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Protein

Proteinase p15

Gene

gag

Organism
Avian myeloblastosis associated virus (MAV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Specifically liberates the five major structural proteins from the common gag precursor, as well as reverse transcriptase and integrase from the gag-pol precursor.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei371

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

BRENDAi3.4.23.B13. 592.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteinase p15 (EC:3.4.23.-)
Gene namesi
Name:gag
OrganismiAvian myeloblastosis associated virus (MAV)
Taxonomic identifieri11960 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeAlpharetrovirusunclassified Alpharetrovirus
Virus hostiGalliformes [TaxID: 8976]

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001995541 – 124Proteinase p15Add BLAST124

Interactioni

Subunit structurei

The protease is active as a homodimer.

Structurei

Secondary structure

1124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 4Combined sources3
Beta strandi7 – 9Combined sources3
Beta strandi12 – 19Combined sources8
Beta strandi21 – 23Combined sources3
Beta strandi28 – 36Combined sources9
Beta strandi44 – 46Combined sources3
Turni47 – 49Combined sources3
Beta strandi56 – 58Combined sources3
Beta strandi74 – 78Combined sources5
Beta strandi80 – 85Combined sources6
Beta strandi95 – 97Combined sources3
Beta strandi100 – 102Combined sources3
Beta strandi105 – 109Combined sources5
Helixi111 – 116Combined sources6
Beta strandi120 – 122Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MVPX-ray2.20A/B1-124[»]
2MVPmodel-A/B1-124[»]
ProteinModelPortaliP26315.
SMRiP26315.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26315.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 113Peptidase A2PROSITE-ProRule annotationAdd BLAST82

Sequence similaritiesi

Contains 1 peptidase A2 domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di2.40.70.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR018061. Retropepsins.
[Graphical view]
PfamiPF00077. RVP. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P26315-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LAMTMEHKDR PLVRVILTNT GSHPVKQRSV YITALLDSGA DITIISEEDW
60 70 80 90 100
PTDWPVMEAA NPQIHGIGGG IPMRKSRDMI EVGVINRDGS LERPLLLFPA
110 120
VAMVRGSILG RDCLQGLGLR LTNL
Length:124
Mass (Da):13,596
Last modified:May 1, 1992 - v1
Checksum:i3B8FF451AF43BBB1
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MVPX-ray2.20A/B1-124[»]
2MVPmodel-A/B1-124[»]
ProteinModelPortaliP26315.
SMRiP26315.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi3.4.23.B13. 592.

Miscellaneous databases

EvolutionaryTraceiP26315.

Family and domain databases

Gene3Di2.40.70.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR018061. Retropepsins.
[Graphical view]
PfamiPF00077. RVP. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGAG_AVIMA
AccessioniPrimary (citable) accession number: P26315
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 2, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is synthesized as a Gag-Pol polyprotein.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.