcription factorPRO_0000204125Add
BLAST

Proteomic databases

MaxQBiP26323.
PaxDbiP26323.
PRIDEiP26323.

PTM databases

PhosphoSiteiP26323.

Miscellaneous databases

PMAP-CutDBP26323.

Expressioni

Tissue specificityi

Expressed in both hematopoietic and nonhematopoietic tissues.

Inductioni

Specifically up-regulated in leukemic clones with F-MuLV insertions up-stream of the FLI-1 locus.

Gene expression databases

BgeeiP26323.
CleanExiMM_FLI1.
ExpressionAtlasiP26323. baseline and differential.
GenevestigatoriP26323.

Interactioni

Subunit structurei

Can form homodimers or heterodimers with ETV6/TEL1.By similarity

Protein-protein interaction databases

BioGridi199702. 1 interaction.
IntActiP26323. 2 interactions.
MINTiMINT-1578124.

Structurei

3D structure databases

ProteinModelPortaliP26323.
SMRiP26323. Positions 114-254, 276-373.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini112 – 19887PNTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG242679.
HOGENOMiHOG000290658.
HOVERGENiHBG001553.
InParanoidiP26323.
KOiK09436.
OMAiKNGPPPN.
OrthoDBiEOG73V6K8.
PhylomeDBiP26323.
TreeFamiTF350537.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26323-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGTIKEALS VVSDDQSLFD SAYGAAAHLP KADMTASGSP DYGQPHKINP
60 70 80 90 100
LPPQQEWINQ PVRVNVKREY DHMNGSRESP VDCSVSKCNK LVGGGEANPM
110 120 130 140 150
NYNSYMDEKN GPPPPNMTTN ERRVIVPADP TLWTQEHVRQ WLEWAIKEYG
160 170 180 190 200
LMEIDTSFFQ NMDGKELCKM NKEDFLRATS AYNTEVLLSH LSYLRESSLL
210 220 230 240 250
AYNTTSHTDQ SSRLNVKEDP SYDSVRRGAW NNNMNSGLNK SPLLGGSQTM
260 270 280 290 300
GKNTEQRPQP DPYQILGPTS SRLANPGSGQ IQLWQFLLEL LSDSANASCI
310 320 330 340 350
TWEGTNGEFK MTDPDEVARR WGERKSKPNM NYDKLSRALR YYYDKNIMTK
360 370 380 390 400
VHGKRYAYKF DFHGIAQALQ PHPTETSMYK YPSDISYMPS YHAHQQKVNF
410 420 430 440 450
VPSHPSSMPV TSSSFFGAAS QYWTSPTAGI YPNPSVPRHP NTHVPSHLGS

YY
Length:452
Mass (Da):51,002
Last modified:May 1, 1992 - v1
Checksum:i1F9A06C6893FE2AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59421 mRNA. Translation: CAA42055.1.
CCDSiCCDS40571.1.
PIRiS17403.
RefSeqiNP_032052.1. NM_008026.5.
UniGeneiMm.258908.

Genome annotation databases

EnsembliENSMUST00000016231; ENSMUSP00000016231; ENSMUSG00000016087.
GeneIDi14247.
KEGGimmu:14247.
UCSCiuc009orz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59421 mRNA. Translation: CAA42055.1.
CCDSiCCDS40571.1.
PIRiS17403.
RefSeqiNP_032052.1. NM_008026.5.
UniGeneiMm.258908.

3D structure databases

ProteinModelPortaliP26323.
SMRiP26323. Positions 114-254, 276-373.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199702. 1 interaction.
IntActiP26323. 2 interactions.
MINTiMINT-1578124.

PTM databases

PhosphoSiteiP26323.

Proteomic databases

MaxQBiP26323.
PaxDbiP26323.
PRIDEiP26323.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000016231; ENSMUSP00000016231; ENSMUSG00000016087.
GeneIDi14247.
KEGGimmu:14247.
UCSCiuc009orz.1. mouse.

Organism-specific databases

CTDi2313.
MGIiMGI:95554. Fli1.

Phylogenomic databases

eggNOGiNOG242679.
HOGENOMiHOG000290658.
HOVERGENiHBG001553.
InParanoidiP26323.
KOiK09436.
OMAiKNGPPPN.
OrthoDBiEOG73V6K8.
PhylomeDBiP26323.
TreeFamiTF350537.

Miscellaneous databases

ChiTaRSiFli1. mouse.
NextBioi285561.
PMAP-CutDBP26323.
PROiP26323.
SOURCEiSearch...

Gene expression databases

BgeeiP26323.
CleanExiMM_FLI1.
ExpressionAtlasiP26323. baseline and differential.
GenevestigatoriP26323.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Erythroleukemia induction by Friend murine leukemia virus: insertional activation of a new member of the ets gene family, Fli-1, closely linked to c-ets-1."
    Ben-David Y., Giddens E.B., Letwin K., Bernstein A.
    Genes Dev. 5:908-918(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Spleen.
  2. "The Fli-1 proto-oncogene, involved in erythroleukemia and Ewing's sarcoma, encodes a transcriptional activator with DNA-binding specificities distinct from other Ets family members."
    Zhang L., Lemarchandel V., Romeo P.-H., Ben-David Y., Greer P., Bernstein A.
    Oncogene 8:1621-1630(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiFLI1_MOUSE
AccessioniPrimary (citable) accession number: P26323
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: February 4, 2015
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.