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Protein

Positive alginate biosynthesis regulatory protein

Gene

algR

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Positive regulator of the algD gene, which codes for a GDP-mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway.

Pathwayi: alginate biosynthesis

This protein regulates the pathway alginate biosynthesis, which is part of Glycan biosynthesis.
View all proteins of this organism that are known to be involved in the pathway alginate biosynthesis and in Glycan biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • alginic acid biosynthetic process Source: UniProtKB-UniPathway
  • bacterial-type flagellum-dependent swarming motility Source: PseudoCAP
  • negative regulation of transcription, DNA-templated Source: CollecTF
  • phosphorelay signal transduction system Source: UniProtKB-KW
  • positive regulation of cell motility Source: PseudoCAP
  • positive regulation of single-species biofilm formation Source: PseudoCAP
  • positive regulation of transcription, DNA-templated Source: CollecTF
  • regulation of response to reactive oxygen species Source: PseudoCAP
  • regulation of transcription, DNA-templated Source: CollecTF
  • transcription, DNA-templated Source: UniProtKB-KW
  • type IV pilus-dependent motility Source: PseudoCAP

Keywordsi

Molecular functionActivator, DNA-binding
Biological processAlginate biosynthesis, Transcription, Transcription regulation, Two-component regulatory system

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-5382-MONOMER.
UniPathwayiUPA00286.

Names & Taxonomyi

Protein namesi
Recommended name:
Positive alginate biosynthesis regulatory protein
Gene namesi
Name:algR
Ordered Locus Names:PA5261
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA5261.

Subcellular locationi

GO - Cellular componenti

  • intracellular Source: GOC
  • protein-DNA complex Source: CollecTF

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000810071 – 248Positive alginate biosynthesis regulatory proteinAdd BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei544-aspartylphosphatePROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP26275.
PRIDEiP26275.

Expressioni

Gene expression databases

CollecTFiEXPREG_000009d0.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA5261.

Structurei

3D structure databases

ProteinModelPortaliP26275.
SMRiP26275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 117Response regulatoryPROSITE-ProRule annotationAdd BLAST116
Domaini142 – 247HTH LytTR-typePROSITE-ProRule annotationAdd BLAST106

Phylogenomic databases

eggNOGiENOG4108NEV. Bacteria.
COG3279. LUCA.
HOGENOMiHOG000242207.
InParanoidiP26275.
KOiK08083.
OMAiKAERPNR.
PhylomeDBiP26275.

Family and domain databases

CDDicd00156. REC. 1 hit.
InterProiView protein in InterPro
IPR011006. CheY-like_superfamily.
IPR007492. LytTR_DNA-bd_dom.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF04397. LytTR. 1 hit.
PF00072. Response_reg. 1 hit.
SMARTiView protein in SMART
SM00850. LytTR. 1 hit.
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiView protein in PROSITE
PS50930. HTH_LYTTR. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

P26275-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVLIVDDEP LARERLARLV GQLDGYRVLE PSASNGEEAL TLIDSLKPDI
60 70 80 90 100
VLLDIRMPGL DGLQVAARLC EREAPPAVIF CTAHDEFALE AFQVSAVGYL
110 120 130 140 150
VKPVRSEDLA EALKKASRPN RVQLAALTKP PASGGSGPRS HISARTRKGI
160 170 180 190 200
ELIPLEEVIF FIADHKYVTL RHAQGEVLLD EPLKALEDEF GERFVRIHRN
210 220 230 240
ALVARERIER LQRTPLGHFQ LYLKGLDGDA LTVSRRHVAG VRRLMHQL
Length:248
Mass (Da):27,608
Last modified:May 1, 1992 - v1
Checksum:iA3C0E614D6CE8C52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23230 Genomic DNA. Translation: AAA25704.1.
AE004091 Genomic DNA. Translation: AAG08646.1.
M29096 Genomic DNA. Translation: AAA25706.1.
M74844 Genomic DNA. Translation: AAA18906.1.
PIRiA32802.
RefSeqiNP_253948.1. NC_002516.2.
WP_003096397.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG08646; AAG08646; PA5261.
GeneIDi877674.
KEGGipae:PA5261.
PATRICifig|208964.12.peg.5514.

Similar proteinsi

Entry informationi

Entry nameiALGR_PSEAE
AccessioniPrimary (citable) accession number: P26275
Secondary accession number(s): Q6LDH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: February 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome