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Protein

Guanine nucleotide-binding protein subunit beta-1

Gene

Gbeta13F

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

GO - Biological processi

  • apical protein localization Source: FlyBase
  • asymmetric neuroblast division Source: FlyBase
  • cell adhesion involved in heart morphogenesis Source: FlyBase
  • convergent extension involved in gastrulation Source: FlyBase
  • establishment or maintenance of cytoskeleton polarity involved in gastrulation Source: FlyBase
  • G-protein coupled receptor signaling pathway Source: FlyBase
  • mesectoderm development Source: FlyBase
  • regulation of gastrulation Source: FlyBase
  • regulation of myosin II filament organization Source: FlyBase

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-DME-1296041. Activation of G protein gated Potassium channels.
R-DME-418555. G alpha (s) signalling events.
R-DME-418594. G alpha (i) signalling events.
R-DME-418597. G alpha (z) signalling events.
R-DME-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
R-DME-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
SignaLinkiP26308.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit beta-1
Gene namesi
Name:Gbeta13F
Synonyms:Gb13F
ORF Names:CG10545
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0001105. Gbeta13F.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001277151 – 340Guanine nucleotide-binding protein subunit beta-1Add BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP26308.
PRIDEiP26308.

PTM databases

iPTMnetiP26308.

Expressioni

Tissue specificityi

In adults, expression is higher in the head than in the body.1 Publication

Developmental stagei

Expressed throughout development.1 Publication

Gene expression databases

BgeeiFBgn0001105.
ExpressionAtlasiP26308. differential.
GenevisibleiP26308. DM.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

BioGridi58892. 9 interactors.
DIPiDIP-18432N.
IntActiP26308. 1 interactor.
MINTiMINT-1016369.
STRINGi7227.FBpp0089182.

Structurei

3D structure databases

ProteinModelPortaliP26308.
SMRiP26308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati53 – 83WD 1Add BLAST31
Repeati95 – 125WD 2Add BLAST31
Repeati141 – 170WD 3Add BLAST30
Repeati182 – 212WD 4Add BLAST31
Repeati224 – 254WD 5Add BLAST31
Repeati268 – 298WD 6Add BLAST31
Repeati310 – 340WD 7Add BLAST31

Sequence similaritiesi

Belongs to the WD repeat G protein beta family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0286. Eukaryota.
ENOG410XQUX. LUCA.
GeneTreeiENSGT00760000119239.
InParanoidiP26308.
KOiK04536.
OMAiTCNVWDT.
OrthoDBiEOG091G0A7T.
PhylomeDBiP26308.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR011042. 6-blade_b-propeller_TolB-like.
IPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR016346. Guanine_nucleotide-bd_bsu.
IPR015943. WD40/YVTN_repeat-like_dom_sf.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR036322. WD40_repeat_dom_sf.
PANTHERiPTHR19850. PTHR19850. 1 hit.
PfamiView protein in Pfam
PF00400. WD40. 6 hits.
PRINTSiPR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
SMARTiView protein in SMART
SM00320. WD40. 7 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

P26308-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNELDSLRQE AESLKNAIRD ARKAACDTSL LQAATSLEPI GRIQMRTRRT
60 70 80 90 100
LRGHLAKIYA MHWGNDSRNL VSASQDGKLI VWDSHTTNKV HAIPLRSSWV
110 120 130 140 150
MTCAYAPSGS YVACGGLDNM CSIYNLKTRE GNVRVSRELP GHGGYLSCCR
160 170 180 190 200
FLDDNQIVTS SGDMSCGLWD IETGLQVTSF LGHTGDVMAL SLAPQCKTFV
210 220 230 240 250
SGACDASAKL WDIREGVCKQ TFPGHESDIN AVTFFPNGQA FATGSDDATC
260 270 280 290 300
RLFDIRADQE LAMYSHDNII CGITSVAFSK SGRLLLAGYD DFNCNVWDTM
310 320 330 340
KAERSGILAG HDNRVSCLGV TENGMAVATG SWDSFLRVWN
Length:340
Mass (Da):37,133
Last modified:May 1, 1992 - v1
Checksum:i5A4B70DCB0A1C32C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22567 Genomic DNA. Translation: AAB59247.1.
AE014298 Genomic DNA. Translation: AAF48530.1.
AY058566 mRNA. Translation: AAL13795.1.
PIRiA40489. RGFFBH.
RefSeqiNP_001303567.1. NM_001316638.2.
NP_525090.1. NM_080351.7.
NP_996459.1. NM_206736.2.
NP_996460.1. NM_206737.2.
NP_996461.1. NM_206738.3.
NP_996462.1. NM_206739.2.
UniGeneiDm.7041.

Genome annotation databases

EnsemblMetazoaiFBtr0074106; FBpp0073920; FBgn0001105.
FBtr0074107; FBpp0073921; FBgn0001105.
FBtr0074108; FBpp0089182; FBgn0001105.
FBtr0074110; FBpp0089184; FBgn0001105.
FBtr0074111; FBpp0089185; FBgn0001105.
FBtr0331597; FBpp0303987; FBgn0001105.
FBtr0346794; FBpp0312372; FBgn0001105.
GeneIDi32544.
KEGGidme:Dmel_CG10545.

Similar proteinsi

Entry informationi

Entry nameiGBB1_DROME
AccessioniPrimary (citable) accession number: P26308
Secondary accession number(s): Q9VXM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 22, 2017
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families