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P26323 (FLI1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Friend leukemia integration 1 transcription factor
Alternative name(s):
Retroviral integration site protein Fli-1
Gene names
Name:Fli1
Synonyms:Fli-1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length452 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.

Subunit structure

Can form homodimers or heterodimers with ETV6/TEL1 By similarity.

Subcellular location

Nucleus.

Tissue specificity

Expressed in both hematopoietic and nonhematopoietic tissues.

Induction

Specifically up-regulated in leukemic clones with F-MuLV insertions up-stream of the FLI-1 locus.

Involvement in disease

Involved in erythroleukemia induction by Friend murine leukemia virus (F-MULV).

Sequence similarities

Belongs to the ETS family.

Contains 1 ETS DNA-binding domain.

Contains 1 PNT (pointed) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 452452Friend leukemia integration 1 transcription factor
PRO_0000204125

Regions

Domain112 – 19887PNT
DNA binding281 – 36181ETS

Sequences

Sequence LengthMass (Da)Tools
P26323 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 1F9A06C6893FE2AB

FASTA45251,002
        10         20         30         40         50         60 
MDGTIKEALS VVSDDQSLFD SAYGAAAHLP KADMTASGSP DYGQPHKINP LPPQQEWINQ 

        70         80         90        100        110        120 
PVRVNVKREY DHMNGSRESP VDCSVSKCNK LVGGGEANPM NYNSYMDEKN GPPPPNMTTN 

       130        140        150        160        170        180 
ERRVIVPADP TLWTQEHVRQ WLEWAIKEYG LMEIDTSFFQ NMDGKELCKM NKEDFLRATS 

       190        200        210        220        230        240 
AYNTEVLLSH LSYLRESSLL AYNTTSHTDQ SSRLNVKEDP SYDSVRRGAW NNNMNSGLNK 

       250        260        270        280        290        300 
SPLLGGSQTM GKNTEQRPQP DPYQILGPTS SRLANPGSGQ IQLWQFLLEL LSDSANASCI 

       310        320        330        340        350        360 
TWEGTNGEFK MTDPDEVARR WGERKSKPNM NYDKLSRALR YYYDKNIMTK VHGKRYAYKF 

       370        380        390        400        410        420 
DFHGIAQALQ PHPTETSMYK YPSDISYMPS YHAHQQKVNF VPSHPSSMPV TSSSFFGAAS 

       430        440        450 
QYWTSPTAGI YPNPSVPRHP NTHVPSHLGS YY 

« Hide

References

[1]"Erythroleukemia induction by Friend murine leukemia virus: insertional activation of a new member of the ets gene family, Fli-1, closely linked to c-ets-1."
Ben-David Y., Giddens E.B., Letwin K., Bernstein A.
Genes Dev. 5:908-918(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Spleen.
[2]"The Fli-1 proto-oncogene, involved in erythroleukemia and Ewing's sarcoma, encodes a transcriptional activator with DNA-binding specificities distinct from other Ets family members."
Zhang L., Lemarchandel V., Romeo P.-H., Ben-David Y., Greer P., Bernstein A.
Oncogene 8:1621-1630(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X59421 mRNA. Translation: CAA42055.1.
CCDSCCDS40571.1.
PIRS17403.
RefSeqNP_032052.1. NM_008026.4.
UniGeneMm.258908.

3D structure databases

ProteinModelPortalP26323.
SMRP26323. Positions 114-254, 276-373.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199702. 1 interaction.
IntActP26323. 2 interactions.
MINTMINT-1578124.

PTM databases

PhosphoSiteP26323.

Proteomic databases

MaxQBP26323.
PaxDbP26323.
PRIDEP26323.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000016231; ENSMUSP00000016231; ENSMUSG00000016087.
GeneID14247.
KEGGmmu:14247.
UCSCuc009orz.1. mouse.

Organism-specific databases

CTD2313.
MGIMGI:95554. Fli1.

Phylogenomic databases

eggNOGNOG242679.
HOGENOMHOG000290658.
HOVERGENHBG001553.
InParanoidP26323.
KOK09436.
OMAKNGPPPN.
OrthoDBEOG73V6K8.
PhylomeDBP26323.
TreeFamTF350537.

Gene expression databases

ArrayExpressP26323.
BgeeP26323.
CleanExMM_FLI1.
GenevestigatorP26323.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSPR00454. ETSDOMAIN.
SMARTSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMSSF47769. SSF47769. 1 hit.
PROSITEPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFLI1. mouse.
NextBio285561.
PMAP-CutDBP26323.
PROP26323.
SOURCESearch...

Entry information

Entry nameFLI1_MOUSE
AccessionPrimary (citable) accession number: P26323
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: July 9, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot