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Protein

Cytochrome c oxidase polypeptide 6, mitochondrial

Gene

cxfA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase polypeptide 6, mitochondrial (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide VI
Gene namesi
Name:cxfA
Synonyms:cox6
ORF Names:DDB_G0282097
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0282097. cxfA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei34 – 5320HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 9392Cytochrome c oxidase polypeptide 6, mitochondrialPRO_0000194086Add
BLAST

Proteomic databases

PaxDbiP26310.
PRIDEiP26310.

Interactioni

Subunit structurei

Slime mold cytochrome c oxidase consists of at least seven different polypeptides species, subunits I, II, III, IV, V, VI, and VIIe/s in order of MW.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase IV family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP26310.
OMAiRYPKGFK.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26310-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTGNESYNL RYPKGFKGYP YNMYKLEGYG TPKGYITLIG VVATLTVSGL
60 70 80 90
FFAKTRSNKR EYPTHNKEWR AKTLAYAKET NADPIYQLPK DKI
Length:93
Mass (Da):10,666
Last modified:January 23, 2007 - v2
Checksum:i6D73D3EA4A448A96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55672 mRNA. Translation: CAA39207.1.
AAFI02000045 Genomic DNA. Translation: EAL66374.1.
PIRiS17190. OGDO6.
RefSeqiXP_640351.1. XM_635259.1.

Genome annotation databases

EnsemblProtistsiDDB0215013; DDB0215013; DDB_G0282097.
GeneIDi8623406.
KEGGiddi:DDB_G0282097.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55672 mRNA. Translation: CAA39207.1.
AAFI02000045 Genomic DNA. Translation: EAL66374.1.
PIRiS17190. OGDO6.
RefSeqiXP_640351.1. XM_635259.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiP26310.
PRIDEiP26310.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0215013; DDB0215013; DDB_G0282097.
GeneIDi8623406.
KEGGiddi:DDB_G0282097.

Organism-specific databases

dictyBaseiDDB_G0282097. cxfA.

Phylogenomic databases

InParanoidiP26310.
OMAiRYPKGFK.

Miscellaneous databases

PROiP26310.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCOX6_DICDI
AccessioniPrimary (citable) accession number: P26310
Secondary accession number(s): Q54T04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: January 23, 2007
Last modified: December 9, 2015
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.