Friend leukemia integration 1 transcription factor

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P26323 (FLI1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 119. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Friend leukemia integration 1 transcription factor

Alternative name(s):
Retroviral integration site protein Fli-1

Gene names

Name:	Fli1
Synonyms:	Fli-1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	452 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.
Subunit structure	Can form homodimers or heterodimers with ETV6/TEL1 By similarity.
Subcellular location	Nucleus.
Tissue specificity	Expressed in both hematopoietic and nonhematopoietic tissues.
Induction	Specifically up-regulated in leukemic clones with F-MuLV insertions up-stream of the FLI-1 locus.
Involvement in disease	Involved in erythroleukemia induction by Friend murine leukemia virus (F-MULV).
Sequence similarities	Belongs to the ETS family. Contains 1 ETS DNA-binding domain. Contains 1 PNT (pointed) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Disease	Proto-oncogene
Ligand	DNA-binding
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	blood circulation Inferred from mutant phenotype PubMed 10981960. Source: MGI megakaryocyte development Inferred from mutant phenotype PubMed 16757682. Source: MGI organ morphogenesis Inferred from mutant phenotype PubMed 10981960. Source: MGI regulation of transcription, DNA-dependent Inferred from mutant phenotype PubMed 10981960. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from direct assay PubMed 12527908. Source: MGI
Molecular_function	RNA polymerase II distal enhancer sequence-specific DNA binding Inferred from direct assay PubMed 17962413. Source: MGI chromatin binding Inferred from direct assay PubMed 16757682. Source: MGI sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 452

452

Friend leukemia integration 1 transcription factor

PRO_0000204125

Regions

Domain

112 – 198

PNT

DNA binding

281 – 361

ETS

Sequences

Sequence

Length

Mass (Da)

Tools

P26323 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 1F9A06C6893FE2AB
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FASTA

452

51,002

        10         20         30         40         50         60 
MDGTIKEALS VVSDDQSLFD SAYGAAAHLP KADMTASGSP DYGQPHKINP LPPQQEWINQ 

        70         80         90        100        110        120 
PVRVNVKREY DHMNGSRESP VDCSVSKCNK LVGGGEANPM NYNSYMDEKN GPPPPNMTTN 

       130        140        150        160        170        180 
ERRVIVPADP TLWTQEHVRQ WLEWAIKEYG LMEIDTSFFQ NMDGKELCKM NKEDFLRATS 

       190        200        210        220        230        240 
AYNTEVLLSH LSYLRESSLL AYNTTSHTDQ SSRLNVKEDP SYDSVRRGAW NNNMNSGLNK 

       250        260        270        280        290        300 
SPLLGGSQTM GKNTEQRPQP DPYQILGPTS SRLANPGSGQ IQLWQFLLEL LSDSANASCI 

       310        320        330        340        350        360 
TWEGTNGEFK MTDPDEVARR WGERKSKPNM NYDKLSRALR YYYDKNIMTK VHGKRYAYKF 

       370        380        390        400        410        420 
DFHGIAQALQ PHPTETSMYK YPSDISYMPS YHAHQQKVNF VPSHPSSMPV TSSSFFGAAS 

       430        440        450 
QYWTSPTAGI YPNPSVPRHP NTHVPSHLGS YY

« Hide

References

[1]	"Erythroleukemia induction by Friend murine leukemia virus: insertional activation of a new member of the ets gene family, Fli-1, closely linked to c-ets-1." Ben-David Y., Giddens E.B., Letwin K., Bernstein A. Genes Dev. 5:908-918(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Spleen.
[2]	"The Fli-1 proto-oncogene, involved in erythroleukemia and Ewing's sarcoma, encodes a transcriptional activator with DNA-binding specificities distinct from other Ets family members." Zhang L., Lemarchandel V., Romeo P.-H., Ben-David Y., Greer P., Bernstein A. Oncogene 8:1621-1630(1993) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X59421 mRNA. Translation: CAA42055.1.
IPI	IPI00331273.
PIR	S17403.
RefSeq	NP_032052.1. NM_008026.4.
UniGene	Mm.258908.
3D structure databases
ProteinModelPortal	P26323.
SMR	P26323. Positions 114-254, 276-373.
ModBase	Search...
Protein-protein interaction databases
IntAct	P26323. 2 interactions.
PTM databases
PhosphoSite	P26323.
Proteomic databases
PaxDb	P26323.
PRIDE	P26323.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000016231; ENSMUSP00000016231; ENSMUSG00000016087.
GeneID	14247.
KEGG	mmu:14247.
Organism-specific databases
CTD	2313.
MGI	MGI:95554. Fli1.
Phylogenomic databases
eggNOG	NOG242679.
HOGENOM	HOG000290658.
HOVERGEN	HBG001553.
InParanoid	P26323.
KO	K09436.
OMA	KYPSDIP.
OrthoDB	EOG49078T.
Gene expression databases
ArrayExpress	P26323.
Bgee	P26323.
CleanEx	MM_FLI1.
Genevestigator	P26323.
GermOnline	ENSMUSG00000016087. Mus musculus.
Family and domain databases
Gene3D	1.10.10.10. 1 hit. 1.10.150.50. 1 hit.
InterPro	IPR000418. Ets_dom. IPR003118. Pointed_dom. IPR013761. SAM/pointed. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00178. Ets. 1 hit. PF02198. SAM_PNT. 1 hit. [Graphical view]
PRINTS	PR00454. ETSDOMAIN.
SMART	SM00413. ETS. 1 hit. SM00251. SAM_PNT. 1 hit. [Graphical view]
SUPFAM	SSF47769. SAM_homology. 1 hit.
PROSITE	PS00345. ETS_DOMAIN_1. 1 hit. PS00346. ETS_DOMAIN_2. 1 hit. PS50061. ETS_DOMAIN_3. 1 hit. PS51433. PNT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FLI1. mouse.
NextBio	285561.
PMAP-CutDB	P26323.
SOURCE	Search...

Entry information

Entry name

FLI1_MOUSE

Accession

Primary (citable) accession number: P26323

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	May 1, 1992
Last modified:	May 1, 2013
This is version 119 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents